PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Young human blood serum factors show potential to rejuvenate skin through bone marrow

“[…] we were able to reproduce systemic rejuvenating effects of circulating blood factors on the human skin, which have been so far only demonstrated in rodent heterochronic parabiosis studies”

2025-08-01
(Press-News.org)

“[…] we were able to reproduce systemic rejuvenating effects of circulating blood factors on the human skin, which have been so far only demonstrated in rodent heterochronic parabiosis studies.”

BUFFALO, NY — August 1, 2025 — A new research paper featured on the cover of Volume 17, Issue 7 of Aging (Aging-US) was published on July 25, 2025, titled “Systemic factors in young human serum influence in vitro responses of human skin and bone marrow-derived blood cells in a microphysiological co-culture system.”

The study, led by first author Johanna Ritter and corresponding author Elke Grönniger from Beiersdorf AG, Research and Development Hamburg, shows that components in young human blood serum can help restore youthful properties to skin, but only when bone marrow cells are also present. This discovery highlights the role of bone marrow in supporting skin health and may allow for novel approaches aimed at slowing or reversing visible signs of aging.

The research explored how factors present in blood serum, already known to influence aging in animal studies, act on human cells. Using an advanced system that mimics human circulation, the researchers connected a 3D skin model with a 3D bone marrow model. They found that young human serum alone was not enough to rejuvenate skin. However, when bone marrow cells were present, these serum factors changed the activity of those cells, which then secreted proteins that rejuvenated skin tissue.

“Interestingly, we detected a significant increase in Ki67 positive cells in the dynamic skin model co-cultured with BM model and young serum compared to the model co-cultured with BM and old serum, indicating an improved regenerative capacity of the tissue.”

Detailed analysis indicated that young serum stimulated the bone marrow to produce a group of 55 proteins, with 7 of them demonstrating the ability to boost cell renewal, collagen production, and other features associated with youthful skin. These proteins included factors that improved energy production in cells and reduced signs of cellular aging. Without the interaction between skin and bone marrow cells, these rejuvenating effects did not occur.

This finding explains why earlier experiments in mice, where young and old animals shared a blood supply, showed rejuvenation across organs. It suggests that bone marrow-derived cells are critical messengers that transform signals from blood into effects on other tissues, including the skin.

While these results are preclinical and not from human trials, they offer a starting point for new strategies in regenerative medicine and skin care. By identifying specific proteins that may carry rejuvenating signals, the study points to a new way to address age-related changes. Researchers emphasize that further studies will be needed to confirm these effects in humans and to test how these proteins can be safely and effectively applied in future therapies.

Overall, this research is an important step in understanding how young blood serum factors influence human tissue and could guide the development of novel methods to maintain healthier skin as people age.

Read the full paper: DOI: https://doi.org/10.18632/aging.206288

Corresponding author: Elke Grönniger – elke.groenniger@beiersdorf.com

Keywords: aging, skin rejuvenation, microphysiological systems, systemic factors, bone marrow model, human serum

Click here to sign up for free Altmetric alerts about this article.

______

To learn more about the journal, please visit our website at www.Aging-US.com​​ and connect with us on social media at:

Facebook X Instagram YouTube LinkedIn Reddit Bluesky Pinterest Spotify, and available wherever you listen to podcasts

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

END



ELSE PRESS RELEASES FROM THIS DATE:

Large language models reshape the future of task planning

2025-08-01
A comprehensive survey published May 23 in Intelligent Computing, a Science Partner Journal maps out the role of large language models in task planning, underscoring the growing influence of artificial intelligence in complex decision-making tasks. Traditionally reliant on expert systems and manual configuration, task planning is essential for organizing action sequences to achieve defined goals, and is now being redefined by the advanced reasoning capabilities of large language models. The survey offers a comprehensive synthesis of how these models are reshaping ...

Narrower coverage of MS drugs tied to higher relapse risk

2025-08-01
Medicare drug plans are increasingly excluding coverage of new specialty drugs that treat complex conditions like cancers and autoimmune diseases. New research from the USC Schaeffer Center shows how these barriers may come at a cost to patients’ health. In a large study of Medicare beneficiaries with multiple sclerosis (MS), researchers found those in plans with broader coverage of MS treatments had significantly lower risk of developing new or worsening symptoms months later. The findings, published Aug. 1 in JAMA Network Open, suggest that plans with narrower coverage of MS treatments may be linked to worse health ...

Researchers harness AI-powered protein design to enhance T-cell based immunotherapies

2025-08-01
A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function. These so-called soluble Notch agonists can be broadly applied to optimize clinical T-cell production and advance immunotherapy development. Notch signaling is central to many cellular differentiation processes and is essential in transforming human immune cells into T-cells that target ...

Smartphone engagement during school hours among US youths

2025-08-01
About The Study: This cross-sectional study found that when adolescents had their phones at school, they spent nearly an hour per school day on smartphones, with most of this time on social media. The results extend prior work indicating that smartphone use during instructional hours, especially social-specific use, is not trivial. These results also highlight developmental differences, with younger adolescents using smartphones and social media less than older adolescents. Corresponding author: To contact the corresponding author, Scott H. Kollins, Ph.D., email scott@aura.com. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi: ...

Online reviews of health care facilities

2025-08-01
About The Study: In this cross-sectional analysis, negative patient experiences frequently centered on quality of communication and administrative issues. Negative feedback centered on unmet expectations, whereas positive reviews emphasized supportive staff interactions. Corresponding author: To contact the corresponding author, Neil K.R. Sehgal, M.E., email neilsehgal99@gmail.com. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi: 10.1001/jamanetworkopen.2025.24505) Editor’s Note: Please see the article for additional ...

MS may begin far earlier than previously thought

2025-08-01
The earliest warning signs of multiple sclerosis (MS) may emerge more than a decade before the first classical neurological symptoms occur, according to new research from the University of British Columbia. Published today in JAMA Network Open, the study analyzed the health records of more than 12,000 people in British Columbia and found that those with MS began using healthcare services at elevated rates 15 years before their first MS symptoms appear. The findings challenge long-held assumptions about when the disease truly begins, offering the most comprehensive ...

New AI tool learns to read medical images with far less data

2025-08-01
A new artificial intelligence (AI) tool could make it much easier—and cheaper—for doctors and researchers to train medical imaging software, even when only a small number of patient scans are available. The AI tool improves upon a process called medical image segmentation, where every pixel in an image is labeled based on what it represents—cancerous or normal tissue, for example. This process is often performed by a highly trained expert, and deep learning has shown promise in automating this labor-intensive task. The big challenge is that deep learning-based ...

Announcing XPRIZE Healthspan as Tier 5 Sponsor of ARDD 2025

2025-08-01
The University of Copenhagen is excited to announce XPRIZE Healthspan as Tier 5 Sponsor of the 12th Aging Research & Drug Discovery Meeting, the world's largest conference on aging research in the biopharmaceutical industry that will transpire on August 25 - August 29, 2025 on-site at the Ceremonial Hall, University of Copenhagen, and online. ARDD has grown to become the largest and most important conference in longevity biotechnology. Each year, ARDD brings together a unique mix of academic luminaries, biotech innovators, investors, top pharmaceutical executives, physicians, and related health care professionals to discuss ...

Announcing Immortal Dragons as Tier 4 Sponsor of ARDD 2025

2025-08-01
The University of Copenhagen is excited to announce Immortal Dragons as Tier 4 Sponsor of the 12th Aging Research & Drug Discovery Meeting, the world's largest conference on aging research in the biopharmaceutical industry that will transpire on August 25 - August 29, 2025 on-site at the Ceremonial Hall, University of Copenhagen, and online. Immortal Dragons is a purpose-driven longevity fund headquartered in Singapore, supporting 15+ portfolio companies in longevity and radical life extension technologies. Immortal Dragons values impact rather than economic return, supporting moonshot longevity startups in radical life extension, key areas include: Wholebody replacement, ...

Reporting guideline for chatbot health advice studies

2025-08-01
About The Article: The rise in chatbot health advice studies is accompanied by heterogeneity in reporting standards, impacting their interpretability. This article provides reporting recommendations for studies evaluating the performance of generative artificial intelligence (AI)–driven chatbots when summarizing clinical evidence and providing health advice. This article is being published jointly in Artificial Intelligence in Medicine, Annals of Family Medicine, BJS, BMC Medicine, BMJ Medicine, JAMA Network Open, The Lancet, NEJM-AI, and Surgical Endoscopy.  Corresponding Author: To contact the corresponding ...

LAST 30 PRESS RELEASES:

Study unexpectedly finds living in rural, rather than urban environments in first five years of life could be a risk factor for developing type 1 diabetes

Editorial urges deeper focus on heart-lung interactions in pulmonary vascular disease

Five University of Tennessee faculty receive Fulbright Awards

5 advances to protect water sources, availability

OU Scholar awarded Fulbright for Soviet cinema research

Brain might become target of new type 1 diabetes treatments

‘Shore Wars:’ New research aims to resolve coastal conflict between oysters and mangroves, aiding restoration efforts

Why do symptoms linger in some people after an infection? A conversation on post-acute infection syndromes

Study reveals hidden drivers of asthma flare-ups in children

Physicists decode mysterious membrane behavior

New insights about brain receptor may pave way for next-gen mental health drugs

Melanoma ‘sat-nav’ discovery could help curb metastasis

When immune commanders misfire: new insights into rheumatoid arthritis inflammation

SFU researchers develop a new tool that brings blender-like lighting control to any photograph

Pups in tow, Yellowstone-area wolves trek long distances to stay near prey

AI breakthrough unlocks 'new' materials to replace lithium-ion batteries

Making molecules make sense: A regional explanation method reveals structure–property relationships

Partisan hostility, not just policy, drives U.S. protests

The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: August 1, 2025

Young human blood serum factors show potential to rejuvenate skin through bone marrow

Large language models reshape the future of task planning

Narrower coverage of MS drugs tied to higher relapse risk

Researchers harness AI-powered protein design to enhance T-cell based immunotherapies

Smartphone engagement during school hours among US youths

Online reviews of health care facilities

MS may begin far earlier than previously thought

New AI tool learns to read medical images with far less data

Announcing XPRIZE Healthspan as Tier 5 Sponsor of ARDD 2025

Announcing Immortal Dragons as Tier 4 Sponsor of ARDD 2025

Reporting guideline for chatbot health advice studies

[Press-News.org] Young human blood serum factors show potential to rejuvenate skin through bone marrow
“[…] we were able to reproduce systemic rejuvenating effects of circulating blood factors on the human skin, which have been so far only demonstrated in rodent heterochronic parabiosis studies”