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Pharmacological insights into Scleromitrion diffusum (Willd.) against gastric cancer: active components and mechanistic pathways

2025-10-30
Gastric cancer remains a major global health challenge, characterized by high mortality and limited therapeutic efficacy, especially in advanced stages. With conventional treatments like surgery and chemotherapy often yielding suboptimal outcomes and significant side effects, there is an urgent need for safer and more effective alternatives. Scleromitrion diffusum (Willd.), a traditional Chinese medicine (TCM) herb with a long history of use in oncology, has shown promising clinical potential against gastric cancer. This review systematically explores the ...

Advanced imaging strategies based on intelligent micro/nanomotors

2025-10-30
Recent research led to impactful achievements in advanced imaging strategies using intelligent micro/nanomotors (MNMs), which offer transformative solutions to traditional bioimaging paradigms by enabling enhanced detection sensitivity and real-time tracking of subcellular events and microenvironmental changes. Nevertheless, full realization of deep-tissue imaging and high resolution remains challenging to achieve, often limited by inherent constraints such as poor penetration depth and signal degradation. Based on research experience in this field, the study ...

How climate-damaging nitrous oxide forms in the ocean

2025-10-30
To many people, nitrous oxide, or laughing gas, is only known as a party drug or from the dentist. However, the nitrogenous substance also contributes significantly to global warming. As a greenhouse gas, its effect in the atmosphere is almost three hundred times more powerful than that of CO2, and it also attacks the ozone layer. “The emission of this almost forgotten greenhouse gas is decisive for the global climate,” says Dr. Claudia Frey from the Department of Environmental Sciences at the University of Basel. The biogeochemist ...

N6-methyladenosine methylation emerges as a key target for treating acute lung injury

2025-10-30
Acute lung injury (ALI) is a critical clinical condition characterized by diffuse inflammation of the lung parenchyma and intractable hypoxemia, typically caused by factors, such as trauma, pneumonia, shock, and sepsis. Clinical symptoms of ALI include pulmonary edema, impaired gas exchange, and hypoxemia. m6A methylation regulates gene expression by influencing RNA translation, splicing, stability, and export. This process is dynamically controlled by m6A writers, such as methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14), which install the m6A mark; m6A erasers such as fat mass and ...

Distributor-type membrane reactor for carbon dioxide methanation

2025-10-30
Climate change, expedited by anthropogenic activities, has become a major environmental concern in this century. Governments and organizations worldwide are gradually making substantial efforts to mitigate this challenge. A concrete step in this direction is to develop novel technologies that capture and convert low-concentration carbon dioxide into useful products. Recently, scientists have proposed carbon dioxide methanation in a membrane reactor as a promising approach. Specifically, distribution-type membrane reactors are appealing owing to high catalyst activity through hotspot formation mitigation. Although the effectiveness ...

Mapping the missing green: An AI framework boosts urban greening in Tokyo

2025-10-30
In rapidly growing cities like Tokyo, incorporating greenery is a challenging task. With limited space for trees or parks, vertical greening—the placement of vegetation on building façades—has become a creative solution to reintroduce nature into crowded urban settings. However, until now, there has been no clear method to assess where this type of greenery is most needed or most effective.   To address this challenge, researchers from Chiba University in Japan have created a data-driven spatial framework that identifies the best locations for vertical greening throughout Tokyo's 23 wards. The study, ...

Pharmacists help cancer patients manage high blood sugar more effectively

2025-10-30
People with cancer who received diabetes care from clinical pharmacists achieved significantly better blood sugar control, according to new research from the University of California San Diego. The study, published in Diabetes Spectrum on Oct. 30, 2025 found that patients referred to a diabetes management and education clinic led by pharmacists saw meaningful improvements in blood sugar levels over time, underscoring the critical role pharmacists can play in supporting this high-risk group. “Cancer and hyperglycemia can be a harmful combination,” said Christina Mnatzaganian, Pharm.D., health sciences clinical professor at UC San Diego Skaggs School of Pharmacy and Pharmaceutical ...

Babies’ gut bacteria may influence future emotional health

2025-10-30
A child’s early gut microbiome may influence their risk of developing depression, anxiety or other internalizing symptoms in middle childhood, according to a new UCLA Health study. The effect appears to be related to the way bacteria are linked to communication across emotion-related brain networks.  Published in the journal Nature Communications, the observational study found that young children whose gut microbiome had higher representation of bacteria in the Clostridiales order and Lachnospiraceae family were at higher risk of experiencing ...

Scientists create new type of semiconductor that holds superconducting promise

2025-10-30
Scientists have long sought to make semiconductors—vital components in computer chips and solar cells—that are also superconducting, thereby enhancing their speed and energy efficiency and enabling new quantum technologies. However, achieving superconductivity in semiconductor materials such as silicon and germanium has proved challenging due to difficulty in maintaining an optimal atomic structure with the desired conduction behavior. In a newly published paper in the journal Nature Nanotechnology, ...

Genes associated with obesity shared across ancestries, researchers find

2025-10-30
UNIVERSITY PARK, Pa. — Obesity is a global epidemic affecting millions of people every day and is associated with comorbidities ranging from heart disease and Type 2 diabetes to osteoarthritis and social stigma. While lifestyle factors, like diet and exercise, affect obesity, years of genetic research have identified about 20 genes that have a high effect on the likelihood of a person developing the condition.  Now, a new study published today (Oct. 30) in Nature Communications, by researchers at Penn State, involving about 850,000 adults ...

Antidepressants improve core depressive symptoms early on

2025-10-30
One of the most common antidepressants, sertraline, contributes to a modest improvement in core depression and anxiety symptoms, including low mood, within two weeks, finds a new analysis of a major clinical trial led by UCL researchers. The study, published in Nature Mental Health, analysed the findings of the PANDA trial, which first published results in 2019 and found that sertraline may have an earlier impact on anxiety than depressive symptoms.* Researchers have now conducted a network analysis of the results, which is an innovative statistical method that allowed them to explore how specific symptoms respond to treatment. The ...

Superconducting germanium made with industry-compatible methods

2025-10-30
Scientists have paved the way for next-generation quantum circuits by successfully making a semiconducting element commonly used in electrical devices superconducting. A research team from The University of Queensland’s School of Mathematics and Physics and Australian Institute for Bioengineering and Nanotechnology and New York University have shown germanium can conduct electricity without resistance. The discovery, which had eluded physicists for more than 60 years, unifies the building blocks of classical electronics and quantum ...

Synthetic biology to supercharge photosynthesis in crops

2025-10-30
Australian researchers have created tiny compartments to help supercharge photosynthesis, potentially boosting wheat and rice yields while slashing water and nitrogen use. Researchers from Associate Professor Yu Heng Lau’s group at the University of Sydney and Professor Spencer Whitney’s group at Australian National University have spent five years tackling a fundamental problem: how can we make plants fix carbon more efficiently? The team engineered nanoscale ‘offices' that can ...

Soil ‘memory’ can help plants respond to drought

2025-10-30
New research has found that microbial communities in soil have the capacity to remember and adapt to past environmental events, helping plants to withstand drought stress. Experts from the University of Nottingham's School of Biosciences in collaboration with scientists from the University of Kansas found that soil microbes carry a long-term memory of past climate, and that this memory can shape how some plants respond to new droughts. The findings have been published today in Nature Microbiology. Droughts ...

Illinois researchers convert food waste into jet fuel, boosting circular economy

2025-10-30
URBANA, Ill. — Airplane travel is more popular than ever, and our desire for fast transportation means jet fuel has become a major contributor to greenhouse gas emissions. Now, researchers at the University of Illinois Urbana-Champaign have discovered a novel way to address that problem—by converting food waste into sustainable aviation fuel (SAF) that meets industry standards without relying on fossil fuel blends. Their process, described in a new Nature Communications study, could help the aviation industry meet its ambitious ...

Under embargo: We learn physical skills by feeling rewarded, even in the absence of a reward, finds new study

2025-10-30
Press release under embargo until 30/10/25 10:00 UK time  We learn physical skills by feeling rewarded, even in the absence of a reward, finds new study  People master new physical skills, such as sports, crafts or controlling a vehicle while driving, by blending lessons learnt from both feedback on the amount of error they had in failures and the rewards of successes, even when reward cues are removed, according to a new study led by Dr Shlomi Haar from the University of Surrey.  Using a high-tech virtual reality pool setup, researchers from Surrey and Imperial College London had 32 participants play pool on a physical table while wearing a virtual ...

Scientists on ‘urgent’ quest to explain consciousness as AI gathers pace

2025-10-30
As AI—and the ethical debate surrounding it—accelerates, scientists argue that understanding consciousness is now more urgent than ever. Researchers writing in Frontiers in Science warn that advances in AI and neurotechnology are outpacing our understanding of consciousness—with potentially serious ethical consequences. They argue that explaining how consciousness arises—which could one day lead to scientific tests to detect it—is now an urgent scientific and ethical priority. Such an understanding would bring major implications for AI, prenatal policy, animal welfare, medicine, mental health, law, and emerging neurotechnologies such as brain–computer ...

Drones reveal unexpectedly high emissions from wastewater treatment plants

2025-10-30
Greenhouse gas emissions from many wastewater treatment plants may be more than twice as large as previously thought. This is shown in a new study from Linköping University, where the researchers used drones with specially manufactured sensors to measure methane and nitrous oxide emissions. “We show that certain greenhouse gas emissions from wastewater treatment plants have been unknown. Now that we know more about these emissions, we also know more about how they can be reduced,” says ...

Dancing alleviated perceived symptoms of depression and helped to understand its root causes

2025-10-30
Dance as a performative art form alleviates perceived symptoms of depression, helps to understand its root causes and promotes self-actualisation, a recent study from the University of Eastern Finland found. The multidisciplinary research collaboration brought together perspectives from psychology and social psychology, as well as from dance as a performative art form, which is rarely included in interventions related to depression. “Depression is a major public health concern, and there is an urgent need for adjunct treatment methods. Robust evidence regarding adjunct treatments for depression already exists for physical exercise, for example. ...

Tricky treats: Why pumpkins accumulate pollutants

2025-10-30
Pumpkins, squash, zucchini and their relatives accumulate soil pollutants in their edible parts. A Kobe University team has now identified the cause, making it possible to both make the produce safer and create plants that clean contaminated soil. The gourd family of plants comprising pumpkins, zucchini, melons, cucumbers and more are known to accumulate high levels of pollutants in their edible parts. Kobe University agricultural scientist INUI Hideyuki says: “The pollutants don’t easily break down and thus pose a health risk to people who eat the fruit. Interestingly, other plants don’t ...

Revealing the molecular structures of sugars using galectin-10 protein crystals

2025-10-30
A quick, purification-free method was developed by researchers at Institute of Science Tokyo, to capture the detailed 3D structures of flexible sugar molecules. By growing crystals of galectin-10 protein using a cell-free crystallization process and soaking them in sugar solution, the researchers were able to trap and analyze the molecular arrangement of sugars and their interactions with the protein. This offers a powerful tool to accelerate research in drug discovery and molecular biology. Sugars, or saccharides, do much more than sweeten food. In living organisms, these molecules decorate the surfaces of cell and also act as vital messengers in processes such as infection control and tissue ...

World’s leading medical journal details the climate emergency

2025-10-30
New global findings in the 2025 Lancet Countdown on Health and Climate Change reveal that the continued overreliance on fossil fuels and failure to adapt to climate change continues to be paid in people’s lives, health, and livelihoods, with 13 of 20 indictors tracking health threats now reaching unprecedented levels.   The University of Sydney’s Heat and Health Research Centre contributed to the global report of the Countdown, which is published annually by The Lancet, the world’s leading medical ...

GLP-1 drugs effective for weight loss, but more independent studies needed

2025-10-30
Three new Cochrane reviews find evidence that GLP-1 drugs result in clinically meaningful weight loss, but industry-funded studies raise questions. The reviews were commissioned by the World Health Organization (WHO) to inform upcoming guidelines on the use of these drugs to treat obesity. The reviews, which examine the effects of three weight loss drugs known as GLP-1 receptor antagonists, have found that all three drugs result in clinically meaningful weight loss compared with placebo. However, evidence on longer-term ...

Researchers uncover previously unexplored details of mosquito’s specialized detection mechanisms

2025-10-30
It’s bound to happen at a summer picnic, a peaceful walk in the woods or simply sitting in your backyard… a mosquito targets your blood for its next meal. You’ve been bitten. But how do mosquitoes find you? Among several methods used to locate new hosts for blood sucking, mosquitoes feature a keen ability to detect carbon dioxide. As we breathe out, we emit CO2 into the air around us, which mosquitoes can sense. But how? Scientists have been aware of the mosquito’s ability to detect our carbon dioxide expirations but the intricate underlying physiological structures enabling these capabilities largely have remained ...

Stem cell therapy linked to lower risk of heart failure after a heart attack

2025-10-30
Patients with weak heart function who receive stem cell therapy shortly after a heart attack are at lower risk of developing heart failure and related hospital stays compared with standard care, finds a clinical trial published by The BMJ today. The researchers say the findings suggest this technique may be a valuable add-on procedure for this particular group of patients after a heart attack to prevent subsequent heart failure and reduce the risk of future adverse events. Advances in heart attack ...
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