Unlike some other forms of lymphoma, advanced stage follicular lymphoma is considered incurable. But a new analysis of long-term data on patients treated for the disease years ago with standard regimens of immunotherapy and a chemotherapy combination known as CHOP suggests that many of those patients can now be considered cured. The analysis is just published in the journal JAMA Oncology.  “A subset of advanced-stage follicular lymphoma patients can achieve cure with CHOP-based chemoimmunotherapy, as relapse rates decline over time,” said Wilmot Cancer Institute Director Jonathan W. Friedberg, MD, MMSc, at the ...

Breasts are necessary for breastfeeding, but their size is not decisive in terms of milk production. A large part of the breast consists of adipose tissue, and earlier theories have suggested that they function, for example, as a body fat reserve. Another theory proposes that breasts evolved through sexual selection as a signal of individual fitness, similar to facial symmetry. The University of Oulu study examined the possible role of breasts in the thermoregulation of a breastfeeding infant. Newborns are particularly susceptible to hypothermia because their own thermoregulatory system is still underdeveloped. The ...

Organ donation after the heart stops beating, a practice called donation after circulatory death, has gone from rare to routine in the United States, a new study shows. This shift over the past 25 years, aided by technological advances, is helping to meet the growing demand for transplants, the authors say.  More than 100,000 Americans are currently waiting for a lifesaving transplant, according to the United Network for Organ Sharing. To address the shortage, experts have long searched for ways to safely and ethically increase the number of usable organs recovered from people who die.  Led by NYU Langone Health researchers, the new analysis traced how the deceased-donor ...

Spending time in nature, even briefly, triggers changes in the brain that calm stress, restore attention and quiet mental clutter, a new study has found. Researchers at McGill University and colleagues at Adolfo Ibáñez University in Chile have examined more than 100 brain-imaging studies from various disciplines. The result is one of the most comprehensive reviews to date of how the brain responds to nature. The findings add neuroscientific weight to the emerging field of nature connectedness, which seeks to better ...

MIAMI, FLORIDA (EMBARGOED UNTIL FEB. 26, 2026, AT 10 A.M. EST) – A new study using serial liquid biopsies to track how metastatic prostate cancer evolves under treatment pressure showed that androgen receptor (AR) alterations consistently emerged and were linked to poorer outcomes across therapies. The findings, published Feb. 26 in Clinical Cancer Research, a journal of the American Association for Cancer Research, suggest that a single genomic test at diagnosis is no longer sufficient for managing advanced prostate cancer ...

The Gulf of America is experiencing accelerated sea-level rise due to a complex interplay of ocean dynamics, steric effects and vertical land motion. These changes pose serious challenges for coastal communities, particularly rural and under-resourced areas that lack the infrastructure and data to plan for flooding and long-term adaptation. Understanding the drivers of regional sea-level variability and developing actionable forecasting tools is critical for supporting decision-making and resilience planning. Florida Atlantic University’s Harbor Branch Oceanographic Institute has been awarded a $900,000, four-year ...

Background and objectives Terminal ileum intubation is considered the completion step of colonoscopy and is usually performed to assess the ileum. The histological examination of the ileal mucosa, which is acquired during terminal ileum intubation, may allow an accurate diagnosis. However, there is no absolute consensus on when ileoscopy and biopsy should be attempted. As a result, we aimed to evaluate whether terminal ileum intubation and biopsy should be performed routinely. Methods Systematic searches were performed in the PubMed, EMBASE, and Cochrane Library databases, as well as the Science Citation Index via the Web of Science ...

PULLMAN, Wash. — A tiny region in a little-known muscle protein may hold the key to a healthy, steady heartbeat, as well as possible clues to future treatment of devastating heart ailments. Washington State University researchers have found a region of a protein called leiomodin that is critical in maintaining the length of tiny filaments that control a person’s heartbeat. The work, in collaboration with researchers from the University of Arizona and Mount Sinai School of Medicine in New York, is featured in the high-profile journal Circulation Research. “It’s a small part of a big protein ...

Background and objectives DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair and chromosomal replication. Mutations in the POLE gene have been linked to cancer, particularly colorectal carcinoma (CRC). However, the genomic landscape and pathological significance of POLE mutant CRC remain underreported. This study aimed to characterize the clinicopathologic features and genomic landscape of CRC harboring POLE mutations and to investigate the implications of co-occurring genetic alterations. Methods We ...

High school students often have trouble getting to bed at a reasonable time, which makes it difficult for them to start school early in the morning. This is because teenagers are biologically wired to fall asleep later than adults, with their biological clock shifting progressively later throughout adolescence. The result is that most teenagers don’t get enough sleep on school days, and their sleep deficits increase as the week progresses. “This is concerning, as chronic sleep deprivation not only affects well-being, but also has a measurable impact on mental health, physical ...

Nations worldwide underestimate greenhouse gas emissions from wastewater facilities, but updating measurements could fix this. Nations worldwide underestimate greenhouse gas emissions from wastewater systems, research from Princeton University shows. Outdated inventory methods and failure to include items like latrines and untreated sewage in national reports are main reasons. In an article published Feb. 11 in the journal Nature Climate Change, the researchers report that nations underestimated emissions of gases including methane ...

The Lancet: New weight loss pill leads to greater blood sugar control and weight loss for people with diabetes than current oral GLP-1, phase 3 trial finds A novel GLP-1 receptor agonist (RA) pill called orforglipron leads to a larger reduction in blood sugar levels after a year than the current available oral GLP-1 RA (semaglutide), finds a phase 3 randomised controlled trial published in The Lancet. Additionally, participants taking orforglipron had significantly greater reductions in body weight than those taking oral semaglutide.   Currently the only available oral ...

Physical fitness and psychological resilience develop side by side during adolescence, a life stage that lays the foundation for adult health. Cardiorespiratory endurance, muscular strength, and agility are well-known predictors of cardiometabolic health, while self-efficacy, defined as the belief in one’s ability to overcome challenges, shapes motivation, persistence, and coping strategies. Although both have independently been linked to healthier lifestyles and improved well-being, less attention has been given to how they may influence ...

Asian Americans are the fastest-growing group of older adults in the U.S., but they often face language and cultural barriers when seeking care for dementia-related symptoms.  As part of a broader mission to tackle these challenges, a Rutgers Health-led study involving internationally renowned clinicians and scientists from the National Institute on Aging-funded Rutgers-NYU Resource Center for Alzheimer’s Disease and Research Center in Asian and Pacific Americans and Stanford Alzheimer’s Disease Research Center has proposed a ...

“They took Dad.” That sentence opens Carolina Valdivia’s new book, Sanctuary Making: Immigrant Families Reshaping Geographies of Deportability, published this month by the University of California Press. The book chronicles what happens to families in the aftermath of those three words, and the extraordinary lengths that ordinary people go to in order to protect the ones they love. “This is a book with a sense of urgency” wrote Emmy Award–winning journalist and former Univision News anchor Jorge Ramos in his review. “From the first line — ...

Lasers cut precisely and without contact – ideal for surgery. The problem is that, in hard tissues such as bone, they are too slow and do not cut deep enough. Researchers at the University of Basel have now demonstrated a way to cut much deeper and faster with a surgical laser than with previous laser systems. The saw, chisel and drill are tried-and-true tools in bone surgery. In the future, lasers could be added to this toolbox, especially when it comes to very precise cuts. Lasers do not exert any mechanical pressure, meaning they can reduce the risk of ...

Research Highlights: In an analysis of data from 2011 to 2022, the number of deaths after first hospitalization for a severe heart attack increased significantly among men and women ages 18-54. At the same time, the number of deaths was higher among women than men in this age range for both a heart attack caused by a complete blockage of a coronary artery and one resulting from a partial coronary artery blockage. After accounting for all risk factors assessed, heart attack deaths remained linked to more nontraditional risk factors—including low income, kidney disease and non-tobacco drug use—rather than traditional risk factors, such as high blood pressure or high cholesterol, ...

For scientists who study the Southern Ocean, a long-standing silver lining in the gloomy forecast of climate change has been the theory of iron fertilization. As temperatures rise and glaciers in Antarctica melt, ice-trapped iron would feed blooms of microscopic algae, pulling heat-trapping carbon dioxide from the atmosphere as they grow. There’s just one problem: The theory doesn’t hold water. In what researchers describe as the most accurate measurement of iron inputs from a glacier in Antarctica, marine scientists from Rutgers University-New Brunswick have discovered that meltwater from an Antarctic ice shelf supplies far less iron to surrounding ...

LOS ANGELES — High-grade astrocytoma, which includes glioblastoma, is a fast-growing, aggressive brain cancer that often returns after the tumor is removed, making it difficult to treat. Patients with recurrent high-grade astrocytoma typically only survive for four to five months.   Immune checkpoint inhibitors, medications that allow the body’s own immune system, particularly cancer-fighting T-cells, to recognize, find and attack tumor cells, can help stop ...

Osaka, Japan – Achondroplasia, also known as short-limb dwarfism, is associated with neurological symptoms and complications due to narrowing of the skeletal structures surrounding the spinal cord. Despite achondroplasia being the most common cause of dwarfism, the mechanisms underlying the condition remain to be analyzed, meaning that current treatment options are insufficient. Now, a team at The University of Osaka has created a mouse model of achondroplasia that has advanced understanding of ...

Water droplets have a unique ability: They can leap from a surface on their own.  This can happen for a variety of reasons, such as when a surface repels water or when heat is involved, such as a water or oil droplet skittering across a hot pan. It also happens at a very small scale. Up to this point, researchers have observed droplets up to 3 millimeters in diameter exhibiting this behavior. When droplets are larger than that, gravity prevents it from jumping. A new study published in Nature identifies a previously unreported way to get a puddle of water up to a centimeter wide to jump into the air, something ...

An international team of scientists has shed light on the development of the malaria parasite and have identified a unique protein essential for its survival and transmission, which offers a promising new target for antimalaria drugs. The discovery centres on a molecule named Aurora-related kinase 1 (ARK1). In a new study published in Nature Communications, researchers from the University of Nottingham, National Institute of Immunology (NII), India, University of Groningen, the Netherlands, the Francis Crick Institute, and international collaborators, have revealed that ARK1 acts as a ‘traffic controller’ during the parasite's unusual cell division and growth process. Malaria ...

A new study spanning eleven years of data has revealed a clear link between wildfire smoke pollution and an increase in violent assaults in Seattle. These findings represent the first direct causal evidence that short-term exposure to wildfire-driven air pollution can increase interpersonal violence in an urban environment.  As wildfires intensify around the world due to climate change, Lion Kircheis, the author of the study warns that air-quality deterioration may be driving ...

An international team of scientists led by the University of Bath has developed a new catalyst – a substance that speeds up chemical reactions – that uses sunlight to break down so-called ‘forever chemicals’ prevalent in the environment and known to accumulate in the human body with unknown long-term health effects. They hope this technology could in the future be scaled up and used to detect or remove these persistent chemicals from the environment. Published today in ...

Green hydrogen is considered an indispensable component of the global energy transition, but its production still faces massive economic and environmental hurdles. For example, the promising PEM (proton exchange membrane) electrolysis process, which is particularly suitable for producing green hydrogen when the supply of electricity from wind power and photovoltaic systems fluctuates, is still very expensive compared to production using fossil fuels. Sustainability also needs to be scrutinised here. This is because it relies on environmentally hazardous ...