Researchers at Helmholtz Munich, the Technical University of Munich and the LMU University Hospital Munich uncovered a mechanism that protects nerve cells from premature cell death, known as ferroptosis. The study provides the first molecular evidence that ferroptosis can drive neurodegeneration in the human brain. These findings open up new avenues for developing future therapies – particularly for severe early-onset childhood dementia. The Enzyme That Protects Nerve Cells Why do neurons die in dementia – and can this process be slowed down? An international team led by Prof. Marcus Conrad, Director of the Institute of Metabolism and Cell Death ...

“Persistent discrepancies by gender, race, and geography underline the importance of individualized cardio-oncology surveillance, equitable preventative initiatives, and focused public health interventions.” BUFFALO, NY — December 4, 2025 — A new research paper was published in Volume 12 of Oncoscience on November 7, 2025, titled “Temporal trends and disparities in sudden cardiac death among colorectal cancer patients: A nationwide study.” In this study, led by first author Eric Sanji of Magnolia Regional Health Center, researchers examined ...

Researchers at the University of Colorado Cancer Center have discovered a novel therapy combination that could offer new hope to ovarian cancer patients who do not respond to existing treatments. Conducted entirely at the University of Colorado Anschutz, this research has advanced from the laboratory to a Phase 1 clinical trial on the campus. The findings, published today in Cancer Research Communications, outline a promising strategy that combines a PARP inhibitor, a targeted drug used to treat certain types of ovarian cancer, with ...

PLYMOUTH MEETING, PA [December 4, 2025] — The National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers that publishes free evidence-based, expert consensus-driven guidelines for cancer prevention and care—today announced the hiring of Renuka Iyer, MD, as the new Chief Medical Officer (CMO) for the organization. Dr. Iyer has a long history of leadership and innovation in oncology. She currently serves as a Professor of Oncology for Roswell Park Comprehensive ...

Los Angeles, CA – December 4, 2025 – Dr. Vadim Jucaud’s lab at the Terasaki Institute has introduced a new organ-on-a-chip platform that recapitulates age-dependent immune responses, offering a more accurate testing bed for evaluating cancer vaccine performance in older adults, the population most affected by cancer and often overlooked in traditional preclinical testing. Immunosenescence, the natural decline of the immune system with age, significantly reduces the effectiveness of cancer vaccines. Yet, despite its clinical importance, age-related immune decline is seldom incorporated into vaccine development pipelines. Current 2D ...

Europe is gobbling up almost 50 square metres of land and topsoil per second. And Norway tops the list of  European countries with the most land lost to construction per person, according to a study initiated by the Arena for Journalism in Europe and the Norwegian Broadcasting Corporation, NRK. At the same time, we have never had access to more data and knowledge about nature and the ecosystems we are building on. "We are acquiring more and more ecological data as a basis for land-use planning. Then you would think that the decisions we make ...

In newly published research, Binghamton University doctoral student Elana Israel, MS ’22, explores which depressive symptoms largely affect children’s neural responses to feedback. Depression in parents can affect a child’s reward processing, or how their brains react to positive and negative feedback. Israel and Psychology Professor Brandon Gibb, director of the Mood Disorders Institute, explored whether a specific symptom of depression in parents known as anhedonia, a loss of interest or pleasure in things, may be specifically responsible for this link. The study will be included in ...

Ambiguous speech production is a common challenge for learners of a second language (L2), but identifying whether the problem lies in pronunciation or deeper linguistic processing is not always straightforward. A new study conducted by Professor Sylvain Detey from Waseda University, with Dr. Verdiana De Fino from IRIT, UT3, University of Toulouse & Archean Labs, France, and Dr. Lionel Fontan, Head of Archean Labs, France, sheds light on this distinction. Their study was published on October 30, 2025, in the journal Language Testing in Asia. The researchers sought to determine whether ambiguous speech errors made by Japanese learners of French could be better categorized through a combined ...

Advances in materials science have led to the development of “smart materials,” whose properties do not remain static but change in response to external stimuli. One such material is poly(N-isopropylacrylamide), or PNIPAM, a polymer gel that alters its solubility with temperature. The polymer contains hydrophilic amide groups and hydrophobic isopropyl groups. At low temperatures, the amide groups form strong hydrogen bonds with water, keeping the material well-swollen and soluble. However, as the temperature increases, these hydrogen bonds weaken while ...

Extracellular vesicles (EVs) have rapidly emerged as one of the most promising frontiers in modern biology. These nano-sized messengers mediate communication between cells, tissues, and organs, influencing processes from immune signaling to cancer progression. Their growing diagnostic, prognostic, and therapeutic relevance has accelerated research worldwide. Yet one major limitation persists: the absence of efficient, scalable, and equipment-independent EV isolation methods. Existing techniques, including ultracentrifugation and size-exclusion chromatography (SEC), remain labor-intensive, instrumentation-heavy, and unsuitable for processing large-volume biofluids. To ...

Nicotine addiction remains one of the most persistent public health challenges worldwide, driven by changes in the brain that reinforce repeated use and make quitting extremely difficult. For decades, scientists have focused primarily on neurons to explain how these changes occur. But growing evidence suggests that other brain cells may play a far more active role in shaping addictive behavior than previously thought. Building on this shift in understanding, a team of researchers led by Professor Eun Sang Choe from the Department of Biological Sciences, Pusan National ...

A study led by researchers at the Hospital del Mar Research Institute advances one of the most significant milestones in breast cancer treatment, making immunotherapy effective against the most common tumor type, estrogen receptor-positive or luminal breast cancer. This subtype accounts for 70% of breast cancer cases, and despite effective treatments, it causes the highest mortality in total cases. Additionally, immunotherapy is not effective or approved because it shows no immune system response in these tumors, ...

CHICAGO – Long-term exposure to common air pollutants is associated with more advanced coronary artery disease—with notable differences between women and men—according to a large-scale study of more than 11,000 adults being presented today at the annual meeting of the Radiological Society of North America (RSNA). The findings show that even levels of pollution below or near regulatory standards and typical urban exposures are associated with early signs of heart disease—often before symptoms appear—and underscore the importance of improving air quality to reduce cardiovascular ...

Kyoto, Japan --  "Why are we here?" is humanity's most fundamental and persistent question. Tracing the origins of the elements is a direct attempt to answer this at its deepest level. We know many elements are created inside stars and supernovae, which then cast them out into the universe, yet the origins of some key elements has remained a mystery. Chlorine and potassium, both odd-Z elements -- possessing an odd number of protons -- are essential to life and planet formation. According to current theoretical models, stars ...

The choreographed movements that cells perform to form complex biological shapes, like our hands, have fascinated scientists for centuries. Now, researchers at EMBL Barcelona have launched LimbNET, an open-access online platform that allows scientists to directly choreograph this dance by computationally simulating how genes guide these intricate growth processes. Their work has recently been published in the journal Molecular Systems Biology. LimbNET is much more than a simple data repository. It is a new type of platform allowing ...

A research team led by Ryo Shimano of the University of Tokyo has successfully visualized two distinct mechanisms through which up and down spins, inherent properties of electrons, switch in an antiferromagnet, a material in which spin alignments cancel each other out. One of the visualized mechanisms provides a working principle for developing ultrafast, non-volatile magnetic memory and logic devices, which could be much faster than today’s technologies. The findings are published in the journal Nature Materials. Paper slips with holes, small metal rods, vacuum tubes, and transistors: these are technologies that have ...

Growing energy demand means the U.S. will almost certainly have to expand its electricity grid in coming years. What’s the best way to do this? A new study by MIT researchers examines legislation introduced in Congress and identifies relative tradeoffs involving reliability, cost, and emissions, depending on the proposed approach.  The researchers evaluated two policy approaches to expanding the U.S. electricity grid: One would concentrate on regions with more renewable energy sources, and the other would create more interconnections across the country. For instance, some of the best untapped wind-power resources in the U.S. lie ...

A recently published article in the journal BioScience has revealed a surprising opportunity for conserving threatened species: sports teams and their branding. The research, led by Dr. Ugo Arbieu of Université Paris-Saclay in France, analyzed 727 sporting organizations across 50 countries and 10 team sports. The authors found that "threatened species and species with a declining population trend are more represented than other species, with differences across regions." Arbieu and colleagues explain that "given the ongoing global biodiversity crisis and the importance of sport in modern societies, representations ...

Media Contact: John Dudley (814) 490-3290 (cell) jjdudley@usf.edu TAMPA, Fla. (Dec. 2, 2025) – A new study led by researchers at the University of South Florida’s College of Marine Science has found that certain populations of the seaweed sargassum have experienced a significant decline over the past decade, even as increased abundance of sargassum in the tropical Atlantic has caused large mats of the seaweed to inundate beaches across the Caribbean and Gulf regions. The abundance of sargassum in the Atlantic’s ...

Magnetic resonance imaging (MRI) is invaluable in the medical world. But despite all the good it does, there is room for improvement. One way to enhance the sensitivity of MRI is called dynamic nuclear polarization (DNP), where target molecules for imaging are modified so they form clearer images when scanned with an MRI machine. But this technique requires some special crystalline materials mixed with polarizing agents which are difficult to create. For the first time, researchers including those from the University of Tokyo demonstrate the use of molecules called fullerenes as polarizing agents. Their new method can make DNP targets sufficient to yield far greater clarity when ...

Addressing Current Limitations in Spatial Omics Existing tools for spatial proteomics often have constraints. Many are not equipped to predict multiple localizations for individual proteins or to quantify across different cellular compartments. In addition, their use frequently requires programming knowledge and lacks accessible interfaces, which can limit broader application. Spatial lipidomics has remained challenging due to the absence of reliable markers for lipid localization. Introducing a Tool for Integrated Spatial Proteomics and Lipidomics C-COMPASS was developed to address these methodological gaps. The software uses neural networks to predict multiple subcellular ...

Lions, tigers, wolves, leopards, and bears are some the world’s favourite sport symbols, but while they thrive on jerseys, many of these species are at risk of extinction in the wild. A new international study, co-authored by Flinders University researchers, reveals that nearly 25% of professional sports teams worldwide use a wild animal in its name, logo, or fan identity, presenting a powerful and largely untapped opportunity to support biodiversity conservation. The research, published in BioScience, examined 727 teams across 50 countries and 10 major sports, identifying at least 161 different wild animals featured in professional ...

Fever, aching limbs and a runny nose – as winter returns, so too does the flu. The disease is triggered by influenza viruses, which enter our body through droplets and then infect cells.  Researchers from Switzerland and Japan have now investigated this virus in minute detail. Using a microscopy technique that they developed themselves, the scientists can zoom in on the surface of human cells in a Petri dish. For the first time, this has allowed them to observe live and in high resolution how influenza viruses enter a living cell.  Led by Yohei Yamauchi, Professor of Molecular Medicine at ETH Zurich, the researchers ...

Destroyed habitats, poaching, and prey depletion have dramatically reduced tiger habitats around the world. Today, tigers occupy just 5 to 10% of their historical habitats. But on the Indonesian island of Sumatra, an important population of critically endangered Sumatran tigers may persevere, a new Frontiers in Conservation Science study showed. Using infrared cameras, researchers working on the island, have set out to estimate sex-specific population densities and tigers’ movements during three surveys. “We documented a robust tiger population, apparently among the healthiest on the island,” said Dr Joe Figel, ...

EMBARGOED Until Thursday, December 4, 2025 12:00 am ET According to the Department of Health and Human Services, the United States is expected to face a significant shortage of OB-GYNs in the next five years. It’s vital for women to have access to highly trained health care providers for all stages of their lives, from the first menstrual cycle to menopause and beyond. Certified nurse-midwives offer this kind of care, but most Americans don’t realize it. A new survey by The Ohio State University Wexner Medical Center reveals 93% of people think midwives only deliver babies and are surprised to ...