PHILADELPHIA—A rare glimpse into the brain activity of a patient with obesity and loss of control eating on tirzepatide, marketed as Mounjaro and Zepbound,  revealed that the medication suppresses signaling in the brain’s “reward center” thought to be involved in food noise – but only temporarily. Research suggests that the medication, a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, originally developed to manage Type 2 diabetes, may be able to treat a wide range of conditions ...

Do All Countries Benefit From Clinical Trials? A New Study Examines the Data A new study led by Yale’s Jennifer Miller, PhD, found that medicines are not physically accessible in many of the countries where they are tested for FDA approval. The findings were published in JAMA Internal Medicine.   For the study, researchers analyzed 172 FDA-approved medicines tested between 2015 and 2018 in nearly 90 countries. They found that five years after testing, only 24 percent of the medicines had received market authorization, or approval for distribution and patient access, in the countries where the clinical ...

The therapeutic landscape for hepatocellular carcinoma (HCC) has been revolutionized by the advent of molecular targeted therapies and immune checkpoint inhibitors (ICIs). While these systemic treatments have significantly improved outcomes for patients with intermediate and advanced HCC, their use is accompanied by a spectrum of adverse events, with drug-induced liver injury (DILI) being a common and potentially serious complication. To address this growing clinical challenge, the Chinese Society of Hepatology convened a multidisciplinary panel of experts to formulate the "Consensus on the Management of Liver Injury Associated with Targeted Drugs and Immune Checkpoint Inhibitors ...

In recent years, robots have increasingly become integral in enhancing human life, particularly with the growing demand for mobile robots with high payload-to-weight ratios and dynamic capabilities. Traditional wheeled or tracked robots are difficult to operate stably in complex real-world environments, which has driven research on legged robots. Legged robots leverage their distinctive “leg” structures to traverse obstacles and adapt to uneven terrain, demonstrating exceptional mobility when confronted with pronounced undulations or soft ground. ...

(Toronto, November 17, 2025) A new study published in the peer-reviewed journal JMIR Mental Health by JMIR Publications highlights a critical risk in the growing use of Large Language Models (LLMs) like GPT-4o by researchers: the frequent fabrication and inaccuracy of bibliographic citations. The findings underscore an urgent need for rigorous human verification and institutional safeguards to protect research integrity, particularly in specialized and less publicly known fields within mental health. Nearly 1 in 5 Citations Fabricated by GPT-4o in Literature Reviews The article, titled "Influence of Topic Familiarity and Prompt Specificity on Citation Fabrication in Mental ...

First tool to estimate percentiles of 30-year heart disease risk for adults ages 30–59 Aims to spark earlier prevention efforts amid rising diabetes and hypertension in young adults Men showed the highest long-term risk in national analysis Free online calculator is based on the American Heart Association’s PREVENT equations CHICAGO --- Just as saving for retirement starts early, so should protecting your heart. A new Northwestern Medicine study introduces a first-of-its-kind online calculator that uses percentiles to help younger adults forecast and understand their risk of a heart event over the next 30 years. ...

SAN ANTONIO — November 17, 2025 — Southwest Research Institute (SwRI) has significantly expanded its heat exchanger performance evaluation capabilities with a new facility designed to industry standards, the Large-Scale Heat Exchanger Test Facility (LS-HXTF) that supports testing up to five megawatts of heat loads as well as a wider range of thermal performance testing. Heat exchangers efficiently transfer heat between two or more fluids without mixing for a wide variety of heating and cooling applications. The ...

WILMINGTON, DEL. (November 14, 2025) – In a major step forward for cancer care, researchers at ChristianaCare’s Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach restores drug sensitivity and slows tumor growth. The findings appear today in the journal Molecular Therapy Oncology. This breakthrough stems from more than a decade of research by the Gene Editing Institute into the NRF2 gene, a known driver of treatment resistance. The results were consistent across multiple in vitro studies using human lung cancer cell lines and in vivo animal models. “We’ve ...

A University of Otago – Ōtākou Whakaihu Waka-led study has produced a detailed blueprint of a bacteriophage, furthering their potential in the fight against drug-resistant bacteria.   Lead author Dr James Hodgkinson-Bean, who completed his PhD in the Department of Microbiology and Immunology, says bacteriophages are “extremely exciting” in the scientific world as researchers search for antibiotic alternatives to combat the increasing risk of antimicrobial resistance.   “Bacteriophage viruses are non-harmful to all multi-cellular life and able to ...

Singapore, 17 November 2025—A new study by researchers from Duke-NUS Medical School has revealed that almost all community-dwelling older adults with advanced dementia in Singapore experience at least one potentially burdensome intervention in their last year of life. The findings highlight an urgent need for new strategies to support families and reduce unnecessary interventions at the end of life. Although the number of individuals living with dementia in the Asia-Pacific region is projected to rise to 71 million by ...

About a quarter of U.S. service members and veterans who start psychotherapy for post-traumatic stress disorder quit before they finish treatment. But not all therapies are equal in their appeal, with some effective approaches reporting the highest dropout rates, according to research published by the American Psychological Association. PTSD affects about 7% of veterans at some point in their lives, slightly higher than the rate seen in the general U.S. adult population, according to the U.S. Department of Veterans Affairs. Beyond PTSD’s emotional impact, the American Heart Association notes that it can also ...

New research examines how social approval from different sources predicts relationship quality for intercultural couples. Researchers found that having supportive friends can be a powerful protective factor, especially when they face disapproval from family or society more broadly. The research, published in Social Psychological and Personality Science, advances research on intercultural relationships by drawing on a large sample of people in such relationships. This sample allowed researchers to study how social approval varies across cultural backgrounds, racial pairing, relationship length, and gender. “The results highlight that friends and family can play distinct roles: for example, ...

Vision is one of the most fundamental senses, shaping how we perceive, navigate and interact with the world around us. Yet for more than 12 million Americans living with visual impairments, even small deficits can profoundly impact daily life, limiting independence and overall quality of life. Researchers have long recognized the potential of visual perceptual learning (VPL) – a process by which the brain improves its ability to detect subtle differences in visual stimuli, such as fine patterns or orientations – to enhance vision. VPL is already being explored ...

SEATTLE, WASH. — NOVEMBER 17, 2025 — Harnessing the muscle of one of the world’s fastest supercomputers, researchers have built one of the largest and most detailed biophysically realistic brain simulations of an animal ever. This virtual copy of a whole mouse cortex allows researchers to study the brain in a new way: simulating diseases like Alzheimer’s or epilepsy in the virtual world to watch in detail how damage spreads throughout neural networks or understanding cognition and consciousness. It simulates both form and function, with almost ten million neurons, 26 billion synapses, and 86 interconnected brain regions.   This spectacular achievement is the product ...

COLUMBUS, Ohio – A study using more than 27,000 sleep records of collegiate athletes provides the best evidence to date that early morning team practices take a toll on healthy sleep.   Researchers at The Ohio State University used data from wearable sleep trackers to measure sleep for 359 varsity athletes over five years.   They found that when male athletes had team practices that began before 8 a.m., they averaged about 30 minutes less sleep the night before when compared to later morning workouts. Female athletes averaged about 20 minutes less sleep.   Findings also showed evidence that ...

DALLAS, Nov. 17, 2025 — Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and impacts an estimated 1 in 500 people in the U.S., according to the American Heart Association, a relentless force changing the future of health for everyone everywhere. Because many cases go undetected and untreated until acute symptoms occur, the Association is scaling up its efforts to improve diagnosis and treatment of HCM. HCM is a thickening of the lower main pumping chamber of the heart (the left ventricle). ...

World COPD Day: Short of Breath, Think COPD Appropriate diagnosis of COPD can have a very significant public health impact.  For Immediate Release In support of World COPD Day on November 19, the Global Initiative for Chronic Obstructive Lung Disease (GOLD), is drawing attention to the importance of correctly diagnosing COPD earlier - with the theme ‘Short of Breath, Think COPD’.   Chronic obstructive pulmonary disease (COPD) is a preventable and treatable condition marked by breathlessness, chronic sputum ...

Research overview A research team led by Associate Professor Tomoko Matsumoto from the Institute of Arts and Sciences at Tokyo University of Science, Japan, along with Associate Professor Daiki Kishishita and Associate Professor Atsushi Yamagishi, both from Hitotsubashi University, Japan, has demonstrated that providing people with information about the universal benefits of public goods significantly increases support for higher taxation. This finding reveals a new mechanism that could contribute to reducing inequality by expanding government size while maintaining tax progressivity. The ...

Fossil fuels release pollutants into the air when extracted and burned, but there’s more to their production than massive oil rigs diving deep into the Earth and smoky power plants. Those processes are examples of only the first and last—and generally most visible—moments in a fossil fuel’s five-stage journey.   Between the initial extraction site and the final power-generating facility, oil and gas are also refined to remove impurities, held in storage facilities, and transported from ...

Mice pups conceived with in vitro fertilization (IVF) in the lab have slightly increased rates of DNA errors, or mutations, compared to pups conceived naturally, a new study on artificial reproductive technologies suggests. While the results do not directly apply to humans, they highlight the importance of understanding how fertility treatments affect an offspring’s DNA. The research is newly published in the journal Genome Research. “What we are seeing is a true biological signal, but we cannot make an apples-to-apples comparison relative to what happens in a clinic. Still, the fact that we see this trend ...

Researchers have taken a significant step toward creating a standardized language for describing the aromas of cannabis and hemp. “Aroma plays a key role in how consumers judge cannabis quality, yet until now there’s been no standardized language to describe it,” said Tom Shellhammer, professor of food science and technology at Oregon State University. “This research lays the groundwork for a shared vocabulary that benefits consumers, retailers and growers.” The study, recently published in PLOS ...

Some babies are born with early blindness due to dense bilateral congenital cataracts, requiring surgery to restore their sight. This period of several months without vision can leave a lasting mark on how the brain processes visual details, but surprisingly little on the recognition of faces, objects, or words. This is the main finding of an international study conducted by neuroscientists at University of Louvain (UCLouvain), in collaboration with Ghent University, KU Leuven, and McMaster University (Canada), published in the prestigious ...

Research Highlights: Chronic pain may be linked to the development of high blood pressure. The duration and location of pain was associated with the likelihood of developing high blood pressure. In addition, depression and inflammation explained some of the association between chronic pain and high blood pressure. These findings highlight the importance of pain management in the prevention and control of high blood pressure, a major risk factor for cardiovascular disease and death, researchers said. Embargoed until 4 a.m. CT/5 a.m. ET Monday, ...

A new study has discovered a molecular signal that tumors exploit to exhaust the T cells meant to destroy them—and how silencing that signal could revive the body’s immunity. The study led by Weill Cornell Medicine researchers was published Nov. 17 in Nature Immunology and shows that tumors not only evade the immune system but can actively reprogram immune cells to stop fighting. “Our dream is to make immune-based therapies available to every patient. To overcome resistance, we must unlock the power of exhausted T cells, reviving them to destroy cancer. This discovery moves us closer to a future where the immune system itself defeats ...

The oceans have to play a role in helping humanity remove carbon dioxide from the atmosphere to curb dangerous climate warming. But are we ready to scale up the technologies that will do the job? The answer, according to an expert group reporting to the European Union, is no. At least, not yet – not until there are measures in place to ensure these technologies, called marine carbon dioxide removal technologies, are doing what they are supposed to do and won’t do more harm than good. Marine carbon dioxide removal technologies build on the ocean’s ability to ...