ROCKVILLE, Md. — Certain serious fungal infections occur in regions of the United States with specific environments and are often tied to soil exposure. These infections can affect both healthy and immunocompromised people, but proper diagnosis remains slow, which delays treatment. The current gold standard for making a diagnosis relies on fungal culturing, which can take weeks, and tests that look for antigens, which lack specificity, or antibodies in the blood, which are often unreliable in early disease. But now researchers from Indiana University Health and the IU School of Medicine have developed a new molecular test capable of detecting ...

Artificial intelligence is being utilized across a variety of industries to reduce human workload, speed up workflows and improve output. Within the field of molecular pathology, AI is being used in part to improve diagnostic processes and accuracy. AI has the potential to not only automate tasks, but also to enhance clinical decision making. Innovative studies in diagnostic applications of artificial intelligence will be presented at the Association for Molecular Pathology (AMP) 2025 Annual Meeting & Expo, taking place Nov. 11–15 in Boston. Journalists are invited to attend the meeting in person or sign up for online access ...

Researchers at Dartmouth Hitchcock Medical Center have developed a way to diagnose Lyme disease earlier and more accurately than traditional testing methods. Over the past 30 years, Lyme disease has been on the rise in the United States, particularly in the Northeast region, where ticks carrying the bacterium Borrelia burgdorferi are active from late spring through early fall. If left untreated, Lyme disease can cause joint, heart and nervous system complications. While the characteristic bull’s eye-like rash is an early sign of the disease, it occurs in only about 25% of patients. Many patients develop skin lesions mimicking other illnesses, complicating ...

Pregnancy loss may occur in as many as 25% of all pregnancies. Most of these losses occur in the first trimester, and about half are caused by genetic or chromosomal issues. When pregnancy loss occurs three or more times, the losses are referred to as recurrent. Often the cause of recurrent pregnancy loss is difficult to uncover and remains unknown to those experiencing it. However, two new studies presented at the Association for Molecular Pathology (AMP) 2025 Annual Meeting & Expo, taking place Nov. 11–15 in Boston, provide some answers. These studies both utilized a cutting-edge technique known as optical ...

ROCKVILLE, Md. —  Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. It develops quickly, with symptoms often coming on within just a few weeks, and requires urgent treatment. Despite advances, many patients relapse and outcomes can be poor —  making faster, more accurate diagnostic tools critical to patient survival. Breakthrough studies in hematopathology — including advances in genetic testing, relapse prediction and detection of hidden, disease-defining gene fusions in AML  — will be presented at the Association for Molecular Pathology (AMP) 2025 Annual Meeting & Expo, taking place Nov. 11–15 ...

Journal: The Laryngoscope Title: Nationwide Analysis of Head and Neck Imaging for Bell’s palsy: Insights from Healthcare Claims Authors: Sujay Ratna, MD Candidate, Icahn School of Medicine at Mount Sinai Mingyang Gray, MD, MPH, Assistant Professor of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai Bottom line: This study analyzes how imaging is used to diagnose and manage Bell’s palsy, a condition that causes sudden weakness ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with obesity, type 2 diabetes (T2DM), and metabolic syndrome. Its pathogenesis is complex, following a "multiple-hit" hypothesis that involves triglyceride accumulation, insulin resistance (IR), lipotoxicity, chronic inflammation, and oxidative stress. Among the various adipokines implicated, leptin, a hormone central to energy homeostasis, has been identified ...

Fondazione Telethon announces the positive opinion issued by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommending marketing authorisation in the European Union for Waskyra™, an ex vivo gene therapy for Wiskott-Aldrich Syndrome (WAS), a rare and life-threatening primary immunodeficiency.  Fondazione Telethon is the first non-profit organization to have successfully led the full pathway from laboratory research to regulatory approval, collaborating with industry partners when available to bring gene therapies from discovery to patients. Developed through decades of research at ...

Vaccine Innovation Center, Korea University College of Medicine (Head of the Center, Jung Hee-jin) held an invited training for Ethiopian health officials on Monday, September 1st.   This program is part of the ‘2025 Vaccine Development and Production Education for Strengthening Ethiopia's Vaccine Ecosystem’ organized by the International Vaccine Institute (IVI). It is designed to enhance the international community's capacity to respond to infectious diseases and contribute to global public health improvement.   The program included ...

Across the United States, children spend more than 1,100 hours in school each year – time that shapes not only their academic success but also their emotional and social growth. Yet, for many students, the school environment can also be a source of anxiety and apprehension. School counselors play a pivotal role in addressing these challenges through evidence-based, comprehensive guidance programs. Addressing this critical need, researchers from Florida Atlantic University’s Department of Counselor ...

Scientists at The Hospital for Sick Children (SickKids) have revealed a previously overlooked layer of genetic variation that could help explain why people experience disease differently, and why some treatments work better for certain populations.  Tandem repeats are repeated sections of a DNA strand that make up about seven per cent of the human genome. The likelihood of those tandem repeats causing errors in gene function increases each time they repeat, and they are known to cause conditions like ...

Melanoma remains one of the hardest skin cancers to diagnose because it often mimics harmless moles or lesions. While most artificial intelligence (AI) tools rely on dermoscopic images alone, they often overlook crucial patient information (like age, gender, or where on the body the lesion appears) that can improve diagnostic accuracy. This highlights the importance of multimodal fusion models that can enable high precision diagnosis. To bridge that gap, Professor Gwangill Jeon from the Department ...

Glioblastoma—the most aggressive form of brain cancer—remains one of medicine’s biggest challenges. Despite surgery, radiotherapy, and chemotherapy, most patients survive only about a year after diagnosis. However, a new discovery might change how doctors understand and monitor this deadly disease. Specifically, the study focused on isocitrate dehydrogenase (IDH) wild-type glioblastoma, the most common and rapidly growing form of the tumor, known for its poor prognosis and limited treatment options.   In a study published online on October 11, 2025, in Neuro-Oncology, ...

The most common technique used for closing the uterus after a cesarean delivery causes so many long-term complications that it’s time to question its use. That’s the conclusion reached by two world-renowned specialists in obstetrics and gynecology in an article published in a special issue of the American Journal of Obstetrics & Gynecology on cesarean delivery. The authors argue in favor of replacing the current approach with a closure technique that respects the natural anatomical structure of the uterus. The authors, Dr Emmanuel Bujold, professor at Université ...

Researchers Kohki Horie, Keiichiro Toda, Takuma Nakamura, and Takuro Ideguchi of the University of Tokyo have built a microscope that can detect a signal over an intensity range fourteen times wider than conventional microscopes. Moreover, the observations are made label-free, that is, without the use of additional dyes. This means the method is gentle on cells and adequate for long-term observations, holding potential for testing and quality control applications in the pharmaceutical and biotechnology industries. The findings are published in the journal Nature Communications. Microscopes have ...

ANN ARBOR—For a long time, evolutionary biologists have thought that the genetic mutations that drive the evolution of genes and proteins are largely neutral: they're neither good nor bad, but just ordinary enough to slip through the notice of selection. Now, a University of Michigan study has flipped that theory on its head.  In the process of evolution, mutations occur which can then become fixed, meaning that every individual in the population carries that mutation. A longstanding theory, called the Neutral Theory of Molecular Evolution, posits that most genetic mutations that are fixed are neutral. Bad mutations ...

Tensor operations are the kind of arithmetic that form the backbone of nearly all modern technologies, especially artificial intelligence, yet they extend beyond the simple maths we’re familiar with. Imagine the mathematics behind rotating, slicing, or rearranging a Rubik’s cube along multiple dimensions. While humans and classical computers must perform these operations step by step, light can do them all at once. Today, every task in AI, from image recognition to natural language processing, relies on tensor operations. However, the explosion of ...

Mangrove ecosystems rank among the most efficient "blue carbon" systems on Earth, capable of absorbing and storing vast quantities of atmospheric carbon dioxide (CO2). However, mangroves also release methane (CH4), a potent greenhouse gas, potentially offsetting a portion of their climate mitigation benefits. While prior research has focused primarily on methane emissions from mangrove soils and water surfaces, the role of tree stems as an emission pathway and its significance for global blue carbon accounting have remained largely unexamined. In a new study, researchers from the South China Botanical Garden of the Chinese Academy of Sciences conducted a global-scale ...

Food brings people together. It serves as a tool to communicate political stances, to cultivate cross-cultural comprehension or, if necessary, create tensions. Menus can reflect these intentions by using food to create specific psychological effects and convey symbolic messages. But how exactly is it done? Now, researchers in Portugal have examined menus from diplomatic dinners, state banquets, and receptions hosted over the 20th and 21st centuries to find out how meals reflected and shaped Portuguese foreign policy and ...

A research team from South China University of Technology has made  progress in understanding both the unconditional global existence and the vanishing viscosity limit of parabolic-elliptic coupled systems, with findings that extend existing research. The work, led by Prof. Changjiang Zhu and Dr. Qiaolong Zhu, is published in Acta Mathematica Scientia.   The study focuses on a parabolic-elliptic coupled system, which is a simplified model critical to understanding phenomena where fluid motion interacts with heat radiation. ...

As global water, energy and food demands intensify under climate change, a scalable, round-the-clock technology that simultaneously produces fresh water, electricity and irrigation water is urgently needed. Now researchers from Harbin Institute of Technology, Wuhan University and Tsinghua University—led by Prof. Shih-Hsin Ho—have unveiled an integrated Water/Electricity-Cogeneration–Cultivation (WEC) platform that couples solar-driven desalination with salinity-gradient power generation and zero-pollution crop irrigation. The work offers a practical blueprint for advancing ...

As data theft and counterfeiting grow ever more sophisticated, cryptography demands devices that are miniature, reconfigurable and almost impossible to reverse-engineer. Now researchers from the Shenyang Institute of Automation (CAS), Shanghai University and City University of Hong Kong—led by Prof. Haibo Yu and Prof. Wen Jung Li—have created a micro-dynamic multiple encryption device (μ-DMED) built from coumarin-based metamaterials that can hide, rewrite and store multilevel information under different light fields. The work establishes a new paradigm for on-chip, high-security optical encryption. Why μ-DMED Matters All-Optical ...

Professor Wen-Bo Liu's research group at Wuhan University reported a nickel-catalyzed regioselective hydrogen metallization/5-exo-trig cyclization reaction. Using β-propargylcyclobutanone as a starting material, multi-substituted bicyclo[2.1.1]hexanol can be synthesized in one step, followed by skeletal rearrangement to yield 1,2,4-trisubstituted bicyclo[2.1.1]hexanone. This structure can be used for diverse derivatization reactions. DFT computational studies elucidated the crucial role of carbonyl coordination in regioselectivity control. This research provides a new method for obtaining structurally ...

LA JOLLA, CA—When labor begins, the uterus must coordinate rhythmic, well-timed contractions to deliver the baby safely. While hormones such as progesterone and oxytocin are key contributors to that process, scientists have long suspected that physical forces—in this case, the stretching and pressure that accompany pregnancy and delivery—also play a role. Now, a new study from Scripps Research published in Science on November 13, 2025, reveals how the uterus senses and responds to those forces at a molecular level. The findings could help scientists better understand the biological roots of conditions such as stalled labor and preterm birth, guiding ...

This study is led by Professor Wanneng Yang (National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, China). The team created the Arabidopsis Phenotypic Trait Estimation System (APTES), an open-access pipeline integrating computer vision with optimized deep learning models to automate organ phenotyping. For individual leaf segmentation, an enhanced Cascade Mask R-CNN model achieved precision, recall, and F1 scores of 0.965, 0.958, and 0.961 respectively, representing consistent ~1% improvements ...