New from JNeurosci, Elaine Pinggal, from Monash University, and colleagues assessed how sleep-like brain activity in awake adults influences sustained attention during a task.  The researchers compared sleep-like brain activity from 32 medication-withdrawn adults with ADHD to 31 neurotypical adults as participants performed a task requiring sustained attention. The ADHD group had more sleep-like brain activity, which was associated with more lapses in attention. Further analyses revealed that this activity may drive the relationship between ADHD and attention ...

Preclinical studies on animals have identified brain pathways that drive quick, protective fear responses to “scary” sounds. New from JNeurosci, Emmanouela Kosteletou-Kassotaki and colleagues, from the University of Barcelona, expand on this work by exploring whether humans also have a brain pathway enabling quick fear responses to certain sounds.  Using publicly accessible data from the Human Connectome Project, the researchers examined ...

RIVERSIDE, Calif. -- A global analysis of more than 2,300 seawater samples from more than 20 field studies around the globe indicates that human-made chemicals make up a significant portion of organic matter in coastal oceans. The international study, led by biochemists Jarmo Kalinski and Daniel Petras at the University of California, Riverside, analyzed seawater samples collected over a decade from coastal regions from the Pacific, Atlantic, and Indian Oceans. Reported in Nature Geoscience, the findings show that ...

Loss of communication can be among the most devastating symptoms for patients with paralysis. A new study by investigators from Mass General Brigham Neuroscience Institute and Brown University describes an investigational implantable brain computer interface (iBCI) typing neuroprosthesis that can restore communication with speed and accuracy. The tool, which utilizes the QWERTY keyboard and attempted finger movements, performed well in two BrainGate clinical trial participants—one with amyotrophic lateral sclerosis (ALS) and the other with a cervical spinal cord injury. Their results are published ...

A new computational tool infers changes occurring at the ends of the chromosomes housing our DNA. It does so by detecting structural alterations in cells and tissues captured in images taken of routine medical biopsies, according to findings published March 16, 2026, in Cell Reports Methods. Scientists at Sanford Burnham Prebys Medical Discovery Institute developed the TLPath model based on the hypothesis that modifications in the shape and structure of cells and tissues could be used to predict the length of repeating sections of DNA called ...

About The Study: This cross-sectional analysis found that delays in treatment initiation for early-onset colorectal cancer—often exceeding 90 days—were more common in all-urban populations and appeared to disproportionately affect young male, Asian or Pacific Islander, Black, or Hispanic patients. Although absolute differences in average treatment timing were modest, the focus in this study on clinically relevant delay thresholds (30, 60, and 90 days) is supported by recent meta-analytic literature. The consistency of these delays across sociodemographic groups challenges assumptions of uniformly timely access in urban settings. Corresponding ...

About The Study: This systematic review and meta-analysis of 42 studies observed a relative increase in the annual rate of self-injury visits to health care and self-reported self-injury among children and youth, with variability in baseline rates across studies in 12 high-income countries. Effective, contextually informed, large-scale prevention initiatives are urgently needed to curb the rise in self-injury within high-income countries, particularly among female individuals.  Corresponding Author: To contact the corresponding author, Natasha ...

In a phase 2b clinical trial, an investigational oral therapy called PrimeC was found to be safe and well tolerated in people living with amyotrophic lateral sclerosis (ALS), with exploratory findings suggesting target engagement and potential clinical benefits. Results of the PARADIGM study, led by researchers at Mass General Brigham Neuroscience Institute and Barrow Neurological Institute, were published in JAMA Neurology. ALS is a progressive neurodegenerative and typically fatal disease marked by the loss of motor neurons and the gradual increase in muscle ...

About The Study: This randomized clinical trial found that continuing glucagon-like peptide-1 (GLP-1) or glucose-dependent insulinotropic polypeptide (GIP) agonist in the preprocedural period increased clinically significant residual gastric volume (RGV) but did not increase the risk of other adverse events. Clear liquids the day prior to the procedure may mitigate the risk of clinically significant RGV regardless of GLP-1/GIP use.  Corresponding Author: To contact the corresponding author, Tilak Shah, MD, MHS, email shaht3@ccf.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2026.0027) Editor’s ...

In a clinical trial supported by the National Institutes of Health (NIH), a research team found that administering weekly injectable extended-release buprenorphine for treatment of opioid use disorder (OUD) during pregnancy led to higher rates of abstinence from illicit opioids than buprenorphine given daily under the tongue (sublingual), one of the standard methods of treatment. Additionally, serious adverse events were less common in those receiving extended-release treatment. The findings, which support the use of this formulation of buprenorphine for treating OUD during ...

BALTIMORE, MD, March 14, 2026, Dr. Thomas Hartung, Director of the Center for Alternatives to Animal Testing (CAAT) at the Johns Hopkins Bloomberg School of Public Health, has endorsed the public launch of ToxIndex, an agentic AI platform developed by Insilica Inc. that produces comprehensive, source-traceable toxicological risk assessments in just a few hours. The launch of ToxIndex meets a critical need in chemical and drug safety, as well as in exposomics, a field of study that considers the effects of environmental exposures on human health and serves as a complement and counterpart to ...

Type 2 diabetes (T2D) and obesity are metabolic conditions with many causes, including overlapping and distinct genetic features. A polygenic risk score (PRS) can capture multiple genetic risk factors to provide an estimate for whether a person may develop a complex medical condition and how they might fare long-term. By integrating genetic findings from several of the world’s largest biobanks, investigators from Mass General Brigham built metabolic PRSs for predicting obesity and T2D, which outperformed existing ...

Dielectric ceramic capacitors are critical components in modern electronics and pulsed power systems, prized for their ultra-fast charge–discharge capabilities and high-power density. However, their real-world application has been constrained by modest recoverable energy storage density (Wrec) and energy efficiency (η), especially under extreme operating conditions. Now, a research team led by Professor Changzheng Hu from the College of Materials Science and Engineering at Guilin University of Technology has developed a new class of lead-free relaxor ferroelectric ceramics that overcome these limitations. By integrating high-entropy design with bandgap engineering, ...

Dielectric ceramic capacitors are essential core components for electronics, smart grids and new energy vehicles, prized for their high power density. As electronic devices move toward miniaturization and intelligence, the demand for lead-free dielectric ceramics with ultrahigh recoverable energy storage density (Wrec) and high efficiency (η) is becoming increasingly urgent. Relaxor ferroelectrics (RFE) suffer from relatively large remnant polarization, while superparaelectric relaxor ferroelectrics (SPE-RFE) see ...

Febrile neutropenia (FN) is a serious chemotherapy complication defined by fever (≥38.3°C) and low neutrophil count (<0.5×10⁹/L). It affects 7–8 per 1,000 cancer patients, with 9.5% mortality. FN often leads to chemotherapy delays, compromising treatment efficacy. Current standard care—antibiotics and granulocyte colony-stimulating factor (G-CSF)—faces limitations including antibiotic resistance, G-CSF side effects (bone pain, vasculitis), and refractory cases. Traditional Chinese ...

Thermal barrier coatings are indispensable shields that protect the hot-end components of gas turbines and aircraft engines from extreme temperatures. Current industry-standard YSZ coatings face several critical limitations: an unstoppable phase transition that restricts operating temperatures below 1200 °C, dramatically rising thermal conductivity due to thermal radiation above 900 °C, severe corrosion by CaO–MgO–Al2O3–SiO2 (CMAS) melts, and vulnerability to moisture degradation. These combined deficiencies have driven urgent demand for next-generation TBC materials capable of sustained service at 1200–1500 °C. High-entropy ...

(Toronto, March 16, 2026) JMIR Publications is proud to announce the appointment of Dr. Sara Simblett as the new editor in chief of JMIR Neurotechnology. Dr. Sara Simblett is a clinical academic whose work focuses on digital health innovation, patient engagement, and the integration of technology into neuropsychology and broader mental health services. Her research is translational, combining clinical psychology, implementation science, and data-driven methodologies, such as ecological momentary assessment and the use of mobile technology, to evaluate and scale digital interventions that improve ...

SAN ANTONIO — March 16, 2026 — Southwest Research Institute (SwRI) has received a contract from the U.S Air Force Academy to characterize inspection methods for bolt holes in aging aircraft to inspect through bushings without removing them. Assessing bolt hole condition inspection supports wider efforts that inform repair decisions and ensure aircraft safety. For decades, SwRI has supported the U.S. Air Force’s Aircraft Structural Integrity Program (ASIP) and the U.S. Air Force Academy Center for Aircraft Structural Life Extension ...

PULLMAN, Wash. — Again and again, Washington State University professor Mesut Cicek and his colleagues fed hypotheses from scientific papers into ChatGPT and asked it to determine whether the statements had been upheld by research — whether they were true or false. They did this with more than 700 hypotheses, repeating each query 10 times. AI answered correctly 76.5% of the time when the experiment was run in 2024. When it was repeated in 2025, the accuracy improved to 80%. When accounting for random guessing, however, AI was only about 60% better than chance ...

Nearly 1 in 5 teens in the United States is obese, putting their long-term health at serious risk. Obesity in adolescence leads to many deleterious medical conditions including diabetes, high blood pressure, sleep apnea, and mental health struggles with low self-esteem and depression.   Understanding patterns of obesity and weight-loss efforts in U.S. adolescents is critical for shaping effective clinical and public health interventions. Yet, data remain sparse on whether and how adolescents attempt to lose weight. To explore these issues, researchers from Florida Atlantic University’s Charles E. Schmidt ...

PULLMAN, Wash. — Livestock breeders could soon have more tools to improve the health and quality of their animals, thanks to a recent study that sheds new light on regulatory elements in the sheep genome. Previous research demonstrated that several areas of the genome, regardless of species, are responsible for modulating or regulating gene expression. This study, the first of its kind on sheep, resulted in a detailed map that illuminates more specifically where those gene promoters and enhancers are located. The findings could help livestock breeders select for beneficial traits such as efficient food digestion or muscle development, while avoiding traits associated with disease.  “A ...

(Boston)—Elevated Lipoprotein(a) [Lp(a)] is an independent, genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD), with levels >50 mg/dL affecting 20–30% of the global population. Despite therapeutic limitations, interest in Lp(a) has increased, driven by its prognostic value and the emergence of targeted therapies. However, with increasing guideline-directed Lp(a) testing, clinician response to elevated concentrations, especially in the absence of guideline-based treatment indications, remains unclear.   In a new study and presentation at the American College of ...

Reliable and scalable water level prediction is crucial in hydrology for effective water resources management, especially when considering challenges owing to climate change, urbanization, improper land use, and high-water demand. It directly impacts the availability and distribution of freshwater in rivers and reservoirs. Therefore, accurate forecasting via early warning systems is a highly useful technique for flood mitigation, agricultural irrigation, ecosystem and environmental sustainability, and numerous other applications. In this regard, physically-based hydrodynamic river models can be used. However, these tools require enormous amounts of data, making them less useful in data-scarce ...

Climate change threatens global food security; however, climate mitigation policies may increase hunger risk by driving competition for land through bioenergy production and afforestation. Based on simulations from six global agroeconomic models, researchers from The University of Tokyo, Ritsumeikan University, Kyoto University, National Institute for Environmental Studies, and E-Konzal Co. Ltd, together with collaborators from other countries, report that the ozone reduction benefits of climate mitigation ...

UNDER EMBARGO UNTIL 10:00 GMT / 6:00 ET MONDAY 16 MARCH 2026 A study led by the University of Oxford has identified a new type of planet beyond our Solar System – one that stores large amounts of sulphur deep within a permanent ocean of magma. The findings have been published today (16 March) in Nature Astronomy. The exoplanet (a planet that orbits a star outside the Solar System), known as L 98-59 d, orbits a small red star about 35 light-years from Earth. Recent observations from the James Webb Space Telescope ...