(Press-News.org) WASHINGTON—A new Scientific Statement released today by the Endocrine Society highlights potential research directions related to the pathogenesis of type 1 diabetes (T1D) that should help with the development of new and improved treatment options.
Type 1 diabetes is a chronic disease where the body's immune system attacks and destroys insulin-producing cells in the pancreatic islet. Type 1 diabetes requires lifelong insulin administration and may result in complications such as eye, kidney, nerve, and heart disease. Type 1 diabetes is usually thought to be a disease of children and adolescents, but it is now recognized that T1D often has its onset in adults and can occur at any age.
The Endocrine Society develops Scientific Statements to explore the scientific basis of hormone-related conditions and diseases, discuss how this knowledge can be applied in practice, and identify areas that require additional research. Topics are selected on the basis of their emerging scientific impact. Scientific Statements are developed by a Task Force of experts appointed by the Endocrine Society, with internal review by the relevant Society committees and expert external reviewers prior to a comment period open to all members of the Society.
“The Endocrine Society chose type 1 diabetes for a Scientific Statement because research related to T1D is rapidly expanding, and the field is poised for new advances. The hope is that the Scientific Statement will provide scientists, physicians, and funding agencies with a guide for areas of research that seem particularly promising,” said Alvin C. Powers, M.D., of Vanderbilt University Medical Center in Nashville, Tenn., a member of the writing group.
According to the International Diabetes Federation, 9 million people had type 1 diabetes in 2024 with considerable variation in the rates across countries.
The causes and factors that lead to type 1 diabetes are unknown. The Scientific Statement summarized research and suggested directions for new research in these areas related to T1D: genetics, heterogeneity, pathology of the pancreas, assessment of β cell function and mass, immunologic biomarkers in peripheral blood, changes in the exocrine pancreas, and screening to identify individuals at-risk for T1D.
“The data highlights the need for population-based screening for type 1 diabetes and more research into the causes of the disease,” Powers said. “We hope addressing these research gaps and incorporating more widespread screening efforts will help identify those at risk sooner and improve treatment and long-term health outcomes for people living with type 1 diabetes.”
The statement is based on the authors’ updated version of the widely cited and often modified Eisenbarth model, which outlines the different stages of progression to type 1 diabetes. The Scientific Statement proposes that Stage 0 be added to this model which already included Stages 1, 2, and 3, to highlight that there are likely events occurring earlier in the disease that currently are not understood or being studied.
“We hope that research in these areas infused with information from the application of emerging technological and analytical tools will lead to a new understanding of the pathogenesis of type 1 diabetes,” Powers concluded.
Other statement authors are Aaron Michels of University of the Colorado School of Medicine in Denver, Colo.; Todd Brusko of the University of Florida in Gainesville, Fla.; Carmella Evans-Molina of Indiana University School of Medicine and the Roudebush VA Medical Center in Indianapolis, Ind.; Dirk Homann of the University of Miami, Miami, Fla.; and Sarah Richardson of the University of Exeter Medical School in Exeter, U.K.
The statement, “Challenges and Opportunities for Understanding the Pathogenesis of Type 1 Diabetes: An Endocrine Society Scientific Statement,” was published online in the Society’s journal, The Journal of Clinical Endocrinology & Metabolism.
# # #
Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world’s oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions.
The Society has more than 18,000 members, including scientists, physicians, educators, nurses and students in 122 countries. To learn more about the Society and the field of endocrinology, visit our site at www.endocrine.org. Follow us on Twitter at @TheEndoSociety and @EndoMedia.
END
Endocrine Society proposes research efforts to improve treatment options for people with type 1 diabetes
Scientific Statement aims to expand our research to advance the understanding of the cause and progression of T1D
2025-07-09
ELSE PRESS RELEASES FROM THIS DATE:
In menopause, sleep is vitally important for women’s long-term heart health, study finds
2025-07-09
PITTSBURGH, July 9, 2025 — During the menopause transition, only 1 in 5 women have optimal scores using the American Heart Association’s health-assessment tool, known as Life’s Essential 8 (LE8). Among the tool’s eight components, four of them — blood glucose, blood pressure, sleep quality and nicotine use — are key in driving future cardiovascular risks, with sleep being particularly crucial for long-term cardiovascular health.
The findings – published today in Menopause – were made by researchers at the University of Pittsburgh, Albert Einstein College of Medicine and Baylor University.
“Previously ...
Why do some brain regions resist Alzheimer’s?
2025-07-09
It’s been recognized for some time that Alzheimer’s disease affects brain regions differently and that tau — a protein known to misbehave — plays an important role in the disease. Normally, tau helps stabilize neurons, but in Alzheimer’s disease, it begins to misfold and tangle inside neurons. It spreads across the brain forming toxic clumps that impair neuronal function and ultimately lead to cell death.
Brain areas like the entorhinal cortex and hippocampus succumb early to tau tangles, while other areas, like the primary sensory cortices, remain resilient to the disease. In the quest to better understand this selective ...
Like humans, monkeys are attracted to videos showing conflict
2025-07-09
COLUMBUS, Ohio – Have you ever wondered what kind of video content would most grab the attention of monkeys?
A new study of long-tailed macaques suggests the monkeys seem to like some of the same kind of content that humans do: videos featuring aggression and individuals they know.
“Humans and macaques are both social animals who have a fundamental need to belong,” said Brad Bushman, co-author of the study and professor of communication at The Ohio State University.
“It’s not surprising that they both would be most interested in the video content that may help ...
Dr. Richard M. Peterson elected 39th president of American Society for Metabolic and Bariatric Surgery
2025-07-09
Newberry, FL – July 9, 2025 – Richard M. Peterson, MD, MPH, FACS, FASMBS, DABS-FPMBS, Professor and Chief of Metabolic and Bariatric Surgery at UT Health San Antonio, TX, has been elected the new president of the American Society for Metabolic and Bariatric Surgery (ASMBS), the nation’s largest professional organization of metabolic and bariatric surgeons and integrated health professionals focused on the treatment of obesity.
Dr. Peterson has been a member of the ASMBS for nearly 20 years and a board member since 2019. He has chaired the society’s ...
Addressing “spay-neuter syndrome" with testosterone restoration for neutered male dogs
2025-07-09
The Parsemus Foundation, a nonprofit dedicated to advancing pet health, today announced the publication of groundbreaking research on the safety and dosing of testosterone therapy for neutered male dogs. Published in BMC Veterinary Research, this pivotal study provides crucial data for veterinarians to treat "spay-neuter syndrome” - a collection of health and behavioral problems associated with hormone loss following sterilization. Results show that injectable testosterone can safely restore physiological hormone levels in neutered dogs, offering ...
The ACMG releases 2025 update to secondary findings gene list; SF v3.3
2025-07-09
BETHESDA, MD – July 9, 2025 | The American College of Medical Genetics and Genomics (ACMG) has released its highly anticipated 2025 update to the recommended minimum gene list for the reporting of secondary findings (SF) in clinical exome and genome sequencing: “ACMG SF v3.3 List for Reporting of Secondary Findings in Clinical Exome and Genome Sequencing: A Policy Statement of the American College of Medical Genetics and Genomics.”
As part of its ongoing commitment to annual updates, ...
More rural, minoritized people get amputations – AI gets closer to why
2025-07-09
Why do rural adults and racial and ethnic minorities with vascular disease get major leg amputations more often? A new study out today in Epidemiology uses AI to solve the mystery, finding an unaccounted-for factor that researchers think points to implicit bias in the clinical decision-making process.
“The AI model allowed us to distinguish among the many reasons behind these much higher rates of amputation among certain groups of people with vascular disease,” said Paula Strassle, ...
First look at defects in single-crystal indium gallium zinc oxide could fix persistent display instability
2025-07-09
Many displays found in smartphones and televisions rely on thin-film transistors (TFTs) made from indium gallium zinc oxide (IGZO) to control pixels. IGZO offers high transparency due to its large bandgap (the gap existing between the valence and conduction bands), high conductivity, and can operate even in an amorphous (non-crystalline) form, making it ideal for displays, flexible electronics, and solar cells. However, IGZO-based devices face long-term stability issues, such as negative bias illumination stress, ...
Understanding childhood maltreatment and its effect on biological aging
2025-07-09
Childhood maltreatment leaves a lasting impact that goes far beyond physical injuries or fading memories. Scientific evidence has long shown that children who experience abuse and neglect face increased risk of chronic diseases, mental health disorders, and premature death throughout their lives. Beneath these visible signs lies a deeper truth: childhood maltreatment can fundamentally alter a child’s biology, triggering molecular changes that can last for decades.
Recent research is unravelling that childhood maltreatment doesn’t ...
Turning step-growth into chain-growth with click polymerization
2025-07-09
A controlled/“living” click polymerization method developed by researchers at Institute of Science Tokyo and Nagoya University enables precise chain-growth of AB-type monomers—traditionally limited to step-growth processes—by leveraging copper-catalyzed azide–alkyne cycloaddition. The approach achieves well-defined polymers with narrow dispersity and enables the bidirectional synthesis of ABA-type block copolymers, offering a powerful new strategy for constructing functional macromolecular architectures from a wide range of monomers.
Traditional polyaddition reactions involving AB-type monomers, which contain both azide and alkyne ...
LAST 30 PRESS RELEASES:
ASU researchers to lead AAAS panel on water insecurity in the United States
ASU professor Anne Stone to present at AAAS Conference in Phoenix on ancient origins of modern disease
Proposals for exploring viruses and skin as the next experimental quantum frontiers share US$30,000 science award
ASU researchers showcase scalable tech solutions for older adults living alone with cognitive decline at AAAS 2026
Scientists identify smooth regional trends in fruit fly survival strategies
Antipathy toward snakes? Your parents likely talked you into that at an early age
Sylvester Cancer Tip Sheet for Feb. 2026
Online exposure to medical misinformation concentrated among older adults
Telehealth improves access to genetic services for adult survivors of childhood cancers
Outdated mortality benchmarks risk missing early signs of famine and delay recognizing mass starvation
Newly discovered bacterium converts carbon dioxide into chemicals using electricity
Flipping and reversing mini-proteins could improve disease treatment
Scientists reveal major hidden source of atmospheric nitrogen pollution in fragile lake basin
Biochar emerges as a powerful tool for soil carbon neutrality and climate mitigation
Tiny cell messengers show big promise for safer protein and gene delivery
AMS releases statement regarding the decision to rescind EPA’s 2009 Endangerment Finding
Parents’ alcohol and drug use influences their children’s consumption, research shows
Modular assembly of chiral nitrogen-bridged rings achieved by palladium-catalyzed diastereoselective and enantioselective cascade cyclization reactions
Promoting civic engagement
AMS Science Preview: Hurricane slowdown, school snow days
Deforestation in the Amazon raises the surface temperature by 3 °C during the dry season
Model more accurately maps the impact of frost on corn crops
How did humans develop sharp vision? Lab-grown retinas show likely answer
Sour grapes? Taste, experience of sour foods depends on individual consumer
At AAAS, professor Krystal Tsosie argues the future of science must be Indigenous-led
From the lab to the living room: Decoding Parkinson’s patients movements in the real world
Research advances in porous materials, as highlighted in the 2025 Nobel Prize in Chemistry
Sally C. Morton, executive vice president of ASU Knowledge Enterprise, presents a bold and practical framework for moving research from discovery to real-world impact
Biochemical parameters in patients with diabetic nephropathy versus individuals with diabetes alone, non-diabetic nephropathy, and healthy controls
Muscular strength and mortality in women ages 63 to 99
[Press-News.org] Endocrine Society proposes research efforts to improve treatment options for people with type 1 diabetesScientific Statement aims to expand our research to advance the understanding of the cause and progression of T1D