Global carbon emissions from fossil fuels are projected to rise by 1.1% in 2025 – reaching a record high, according to new research by the Global Carbon Project. The 2025 Global Carbon Budget projects 38.1 billion tonnes of fossil carbon dioxide (CO2) emissions this year. Decarbonisation of energy systems is progressing in many countries – but this is not enough to offset the growth in global energy demand. With projected emissions from land-use change (such as deforestation) down to 4.1 billion ...

A fundamental rethink of how the NHS trains its future workforce is urgently needed, according to a new paper from the Higher Education Policy Institute (www.hepi.ac.uk), Rethinking Placement: Increasing Clinical Placement Efficacy for a Sustainable NHS Future (HEPI Report 194). The paper, written by senior leaders from the University of East London (UEL), argues that the National Health Service (NHS) cannot achieve its ambitious workforce goals without bold system-wide reform of how students gain real-world experience – the essential bridge between classroom learning and frontline care. The HEPI Report, which has been published with the support of the Council for Deans ...

Most commonly reported error in the physical exam is that the exam was never performed Report in the New England Journal of Medicine is part of a six-issue series on medical education ‘If we don’t intentionally cultivate these bedside skills, they’re at risk of being lost’ CHICAGO --- Today’s doctor visits look and feel a lot different than they did even just a couple decades ago.  Rushed physicians and medical trainees are spending less time with patients, leading to diagnostic errors, ...

New York, NY (November 12, 2025) – A new study from the Icahn School of Medicine at Mount Sinai helps explain why some people with multiple myeloma, a type of blood cancer, stay in remission for many years after receiving CAR T cell therapy, while others see their cancer return sooner. Published in Blood Advances, the research is the first longitudinal, single-cell, multi-omic study of cilta-cel in multiple myeloma. Cilta-cel (ciltacabtagene autoleucel) is a type of CAR T cell therapy used to treat relapsed or refractory multiple myeloma. It works ...

As climate change increases the frequency of droughts, UCLA and UC Davis researchers found one overlooked side effect: People report more conflicts with wildlife during drought, when resources are scarce. For every inch that annual rainfall decreases, scientists found a 2% to 3% increase in reported clashes with a variety of carnivores during drought years, according to a paper published today, Nov. 12, in the journal Science Advances.  The researchers pored through seven years of data from the Wildlife Incident Reporting database, run by the California Department of Fish and Wildlife. The results are likely broadly applicable outside of California, said lead author Kendall Calhoun, ...

Mutations drive evolution, but they can also be risky. New research led by plant biologists at the University of California, Davis, published Nov. 10 in Proceedings of the National Academy of Sciences, reveals how plants control mutation rates in different stem cells to balance adaptability with safety and stability. The findings have implications for breeding some of the world’s most important fruit and vegetable crops, such as potatoes and bananas.  The researchers showed that DNA mutations accumulated up to 4.5 times more frequently in the stem cells that produce a plant’s ...

The Cyvia and Melvyn Wolff Center for Entrepreneurship in the University of Houston’s C.T. Bauer College of Business has once again been named the No. 1 undergraduate entrepreneurship program. The Wolff Center is the first undergraduate program to secure seven consecutive No. 1 rankings on The Princeton Review’s list, besting its own record of six consecutive wins in the 2025 ranking last November. Each year, The Princeton Review ranks undergraduate and graduate entrepreneurship programs based on a survey of nearly 300 schools across the U.S., Canada, Mexico and Europe. ...

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) survivors encounter rare, life-threatening drug reactions and years of physical, emotional and social consequences long after leaving the hospital, according to a study published today in JAMA Dermatology.    Investigators from Vanderbilt University Medical Center’s Center for Drug Safety and Immunology (CDSI), in collaboration with the VUMC Qualitative Research Core, conducted one of the largest qualitative studies in the United States exploring SJS/TEN recovery and long-term residual effects from the patients’ ...

EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, NOVEMBER 12, 2025 Highlights: Your income may be associated with your risk factors for dementia. Researchers found that having a lower income was associated with a higher prevalence of dementia risk factors like hearing loss, high blood pressure, depression and physical inactivity. For people living below the poverty level, one in five cases of dementia may be associated with vision loss and social isolation in older people. After adjusting for income, several risk factors still showed higher prevalence among historically underrepresented groups in clinical research, including diabetes, physical inactivity, obesity and vision ...

In a groundbreaking study, scientists from the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) have utilized cutting-edge artificial intelligence methods to identify a region of the X chromosome that has maintained the distinctiveness of mammal species for millions of years. Their findings shed new light on how species maintain their genetic identity, even when hybridization acts to homogenize their gene pools. “We know that species like big cats; wolves, dogs and coyotes; and even whales and dolphins have interbred ...

The transmission of malaria by the Anopheles cruzii mosquito in the South and Southeast of Brazil was so alarming in the 1940s – with approximately 4,000 cases per 100,000 people – that the disease became known as bromeliad malaria. This is because the Kerteszia subgenus of the mosquito, which transmits the disease in the Atlantic Forest, develops only in bromeliads, plants that accumulate water and maintain conditions favorable for the development of this and other species. Although ...

RIVERSIDE, Calif. -- Last year, researchers at the University of California, Riverside, developed a novel “molecular crowbar” strategy to degrade the oncogenic enzyme Pin1, a protein that is overexpressed in many tumors including pancreatic cancer. They designed compounds that bind to Pin1 and destabilize its structure, causing its cellular degradation.  This approach not only targets cancer cells directly but also addresses tumor-supporting cells like cancer-associated fibroblasts and macrophages where Pin1 is active, potentially overcoming the treatment resistance posed by the fibrous tumor microenvironment in pancreatic cancer.   The UCR team led ...

Three Tufts faculty have been named to a ranking of the world’s most highly cited researchers. The researchers in the Clarivate 2025 list have a significant impact on the research community as judged by the rate their work is cited by their peers, according to Clarivate, an information and analytics firm focused on research. The highly cited papers rank in the top 1% by citations for a field or fields and publication year, and only about 1 in 1,000 researchers worldwide qualify. The Tufts researchers are Chunmei Li, Renata Micha, and Dariush Mozaffarian.  For this year’s analysis, the ...

Huntsman Cancer Institute at the University of Utah (the U) has opened its first specialized angiography-CT suite to enhance treatment options offered in interventional radiology, a field of medicine that uses imaging to conduct minimally invasive procedures. The only one of its kind in the Mountain West, this new technology aims to improve patient outcomes and reduce travel burdens for patients.  “I am thrilled to be able to offer this novel technology in the care of our cancer patients from across ...

Engineers at the University of California, Davis, have invented a device that can generate mechanical power at night by linking the natural warmth around us to the cold depths of space. The invention could be used, for example, to ventilate greenhouses or other buildings. The work is described Nov. 12 in Science Advances.  The invention is a type of machine called a Stirling engine. Other machines such as internal combustion engines generate power from a large heat gradient, said Jeremy Munday, professor of electrical and ...

The vast North American Phosphoria Rock Complex might be rich in silica because it was home to millions of sea sponges almost 300 million years ago, whose fossils were misdiagnosed until now Article URL: http://plos.io/47syMdi Article title: Glass factory found: Basinwide (600 km) preservation of sponges on the Phosphoria glass ramp, Permian, USA Author countries: U.S. Funding: WM- Idaho State University Geosciences Geslin Award, https://www.isu.edu/geosciences/resources/endowments_grants_scholarships/Tobacco WM- Root Geological Society, www.trgs.org KR- ACS PRF 56988, American Chemical Society, https://www.acs.org/ ZW-Paleontological ...

The link between air pollution and breast cancer is weakened in greener environments, suggests study using UK Biobank data Article URL: http://plos.io/4oHyRAF Article title: Greenness and its interaction with air pollution in relation to postmenopausal breast cancer risk in UK Biobank Author countries: U.S. Funding: BS effort was supported in part by grant P20GM103644 from the National Institute of General Medical Sciences. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. END ...

Dutch Afghanistan veterans with battle-related injuries report a similar physical and psychological quality of life as they did five years prior in a ten-year follow-up study Article URL: https://plos.io/3LpG1uY Article title: Long-term impact of battle injuries; Ten-year follow-up of Dutch servicemembers injured in Afghanistan Author countries: The Netherlands Funding: The author(s) received no specific funding for this work. END ...

Loneliness in young adults - especially educated females - often coexists alongside friendship and social connectedness, and might instead be linked with experiencing major life changes, per large US study Article URL: http://plos.io/3JyFOoG Article title: Lonely and connected in emerging adulthood: The ambivalence of sociality in a time of transitions Author countries: U.S. Funding: This paper was supported by the University of Kansas GRF #2177080 (2022); the University of Nevada, Las Vegas Faculty Opportunity Award (2022-2023) received by Natalie Pennington; and the Michigan State University ComArtSci Research and Creative Incubator and Accelerator (CRCIA) award (2022–2025) ...

From medicine to agriculture and aquaculture, bacteriophages are poised to have a huge global impact. As viruses which target only bacterial cells, they hold promise as an alternative to antibiotics, overcoming increasing issues around antibiotic resistance. However, the size, complexity and growth conditions of phages make them difficult to study, limiting progress in the field. Now in Science Advances, researchers from the Okinawa Institute of Science and Technology (OIST) and University of Otago describe the bacteriophage Bas63 in unprecedented detail, supporting new mechanistic understanding into how these viruses function. Co-author Professor Matthias Wolf, head of the Molecular ...

LAWRENCE — A new study challenges common assumptions about loneliness in young adulthood, finding that feelings of disconnection can coexist with rich, active social lives. The research, co-authored by Jeffrey A. Hall, professor and chair of the University of Kansas Department of Communication Studies, reveals that ongoing life changes, delayed intimacy and prolonged instability — especially among college-educated women — may contribute to social ambivalence, even though young adults have supportive friendships and strong ...

One of humanity’s most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic lupus erythematosus or, colloquially, lupus, Stanford Medicine investigators and their colleagues have found. The Epstein-Barr virus (EBV), which resides silently inside the bodies of 19 out of 20 Americans, is directly responsible for commandeering what starts out as a minuscule number of immune cells to go rogue and persuade far more of their fellow immune cells to launch a widespread assault on the body’s tissues, the scientists have ...

AMHERST, Mass. — Mass shootings can spur higher voter turnout in nearby communities, but the effect is highly localized and doesn’t appear to change how people vote for president, according to new findings from researchers at the University of Massachusetts Amherst and the Brennan Center for Justice at NYU Law. The study, published today in Science Advances, analyzed whether mass shootings motivate Americans to vote—and if they change whom voters support at the polls. “Mass shootings boost turnout generally, but especially in deeply blue areas [and] without changing minds,” says Kelsey Shoub, associate ...

Swift observations with the European Southern Observatory’s Very Large Telescope (ESO’s VLT) have revealed the explosive death of a star just as the blast was breaking through the star’s surface. For the first time, astronomers unveiled the shape of the explosion at its earliest, fleeting stage. This brief initial phase wouldn’t have been observable a day later and helps address a whole set of questions about how massive stars go supernova. When the supernova explosion SN 2024ggi was first detected on ...

Alcohol, cocaine use, and cigarette use are positively correlated with problematic pornography use (PPU), though studies saw no significant correlation between use of other substances and PPU, finds scoping review.    Article Title: Substance use patterns among individuals with problematic pornography use: A scoping review Author Countries: Canada, United States Funding: The authors received no specific funding for this work. Competing Interests: The authors have declared that no competing interests exist. END ...