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BioCompNet: a deep learning workflow enabling automated body composition analysis toward precision management of cardiometabolic disorders

2025-11-14
Body composition—including bones, muscles, and adipose compartments—constitutes a crucial imaging biomarker for cardiometabolic risk stratification, as supported by extensive evidence; however, conventional imaging quantification remains constrained by labor-intensive workflows and limited anatomical coverage, hindering scalable and comprehensive assessment. Meanwhile, existing deep-learning efforts have largely focused on abdominal fat compartments (e.g., VAT and SAT), overlooking critical tissues such as muscle, ...

Skin cancer cluster found in 15 Pennsylvania counties with or near farmland

2025-11-14
UNIVERSTIY PARK, Pa. — Counties in Pennsylvania that contained or were near cultivated cropland had significantly higher melanoma rates compared to other regions, according to a new study led by scientists at Penn State. Researchers at Penn State Cancer Institute analyzed five years of cancer registry data, 2017 through 2021, and found that adults over the age of 50 living in a 15-county stretch of South Central Pennsylvania were 57% more likely to develop melanoma, the deadliest form of skin ...

For platforms using gig workers, bonuses can be a double-edged sword

2025-11-14
ITHACA, N.Y. –  In the growing gig economy, where a company’s success depends on contractors whose schedules they can’t control, businesses often turn to bonuses to lure and retain these workers. But according to new Cornell-led research, bonuses can be a losing strategy for the stakeholders involved in platform operations. “Bonus Competition in the Gig Economy,” published in the journal Production and Operations Management, shows that not all bonuses are created equal, and the availability of labor dictates which type of bonus is more effective for firms. Fixed bonuses, also known as subsidies – given as part of the contract – ...

Chang'e-6 samples reveal first evidence of impact-formed hematite and maghemite on the Moon

2025-11-14
A joint research team from the Institute of Geochemistry of the Chinese Academy of Sciences (IGCAS) and Shandong University has for the first time identified crystalline hematite (α-Fe2O3) and maghemite (γ-Fe2O3) formed by a major impact event in lunar soil samples retrieved by China's Chang'e-6 mission from the South Pole–Aitken (SPA) Basin. This finding, published in Science Advances on November 14, provides direct sample-based evidence of highly oxidized materials on the lunar surface. Redox reactions are a fundamental component of planetary formation and evolution. ...

New study reveals key role of inflammasome in male-biased periodontitis

2025-11-14
CHAPEL HILL, NC — A study out of the University of North Carolina at Chapel Hill has unveiled new insights into the inflammatory processes behind periodontitis, a common and debilitating gum disease. Research conducted by UNC Adams School of Dentistry’s Julie Marchesan, DDS, PhD, and UNC School of Medicine’s Jenny Y. Ting, PhD, found that a part of the immune system called the inflammasome plays a key role in disease development, and that blocking this system prevents bone resorption only in males. The study, published in the journal Proceedings of the National Academy of Sciences, suggests developing treatments specifically for male patients can have benefits and prompted ...

MD Anderson publicly launches $2.5 billion philanthropic campaign, Only Possible Here, The Campaign to End Cancer

2025-11-14
HOUSTON, NOV. 12, 2025 ― The University of Texas MD Anderson Cancer Center today launches its historic $2.5 billion comprehensive philanthropic campaign, Only Possible Here, The Campaign to End Cancer. The campaign represents the largest fundraising effort in MD Anderson’s 84-year history, bringing together philanthropic support from around the world to advance the institution’s mission to end cancer. Initial donor support already has raised $1.9 billion toward the campaign goal. “We are ...

Donors enable record pool of TPDA Awards to Neuroscience 2025

2025-11-14
SAN DIEGO – The Society for Neuroscience (SfN) announces awards to a record 497 neuroscience trainees to attend Neuroscience 2025, the world’s largest gathering of neuroscientists, through the Trainee Professional Development Award (TPDA) program. This cohort represents the largest pool of TPDA recipients in the program’s history. Over $620,000 in generous donations —  an 11% increase from 2024 — were contributed by individual donors to the Friends of SfN Fund, foundation and corporate supporters, and SfN Council. SfN Council leads this TPDA fundraising initiative and matched many of the donations. “With the generosity of this year’s donors, SfN ...

Society for Neuroscience announces Gold Sponsors of Neuroscience 2025

2025-11-14
SAN DIEGO – The Society for Neuroscience (SfN) is pleased to announce Amazon Web Services (AWS), the Dana Foundation, and Johnson & Johnson as the three Gold Sponsors of Neuroscience 2025, SfN’s annual meeting. All three Gold Sponsors will be recognized and featured regularly before, during, and after Neuroscience 2025. Taking place November 15–19 in San Diego, Neuroscience 2025 is the largest gathering of researchers studying the brain and nervous system. The meeting will showcase cutting-edge science from all corners of the vibrant and diverse neuroscience field, with over 20,000 attendees and including 11,000+ presentations and more than 450 exhibiting ...

The world’s oldest RNA extracted from woolly mammoth

2025-11-14
Researchers from Stockholm University have – for the first time ever – managed to successfully isolate and sequence RNA molecules from Ice Age woolly mammoths. These RNA sequences are the oldest ever recovered and come from mammoth tissue preserved in the Siberian permafrost for nearly 40,000 years. The study, published in the journal Cell, shows that not only DNA and proteins, but also RNA, can be preserved for very long periods of time, and provide new insights into the biology of species that have long since become extinct. “With RNA, we can obtain direct evidence of which genes are ‘turned ...

Research alert: When life imitates art: Google searches for anxiety drug spike during run of The White Lotus TV show

2025-11-14
In season three of the hit television series The White Lotus, the character Victoria Ratliff takes the prescription anti-anxiety medication lorazepam to help with her social anxiety and inability to sleep. Her casual usage of the powerful benzodiazepine — often in combination with white wine — leads to her becoming visibly loopy, slurring her words, and falling asleep at dinner. A recent study led by researchers at University of California San Diego has found that the show's portrayal of lorazepam use was associated with a surge in Google searches for the medication, including queries related to acquiring it online. The findings suggest that the show generated 1.6 million ...

Reading a quantum clock costs more energy than running it, study finds

2025-11-14
A study led by the University of Oxford has identified a surprising source of entropy in quantum timekeeping - the act of measurement itself. In a study published today (14 Nov) in Physical Review Letters, scientists demonstrate that the energy cost of reading a quantum clock far outweighs the cost of running it, with implications for the design of future quantum technologies. Clocks, whether pendulums or atomic oscillators, rely on irreversible processes to mark the passage of time. At the quantum scale, where such processes are weak or nearly absent, timekeeping becomes much more ...

Early MMR vaccine adoption during the 2025 Texas measles outbreak

2025-11-14
About The Study: In concordance with Centers for Disease Control and Prevention (CDC) recommendations, the data from this study show a rapid rise in early measles vaccination in early 2025. These data suggest an increase in early vaccination started in February, even before the updated guidelines were issued, potentially due to clinician and/or parental concern. Corresponding Author: To contact the corresponding author, Brianna M. Goodwin Cartwright, MS, email briannac@truveta.com. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.43002) Editor’s ...

Traces of bacteria inside brain tumors may affect tumor behavior

2025-11-14
Researchers found bacterial genetic and cellular elements inside brain tumor cells that appear biologically active and may influence tumor progression and treatment outcomes  These bacterial elements were also found to be linked to specific immune and metabolic responses in brain tumors  Outcomes for glioma and other brain tumor patients remain poor, underscoring the need for better treatments, which these findings may help advance  HOUSTON, NOVEMBER 14, 2025 – ...

Hypertension affects the brain much earlier than expected

2025-11-14
Hypertension impairs blood vessels, neurons and white matter in the brain well before the condition causes a measurable rise in blood pressure, according to a new preclinical study from Weill Cornell Medicine investigators. The changes help explain why hypertension is a major risk factor for developing cognitive disorders, such as vascular cognitive impairment and Alzheimer’s disease. The preclinical findings, published Nov. 14 in Neuron, reveal that hypertension may induce early gene expression changes in individual brain cells that could interfere with thinking and memory. The findings may lead to medications that ...

Nonlinear association between systemic immune-inflammation index and in-hospital mortality in critically ill patients with chronic obstructive pulmonary disease and atrial fibrillation: a cross-sectio

2025-11-14
Background: Chronic obstructive pulmonary disease (COPD) and atrial fibrillation (AF) frequently coexist, and their concurrence is associated with worse clinical outcomes than either condition alone. Inflammation plays a central role in the pathogenesis of both diseases. The systemic immune-inflammation index (SII), derived from neutrophil, platelet, and lymphocyte counts, has emerged as a promising marker reflecting systemic inflammation. However, its prognostic value in critically ill patients with concurrent COPD and AF remains unclear. This study aimed to investigate the association between SII and in-hospital mortality in intensive care unit (ICU) ...

Drift logs destroying intertidal ecosystems

2025-11-14
Logs are a familiar sight on the beaches along the coast of Vancouver Island and Haida Gwaii and are often viewed positively, as they can stabilize the banks, be used for firewood or act as benches by beach-goers. However, new research from the University of Victoria (UVic) shows that these logs are not as innocuous as they seem.  According to a study published by UVic biologist Tom Reimchen and two of his students, free-floating logs that wash ashore, referred to as drift logs, are causing widespread destruction of rocky intertidal ecosystems communities along the coast of Western Canada.  “In this study, we looked at both the ecological impact of drift ...

New test could speed detection of three serious regional fungal infections

2025-11-14
ROCKVILLE, Md. — Certain serious fungal infections occur in regions of the United States with specific environments and are often tied to soil exposure. These infections can affect both healthy and immunocompromised people, but proper diagnosis remains slow, which delays treatment. The current gold standard for making a diagnosis relies on fungal culturing, which can take weeks, and tests that look for antigens, which lack specificity, or antibodies in the blood, which are often unreliable in early disease. But now researchers from Indiana University Health and the IU School of Medicine have developed a new molecular test capable of detecting ...

New research on AI as a diagnostic tool to be featured at AMP 2025

2025-11-14
Artificial intelligence is being utilized across a variety of industries to reduce human workload, speed up workflows and improve output. Within the field of molecular pathology, AI is being used in part to improve diagnostic processes and accuracy. AI has the potential to not only automate tasks, but also to enhance clinical decision making. Innovative studies in diagnostic applications of artificial intelligence will be presented at the Association for Molecular Pathology (AMP) 2025 Annual Meeting & Expo, taking place Nov. 11–15 in Boston. Journalists are invited to attend the meeting in person or sign up for online access ...

New test could allow for more accurate Lyme disease diagnosis

2025-11-14
Researchers at Dartmouth Hitchcock Medical Center have developed a way to diagnose Lyme disease earlier and more accurately than traditional testing methods. Over the past 30 years, Lyme disease has been on the rise in the United States, particularly in the Northeast region, where ticks carrying the bacterium Borrelia burgdorferi are active from late spring through early fall. If left untreated, Lyme disease can cause joint, heart and nervous system complications. While the characteristic bull’s eye-like rash is an early sign of the disease, it occurs in only about 25% of patients. Many patients develop skin lesions mimicking other illnesses, complicating ...

New genetic tool reveals chromosome changes linked to pregnancy loss

2025-11-14
Pregnancy loss may occur in as many as 25% of all pregnancies. Most of these losses occur in the first trimester, and about half are caused by genetic or chromosomal issues. When pregnancy loss occurs three or more times, the losses are referred to as recurrent. Often the cause of recurrent pregnancy loss is difficult to uncover and remains unknown to those experiencing it. However, two new studies presented at the Association for Molecular Pathology (AMP) 2025 Annual Meeting & Expo, taking place Nov. 11–15 in Boston, provide some answers. These studies both utilized a cutting-edge technique known as optical ...

New research in blood cancer diagnostics to be featured at AMP 2025

2025-11-14
ROCKVILLE, Md. —  Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. It develops quickly, with symptoms often coming on within just a few weeks, and requires urgent treatment. Despite advances, many patients relapse and outcomes can be poor —  making faster, more accurate diagnostic tools critical to patient survival. Breakthrough studies in hematopathology — including advances in genetic testing, relapse prediction and detection of hidden, disease-defining gene fusions in AML  — will be presented at the Association for Molecular Pathology (AMP) 2025 Annual Meeting & Expo, taking place Nov. 11–15 ...

Analysis reveals that imaging is overused in diagnosing and managing the facial paralysis disorder Bell’s palsy

2025-11-14
Journal: The Laryngoscope Title: Nationwide Analysis of Head and Neck Imaging for Bell’s palsy: Insights from Healthcare Claims Authors: Sujay Ratna, MD Candidate, Icahn School of Medicine at Mount Sinai Mingyang Gray, MD, MPH, Assistant Professor of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai Bottom line: This study analyzes how imaging is used to diagnose and manage Bell’s palsy, a condition that causes sudden weakness ...

Research progress on leptin in metabolic dysfunction-associated fatty liver disease

2025-11-14
Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with obesity, type 2 diabetes (T2DM), and metabolic syndrome. Its pathogenesis is complex, following a "multiple-hit" hypothesis that involves triglyceride accumulation, insulin resistance (IR), lipotoxicity, chronic inflammation, and oxidative stress. Among the various adipokines implicated, leptin, a hormone central to energy homeostasis, has been identified ...

Fondazione Telethon announces CHMP positive opinion for Waskyra™, a gene therapy for the treatment of Wiskott-Aldrich syndrome (WAS)

2025-11-14
Fondazione Telethon announces the positive opinion issued by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommending marketing authorisation in the European Union for Waskyra™, an ex vivo gene therapy for Wiskott-Aldrich Syndrome (WAS), a rare and life-threatening primary immunodeficiency.  Fondazione Telethon is the first non-profit organization to have successfully led the full pathway from laboratory research to regulatory approval, collaborating with industry partners when available to bring gene therapies from discovery to patients. Developed through decades of research at ...

Vaccine Innovation Center, Korea University College of Medicine hosts an invited training program for Ethiopian Health Ministry officials

2025-11-14
Vaccine Innovation Center, Korea University College of Medicine (Head of the Center, Jung Hee-jin) held an invited training for Ethiopian health officials on Monday, September 1st.   This program is part of the ‘2025 Vaccine Development and Production Education for Strengthening Ethiopia's Vaccine Ecosystem’ organized by the International Vaccine Institute (IVI). It is designed to enhance the international community's capacity to respond to infectious diseases and contribute to global public health improvement.   The program included ...
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