Steatotic liver disease (SLD), mainly encompassing metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and metabolic dysfunction and ALD (MetALD), has emerged as the dominant cause of chronic liver disease worldwide, displacing viral hepatitis as the primary aetiology. Globally, the prevalence of MASLD is estimated even over 30%, affecting over one-third of adults. Parallelly, alcohol remains a major risk factor, with heavy drinking contributing to 90–95% of SLD cases and up to 10% advancing to cancer.   Genetic ...

About The Study: The findings of this study support the routine use of sodium-glucose cotransporter 2 (SGLT2) inhibitors to improve kidney outcomes across the full spectrum of kidney function and albuminuria among patients with type 2 diabetes, chronic kidney disease, or heart failure.  Corresponding Authors: To contact the corresponding authors, email Brendon L. Neuen, PhD (bneuen@georgeinstitute.org.au) and Hiddo J. L. Heerspink, PhD (h.j.lambers.heerspink@umcg.nl). To access the embargoed study: Visit our For The ...

In late-breaking presentations at the American Society of Nephrology Kidney Week meeting and simultaneously published in two companion papers in JAMA, the findings are based on data from over 70,000 participants across 10 major randomised controlled trials.  The meta-analyses were conducted by the SGLT2 Inhibitor Meta-analysis Cardio-Renal Trialists’ Consortium (SMART-C), led by The George Institute for Global Health. SGLT2 inhibitors, originally developed to treat type 2 diabetes, have since demonstrated substantial protection against heart failure and chronic ...

Despite effective HIV medication, the immune system of people with HIV remains disrupted in the long term. Researchers at Amsterdam UMC investigated whether this dysregulation can be prevented by starting HIV medication immediately after infection – i.e. within a few days. They saw that six months after this early treatment, the immune system did indeed work as in people without HIV. But in the longer term, the immune system was disrupted again. This is shown by research by Amsterdam UMC, published in the journal EBioMedicine. Early treatment protects immune systems only temporarily For this study, the scientists examined ...

Record numbers of men and women globally are now estimated to have reduced kidney function, a new study shows. Figures rose from 378 million people with the disease in 1990 to 788 million in 2023 as the world population grew and aged, making it for the first time a top 10 cause of death worldwide.   Led by researchers at NYU Langone Health, the University of Glasgow, and the Institute for Health Metrics and Evaluation (IHME) at the University of Washington, the analysis explored the rise of the illness, in which the kidneys gradually lose their ability to filter waste and excess fluid from the blood. Mild cases may have no symptoms while the most severe stages ...

In 2023, chronic kidney disease (CKD) was the 9th-leading cause of death worldwide, responsible for nearly 1.5 million deaths. Unlike most other leading causes of death, CKD mortality rates continue to rise, signaling a growing global health crisis.  In 2023, CKD ranked as the 12th-leading cause of disability worldwide and the 7th-leading driver of cardiovascular deaths. Kidney dysfunction alone accounted for almost 12% of all global cardiovascular deaths. Diabetes, obesity, and high blood pressure remain the top drivers of CKD, alongside dietary risks and environmental factors.  SEATTLE, Wash. – Nov. 7, ...

About The Study: The results of this study suggest that community health workers played a vital role in improving patient engagement, emotional wellbeing, and self-efficacy, suggesting their integration into dialysis care teams may enhance holistic, patient-centered care.  Corresponding Author: To contact the corresponding author, Lilia Cervantes, MD, email Lilia.Cervantes@cuanschutz.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.48506) Editor’s ...

About The Study: In this randomized clinical trial, a culturally tailored community health worker intervention modestly lowered interdialytic weight gain and improved dialysis adherence and patient activation among Hispanic and Latino patients with hemodialysis-dependent kidney failure.  Corresponding Author: To contact the corresponding author, Lilia Cervantes, MD, MSc, email lilia.cervantes@cuanschutz.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2025.5305) Editor’s Note: Please see the article for additional information, including other authors, author ...

As China’s most important grain-producing region, Northeast China plays a vital role in safeguarding national food security. Yet this agricultural powerhouse faces a growing dilemma: how to maintain high crop yields while protecting the fragile ecosystems that sustain long-term productivity. A new study published in Agricultural Ecology and Environment identifies the key conflicts between agricultural expansion and ecological protection in the region and proposes integrated strategies to achieve a more sustainable balance. Over the past four decades, Northeast China’s farmlands ...

SAN ANTONIO, Nov. 7, 2025 – Traumatic brain injury, or TBI, affects millions of Americans each year, often resulting in long-term health challenges. New national recommendations are now paving the way for more effective short- and long-term care for patients with TBI. Monica Verduzco-Gutierrez, MD, a physiatrist with UT Health San Antonio, the academic health center of The University of Texas at San Antonio, and professor and chair of the Department of Physical Medicine and Rehabilitation at UT San Antonio’s Long School of Medicine, served on the National Academies of Sciences, ...

As the planet warms and rainfall patterns shift, new research suggests that the world’s largest grassland region may become a growing source of nitrous oxide, a greenhouse gas nearly 300 times more potent than carbon dioxide. A team of scientists led by Dr. Shuping Qin from the Chinese Academy of Sciences examined how soil and climate conditions control the process of denitrification, a key microbial pathway that converts nitrogen compounds in soil into gases including nitrous oxide (N₂O) and nitrogen gas (N₂). Their study, recently published in Environmental and Biogeochemical Processes, is the first to map how denitrification responds ...

Houston, TX (November 7, 2025) — New research reveals that contrary toconventional belief, primary glomerular diseases are not necessarily benign for children and young adults. In fact, some subsets of children and young adults may experience faster kidney function decline than older patients. The findings will be presented at ASN Kidney Week 2025 November 5–9. Direct comparisons of outcomes between adult and pediatric patients with primary glomerular diseases are rare—including minimal change disease (MCD), focalsegmental ...

Houston, TX (November 7, 2025) — Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed to treat type 2 diabetes, have significant heart- and kidney- protective effects. In the kidney, SGLT2 reabsorbs approximately 97% offiltered glucose in the S1 and S2 segments of the proximal tubule, while SGLT1reabsorbs the remainder in the S3 segment. In research conducted in rats, investigators found that dual inhibition of SGLT1 and SGLT2 more effectively reduces salt-sensitive hypertension and kidney injury than SGLT2 inhibition alone. The findings will be presented ...

Houston, TX (November 7, 2025) — An analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) indicates that nearly all adults with chronic kidney disease (CKD) would have benefits that outweigh the harm from a systolic blood pressure target of <120 mm Hg compared with a target of <140 mm Hg. Thefindings will be presented at ASN Kidney Week 2025 November 5– 9. In a benefit-harm trade-off analysis of 2,012 participants with CKD, investigators found that when predicting individualized treatment effects for multiple outcomesand simulating ...

A husband’s optimism and confidence may play a crucial, if often unseen, role in helping babies arrive healthy and on time. A new study from University of California Merced psychology researchers found that when married fathers reported higher levels of resilience — a quality that includes traits such as optimism, self-esteem, and perceived social support — their partners showed lower levels of inflammation during pregnancy and carried their babies longer. “This is one of the first studies to show that a father’s inner strengths, such as his optimism and ability to cope with challenges, can ripple through the family in measurable, ...

MSU has a satellite uplink/LTN TV studio and Comrex line for radio interviews upon request. Images EAST LANSING, Mich. – To mark the 250th anniversary of the Declaration of Independence next July, Michigan State University’s James Madison College has plans to launch summer programs for Michigan high school students and teachers that explore America’s founding principles. A three-year grant, totaling $1.3 million from the U.S. Department of Education, will fund the James Madison College Academy for Civic Education, or ACE, offering intensive seminars built around primary sources like the U.S. Constitution, Federalist Papers, works ...

University of Phoenix College of Doctoral Studies announces the publication of a new white paper, “Recovering from Burnout Through Mentoring,” authored by Carla M. Harris, Ed.D., and Sandra Sessoms-Penny, Ed.D, both Fellows at the University of Phoenix Center for Organizational Wellness, Engagement, and Belonging (CO-WEB). The paper examines how structured mentorship can support employees experiencing burnout and offers actionable guidance for organizations and leaders to foster resilience and engagement.   Grounded in current research and insights from the University’s Career Optimism Index® study, the authors note that employee burnout ...

UNIVERSITY PARK, Pa. — In the dense forests of northwestern Pennsylvania, hundreds of thousands of retired oil and gas wells — some dating back to the mid-1800s, long before modern construction standards — dot the landscape, according to geochemists in Penn State’s College of Earth and Mineral Sciences who recently led a study in the region. Left uncapped and exposed to air and erosion, they break down, leaching harmful chemicals into the atmosphere and, the researchers reported, into the groundwater. Led by Susan L. Brantley, ...

East Hanover, NJ – Nov. 7, 2025 – John DeLuca, PhD, of Kessler Foundation received the 2025 Reitan Clinical Excellence Award from the National Academy of Neuropsychology (NAN) at its annual conference today. This honor recognizes individuals who have made significant contributions to the clinical practice of neuropsychology, influencing methods, settings, and training in ways that benefit both the profession and its clients. Dr. DeLuca is senior vice president of Research and Training at the Foundation and a recognized leader in the field of neuropsychology. ...

About The Study: In the Chronic Kidney Disease Prognosis Consortium, 11% of outpatient participants and 35% of hospitalized patients had a cystatin C–based estimated glomerular filtration rate (eGFRcys) that was at least 30% lower than their creatinine-based eGFR (eGFRcr). In the outpatient setting, presence of eGFRcys at least 30% lower than eGFRcr was associated with significantly higher rates of all-cause mortality, cardiovascular events, and kidney failure.  Corresponding Authors: To contact the corresponding authors, email Morgan E. Grams, ...

A mismatch between two common tests for kidney function may indicate a higher risk for kidney failure, heart disease, and death, a new study shows.  Health care providers for decades have measured blood levels of the molecule creatinine to track the rate at which kidneys filter waste from muscle breakdown in the bloodstream. According to more recent guidelines, levels of cystatin C, a small protein made by all cells in the body, can also be used to measure kidney function. Since these two tests are influenced by different factors — including some related to disease or aging — using both markers together can provide a better measure of kidney function and risk of organ ...

The American College of Cardiology (ACC) and OpenEvidence are entering a strategic partnership to accelerate the translation of cardiovascular clinical guidance and research into clinical implementation at the point of care. By combining ACC’s leadership in cardiovascular science and education with OpenEvidence’s advanced generative artificial intelligence (AI) technology, clinicians will have access to the latest relevant and actionable medical evidence to support shared decision-making with their patients. “At the American College of Cardiology, our mission is to transform ...

A new molecule developed by researchers at Oregon Health & Science University offers a promising avenue to treat intractable cases of triple-negative breast cancer — a form of cancer that is notoriously aggressive and lacks effective treatments. In a study published today in the journal Cell Reports Medicine, researchers describe the effect of a molecule known as SU212 to inhibit an enzyme that is critical to cancer progression. The research was conducted in a humanized mouse model. “It’s an important step forward to treat triple-negative breast cancer,” said senior author Sanjay V. Malhotra, Ph.D., co-director of the Center for Experimental ...

Identifying ways that we can optimize Borderline Personality Disorder (BPD) treatment and prevention is an important public health priority. One area for further research is the relationship between sleep and BPD. Disrupted sleep is closely linked to key BPD features, and prior research has found a range of sleep problems among people with BPD. The Brain & Behavior Research Foundation (BBRF) will host a free webinar, “Evaluating the Potential of a Sleep Intervention Among Youth at High-Risk for Borderline Personality Disorder” on Tuesday, November 11, 2025, at 2:00 pm ET. In this webinar, Erin A. Kaufman, Ph.D., Assistant Professor in the Department ...

New findings from NASA’s Cassini mission show that Enceladus, one of Saturn’s moons and a top contender for extra-terrestrial life, is losing heat from both poles – indicating that it has the long-term stability required for life to develop. The findings have been published today (7 November) in Science Advances. A new study led by researchers from Oxford University, Southwest Research Institute and the Planetary Science Institute in Tucson, Arizona has provided the first evidence of significant heat flow at Enceladus’ north pole, overturning previous assumptions that heat loss was confined ...