Contact: Chris Martin, MPH IASLC Media Relations cmartin@davidjamesgroup.com (Barcelona, Spain September 7, 2025, 10:45 a.m. CEST / UTC +2) – New results from the ACROSS 2 Phase III trial demonstrate that aumolertinib combined with platinum-pemetrexed chemotherapy significantly improves progression-free survival compared to aumolertinib monotherapy in patients with advanced/metastatic non-small cell lung cancer (NSCLC) harboring EGFR sensitizing mutations and concomitant tumor suppressor gene mutations. The results were presented by Dr. Jie Wang, National Cancer Center, ...

Contact: Chris Martin, MPH/IASLC Media Relations/cmartin@davidjamesgroup.com (Barcelona, Spain — September 6, 2025, 5:45 p.m. CEST / UTC +2 ) — A novel antibody-drug conjugate (ADC), iza-bren (BL-B01D1), demonstrated encouraging safety and efficacy results in previously treated patients with EGFR-mutated non-small cell lung cancer (NSCLC), according to findings presented at the International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC). Iza-bren is a first-in-class EGFR x HER3 bispecific ADC linked to a novel topoisomerase I inhibitor payload (Ed-04). The drug was evaluated ...

Iza-Bren in combination with Osimertinib Shows 100% Response Rate in EGFR-Mutated NSCLC, Phase II Study Finds Barcelona, Spain (September, 2025) —A combination of iza-bren (BL-B01D1), a novel bispecific antibody-drug conjugate (ADC), with osimertinib demonstrated a 100% objective response rate (ORR) in patients with first-line EGFR-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC). This study was presented today at the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer (WCLC). Iza-bren is a first-in-class ADC combining EGFR and HER3 targeting with a topoisomerase I inhibitor payload. The study tested iza-bren at multiple ...

(Barcelona, Spain September 6, 2025, 5:45 p.m. CEST / UTC +2 ) — A new analysis from the COMPEL trial shows that patients with EGFR-mutated (EGFRm) advanced non-small cell lung cancer (NSCLC) who experienced non-central nervous system (CNS) progression on first-line osimertinib benefit from continuing osimertinib treatment in combination with platinum-based chemotherapy. The study was presented today at the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer (WCLC). The COMPEL study is a global, randomized, double-blind trial, in which adult patients with non-CNS progression on first-line osimertinib were randomized 1:1 to receive either osimertinib ...

(Barcelona, Spain September 6, 2025, 5:45 p.m. CEST / UTC +2 ) — An analysis from the Phase 3 CheckMate 77T trial confirms that perioperative nivolumab does not compromise health-related quality of life (HRQoL) in patients with resectable non-small cell lung cancer (NSCLC), including those with Stage III N2 disease. These results were presented today at the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer (WCLC). The study assessed HRQoL by nodal status and surgical outcomes using patient-reported outcome (PRO) measures such as the NSCLC-Symptom Assessment Questionnaire (NSCLC-SAQ) and the EQ-5D-3L visual ...

(Barcelona, Spain September 6, 2025, 5:45 p.m. CEST / UTC +2 ) — A new study presented at the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer (WCLC) validates the use of Sybil, a deep learning artificial intelligence model, for predicting future lung cancer risk in a predominantly Black population. The study, conducted by the University of Illinois Hospital & Clinics, (UI Health), the academic health enterprise of the University of Illinois Chicago (UIC), highlights Sybil’s strong performance in a real-world clinical setting with racially and socioeconomically ...

Research Highlights: Results from the FigHTN Phase 2 clinical trial showed baxdrostat, a new medication that inhibits the production of the hormone aldosterone, lowered systolic blood pressure by about 5% when added to the existing medications taken by people with chronic kidney disease and who also have uncontrolled high blood pressure. The analysis also found that baxdrostat lowered the loss of albumin in the urine, which is a marker of kidney and cardiovascular risk, by 55% compared to placebo, suggesting that this medication may help delay the progression of kidney disease . These findings suggest the potential for baxdrostat to improve longer-term health outcomes like kidney and ...

  The integration of oncolytic viruses (OVs) with immunotherapy is reshaping the landscape of tumor treatment, offering new hope for patients. This cutting-edge approach harnesses the ability of OVs to selectively infect and destroy tumor cells, while simultaneously stimulating anti-tumor immune responses. The latest advancements in genetic engineering have further optimized these therapies, leading to improved clinical outcomes and enhanced patient quality of life.   By combining OVs with cellular immunotherapy, immune checkpoint inhibitors, cancer vaccines, cytokines, and bi- or tri-specific T cell engagers, researchers have developed innovative ...

  Head and neck cancer remains a major global health challenge, ranking among the six most common cancers worldwide and claiming hundreds of thousands of lives each year. A growing body of evidence now points to an intricate connection between energy metabolism and immune regulation as a driving force behind the onset, progression, and treatment resistance of these cancers. The latest comprehensive review on this topic underscores the potential of targeting these intertwined processes to unlock more effective therapies.   Tumor cells in head and neck cancer exhibit profound metabolic reprogramming, altering the way they process glucose, lipids, and ...

BATON ROUGE – Pennington Biomedical Research Center is proud to announce that Dr. Steven B. Heymsfield, Professor of Metabolism and Body Composition, has been named a Boyd Professor of Louisiana State University – the highest faculty rank and honor awarded within the LSU System. The Boyd Professorship is reserved for faculty whose outstanding achievements and international reputations bring significant prestige to LSU. Dr. Heymsfield joins an elite group of scholars recognized for advancing knowledge and transforming ...

  Hed: Study prompts new theory of human-machine communication   LAWRENCE – In a new paper, two University of Kansas scholars propose a novel theory of communication analysis that takes into better account how people interact with ubiquitous technology in the 21st-century workplace. In “Socio-Technical Exchange with Machines: Worker Experiences with Complex Work Technologies,” ----- link to https://doi.org/10.30658/hmc.10.3 ----------- in the Human-Machine Communications ...

UNIVERSITY PARK, Pa. — Essentially all cells in an organism’s body have the same genetic blueprint, or genome, but the set of genes that are actively expressed at any given time in a cell determines what type of cell it will be and its function. How rapidly gene expression in a single cell changes over time can provide insight into how cells might become more specialized, but current measurement approaches are limited. A new method developed by researchers at Penn State and Yale University incorporates spatial information from the cell as well as data from cells processed at different times, improving researchers’ ability to understand the nuances of gene expression ...

The movement of genetic material between organisms that aren’t directly related is a significant driver of evolution, especially among single-celled organisms like bacteria and archaea. A team led by researchers at Bigelow Laboratory for Ocean Sciences have now estimated that an average cell line acquires and retains roughly 13 percent of its genes every million years via this process of lateral gene transfer. That equates to about 250 genes swapped per liter of seawater every day. The new study, recently published in The ISME Journal, provides the first quantitative analysis of gene transfer rates across an entire microbiome. It calls into question the strict classification ...

The U.S. Air Force awarded startup SkyNano, led by Innovation Crossroads alumna Anna Douglas, a $1.25 million contract to advance its CO2-to-carbon nanotube technology as part of a project to develop low-cost, battery-grade graphite. SkyNano’s partners include American Energy Technologies Company and Eonix, led by Innovation Crossroads alumnus Don DeRosa. SkyNano and Eonix were recruited to Knoxville through Innovation Crossroads, a Lab-Embedded Entrepreneurship Program node at Oak Ridge National Laboratory.  “In addition to accessing ...

Some of the populations with the highest risk for Alzheimer’s disease remain greatly underrepresented in clinical trials—and a new study helps explain why. Researchers from the Keck School of Medicine of USC found that participants from these high-risk groups are less likely to have elevated amyloid in the brain based on blood levels of p-tau217.  Elevated amyloid is a requirement for clinical trials of Alzheimer’s disease treatments, and amyloid is known to accumulate in the brain years before any signs of cognitive decline. The study, funded in part by the National Institutes of Health (NIH), builds on earlier research with similar findings, but leverages ...

    This review article highlights the transformative potential of in vivo CAR T cell therapy in addressing the limitations of traditional CAR T cell production. This innovative approach could revolutionize cancer treatment, offering a more efficient, scalable, and cost-effective alternative to conventional methods.   CAR T cell therapy has shown remarkable success in treating hematological malignancies; however, current production methods are laborious, time-consuming, and expensive. Traditional in vitro CAR T cell production typically requires 2–3 weeks and involves complex processes, including T cell isolation, activation, genetic modification, ...

  Recent advances in cancer treatment highlight the potential of natural medicines to target the tumor vascular microenvironment, offering a novel strategy to inhibit tumor growth and metastasis. Unlike conventional therapies that directly target tumor cells, natural compounds focus on normalizing tumor vasculature and inhibiting pathological angiogenesis, crucial processes in cancer progression. This innovative approach holds promise in enhancing anti-cancer therapies while minimizing side effects.   The tumor vascular microenvironment plays a pivotal role in cancer development. Tumor blood vessels are often irregular, immature, ...

In the depths of the ocean, marine corals have evolved intricate, porous structures that shelter diverse microbial communities. Now, researchers have borrowed this biological blueprint to create an ingestible pill that can sample bacteria from one of the most inaccessible regions of the human body: the small intestine. The CORAL (Cellularly Organized Repeating Lattice) capsule, developed by Khalil Ramadi – assistant professor of bioengineering at NYU Tandon School of Engineering and NYU Abu Dhabi (NYUAD) – and ...

East Hanover, NJ – September 5, 2025 – The latest National Trends in Disability Employment (nTIDE) report shows that, in contrast to people without disabilities, the employment and labor force participation of people with disabilities of people with disabilities increased, narrowly reaching all-time highs, according to nTIDE experts. nTIDE is issued by Kessler Foundation and the University of New Hampshire’s Institute on Disability. Month-to-Month nTIDE Numbers (comparing July 2025 to August 2025) Based on data from the U.S. Bureau of Labor Statistics (BLS) Jobs Report released today, the employment-to-population ratio ...

Key points: Utah refugees face very high levels of food insecurity. Food insecurity spikes when refugees become ineligible for food assistance. Proposed solutions include improving education about resources and increasing access to gardens. IMPACT: Timely interventions to reduce food insecurity could benefit health and save the U.S. healthcare system billions. Three months ago, you left your country fearing for your life.  Now, you’re learning to navigate a new city, where the street signs are in a new language. You’re ...

ITHACA, N.Y. – In the quest to address infertility, Cornell University researchers have developed a groundbreaking device that could simplify and automate oocyte cumulus removal, a critical step in assisted reproductive technologies. Their vibration-powered chip not only simplifies a complex procedure but also extends it to areas of the world lacking skilled embryologists or well-funded labs—reducing overall costs. This offers hope to millions of couples struggling with infertility – and makes fertility treatments more accessible worldwide. “This ...

Embargoed: Not for Release Until 2:00 pm U.S. Eastern Time Friday, 05 September 2025 In brief:  Countries that have ratified the Port State Measures Agreement, which entered into force in 2016, are required to designate certain ports for foreign vessels to land their fish and undergo standardized inspections to identify illegal catches.  As more countries adopted the internationally binding agreement between 2016 and 2021, the distance that foreign fishing vessels needed to travel to reach a port within a country that had not ratified the treaty doubled. Domestic fishing ...

Scientists transform plastic waste into efficient CO2 capture materials From waste to valuable resource: Chemists at the University of Copenhagen have developed a method to convert plastic waste into a climate solution for efficient and sustainable CO2 capture. This is killing two birds with one stone as they address two of the world’s biggest challenges: plastic pollution and the climate crisis. As CO2 concentrations in the atmosphere keep rising regardless of years of political intentions to limit emissions, the world’s ...

The study, published today (5 September) in the journal Science Advances, indicates how the heating in North America can trigger remote effects in Asia – this could be further exacerbated by anthropogenic global warming and human modification of the North American land surface. The authors of the study say their findings emphasise the importance of global cooperation in addressing climate change. Using climate models, scientists from the University of Bristol and the Institute of Tibetan Plateau Research (ITP) from the Chinese Academy of Sciences ...

  Agreement focuses on rimiducid, an agent used to activate certain safety switch technologies in cell therapies Phoenix receives a supply of rimiducid and support to seek regulatory approval of a new proprietary injectable formulation, retaining exclusive rights for use in its novel in vivo gene therapy programs MD Anderson receives rights to the new formulation of rimiducid for use with its inducible switches exclusively in ex vivo cell therapies Collaborators hope to use these tools to further enhance cell and gene therapies HOUSTON and MIAMI, SEPTEMBER 5, 2025 ― The University of Texas MD Anderson Cancer Center and Phoenix SENOLYTIX, Inc., today announced ...