Clinical trials affected by research grant terminations at the National Institutes of Health

About The Study: Approximately 1 in 30 trials and more than 74,000 trial participants were affected by grant funding disruptions. Affected trials disproportionately studied infectious diseases, prevention, and behavioral interventions, and were based in the Northeastern U.S. or in other countries. Because trials require sustained financial support to ensure operations and participant safety, unanticipated funding disruptions raise concerns about avoidable waste, data quality, and compromised ethical obligations to participants. 

Corresponding Author: To contact the corresponding author, Anupam B. Jena, MD, PhD, email jena@hcp.med.harvard.edu.

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(doi:10.1001/jamainternmed.2025.6088)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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