Washington, D.C. – May 1, 2025 – New technology shows promise for restoring blood flow and advancing care for patients with pulmonary embolism (PE) and carotid artery stenosis (CAS). The data were presented today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Scientific Sessions. Over the past 30 years, deaths from cardiovascular diseases have increased by 60%. There is a growing need for cardiovascular innovation with a focus on patient outcomes, whether that’s through advancements in technology, the use of digital therapeutics, or the research and development of revolutionary devices.  “Constant innovation ...

Washington, D.C. – May 2, 2025 – New analysis from the EARLY TAVR trial showed patients between the age of 65 and 70 years old derived the most benefits of a strategy of early intervention with transcatheter aortic valve replacement (TAVR) compared to other age groups, especially in regards to stroke risk, and in regards to the composite of death, stroke, and heart failure hospitalization. The late-breaking results were presented today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Scientific ...

Washington, D.C. – MAY 2, 2025 – New data from a large, international registry showed balloon-assisted anterior mitral leaflet modification (BATMAN) was safe, effective, and resulted in shorter procedure times among patients undergoing transcatheter mitral valve replacement (TMVR). The data were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Scientific Sessions. An estimated four million people in the U.S. have mitral valve regurgitation (the most common form of heart ...

Background and Aims Heme oxygenase 1 (HO-1) has an influential yet insufficiently investigated effect on Sirtuin 1 (SIRT1), a histone deacetylase activated by nicotinamide adenine dinucleotide, which may impact the transforming growth factor-β (TGF-ß)/Smad3 pathway in nonalcoholic fatty liver disease (NAFLD)-related liver fibrosis. This study aimed to elucidate the regulation of NAFLD-related liver fibrosis induced by HO-1 through the SIRT1/TGF-ß/Smad3 pathway. Methods HO-1 induction and inhibition were established in C57BL/6J mice fed a methionine- and choline-deficient (MCD) diet. Additionally, wild-type mice were fed either ...

Mitochondrial diseases affect approximately 1 in 5,000 people worldwide, causing debilitating symptoms ranging from muscle weakness to stroke-like episodes. Some of these conditions result from mutations in mitochondrial DNA (mtDNA), the genetic material housed in these organelles. For patients with the common m.3243A>G mutation, which can cause MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) and diabetes mellitus, treatments remain limited. A fundamental challenge in mitochondrial disease research is that patients typically have a mix of both normal and mutated mtDNA within their cells. This ...

What is the secret to happiness? Does happiness come from within, or is it shaped by external influences such as our jobs, health, relationships and material circumstances? A new study published in Nature Human Behaviour shows that happiness can come from either within or from external influences, from both, or neither – and which is true differs across people. People have long contemplated the sources of happiness. In recent years, efforts such as the World Happiness Report seek to improve wellbeing across the world. “We have to understand the sources of happiness to build effective ...

Okazaki, Japan – The communication between the brain and bodily organs is fundamental to emotion regulation and overall mental health. The nucleus tractus solitarii (NTS) in the brainstem is a critical hub structure mediating this interaction via the vagus nerve. Despite its importance, the NTS's deep location has historically posed challenges for observation in living animals. In a study recently published in Cell Reports Methods (April 4, 2025), the research team has developed the live NTS imaging method ...

For centuries, many cultures around the world embalmed their dead, often for religious reasons. Accordingly, embalming methods differ, but not all of them are studied equally well. In a first report of a previously undocumented embalming method, an international team of researchers has analyzed a mummy from a small Austrian village. Detailed analyses provided insights into little-known mummification techniques and allowed them to identify the body. “The unusually well-preserved mummy in the church crypt of St Thomas am Blasenstein is the corps of a local parish vicar, ...

Children and young adults with depression, schizophrenia, ADHD, asthma and epilepsy can get great relief from medications to control their symptoms, helping them stay in school or work and prepare for their futures.   But they should keep taking those medications regularly to get the best results; interruptions can cause flare-ups of these chronic health conditions.   Now, a new study suggests that such interruptions happened more often in states that had the biggest drops in Medicaid enrollment during the recent “unwinding” process.   That process, which brought to an end the special Medicaid eligibility rules made at the start ...

The Lancet Child & Adolescent Health: Monoclonal antibody nirsevimab provides strong real-world protection against severe RSV in infants, suggests meta-analysis Nirsevimab, a monoclonal antibody, is highly effective in real-world conditions at preventing severe respiratory syncytial virus (RSV) infections in infants, suggests a meta-analysis published in The Lancet Child & Adolescent Health journal. RSV is a leading cause of serious respiratory illness in young children particularly in the first six months of life, responsible for millions of hospitalisations of children ...

Is your heart aging too fast? MRI technology reveals unhealthy lifestyles add decades Peer reviewed – observational study - humans Scientists at the University of East Anglia (UEA) have developed a revolutionary new way of uncovering the ‘true age’ of your heart using MRI. Research published today shows how an MRI scan can reveal your heart’s functional age - and how unhealthy lifestyles can dramatically accelerate this figure. It is hoped that the findings could transform how heart disease is diagnosed - offering a lifeline to millions by catching problems before they become deadly. The team say their cutting-edge technique ...

Digital Planet, published by The Fletcher School at Tufts University has unveiled the Digital Evolution Index, charting the progress of 125 economies around the world have made in advancing their digital economies, developing artificial intelligence (AI), and integrating connectivity into the lives of billions. This latest edition of the index, developed in collaboration with Mastercard, illustrates global digital development, provides insights into the key factors driving change and momentum, and explores the implications for economies grappling with the aftermath of a global pandemic, ...

Rice University’s Scott Solomon, a biologist, science communicator and teaching professor in the Department of Biosciences, has been named a 2025 Piper Professor by the Minnie Stevens Piper Foundation, one of the most prestigious accolades awarded to educators in Texas. The award honors professors for exceptional teaching and service to students and is given annually to 10 faculty members from colleges and universities across the state. Each recipient receives a $5,000 honorarium and a place in the distinguished roster of Piper Professors, which has recognized outstanding educators since 1958. Solomon, who has taught at Rice for more than 15 years, ...

A new analysis provides evidence that reductions in access to Medicaid could increase deaths and cause financial hardship to people currently covered under an expansion of Medicaid that was implemented under the Affordable Care Act (ACA). Medicaid is a joint federal and state program that provides health insurance to qualifying individuals who are unable to obtain it through their employer, private insurance companies, or Medicare, the public insurance program for seniors and people with disabilities. About two in five births in the United States ...

OKLAHOMA CITY – In a study published Wednesday in the Proceedings of the National Academy of Sciences (PNAS), University of Oklahoma researchers detail their discoveries about why the brain tumor glioblastoma is so aggressive. Their findings center on ZIP4, a protein that transports zinc throughout the body and sets off a cascade of events that drive tumor growth. About half of all malignant brain tumors are glioblastomas, the deadliest form of brain cancer with a median survival rate of 14 months. “Surgery ...

Imagine trying to tell identical twins apart just by looking at their fingerprints. That’s how challenging it can be for scientists to distinguish the tiny powdery pollen grains produced by fir, spruce and pine trees. But a new artificial intelligence system developed by researchers at The University of Texas at Arlington, the University of Nevada and Virginia Tech is making that task a lot easier—and potentially bringing big relief to allergy sufferers. “With more detailed data on which tree species are most allergenic and ...

UNIVERSITY PARK, Pa. — In the United States, syphilis cases rose by nearly 80% between 2018 and 2023, with 209,253 cases reported in the latest year of data. The infection, which can be transmitted sexually or passed from mother to infant during birth, is curable but only if diagnosed quickly. Left untreated, syphilis can progress from painless lesions to brain and cardiovascular damage. Despite the first recorded outbreak of syphilis occurring more than 500 years ago — with some researchers theorizing that it has plagued humans for thousands of years — there still isn’t a way to quickly and reliably test for active ...

COLUMBUS, Ohio – After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of “good” microbes in the gut is linked to rheumatoid arthritis and, potentially, other autoimmune diseases. Scientists first reported in 2016 that specific gut microbes known as commensal bacteria, which cause no harm and often contribute to host health, set off production and release of a gut-originated T cell that drives up body-wide autoimmune disease in mice. Since then, the team has focused on explaining this unexpected twist in the typically harmonious ...

Washington, D.C. – May 1, 2025 – New clinical results from multiple studies show coronary heart disease death associated with tobacco use is anticipated to rise up to 40% in the next five years and people with cannabis use disorder are 50% more likely to experience cardiogenic shock, acute myocardial infarction, and arrhythmias. These studies were presented today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Scientific Sessions. Tobacco and cannabis are two of the most used substances in ...

Urgent action must be taken to reduce the ever-rising number of people killed by extreme temperatures in India, say the authors of a new 19-year study which found that 20,000 people died from heatstroke in the last two decades.  Cold exposure claimed another 15,000 lives.    Findings published today in the peer-reviewed journal Temperature, also revealed that deaths from heatstroke are more common in men of working age and identified the states that are hotspots for deaths from heatstroke and from hypothermia and other conditions fuelled by the cold.    There is an upward moving, increasing trend ...

Psychotherapy assumed a larger role in outpatient mental health care while psychiatric medication without psychotherapy became less common, according to a new study at Columbia University Mailman School of Public Health and Columbia University Irving Medical Center. The findings are published in the American Journal of Psychiatry.  “After years of American mental health care moving towards greater use of psychiatric medications, the pendulum has started swinging back towards psychotherapy,”  said Mark Olfson, MD, MPH, Columbia Mailman ...

WASHINGTON, D.C., May 1, 2025 — The latest issues of three American Psychiatric Association journals (The American Journal of Psychiatry, Psychiatric Services and Focus) are now available online. The May issue of The American Journal of Psychiatry brings together new research on diverse treatment strategies. Highlights of the issue include: Randomized Controlled Trial of Bounce Back Now, a Mobile Application to Reduce Post-Disaster Symptoms of Posttraumatic Stress, Depressed Mood, and Sleep Disturbance. (Lead author Kenneth J. Ruggiero, Ph.D., is the guest on May's AJP Audio podcast episode, and AJP Deputy Editor Daniel Pine, M.D. highlights ...

More than 1,200 physicists from around the world will convene to present new research at the 56th Annual Meeting of the American Physical Society’s Division of Atomic, Molecular and Optical Physics. The conference will be held in person only at the Oregon Convention Center in Portland, Oregon June 16-20. Press registration News media with valid APS press credentials may register for the meeting at no cost. To request press credentials, visit APS’ online newsroom. Registration will remain open throughout the meeting. Housing information Discounted hotel rates are available at select hotels near the Oregon Convention Center. Book ...

A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments. The proof-of-concept study, published today in Science, introduced a mechanism called ‘GlycoCaging’ that releases medicine exclusively to the lower gut at doses up to 10 times lower than current therapies. “With this technique, we have the ability to deliver not just steroids, but a range of drugs including anti-microbial compounds directly to the gut, ...

A partnership announced in January between the American Association for the Advancement of Science (AAAS) and Arizona State University (ASU) includes a new prize for early-career scientists whose research focuses on societal impact. As of 1 May, this prize, developed with AAAS’s flagship peer-reviewed journal, Science, is open for submissions. The ASU-Science Prize for Transformational Research will be awarded to a researcher who uses new methods to identify problems and produce findings with impacts ...