Traditional medical tests often require clinical samples to be sent off-site for analysis in a time-intensive and expensive process. Point-of-care diagnostics are instead low cost, easy-to-use, and rapid tests performed at the site of patient care. Recently, researchers at the Carl R. Woese Institute for Genomic Biology reported new and optimized techniques to develop better biosensors for the early detection of disease biomarkers. People have long been fascinated with iridescence of peacock feathers, appearing to change color as light hits them from different angles. With ...

A recent study published in Genes & Diseases has unveiled a novel mechanism by which the restriction of YWHAB-mediated YAP cytoplasmic retention plays a crucial role in maintaining stemness and chemoresistance in ovarian cancer peritoneal metastasis (OCPM). Researchers have found that the down-regulation of YWHAB in OCPM cells promotes the activation of YAP signaling, enhancing the cancer cells' ability to resist chemotherapy and maintain stem-like characteristics. This discovery may lead to innovative therapeutic strategies targeting the YWHAB-YAP pathway to ...

A recent study published in Genes & Diseases reveals new insights into the relationship between immune cell characteristics, blood metabolites, and the risk of urolithiasis. Using Mendelian randomization (MR) and mediation analysis, the research highlights how genetically predicted blood metabolites mediate the association between specific immune cell profiles and the development of urinary stones. The findings shed light on potential pathogenic mechanisms and suggest novel therapeutic targets for this widespread and recurrent condition.   Urolithiasis, ...

  A groundbreaking study published in Genes & Diseases has revealed that exogenous pyruvate significantly alleviates the symptoms of ulcerative colitis (UC) by targeting cytosolic phospholipase A2 (cPLA2). This discovery opens new avenues for the treatment of UC, which remains a chronic inflammatory bowel disease with limited therapeutic options. The study shows that pyruvate can suppress the TNFα/NFκB signaling pathway, which is pivotal in driving inflammation, thereby offering a novel approach to mitigating UC symptoms.   Ulcerative colitis is characterized by chronic intestinal inflammation, leading ...

A recent study published in Genes & Diseases explores the clinical implications of loss-of-function mutations in IKBKG/NEMO, a key regulator in the NF-κB signaling pathway. These mutations are linked to a range of rare and often severe genetic disorders, including Incontinentia Pigmenti (IP), Anhidrotic Ectodermal Dysplasia with Immunodeficiency (EDA-ID), Immunodeficiency (ID), and NEMO Deleted Exon 5 Autoinflammatory Syndrome (NDAS). The research aims to provide a comprehensive review of the diverse clinical manifestations ...

Images    A new blue fluorescent molecule set new top emission efficiencies in both solid and liquid states, according to a University of Michigan-led study that could pave the way for applications in technology and medicine.    Able to absorb light and emit it at lower energy levels, fluorescent molecules called fluorophores glow in OLED displays and help doctors and scientists figure out what's happening in cells and tissues. They need to be solid in displays and many sensing applications, but liquids are typically preferred for biological uses. ...

For a decade, scientists have believed that plants sensed temperature mainly through specialized proteins, and mainly at night when the air is cool. New research suggests that during the day, another signal takes over. Sugar, produced in sunlight, helps plants detect heat and decide when to grow. The study, led by Meng Chen, a University of California, Riverside professor of cell biology, shows that plants rely on multiple heat-sensing systems, and that sugar plays a central and previously unrecognized role in daytime temperature response. The findings, published in Nature Communications, reshape a long-standing view of how plants ...

The lucrative pay for American CEOs often makes headlines. In 1965, CEO compensation was 22 times higher than the pay of an average worker. In recent years, CEOs have been paid 344 times more than the people who work for them. The personality of a CEO is one factor driving the increase in executive compensation, according to a new study from a team of researchers that includes Sam M. Walton College of Business strategic management professor Jason Ridge. Leaders with a Machiavellian personality, someone who is self-interested, unemotional and manipulative, earn more than $1.5 million a year in additional pay. While ...

While the current generation of artificial intelligence chatbots still flub basic facts, the systems answer with such confidence that they’re often more persuasive than humans. Adults, even those such as lawyers with deep domain knowledge, still regularly fall for this. But spotting errors in text is especially difficult for children, since they often don’t have the contextual knowledge to sniff out falsehoods. University of Washington researchers developed the game AI Puzzlers to show kids an area where AI systems still typically and blatantly ...

By Greg Watry, UC Davis Archaeologists have long thought that monumental architecture — large, human-built structures that emphasize visibility — were products of societies with power structures, including social hierarchy, inequality and controlled labor forces. But this notion is being questioned as researchers uncover evidence that hunter-gatherer groups also built such structures. In new research published June 24 in the journal Antiquity, University of California researchers report evidence of monumental structures built by hunter-gatherer groups at Kaillachuro, a collection of burial mounds located in the Titicaca Basin of the ...

The strength of certain neural connections can predict how well someone can learn math, and mild electrically stimulating these networks can boost learning, according to a study published on July 1st in the open-access journal PLOS Biology by Roi Cohen Kadosh from University of Surrey, United Kingdom, and colleagues. When it comes to cognitive skills like reading and math, early advantages tend to compound over time. Mathematical abilities, however, seem to plateau from childhood to adulthood, raising the possibility that innate brain characteristics ...

Putting the brakes on an enzyme might rescue neurons that are dying due to a type of Parkinson’s disease that’s caused by a single genetic mutation, according to a new Stanford Medicine-led study conducted in mice. The genetic mutation causes an enzyme called leucine-rich repeat kinase 2, or LRRK2, to be overactive. Too much LRRK2 enzyme activity changes the structure of brain cells in a way that disrupts crucial communication between neurons that make the neurotransmitter dopamine and cells in the striatum, ...

Safe, painless, and non-invasive brain stimulation could help people who are at risk of falling behind in maths, according to a new study led by the University of Surrey.  The study, published in PLoS Biology, found that applying safe electrical currents to the dorsolateral prefrontal cortex (dlPFC) – a region involved in learning and memory, focus, and problem-solving – helped people aged 18 to 30 solve maths problems more efficiently.  Seventy-two healthy adults took part in a five-day maths training programme – 24 received a form of brain stimulation known as transcranial random noise stimulation (tRNS) to the dlPFC, ...

Under embargo until July 1, 2025 at 11am PST / 2pm EST / 7pm GMT)  Neurotechnology reverses biological disadvantage in maths learning    Safe, painless, and non-invasive brain stimulation could help people who are at risk of falling behind in maths, according to a new study led by the University of Surrey.    The study, published in PLoS Biology, found that applying safe electrical currents to the dorsolateral prefrontal cortex (dlPFC) – a region involved in learning and memory, focus, and problem-solving – helped people aged 18 to ...

Scientists have studied a new target for antibiotics in the greatest detail yet – in the fight against antibiotic resistance. The ‘molecular machine’ flagellum is essential for bacteria to cause infection, allowing bacteria to ‘swim’ around the bloodstream until finding something to infect. But it could also be a target for antibiotics. Impairing the flagellum would deliver a critical, but not fatal, blow to bacteria. This is a new approach and contrasts to traditional antibiotics, which are designed to kill all bacteria ...

In recent years, deep learning methods have been increasingly applied in atmospheric and oceanic forecasting, showing superior forecast skills. Unlike time-stepping numerical models, deep learning forecasting models (DLMs) typically adopt a “multi-time-slice input” structure. This structure breaks the deterministic causality in the time dimension that exists in the numerical models. In this case, the forecast errors in DLMs should be attributed to all input slices, rather than any single one. This fundamental difference limits the applicability of the classical conditional nonlinear optimal perturbation (CNOP) method, ...

Dr Katie Edwards studied the feeding practices of parents of children with ‘avid’ eating traits, which can lead to obesity Focusing on health or deciding when it is time for a meal or snack helps parents to use supportive feeding practices. Supportive feeding practices could include involving children in decisions about food, or sitting together for mealtimes New research from Aston University has shone a light on the best ways for parents to encourage healthy eating in their children. The ...

Trees in tropical forests are dying at an increased rate, with consequences for biodiversity, carbon storage, and the global climate. While deforestation is the primary cause of forest loss, intact forests are also experiencing a rise in tree death. Drought, higher temperatures, and fires have been the leading suspects, but a new paper led by Evan Gora, a forest ecologist at Cary Institute of Ecosystem Studies, identifies an underappreciated threat: thunderstorms, which are becoming more frequent with climate change. Not to be confused with hurricanes or cyclones, these convective storms ...

ST. LOUIS, MO, July 1, 2025– The Donald Danforth Plant Science Center today announced two new faculty members. Justin Conover, PhD, joined as assistant member and Erin Sparks, PhD, joined as associate member at the Danforth Center and associate professor at the University of Missouri – Columbia (MU) a joint hire between the Danforth Center and MU. “We’re excited to welcome two exceptional scientists who will add new expertise and complement several research areas at the Danforth Center,” ...

WASHINGTON, July 1, 2025 — In blinding bright light or pitch-black dark, our eyes can adjust to extreme lighting conditions within a few minutes. The human vision system, including the eyes, neurons, and brain, can also learn and memorize settings to adapt faster the next time we encounter similar lighting challenges. In an article published this week in Applied Physics Letters, by AIP Publishing, researchers at Fuzhou University in China created a machine vision sensor that uses quantum dots to adapt to extreme changes in light far faster than the human eye can ...

About The Study: This cross-sectional study found that racial and ethnic disparities in COVID-19 treatment are substantial and partially explainable by encounter-level factors, particularly differences in diagnostic test type, virtual care access, and site of care. These findings suggest that targeted interventions, including expanding rapid test access and virtual care, may improve equity in outpatient COVID-19 treatment.  Corresponding Author: To contact the corresponding author, Rebecca Bromley-Dulfano, MS, email rbromleydulfano@g.harvard.edu. To ...

About The Study: The results of this study suggest that structural racism embedded in neighborhood conditions contributes to lung cancer development and provides evidence for policymakers and public health leaders working to reduce disparities.  Corresponding Author: To contact the corresponding author, Loretta Erhunmwunsee, MD, email LorettaE@coh.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.18481) Editor’s ...

 JUPITER, Fla. — A potential treatment for glioblastoma crafted by scientists at The Wertheim UF Scripps Institute renders the deadly brain cancer newly sensitive to both radiation and chemotherapy drugs, and blocks the cancer’s ability to invade other tissue, a new study shows. The experimental medication, called MT-125, has received approval from the FDA to move to clinical trials as a possible first-line treatment for the most aggressive form of the brain cancer. Each year, 14,000 people in the United States receive the devastating news that they have glioblastoma. It is a cancer with an average survival of just 14 to 16 months. ...

In the guidance law capturability analysis, the differential game theory is complemented by considering the optimal situation for both the evader and the pursuer as the capture boundary, and it is commonly used to derive the necessary and sufficient conditions of capture zones. However, in previous studies, capturability was analyzed for continuous guidance laws. Still, pulsed guidance laws, which are sometimes used in reality, such as pulsed orbital thrust control for exo-atmospheric vehicles, have different capture zones and influence factors.   To address the above-mentioned challenge, a team of automation scientists led ...

Glenview, Illinois – On World Bronchiectasis Day (July 1), the American College of Chest Physicians (CHEST) is announcing the launch of Bridging Specialties®: Timely Diagnosis for NTM Disease and Bronchiectasis. Nontuberculous mycobacteria (NTM) disease and bronchiectasis are complex, often underrecognized lung conditions that can mimic more common respiratory diseases, such as chronic bronchitis or TB. This can lead to delays in diagnosis and treatment. To address these delays, pulmonary and primary care professionals ...