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The role of hepatic SIRT1: From metabolic regulation to immune modulation and multi-target therapeutic strategies

2025-11-13
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disorder globally, with a rising incidence linked to metabolic syndrome. Its pathogenesis involves a complex interplay of lipid metabolic dysregulation, insulin resistance, oxidative stress, chronic inflammation, and gut-liver axis disruption. Despite recent advances such as Resmethron for advanced metabolic-associated steatohepatitis (MASH), early-stage interventions remain limited. This ...

Lymphoma and targeted therapy: resistance mechanisms and future solutions

2025-11-13
“This review synthesizes current evidence to inform clinical decision-making and outlines future directions for durable, personalized lymphoma care.” BUFFALO, NY — November 13, 2025 — A new review was published in Volume 12 of Oncoscience on October 13, 2025, titled “Targeted therapies and resistance mechanisms in lymphoma: Current landscape and emerging solutions.” In this article by Bishal Tiwari, Roshan Afshan and Shruthi Sridhar, from Nassau University Medical Center and Detroit Medical Center Wayne State University, researchers reviewed the latest scientific ...

2025 AAAS Kavli Science Journalism Award Winners Named

2025-11-13
Stories describing what can happen when science is manipulated or misapplied are among the winners of the 2025 AAAS Kavli Science Journalism Awards. Winning journalists also did stories on science at its best, revealing new understanding about the natural world. Independent panels of science journalists select the winners of the awards, which are administered by the American Association for the Advancement of Science (AAAS) and endowed by The Kavli Foundation. There is a Gold Award ($5,000) and Silver Award ($3,500) for each of the eight categories. The global awards program drew entries from 67 countries this year, and 55 percent of the ...

Helping the youngest children thrive at school

2025-11-13
Well-being and school results are inter-connected, but some children simply do not enjoy school. So what can we do to make school a happier experience for more children? Professor Hermundur Sigmundsson works at the Norwegian University of Science and Technology (NTNU’s) Department of Psychology and has spent many years conducting research on learning and schooling. He and his colleagues are currently carrying out a project in Vestmannaeyjar in Iceland. Among other things, they have investigated ...

During a heart attack immediate stenting of other arteries isn’t always necessary

2025-11-13
A blocked coronary artery causing an acute heart attack must be opened immediately with a stent procedure. However, if other coronary arteries also appear to be narrowed, it is safe to wait and treat those later. This approach cuts the number of stent procedures in half, according to cardiologists from Radboud university medical center, writing in The New England Journal of Medicine. Each year, 33,600 people are admitted to the hospital with a heart attack. In those cases, doctors must quickly open the blocked artery with angioplasty to prevent part of the heart muscle from dying. Yet during the procedure, it often becomes ...

Reducing the risks of wildlife corridors 

2025-11-13
Peer-reviewed. Literature Review. Ecology.  University of Leeds news    Efforts to join up isolated plant and animal habitats across the world should also protect against unintentionally harming them, new research shows.   The paper, led by the Universities of Leeds and Oxford and published today in Nature Reviews Biodiversity journal, states that work to connect fragmented wildlife habitats is essential - but it may also pose ecological risks including the unintentional spread of wildlife diseases and invasive species.  Wildlife or ecological corridors ...

Manganese is Lyme disease’s double-edge sword

2025-11-13
For decades, Lyme disease has frustrated both physicians and patients alike. Caused by the corkscrew-shaped bacterium Borrelia burgdorferi, the infection, if left untreated, can linger for months, leading to fever, fatigue and painful inflammation. In a new study, Northwestern University and Uniformed Services University (USU) scientists have uncovered a surprising — and ironic — vulnerability in the hardy bacterium. By exploiting this vulnerability, researchers could help disarm B. burgdorferi, potentially leading to new therapeutic strategies for Lyme disease. The Northwestern and USU team discovered ...

Drones map loggerhead sea turtle nesting site hotspots

2025-11-13
Florida’s beaches – particularly those in Palm Beach County – are among the world’s most vital nesting grounds for loggerhead sea turtles (Caretta caretta), accounting for 90% of all loggerhead nests in the Southeastern United States. Where a sea turtle chooses to nest is a delicate balance between the energy spent searching for the right spot and the benefits that location provides for successful egg incubation. Because nest placement directly influences hatchling survival, emergence success, and even sex ratios, ...

City of Hope Research Spotlight, October 2025: This roundup of 10 studies highlights pivotal findings—from smarter cancer treatments and AI-powered care to new clues for health equity and immune rec

2025-11-13
LOS ANGELES — City of Hope® Research Spotlight offers a glimpse into groundbreaking scientific and clinical discoveries advancing lifesaving cures for patients with cancer, diabetes and other chronic, life-threatening diseases. Each spotlight features research-related news, such as recognitions, collaborations and the latest research defining the future of medical treatment.  To learn more about research at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center ranked among the nation’s top cancer centers by U.S. News & World Report, visit our newsroom.    Long-Term ...

Model construction and dominant mechanism analysis of Li-ion batteries under periodic excitation

2025-11-13
The lithium-ion battery is a new energy storage device widely employed in various fields such as mobile power, electric vehicles, unmanned aerial vehicles, and spacecrafts due to its high energy, high efficiency, lightweight, and environmental friendliness. Understanding the internal mechanism of the battery is of utmost importance. The electrochemical model provides detailed insights into the internal mechanism of lithium batteries and encompasses the single-particle model and the P2D model, as well as ...

Scientists unveil the world's most comprehensive AI-powered tool for neuroscience

2025-11-13
SEATTLE, WASH. —NOVEMBER 13, 2025— Imagine if every neuroscientist in the world could suddenly speak the same language and share their discoveries instantly.  Allen Institute researchers and engineers have now unlocked that potential and the vast discoveries it could lead to through the new Brain Knowledge Platform (BKP).    This first-of-its-kind database and research tool has just launched with data from over 34 million brain cells. It compiles and standardizes the world’s neuroscience data into a common format and language allowing deep, seamless collaboration between international ...

American College of Medical Genetics and Genomics announces CEO transition

2025-11-13
BETHESDA, MD – November 13, 2025 | The American College of Medical Genetics and Genomics (ACMG) announced today that Melanie Wells, MPH, CAE, Chief Executive Officer of ACMG and the ACMG Foundation for Genetic and Genomic Medicine (ACMGF), will step down from her role, concluding her tenure on November 21, 2025. Wells will continue to support the organizations through the transition period, and ACMG and ACMGF will appoint an interim CEO shortly to ensure continuity of leadership and operations. Wells joined the organizations in 2016 and has served in multiple leadership capacities, ...

Hidden signatures of ancient Rome’s master craftsmen revealed

2025-11-13
In the hushed light of a museum gallery, Hallie Meredith discovered something intriguing about ancient Roman glasswork hiding in plain sight. It was February 2023, and the Washington State University art history professor and glassblower was examining a private collection of Roman glass cage cups at the Metropolitan Museum of Art in New York City. These delicate works of luxury were carved from a single block of glass between 300 and 500 CE and have been studied for centuries for their beauty. Meredith’s revelation was not the result of advanced imaging or new technology but rather a simple act of curiosity: turning one of the vessels around. On the reverse side ...

Gas-switch reduction enables alloying in supported catalysts

2025-11-13
Supported catalysts are systems in which the active catalytic materials, such as metals, are dispersed on a solid support material, such as alumina, silica, etc. These catalysts are widely used in various chemical processes. Several methods are available for preparing supported catalysts. Among these, the simple impregnation method is particularly suited for industrial settings. In this method, metal precursors and oxide supports are mixed, dried, and crystallized via heat treatment under certain gases. Various high-performance supported catalysts have been prepared using impregnation. However, this method has mostly been used to synthesize conventional monometallic ...

Pusan National University researchers reveal how sea ice decline intensifies ocean mixing in warming polar regions

2025-11-13
“Shaken, not stirred” — it is widely known how James Bond prefers his martinis. In physics, stirring stretches a fluid into thin streaks, creating turbulence and mixing its properties. In the ocean, a similar process occurs as winds and other forces move seawater. When this happens horizontally over tens to hundreds of kilometres, it is called mesoscale horizontal stirring (MHS). MHS plays a crucial role in redistributing heat, nutrients, and dissolved substances in the upper ocean, shaping plankton distribution and influencing ...

Pusan National University scientists develop robust “Huber mean” for geometric data

2025-11-13
In an era driven by complex data, scientists are increasingly encountering information that doesn’t lie neatly on flat, Euclidean surfaces. From 3D medical scans to robot orientations and AI transformations, much of today’s data lives on curved geometric spaces, called Riemannian manifolds. Analyzing such data accurately has remained a challenge, especially when noise or outliers distort results. To address this, Professor Jongmin Lee from the Department of Statistics, Pusan National University in collaboration with Professor Sungkyu Jung of Seoul National University developed a new statistical method called the ...

Researchers use living fossils to uncover a wealth of genes for seed improvement

2025-11-13
Seed plants are essential as a source of food, fuel, medicine, and more. Now, a multidisciplinary team of researchers has combined deep botanical knowledge with powerful genomic technology to decode and mine the DNA of non-flowering seed plants and uncover genes that evolved to help plants build seeds. These findings, published in Nature Communications, may aid scientists in improving seed crop production in agriculture and in the conservation of these ancient endangered seed plants. In this study by members of the New York Plant Genomics Consortium—a multi-institutional collaboration of botanists, evolutionary and genomics scientists, and bioinformaticians—the researchers ...

Ocean in coastal areas becoming more acidic than previously thought

2025-11-13
UNDER EMBARGO UNTIL THURSDAY 13TH NOVEMBER 1000 GMT   New research from the university of St Andrews has found that some coastal areas will become much more acidic than previously anticipated. With added atmospheric CO2, these areas are acidifying more quickly than thought, posing an existential threat to coastal economies around the world.                                                  ...

Genes may predict suicide risk in depression

2025-11-13
Depression in young adulthood has a stronger hereditary component and is associated with a higher risk of suicide attempts than depression that begins later in life, according to a new study published in Nature Genetics by researchers at Karolinska Institutet, among others. “We hope that genetic information will be able to help healthcare professionals identify people at high risk of suicide, who may need more support and closer follow-up,” says Lu Yi, senior researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, and one of the study’s corresponding authors. Depression is a ...

Cellarity publishes groundbreaking framework for predicting drug safety in Nature Communications

2025-11-13
SOMERVILLE, Mass., November 13, 2025 – Cellarity, a clinical-stage biotechnology company developing Cell State-Correcting therapies through integrated multi-omics and AI modeling, today announced the publication of a seminal manuscript in Nature Communications, which describes a novel framework for the prediction and characterization of drug-induced liver injury (DILI), along with open-source posting of the model and validation data. DILI is one of the most significant safety challenges in developing therapeutics today, as hepatic safety events undetected in preclinical testing ...

Study provides new forecasts of remote islands’ vulnerability to sea level rise

2025-11-13
In the summer of 2022, 20 islands in the Maldives were flooded when a distant swell event in the Indian Ocean coincided with an extremely high tide level. A new and detailed analysis of that incident, compiled using fieldwork and computer modelling, has shown it to be a relatively rare occurrence with the worst flooding seen in the region since the Boxing Day tsunami of 2004. However, scientists have warned that future predicted rises in sea levels, potentially coupled with an increase in extreme weather events and wave conditions, could result in such flooding becoming far more common, perhaps happening every two to three years by around 2050. It has led them to ...

Eric Nestler receives the UNIGE Synapsy Prize 2025

2025-11-13
The Synapsy Centre for Neuroscience Research in Mental at the University of Geneva (UNIGE) Faculty of Medicine has awarded its first prize to Professor Eric Nestler, a leading figure in the neurobiology of depression and addiction. The prize recognises a career dedicated to linking fundamental discoveries about the brain to concrete clinical advances in mental health. Psychiatry has been evolving over the past twenty years. Driven by a new scientific ambition, it seeks to understand the biological mechanisms underlying mental disorders to improve their diagnosis and treatment. This translational approach aims to foster dialogue ...

Artificial intelligence, wellness apps alone cannot solve mental health crisis

2025-11-13
Emotional support is an increasingly common reason people turn to generative artificial intelligence chatbots and wellness applications, but these tools currently lack the scientific evidence and the necessary regulations to ensure users’ safety, according to a new health advisory by the American Psychological Association. The APA Health Advisory on the Use of Generative AI Chatbots and Wellness Applications for Mental Health examined consumer-focused technologies that people are relying on for mental health advice and treatment, ...

Fair fare

2025-11-13
The unforeseen consequences of modern lifestyles are coming to the forefront as healthcare costs spike in developed countries worldwide. One method to mitigate this is to encourage walking to promote good health. Therefore, initiatives to increase daily steps have been taking shape and becoming subjects for in-depth study. Dr. Haruka Kato, a junior associate professor at Osaka Metropolitan University, with policy planners from the Sakai City Government investigated the ...

Two Keck Medicine of USC hospitals earn ‘A’ Leapfrog hospital safety grade

2025-11-13
LOS ANGELES — Keck Hospital of USC and USC Verdugo Hills Hospital (USC-VHH) each earned a Fall 2025 “A” Hospital Safety Grade from The Leapfrog Group, an independent national nonprofit focused on patient safety. The hospitals are part of Keck Medicine of USC, the University of Southern California’s health system.   “This is the first time the health system has received two ‘A’s simultaneously, which is a huge accomplishment,” said Rod Hanners, CEO of Keck Medicine. “The Leapfrog Group grades hospitals ...
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