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Molecular mechanism of chemical diversity of thermophilic fungus and its ecological and biological functions

Molecular mechanism of chemical diversity of thermophilic fungus and its ecological and biological functions
2024-04-23
Thermophilic fungi are chief components of mycoflora in a variety of natural and manmade composting systems, including rotting hay, stored grains, wood mulch, nesting material of birds and animals, municipal refuse, and self-heating accumulated organic matter. Thermophilic fungi are also a potential source of natural products, which complement the metabolite libraries of mesophilic fungi and bacteria.   The research team led by Prof. Dr. Xuemei Niu (State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University) has been working on the discovery of secondary metabolites in thermophilic fungi and their biological ...

Engaging pharmacists to improve atrial fibrillation care

2024-04-23
DALLAS, April 23, 2024 — Atrial fibrillation, or AFib, is the most common type of irregular heartbeat, estimated to affect about 12.1 million U.S. adults by 2030.[1] The abnormal firing of electrical impulses causes part of the heart to quiver, or fibrillate, often leading to complications and up to a fivefold increased risk of stroke. ​To help ensure all patients with AFib receive the most appropriate care, the American Heart Association is launching a new effort to educate and engage pharmacists, an important but underrepresented voice in AFib care. This ...

Exploring brain synchronization patterns during social interactions

Exploring brain synchronization patterns during social interactions
2024-04-23
We experience the world and connect with others through social interactions. Engaging in activities, such as conversations, cooperative tasks, and intimate relationships, deeply affect brain activity leading to coordinated neural activity within an individual's brain (intra-brain synchronization) and between the brains of multiple individuals (inter-brain synchronization). Researchers study brain synchronizations to understand the neural processes behind social behaviors. This knowledge can help diagnose and treat conditions like social anxiety and communication-related disorders. However, investigations on brain synchronization ...

Unveiling the molecular functions of lipid droplet proteins in Arabidopsis thaliana leaves

Unveiling the molecular functions of lipid droplet proteins in Arabidopsis thaliana leaves
2024-04-23
Lipids are biomolecules essential for the proper functioning of the living cell, ranging from comprising cell membranes to forming integral components of cell signaling pathways. Plant cells possess cell subcellular structures or organelles called lipid droplets (LDs) in the leaves and seeds, which store excess lipids (fats).  Recent studies have shown that LDs also localize unique plant proteins that perform essential molecular functions. For example, seed LDs localize plant proteins called oleosins, which help seeds weather freezing temperatures and germinate properly. With an expanding body of proof ...

Perfecting the view on a crystal’s imperfection

Perfecting the view on a crystal’s imperfection
2024-04-23
NEW YORK, April 23, 2024 — Single-photon emitters (SPEs) are akin to microscopic lightbulbs that emit only one photon (a quantum of light) at a time. These tiny structures hold immense importance for the development of quantum technology, particularly in applications such as secure communications and high-resolution imaging. However, many materials that contain SPEs are impractical for use in mass manufacturing due to their high cost and the difficulty of integrating them into complex devices. In 2015, scientists discovered SPEs within a material called hexagonal boron nitride (hBN). Since then, hBN has gained widespread attention and ...

Fossil frogs share their skincare secrets

Fossil frogs share their skincare secrets
2024-04-23
Palaeontologists at University College Cork (UCC), Ireland, have solved a hundred-year-old mystery of how some fossil frogs preserve their fleshy parts – it’s all down to their skin.  Palaeontologists Daniel Falk and Prof. Maria McNamara, together with scientists from Ireland, Germany and the UK, studied 45-million-year-old fossil frogs from the Geiseltal site in central Germany. Remarkably, the fossils show full body outlines of the soft tissues. The team discovered that the excellent condition of the fossil frogs is due to preservation of ancient skin remnants.  The team studied the fossils with high-precision ...

Existing drugs studied in patients with rare immune diseases

Existing drugs studied in patients with rare immune diseases
2024-04-23
Existing drugs studied in patients with rare immune diseases This month the first study within the DRIMID consortium (DRIMID stands for Drug Rediscovery for Rare Immune Mediated Inflammatory Diseases) has started. This study will investigate the efficacy and safety of the drug filgotinib (approved for treatment of rheumatoid arthritis and ulcerative colitis) in three rare immune diseases (Behçet's disease, idiopathic inflammatory myositis, IgG4-related disease). DRIMID aims to investigate whether this drug - despite the absence of formal ...

Loma Linda University study reveals alarming rates of pediatric injuries from mechanical bull riding

2024-04-23
A new study conducted by researchers at Loma Linda University Children’s Health has shed light on the alarming rates of pediatric injuries resulting from mechanical bull riding. The study, titled "Mechanical Bull Injuries in Pediatric Patients: A Call for Safety Regulations," highlights the urgent need for enhanced safety measures and regulations. The findings were published in the journal Children's Health Care and revealed that mechanical bull riding poses a significant risk to children, with traumatic brain injuries being the most common outcome.  “Mechanical bulls, even when ...

Excessive pregnancy weight gain and substantial postpartum weight retention common in military health care beneficiaries

2024-04-23
ROCKVILLE, Md.— Compared to their civilian counterparts, excessive pregnancy weight gain is more frequent among military health care beneficiaries, in particular active duty personnel, and is associated with costly maternal/neonatal complications. Women in this sample with excessive pregnancy weight gain were also three times more likely to have substantial postpartum weight retention, according to a new study published in the journal Obesity, The Obesity Society’s (TOS) flagship journal. Substantial weight retention ...

Odor-causing bacteria in armpits targeted using bacteriophage-derived lysin

Odor-causing bacteria in armpits targeted using bacteriophage-derived lysin
2024-04-23
Body odor from the armpits comes from bacteria metabolizing sweat produced by the apocrine glands. These bacteria are native to our skin, but the odors produced differ among people. Generally, people use deodorants on their armpits, but perhaps there is a way to get rid of the bacteria. To find out, a research team led by Osaka Metropolitan University Professor Satoshi Uematsu and Associate Professor Kosuke Fujimoto at the Graduate School of Medicine collected body fluid samples from the armpits of 20 men that were deemed healthy. In advance, a subjective olfactory panel classified ...

Women’s heart disease is underdiagnosed, but new machine learning models can help solve this problem

2024-04-23
When it comes to matters of the heart, cardiovascular disease in women is underdiagnosed compared to men. A popular scoring system used to estimate how likely a person is to develop a cardiovascular disease within the next 10 years is the Framingham Risk Score. It is based on factors including age, sex, cholesterol levels, and blood pressure. Researchers in the US and the Netherlands have now used a large dataset to build more accurate cardiovascular risk models than the Framingham Risk Score. They also quantified the underdiagnosis of women compared to men. The results were published in Frontiers ...

Extracting high-purity gold from electrical and electronic waste

Extracting high-purity gold from electrical and electronic waste
2024-04-23
Korea relies on imports for most of its metal resources, and in recent years, due to resource depletion and rising raw material prices, 'circular resources' that recycle waste metal resources have emerged. In response, SK hynix has established a mid- to long-term plan to increase the percentage of copper, gold, etc. recovered and reused from waste generated in the semiconductor manufacturing process to more than 30% by 2030, and Samsung Electronics is running a collection program for used mobile phones in cooperation with E-circulation Governance, a non-profit corporation. The global circular economy market is expected ...

Tropical fish are invading Australian ocean water

Tropical fish are invading Australian ocean water
2024-04-23
A University of Adelaide study of shallow-water fish communities on rocky reefs in south-eastern Australia has found climate change is helping tropical fish species invade temperate Australian waters. “The fish are travelling into these Australian ecosystems as larvae caught in the Eastern Australian Current, which is strengthening due to the warming climate,” said the University of Adelaide’s Professor Ivan Nagelkerken, Chief Investigator of the study. “These larvae would not normally survive in the cooler Australian ...

No bull: How creating less-gassy cows could help fight climate change

2024-04-23
A Curtin University study has revealed breeding less-flatulent cows and restoring agricultural land could significantly reduce rising methane emission levels, which play a considerable role in climate change.   The food system, including grazing animals such as cows, generates major sources of methane mainly due to cattle digestion, manure decomposition and land use for grazing.   To look for solutions, researchers from the Curtin University Sustainability Policy Institute analysed 27 academic publications and identified dozens of potential strategies to reduce methane emissions from Australia’s beef and dairy sectors.   Study ...

ECU researchers call for enhanced research into common post-stroke condition

2024-04-23
Lateropulsion, a clinical condition which results in the body leaning to one side, affects about half of all stroke survivors.     Edith Cowan University (ECU) PhD graduate Dr Jessica Nolan said while the problem is common, lateropulsion is still severely under recognised and under assessed around the world.    “A person with lateropulsion uses the limbs on their stronger side, to push themselves over toward their weaker side. Often those with lateropulsion resist correction back towards their stronger ...

SharpeRatio@k: novel metric for evaluation of risk-return tradeoff in off-policy evaluation

SharpeRatio@k: novel metric for evaluation of risk-return tradeoff in off-policy evaluation
2024-04-23
Reinforcement learning (RL) is a machine learning technique that trains software by mimicking the trial-and-error learning process of humans. It has demonstrated considerable success in many areas that involve sequential decision-making. However, training RL models with real-world online tests is often undesirable as it can be risky, time-consuming and, importantly, unethical. Thus, using offline datasets that are naturally collected through past operations is becoming increasingly popular for training and evaluating RL and bandit ...

$1.8M NIH grant will help researchers follow a virus on its path to the nucleus

$1.8M NIH grant will help researchers follow a virus on its path to the nucleus
2024-04-23
Researchers at the University of Arizona College of Medicine – Tucson were awarded a $1.8 million grant by the National Institute of General Medical Sciences, a division of the National Institutes of Health, to learn how human papillomavirus makes its way to a cell’s nucleus. Human papillomavirus, or HPV, which can cause warts and certain cancers, has been with us since the dawn of humanity and causes about 5% of cancers worldwide. It also is an important source of information about human biology, according to Samuel K. Campos, PhD, an associate professor of immunobiology at the University of Arizona College of Medicine ...

Follow-up 50 years on finds landmark steroid study remains safe

2024-04-23
A new study has found there are no adverse long-term cardiovascular health consequences for the now-adult children of mothers who were given corticosteroids because they were at risk of early birth in a landmark trial conducted in Auckland, New Zealand, 50 years ago. The Auckland Steroid Study by obstetrician Professor Graham ‘Mont’ Liggins and paediatrician colleague Dr Ross Howie from 1969 to 1974 in Green Lane Hospital, Auckland, found that two corticosteroid injections given to pregnant women at risk of early (preterm) birth halved the incidence of respiratory distress in the babies and significantly reduced neonatal deaths. Co-author of the new study, Dr ...

Active military service may heighten women’s risk of having low birthweight babies

2024-04-23
Active military service may heighten a woman’s risk of having a low birthweight baby, suggests a review of the available scientific evidence published online in the journal BMJ Military Health.   The findings highlight the need for more research specifically focused on women in the armed forces, and their reproductive health in particular, conclude the study authors. Worldwide, increasing numbers of women are on active service in their country’s armed forces. The UK Armed Forces, for example, has set a target of 30% female representation by 2030. And more and more countries are deploying women in combat ...

Significant global variation in national COVID-19 treatment guidelines

2024-04-23
National clinical guidelines for the treatment of COVID-19 vary significantly around the world, with under-resourced countries the most likely to diverge from gold standard (World Health Organization; WHO) treatment recommendations, finds a comparative analysis published in the open access journal BMJ Global Health.   And nearly every national guideline recommends at least one treatment proven not to work, the analysis shows. Significant variations in national COVID-19 treatment recommendations have been suspected since the advent of the pandemic, but these haven’t been ...

Cost increasingly important motive for quitting smoking for 1 in 4 adults in England

2024-04-23
Health concerns are still the primary motive for more than half of those who say they want to stop smoking in England, but cost is now a key factor for more than 1 in 4, finds an analysis of national survey responses, published in the open access journal BMJ Public Health. Given this shift in thinking, making much more of the potential savings to be had might encourage more people to stub out for good, suggest the researchers. Health concerns are generally the primary motive for people trying to stop smoking, with social and ...

Is there an association between HPV vaccination and anti-NMDA receptor encephalitis?

Is there an association between HPV vaccination and anti-NMDA receptor encephalitis?
2024-04-22
Anti-N-methyl-d-aspartate (Anti-NMDA) receptor encephalitis is an acute autoimmune disorder that develops both neurological symptoms and psychiatric symptoms, including hallucination, cognitive disturbance, epilepsy, movement disorder, and impaired consciousness. This disease may be misdiagnosed at the early stage as a psychosis disease because of primary psychiatric symptoms. The misdiagnosis may delay appropriate therapeutic intervention. Most patients with anti-NMDA receptor encephalitis respond to immunotherapy [1, 2]. The pathology of this disease is ...

Blood-based multi-omics guided detection of a precancerous pancreatic tumor

Blood-based multi-omics guided detection of a precancerous pancreatic tumor
2024-04-22
A new case report published in the peer-reviewed OMICS: A Journal of Integrative Biology describes how longitudinal multi-omics monitoring (LMOM) helped to detect a precancerous pancreatic tumor and led to a successful surgical intervention. Click here to read the article now.  The patient had undergone annual blood-based LMOM, in which 143 endogenous metabolites in serum and a panel of 140 proteins in plasma were measured. David Wishart, PhD, from the University of Alberta, ...

Eye-opener: Pupils enlarge when people focus on tasks

Eye-opener: Pupils enlarge when people focus on tasks
2024-04-22
Working memory is one of the brain’s executive functions, a skill that allows humans to process information without losing track of what they’re doing. In the short term, working memory allows the brain to complete an immediate task, like loading the dishwasher. Long term, it helps the brain decide what to store for future use, such as whether more dishwasher soap will be needed. University of Texas at Arlington researchers know that working memory varies greatly among individuals, but they aren’t sure exactly why. To better understand, Matthew Robison, assistant professor of psychology, and doctoral student Lauren D. Garner conducted an experiment to see if ...

Current Nanomaterials and Current Analytical Chemistry have been indexed in Ei Compendex

2024-04-22
Bentham Science is pleased to announce that two of its journals, Current Nanomaterials and Current Analytical Chemistry, have been officially indexed in the EI Compendex. EI Compendex is one of the most comprehensive subject-specific literature databases, encompassing high-quality research articles from prominent engineering and applied science journals worldwide. Current Nanomaterials, a leading peer-reviewed journal devoted to the exploration and dissemination of cutting-edge research in the field of nanomaterials, covers a broad spectrum ...
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