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Medicine 2026-03-18

Jagged1 protein builds a highway for breast cancer cells to spread

Researchers at Abo Akademi University found that the protein Jagged1 activates fibroblasts to deposit and align collagen fibers, creating physical pathways for breast cancer metastasis. The mechanism feeds a self-reinforcing cycle through TGF-beta signaling, suggesting new targets for aggressive, hormone-receptor-negative tumors.
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Science 2026-03-18

Iran called him a spy. Now he has won the world's top water prize

Professor Kaveh Madani, branded a 'water terrorist' and forced into exile from Iran for speaking about the country's water crisis, has been named the 2026 Stockholm Water Prize laureate. The CCNY professor and UN water institute director is the youngest recipient in the award's 35-year history.
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Medicine 2026-03-18

One drop of fingertip blood now measures T cell immunity to TB and COVID

A new platform called TOI-IGRA measures pathogen-specific T cell responses using just 15-25 microliters of fingertip blood. The system simultaneously evaluates cellular and antibody immunity, requires no venous draw or expensive lab infrastructure, and can be adapted for different pathogens by swapping antigen libraries.
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Medicine 2026-03-18

CRISPR nanoparticles built CAR-T cells inside mice and beat lab-made ones

A dual-nanoparticle system delivered CRISPR editing tools directly to T cells in living mice, inserting cancer-fighting CAR genes at a precise genomic location. The in vivo-engineered cells cleared aggressive leukemia within two weeks, fought solid tumors, and showed superior stemness compared to conventionally manufactured CAR-T cells.
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Science 2026-03-18

How the cinchona tree makes quinine - solved after a century of effort

After a century of searching, researchers have identified the complete enzymatic pathway by which cinchona trees produce quinine and related alkaloids. The discovery of five new enzymes - including a transferase that performs an unusual ring-forming reaction - enables biotechnological production of these compounds for the first time.
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