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Future parents more likely to get RSV vaccine when pregnant if aware that RSV can be a serious illness in infants

2024-04-25
A nationwide survey of people who were pregnant or trying to become pregnant found that overall 54 percent expressed interest in the RSV vaccine during pregnancy. Perceiving RSV as a serious illness in infants was the strongest predictor of likely vaccination during pregnancy. Likelihood to receive the RSV vaccine during pregnancy was also higher among parents with a child at home already. Findings were published in the journal Pediatrics. Respiratory syncytial virus (RSV) is a leading cause of infection among infants, frequently resulting in hospital or intensive care admission. RSV infection severe enough to require hospitalization has been associated with long-term wheezing ...

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1
2024-04-25
Tumor-resident microbiota in breast cancer promotes both the initiation and progression of cancer. However, the potential of targeting microbiota to enhance the efficacy of breast cancer treatment has not been comprehensively explored. In this study, researchers analyzed the microbial composition within breast tumors and identified a notable enrichment of ETBF in patients who exhibited resistance to taxane-based neoadjuvant chemotherapy. Key findings from the study include: Even at low biomass levels, ETBF ...

The Lundquist Institute receives $2.6 million grant from U.S. Army Medical Research Acquisition Activity to develop wearable biosensors

The Lundquist Institute receives $2.6 million grant from U.S. Army Medical Research Acquisition Activity to develop wearable biosensors
2024-04-25
The U.S. Army Medical Research Acquisition Activity (USAMRAA) has awarded The Lundquist Institute (TLI) a four-year grant totaling $2,623,234. The research project is led by Dr. Harry Rossiter, an investigator at TLI and Professor at the David Geffen School of Medicine at UCLA. The project aims to develop wearable multiplex biosensors to monitor exacerbation risk in chronic obstructive pulmonary disease (COPD). COPD affects approximately 16 million Americans and is the third leading cause of death globally. Acute exacerbations of COPD (AECOPD), typically caused by a lung infection, are associated ...

Understanding the cellular mechanisms of obesity-induced inflammation and metabolic dysfunction

Understanding the cellular mechanisms of obesity-induced inflammation and metabolic dysfunction
2024-04-25
A research team led by Professor Jong Kyoung Kim and Yujin Jeong (PhD candidate), from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH) in collaboration with Professor Yun-Hee Lee and Cheoljun Choi (PhD candidate) from the College of Pharmacy at Seoul National University, Professor Young-Min Hyun and Koung-Min Park (PhD candidate) from Yonsei University College of Medicine, Professor James Granneman from Wayne State University (WSU), and Professor Young-Suk Jung from the College of Pharmacy at Pusan National University, ...

Study highlights increased risk of second cancers among breast cancer survivors

2024-04-25
Survivors of breast cancer are at significantly higher risk of developing second cancers, including endometrial and ovarian cancer for women and prostate cancer for men, according to new research studying data from almost 600,000 patients in England. For the first time, the research has shown that this risk is higher in people living in areas of greater socioeconomic deprivation. Breast cancer is the most commonly diagnosed cancer in the UK. Around 56,000 people in the UK are diagnosed each year, the vast majority (over 99%) of whom are women. Improvements in earlier diagnosis and in treatments mean that ...

International DNA Day launch for Hong Kong’s Moonshot for Biology

International DNA Day launch for Hong Kong’s Moonshot for Biology
2024-04-25
International DNA Day Launch for Hong Kong’s Moonshot for Biology The first emblematic species sequenced by the Hong Kong Biodiversity Genomics Consortium are published to coincide with International DNA Day. Joining a global “moonshot for biology” that aims to sequence, catalogue, and characterize the genomes of all of Earth's eukaryotic biodiversity. A significant portion of modern knowledge in biology has emerged through sequencing the genetic code of the world’s biodiversity, which to date has been largely uncharacterized and increasingly ...

New scientific resources map food components to improve human and environmental health

2024-04-25
DALLAS, April 24, 2024 — The Periodic Table of Food Initiative ('the Initiative'), a pioneering collaboration led by the American Heart Association, the Alliance of Bioversity and CIAT, with support from The Rockefeller Foundation, has unveiled an initial suite of scientific tools, data, and training aimed at revolutionizing global agriculture and nutrition. This first phase introduces two data interfaces–the PTFI MarkerLab interface and the American Heart Association Precision Medicine Platform–which provide standardized data on the biomolecular composition of 500 foods that are representative of global consumption. ...

Mass General Brigham research identifies pitfalls and opportunities for generative artificial intelligence in patient messaging systems

Mass General Brigham research identifies pitfalls and opportunities for generative artificial intelligence in patient messaging systems
2024-04-25
Study found GPT-4-generated messages to patients were acceptable without any additional physician editing 58% of the time and provided more detailed educational information than those written by physicians AI-generated messages had shortcomings, including 7% of responses being deemed unsafe if left unedited Generative AI may promote efficiency and patient education, but require a “doctor in the loop” and a cautious approach as hospitals integrate algorithms into electronic health records A new study by investigators from Mass General Brigham demonstrates that large language models (LLMs), a type of generative ...

Opioids during pregnancy not linked to substantially increased risk of psychiatric disorders in children

2024-04-25
Opioid use during pregnancy is not associated with a substantial increase in the risk of neuropsychiatric disorders such as ADHD in children, finds a large study from South Korea published by The BMJ today. A slightly increased risk of neuropsychiatric disorders was found, but the researchers say this should not be considered clinically meaningful because it was limited to mothers exposed to more than one opioid prescription, high doses, and over longer time periods during pregnancy. According to 2019 data from the Centers for Disease Control and Prevention, around 7% of women in the United States were prescribed opioids during pregnancy. Previous ...

Universities and schools urged to ban alcohol industry-backed health advice

2024-04-25
Public health experts are calling for a ban on alcohol industry funded education programmes in UK universities and schools, which they say normalise drinking and downplay the long term health risks of alcohol.  They include an industry-backed “freshers’ week survival guide” for university students and a theatre based educational programme in schools funded by Diageo, one of the world’s biggest alcoholic beverage companies, reports an investigation by The BMJ.   The call follows a successful campaign in Ireland that has led to educational programmes ...

From Uber ratings to credit scores: What’s lost in a society that counts and sorts everything?

From Uber ratings to credit scores: What’s lost in a society that counts and sorts everything?
2024-04-25
Have you ever hailed a ride from an unrated Uber driver? Dined at a zero-star restaurant? Made a pricey online order from the lowest-rated Amazon vendor? Likely not. That's because rating systems have overhauled the way we travel, eat and shop. Born from the early days of e-commerce on sites like eBay, ratings help weed out scammers and lend some semblance of order to a fast-changing online marketplace. But there's a darker side to this reliance on ratings and rankings, says Marion Fourcade, a UC Berkeley sociology professor and director of Social Science Matrix. Supercharged ...

Political ‘color’ affects pollution control spending in the US

2024-04-25
A new study led by the University of East Anglia (UEA) shows how firms in the United States behave differently depending on the political party in charge - even if they do not change policies. The researchers, from UEA in the UK and Colorado School of Mines in the US, investigated the implications of changes in energy companies’ behaviour in response to the outcome of gubernatorial elections, which take place to elect state governors. Using elections where the outcome is very close to see how unpredictable changes in the ruling party affect things, they focused on the behaviour of ...

Managing meandering waterways in a changing world

Managing meandering waterways in a changing world
2024-04-25
(Santa Barbara, Calif.) — Just as water moves through a river, rivers themselves move across the landscape. They carve valleys and canyons, create floodplains and deltas, and transport sediment from the uplands to the ocean. A new paper out of UC Santa Barbara presents an account of what drives the migration rates of meandering rivers. The two authors compiled a global dataset of these waterways, analyzing how vegetation and sediment load effect channel movement. “We find a global-scale trend between the amount of sediment that rivers ...

Expert sounds alarm as mosquito-borne diseases becoming a global phenomenon in a warmer more populated world

2024-04-25
Improved climate conditions in Europe for a range of climate-sensitive infectious diseases increase the risk of local transmission. Researchers are fighting back with early warning systems that combine mosquito surveillance with climate forecasts to give local communities time to prepare and protect themselves. **ECCMID has now changed its name to ESCMID Global, please credit ESCMID Global Congress (formerly ECCMID, Barcelona, Spain, 27-30 April) in all future stories** The geographical range of vector-borne diseases, especially diseases that ...

Climate change is multiplying the threat caused by antimicrobial resistance

2024-04-25
*Please mention the ESCMID Global Congress (formerly ECCMID) Barcelona, 27-30 April) if using this material* Climate change is multiplying the threat caused by antimicrobial resistance (AMR), amplifying its growing risk through increasing global temperatures, greenhouse gas emissions and rising sea levels. This warning along  will be given in a new evidence review at this year’s ESCMID Global Congress (formerly ECCMID) (27-30 April), by Professor Sabiha Essack, South African Research Chair in Antibiotic Resistance and One ...

UK/German study - COVID-19 vaccine effectiveness and fewer common side-effects most important factors in whether adults choose to get vaccinated

2024-04-25
*Embargo 0001H CEST Barcelona time Thursday 25 April* Concerns about the common side-effects of COVID-19 vaccines and their effectiveness are key to determining whether adults in Germany and the UK choose to get vaccinated against the virus, according to new research being presented at this year’s ESCMID Global Congress (formerly ECCMID) in Barcelona, Spain (27-30 April). In contrast, timing of COVID-19 and influenza vaccines, as well as their type, have little influence on people’s willingness to get vaccinated in both countries. The ...

New ultraviolet light air disinfection technology could help protect against healthcare infections and even the next pandemic

2024-04-25
**ECCMID has now changed its name to ESCMID Global, please credit ESCMID Global Congress (formerly ECCMID, Barcelona, Spain, 27-30 April) in all future stories** Experts are working on a new type of ultraviolet light called far-UVC that could be highly effective for reducing air-borne transmission of diseases such as COVID-19 and influenza, as well as surface contamination in hospitals, with hopes that it could even reduce the risk of the next pandemic. In a new research review presented at this year’s ...

Major genetic meta-analysis reveals how antibiotic resistance in babies varies according to mode of birth, prematurity, and where they live

2024-04-25
Meta-analysis of genetic studies from 10 countries finds infants born by C-section have more antibiotic resistance genes; antibiotic use and prematurity also fuel resistance. Infants living in Africa had more antibiotic resistant genes than those from Europe. Findings indicate that interventions targeting the gut microbiome of mothers and their infants, such as probiotics, could help reduce antibiotic resistance spread. **ECCMID has now changed name to ESCMID Global, please credit ESCMID Global Congress in all future stories** A meta-analysis of genetic studies analysing the microbiota (bacteria in the gut) of 1,275 infants from 10 countries finds that caesarean delivery and antibiotic ...

Q&A: How TikTok’s ‘black box’ algorithm and design shape user behavior

2024-04-24
TikTok’s swift ascension to the upper echelons of social media is often attributed to its recommendation algorithm, which predicts viewer preferences so acutely it’s spawned a maxim: “The TikTok algorithm knows me better than I know myself.” The platform’s success was so pronounced it’s seemed to spur other social media platforms to shift their designs. When users scroll through X or Instagram, they now see more recommended posts from accounts they don’t follow. Yet for all that influence, the public knows little about how TikTok’s ...

American Academy of Arts and Sciences elects three NYU faculty as 2024 fellows

2024-04-24
The American Academy of Arts and Sciences has elected three New York University faculty as 2024 fellows: Glennys R. Farrar, a professor in the Department of Physics; André A. Fenton, a professor and chair of the Center for Neural Science; and Rachel L. Swarns, a professor in the Arthur L. Carter Journalism Institute.   “We honor these artists, scholars, scientists, and leaders in the public, non-profit, and private sectors for their accomplishments and for the curiosity, creativity, and courage required ...

A closed-loop drug-delivery system could improve chemotherapy

2024-04-24
When cancer patients undergo chemotherapy, the dose of most drugs is calculated based on the patient’s body surface area. This is estimated by plugging the patient’s height and weight into an equation, dating to 1916, that was formulated from data on just nine patients. This simplistic dosing doesn’t take into account other factors and can lead to patients receiving either too much or too little of a drug. As a result, some patients likely experience avoidable toxicity or insufficient benefit from the chemotherapy they receive. To make chemotherapy dosing more ...

MIT scientists tune the entanglement structure in an array of qubits

2024-04-24
Entanglement is a form of correlation between quantum objects, such as particles at the atomic scale. This uniquely quantum phenomenon cannot be explained by the laws of classical physics, yet it is one of the properties that explains the macroscopic behavior of quantum systems. Because entanglement is central to the way quantum systems work, understanding it better could give scientists a deeper sense of how information is stored and processed efficiently in such systems.  Qubits, or quantum bits, are the building blocks of a quantum computer. However, it is extremely difficult to make specific entangled states in many-qubit ...

Geologists discover rocks with the oldest evidence yet of Earth’s magnetic field

Geologists discover rocks with the oldest evidence yet of Earth’s magnetic field
2024-04-24
Geologists at MIT and Oxford University have uncovered ancient rocks in Greenland that bear the oldest remnants of Earth’s early magnetic field.  The rocks appear to be exceptionally pristine, having preserved their properties for billions of years. The researchers determined that the rocks are about 3.7 billion years old and retain signatures of a magnetic field with a strength of at least 15 microtesla. The ancient field is similar in magnitude to the Earth’s magnetic field today.  The open-access findings, appearing ...

It’s easier now to treat opioid addiction with medication -- but use has changed little

2024-04-24
For years, even as opioid overdose deaths dramatically increased, doctors and other prescribers in the United States needed special permission from the federal government if they wanted to prescribe buprenorphine, a medication that helps patients overcome opioid addiction and prevents fatal overdoses. That requirement, called an “X waiver”, was eliminated on January 12, 2023 due to an item in a major federal budget bill. This meant that suddenly, any clinician who had a license to prescribe controlled substances could prescribe ...

Researchers publish final results of key clinical trial for gene therapy for sickle cell disease

2024-04-24
Philadelphia, April 24, 2024 – In a landmark study, an international consortium led by researchers at Children’s Hospital of Philadelphia (CHOP) published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs). The study found that 96.7% of patients in the study did not have any vaso-occlusive crises (VOCs) – a blockage that results in lack of oxygen and painful episodes – for at least one year, and 100% were able to remain hospitalization-free for the same ...
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