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Anticancer drugs could make immunotherapies more effective

Anticancer drugs could make immunotherapies more effective
2024-12-05
An emerging class of anticancer drugs called EZH2 inhibitors may greatly enhance the potency of some cancer immunotherapies, according to a preclinical study led by Weill Cornell Medicine lymphoma researchers. The inhibitors target the EZH2 enzyme, whose activity in tumor cells is now recognized as a significant factor in many cancers. The study, published Dec. 5 in Cancer Cell, found that EZH2 inhibition combined with T-cell based immunotherapy worked better at shrinking non-Hodgkin B-cell lymphomas ...

UN report: Invest in nature to cut billion-dollar costs of droughts

2024-12-05
Riyadh, Saudi Arabia —  As droughts fueled by human destruction of the environment are projected to affect 3 in 4 people by 2050, investing in sustainable land and water management is essential to reduce their costs, which already exceed $ 307 billion per year globally, according to a new report launched at the Conference of the Parties (COP16) of the United Nations Convention to Combat Desertification (UNCCD) earlier today.  Drawing on a wealth of evidence and case studies from countries all around the world —like Chile, India, Jordan, Kenya, Spain, and Tunisia— the report makes the economic ...

JMIR Perioperative Medicine invites submissions on clinician wellness and burnout

JMIR Perioperative Medicine invites submissions on clinician wellness and burnout
2024-12-05
(Toronto, December 4, 2024) JMIR Publications invites submissions to a new theme issue titled “Clinician Wellness and Burnout in Perioperative Medicine” in its premier open access journal JMIR Perioperative Medicine. The premier, peer-reviewed journal is indexed in PubMed and focuses on how technology and data science can improve care delivery and surgical patient outcomes. Recognizing the unique challenges faced by perioperative clinicians—including anesthesiologists (trainees and attendings), perioperative advanced practice providers (nurse practitioners ...

Researchers develop new coronary risk score for women

2024-12-05
OAK BROOK, Ill. – A new risk score accurately predicts and categorizes the risk of major adverse cardiovascular events, such as heart attack, in women. The findings were published today in  Radiology: Cardiothoracic Imaging, a journal of the Radiological Society of North America (RSNA). According to the Centers for Disease Control and Prevention, heart disease is the leading cause of death in U.S. women. The same can be said for women in Latin America, Europe, Asia and Pacific countries. However, since men are more likely to suffer from ...

KIER's breakthrough in solving waste plastic processing with heat circulation

KIERs breakthrough in solving waste plastic processing  with heat circulation
2024-12-05
Dr. Byungwook Hwang’s research team from the CCS Research Department at the Korea Institute of Energy Research (KIER) has successfully developed a process that applies the circulating fluidized bed technology, commonly used in coal-fired power plant boilers, to recycle waste plastics and produce pyrolysis oil on a large scale. The COVID-19 pandemic has led to a sharp increase in household plastic waste worldwide. In response, countries around the globe are focusing on recycling technologies, such as pyrolysis, for eco-friendly waste plastic management. Recently, the Korean government announced plans to expand the ...

Impact studies should include high-sensitivity climate models

2024-12-05
High-sensitivity climate models should not be excluded when predicting future regional climate impacts because the level of warming measured globally is not always the only good indicator of regional changes, a new study suggests.  Some models which scientists use to predict future changes in Earth's climate show faster global warming than others, leading to temperature projections that are considered unlikely. Some experts suggest that these more sensitive (or ‘hotter’) models should be omitted when studying future climate impacts.   New research published today (Thursday, ...

‘Layer down’ — Thin coating of mxene material could replace thick layers of insulation

2024-12-05
In everyday life, materials that conduct electricity well, like metals, also tend to conduct heat. For instance, a metal spoon left in a hot cup of tea will get hot, while the ceramic mug remains cool. This is because good electrical conductors are usually good heat conductors too. However, researchers at Drexel University and Université catholique de Louvain (UCLouvain) in Belgium have discovered that MXenes, a type of material known for its excellent electrical conductivity, actually have very low ...

Break through cancer launches team to prevent lung cancer recurrence with the hope of long-term cures

Break through cancer launches team to prevent lung cancer recurrence with the hope of long-term cures
2024-12-05
(CAMBRIDGE, MASS.) December 05, 2024 – Lung cancer is the leading cause of cancer death worldwide, with various subtypes affecting millions of people each year. Among these, ALK-positive lung cancer frequently strikes younger people who have never smoked, including those aged between 20 and 50. Upon diagnosis, 80% of individuals already have stage 4 metastatic cancer, spread beyond the lungs to other parts of the body. Despite initially effective ALK inhibitor treatments, the cancer recurs in most patients, and there are about 70,000 people living with ALK+ lung cancer in the ...

Durian helps rice plants thrive in salty soil

Durian helps rice plants thrive in salty soil
2024-12-05
Extreme weather and pollution have increased the salt content in some soil, making growing conditions harsh for salt-sensitive crops like rice. Now, researchers reporting in ACS Nano detail a possible solution that doesn’t require genetic modification to make rice plants thrive in these conditions. In lab experiments, they determined that coating rice seedlings with magnesium-doped carbon dots — derived from durian peels — increased the seedlings’ antioxidant activity and photosynthesis, reducing the stress caused by salty soil.   To increase stress resistance in plants, the current ...

Researchers: If Power-to-X is to be a real climate solution, the state needs to use the stick

2024-12-05
Despite the massive hype surrounding Power-to-X (PtX), most of the world's announced green hydrogen projects lack financing. The market is deemed far too risky by stakeholders. And, there are many potential pitfalls. According to the authors of a study from the University of Copenhagen, actors must be ‘compelled’ to invest in a genuinely green manner. Green hydrogen has long been touted as the climate-friendly energy solution of the future. Indeed, there has been no shortage of hype surrounding Power-to-X – which converts green electricity into hydrogen and other molecules. In Denmark, politicians have referred to PtX as a cornerstone of ...

Discovering the mechanism behind brain’s inhibition network: From vision to action control

Discovering the mechanism behind brain’s inhibition network: From vision to action control
2024-12-05
In the split second that is needed to view a stop sign and react to it, our brain navigates a complex process that transitions seamlessly from perception to action control. This ability to halt or inhibit actions, known as response inhibition, is fundamental to human cognition. It plays a key role in decision-making and self-control, enabling us to suppress impulsive or inappropriate behaviors. Understanding the mechanisms underlying this process is essential for grasping how we manage our thoughts and actions and for treating impulse control disorders like attention deficit hyperactivity ...

Unveiling unknown chemicals in human serum samples

Unveiling unknown chemicals in human serum samples
2024-12-05
From the 1960s to the 1980s, the use of lead in fuel, paints, and pipes caused widespread contamination. It is estimated that 170 million Americans alive today were exposed to high lead levels as children, which caused significant harm, including a measurable drop in IQ scores. While we now understand the dangers of these chemicals, large sections of the population are still exposed to them. UNICEF reports that about 800 million children globally, nearly half of whom live in South Asia, are still exposed to unsafe levels of lead resulting from the hazardous ...

Advanced hybrid controller could boost efficiency in biosynthetic production

Advanced hybrid controller could boost efficiency in biosynthetic production
2024-12-05
Control systems are ubiquitous in modern day technology. In industrial contexts, these systems ensure that relevant variables remain within a desirable range to keep processes running safely and efficiently. A vast array of control strategies exists, and it is not uncommon to combine different types of controllers to improve performance. For instance, high-level controllers based on mathematical modeling of a given process are routinely combined with low-level controllers, such as the widely used ...

A new method for efficient synthesis of anti-cancer drugs

A new method for efficient synthesis of anti-cancer drugs
2024-12-05
The Horner–Wadsworth–Emmons (HWE) reaction is a fundamental reaction in organic chemistry, widely used to create conjugated carbonyl compounds. Conjugated carbonyl compounds are used in many industries for synthesizing perfumes, plastics, and pharmaceuticals and are also involved in biological processes. Consequently, methods for improving HWE reactions are an active area of research. One potential application of HWE reactions is to develop (E)-isomers of conjugated carbonyl compounds that are useful for synthesizing chemicals called hynapene analogues with promising anti-cancer ...

Food allergy anxiety at 30,000 feet

2024-12-05
Patients and families affected by food allergy worry when they fly and often make travel decisions with food allergy management top-of-mind Airlines don’t always honor buffer zones, allergen-free food or cabin announcements that were promised to travelers during the booking process  Simple steps to help ensure the safety of travelers with food allergy can go a long way CHICAGO ---The skies aren’t always so friendly for patients and families affected by food allergies, who may often experience worry and anxiety regarding airline travel, according to a new study from the Center for Food Allergy and Asthma Research at Northwestern University ...

Chimpanzees perform the same complex behaviors that have brought humans success

Chimpanzees perform the same complex behaviors that have brought humans success
2024-12-05
More images and video available- see link in the Notes section. A new study suggests that the fundamental abilities underlying human language and technological culture may have evolved before humans and apes diverged millions of years ago. The findings will be published 5th December 2024 in the journal PeerJ. Many human behaviours are more complex than those of other animals, involving the production of elaborate sequences (such as spoken language, or tool manufacturing). These sequences include the ability to organise behaviours by hierarchical chunks, and to understand relationships between distantly separated elements. For example, even relatively simple human behaviours like making ...

Potential epigenetic biomarker found for preeclampsia in pregnancy

2024-12-05
PULLMAN, Wash. – Analysis of cheek swabs taken from pregnant women revealed a potential epigenetic biomarker for preeclampsia, a potentially life-threatening condition that often leads to preterm births. While a clinical trial is needed to confirm the results, a study published in the journal Environmental Epigenetics offers hope that a simple test can be developed to identify preeclampsia earlier in pregnancy. Currently preeclampsia is usually identified by symptoms, such as abnormally high blood pressure, which only appear in the second trimester of pregnancy. Sometimes the condition can go undetected ...

Women pay for AI to boost mammogram findings

Women pay for AI to boost mammogram findings
2024-12-05
CHICAGO – More than a third of women across 10 health care practices chose to enroll in a self-pay, artificial intelligence (AI)-enhanced breast cancer screening program, and the women who enrolled were 21% more likely to have cancer detected, according to research being presented today at the annual meeting of the Radiological Society of North America (RSNA). AI has shown great promise in mammography as a “second set of eyes” for radiologists providing decision support, risk prediction and other benefits. Despite its promise, AI is not yet reimbursed by insurance, which likely is slowing its adoption ...

Gene editing and plant domestication essential to protect food supplies in a worsening climate, scientists say

Gene editing and plant domestication essential to protect food supplies in a worsening climate, scientists say
2024-12-05
We all need to eat, but the impact of the climate crisis on our crops is throwing the world’s food supply into question. Modern crops, domesticated for high food yields and ease of harvesting, lack the genetic resources to respond to the climate crisis. Significant environmental stresses are reducing the amount of food produced, driving supplies down and prices up. We can’t sustainably take over more land for agriculture, so we need to change our crops—this time to adapt them to the world we have altered. “Agriculture is highly vulnerable to climate change, and the intensity and frequency of extreme events is only going to increase,” said Prof Sergey ...

A film capacitor that can take the heat

A film capacitor that can take the heat
2024-12-05
— By Michael Matz The Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and several collaborating institutions have successfully demonstrated a machine-learning technique to accelerate discovery of materials for film capacitors — crucial components in electrification and renewable energy technologies. The technique was used to screen a library of nearly 50,000 chemical structures to identify a compound with record-breaking performance. The other collaborators from University of Wisconsin–Madison, Scripps Research Institute, University of California, ...

New pathways to long-term memory formation

New pathways to long-term memory formation
2024-12-05
Researchers from Max Planck Florida Institute for Neuroscience have discovered a new pathway to forming long-term memories in the brain. Their work suggests that long-term memory can form independently of short-term memory, a finding that opens exciting possibilities for understanding memory-related conditions. A New Perspective on Memory Formation Our brain works diligently to record our experiences into memories, creating representations of our daily events that stay with us for short time periods. Current scientific theories of memory formation suggest that short-term memories are stored in what we can imagine as a temporary art exhibition in our ...

Iberian Neolithic societies had a deep knowledge of archery techniques and materials

Iberian Neolithic societies had a deep knowledge of archery techniques and materials
2024-12-05
• A research team led by the UAB has made exceptional discoveries on prehistoric archery from the early Neolithic period, 7,000 years ago. • The well organic preservation of the remains of the Cave of Los Murciélagos in Albuñol, Granada, made it possible for scientists to identify the oldest bowstrings in Europe, which were made from the tendons of three animal species. • The use of olive and reed wood and birch bark pitch in the making of arrows reveals an unprecedented degree of precision and technical mastery, as highlighted in the study, published in Scientific Reports. ...

Tyrannosaur teeth discovered in Bexhill-on-Sea with help of retired quarryman

Tyrannosaur teeth discovered in Bexhill-on-Sea with help of retired quarryman
2024-12-05
EMBARGOED: NOT FOR RELEASE UNTIL 00.01 UK TIME ON THURSDAY 5 DECEMBER 2024 Tyrannosaur teeth discovered in Bexhill-on-Sea with help of retired quarryman Spinosaur and Velociraptor-like predators also roamed East Sussex 135 million years ago Research led by the University of Southampton has revealed that several groups of meat-eating dinosaur stalked the Bexhill-on-Sea region of coastal East Sussex 135 million years ago. The study, published today [5 December 2024] in Papers in Palaeontology, has discovered a whole community of predators belonging to different ...

Women with ovarian removal have unique risk and resilience factors for Alzheimer disease

2024-12-05
TORONTO - New research published by a team of researchers from the University of Toronto in collaboration with colleagues from the University of Alberta has found that women who have had both ovaries surgically removed before the age of 50 and carry a variant of the apolipoprotein gene, the APOE4 allele, are at high risk of late-life Alzheimer disease (AD).  Use of hormone therapy mitigates this risk. Why does this matter? By 2050, Alzheimer’s disease is projected to affect 12.7 million individuals 65 and older with women comprising two-thirds of that number. It is still unclear why Alzheimer’s disease is more prevalent in women than in men, but it may have to do with ...

Researchers discover new neurons that suppress food intake

2024-12-05
BALTIMORE, Dec. 5, 2024:  Obesity affects a staggering 40 percent of adults and 20 percent of children in the United States. While some new popular therapies are helping to tackle the epidemic of obesity, there is still so much that researchers do not understand about the brain-body connection that regulates appetite. Now, researchers have discovered a previously unknown population of neurons in the hypothalamus that regulate food intake and could be a promising new target for obesity drugs. In a study published in the Dec. 5 issue of Nature, a team of researchers from the Laboratory ...
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