Bethesda, MD (Nov. 17, 2025) — The American Gastroenterological Association (AGA) has released a comprehensively updated clinical guideline on the pharmacological management of moderate-to-severe Crohn’s disease. The new guideline uses cutting-edge network meta-analyses to recommend prescribing medications based on patients’ prior treatments for moderate-to-severe Crohn’s disease.  The guideline organizes treatments by efficacy to simplify decision-making for gastroenterologists and over 3 million people worldwide living with Crohn’s disease. This living guideline reflects the rapid pace of innovation in medical ...

Cancer research, drug safety testing and ageing biology may all gain a major boost from a new fluorescent sensor developed at Utrecht University. This new tool allows scientists to watch DNA damage and repair unfold in real time inside living cells. The development, which opens the door to experiments that weren’t feasible before, is published today in the journal Nature Communications. DNA inside our cells is constantly damaged by sunlight, chemicals, radiation or simply by the many processes that keep us alive. Usually, the cell fixes this damage quickly and efficiently. But when repair fails, the consequences can be serious, contributing ...

With a five-year survival rate of less than 5%, glioblastoma is one of the most aggressive types of brain cancer. Until now, all available treatments, including immunotherapy — which involves strengthening the immune system to fight cancer— have proved disappointing. CAR-T cells are genetically modified immune cells manufactured in the laboratory and designed to identify and destroy cancer cells. By targeting a protein present in the tumour environment, a team from the University of Geneva (UNIGE) and ...

A geomagnetic superstorm is an extreme space weather event that occurs when the Sun releases massive amounts of energy and charged particles toward Earth. These storms are rare, occurring about once every 20-25 years. On May 10-11, 2024, the strongest superstorm in over 20 years, known as the Gannon storm or Mother’s Day storm, struck Earth.   A study led by Dr. Atsuki Shinbori from Nagoya University's Institute for Space-Earth Environmental Research has captured direct measurements of this extreme event and provided the ...

The immune system plays a crucial role in fighting tumours and metastases. Consequently, it is decisive to conduct cancer research in mouse models with an immune system that is as natural as possible – which is easier said than done. Thanks to CRISPR/Cas9 technology, researchers can quickly create a pool of hundreds of tumour cells, each with a different gene switched off. When transplanted into mice, it becomes apparent which of these silenced genes influences the development and spread of cancer. Assisted by such CRISPR screens, scientists are able to identify valuable approaches for the development of new therapies. But the method comes with a catch. The components of ...

November 20, 2025 - A novel study empirically linking a standardized measure of community resilience in more than 3,100 U.S. counties to cognitive, mental, and physical health outcomes shows that counties with fewer healthcare resources, limited digital tools, and weaker support systems exhibit poorer overall health among their residents. The article appearing in the American Journal of Preventive Medicine, published by Elsevier, indicates that resilience can be measured, strengthened, and designed into our systems of care using modifiable tools like healthcare access, support networks, and technology. Resilience ...

Bribery and money laundering are far more common among the public than many assume, with millions of people in the UK approached to take part in these activities in the past year, according to a new report co-authored by a researcher from the University of Surrey on behalf of the International Society of Economic Criminology (ISEC).  The report found that 16% of UK adults had been asked for a bribe in the last 12 months and 11% (5.8 million UK adults per year) had been asked to help move money that ...

What makes art art? Is it the method or the creator? Does it need a color palette and oil paints, or a canvas laid flat on the floor and paint splattered across it? Does it require a critically acclaimed painter, or a toddler with crayons? And when it comes to the artist, can we even reliably tell if an artwork has been created by children or adults? In a new Frontiers in Physics study, researchers in the US put it to the test. “Our study shows that the artistic patterns generated by children are distinguishable from those created by adults ...

Embargo: 20th November 2025 at 05:01 UK time Broad support for lethal control of wild deer among nature organisation subscribers There is broad support for regulated lethal control of wild deer to reduce their numbers and impacts among subscribers of nature organisations in England and Wales, a new study has found. According to research led by Bangor University and published in People and Nature, it was the most supported and widely used deer management practice. The authors of the study believe that the findings might help nature organisations and decision makers feel more confident about recommending its use. Researchers ...

In a discovery shaped by more than a decade of steady, incremental effort rather than a dramatic breakthrough, scientists from the National University of Singapore (NUS) and their collaborators demonstrated that great ideas flourish when paired with patience. Flashback to 2011: a small group of young researchers gathered around an aging optical bench at the NUS Department of Chemistry, watching a faint, flickering glow on a screen. Their goal seemed deceptively simple: make an insulating crystal emit light when electricity flowed through it. The challenge, however, was nearly impossible. Lanthanide nanocrystals, known for their chemical stability and ...

Deadly hotter and longer heatwaves, which worsen in severity the longer it takes to reach net zero carbon emissions, will become the norm predicts new climate research. Published in Environmental Research: Climate, researchers at the ARC Centre of Excellence for 21st Century Weather and CSIRO used climate modelling and supercomputers to understand how heatwaves will respond over the next 1,000 years, after the world reaches net zero carbon emissions. They chose a range of dates between 2030 and 2060 and calculated the long-term difference in heatwaves for each ...

A new study of 1960s maps, many of which were created by young people, has provided important fresh evidence of the timing and extent of habitat losses caused by agricultural intensification and urban growth in England and Wales.  Prior to the analysis by the UK Centre for Ecology & Hydrology (UKCEH), there were gaps in understanding about how our landscape gradually changed in the intervening years between the 1930s and 1990.   The 1960s survey involved 3,000 volunteers – many of them schoolchildren and students – marking maps with different colours and shadings, corresponding to a type of land cover such ...

As global temperatures rise and heatwaves intensify, a new textile innovation co-developed by University of South Australia scientists promises to keep people cooler, drier, and more comfortable in extreme heat. Partnering with researchers from Zhengzhou University in China, UniSA materials scientist Professor Jun Ma has helped to create a lightweight breathable fabric that reflects 96% of the sun’s rays in outdoor conditions. The moisture-wicking composite fabric is described in the journal Nano Research. In outdoor field tests, the new textile lowered skin temperature by 2 degrees celsius under direct sunlight ...

A new study published in Nitrogen Cycling presents the most comprehensive assessment to date of how China can reduce nationwide nitrogen pollution while continuing to meet the rising food demands of its population. The research analyzes nearly six decades of data and concludes that smarter nitrogen management could reduce fertilizer use by more than one third, significantly improving air and water quality without compromising crop yields. Nitrogen fertilizers have played a central role in feeding China since the 1960s, supporting ...

Around two-thirds (68%) of pregnancies have weight gain that is more or less than recommended and that is associated with complications such as preterm birth, large birth weight, and admission to intensive care, finds a review of data from 1.6 million women published by The BMJ today. These findings reinforce the need for international standards for healthy GWG alongside lifestyle support and public health measures to improve outcomes for mothers and babies worldwide, say lead researchers Helene Teede and Rebecca Godstein. Gaining too much or too ...

Thousands of locally employed doctors (LEDs) - many of them international graduates and from ethnic minority backgrounds - are trapped on insecure NHS contracts with no access to training, career progression, or national safeguards, reveals an investigation published by The BMJ today. LEDs are the fastest growing group of doctors in the UK, driven mostly by those who graduated outside the UK. From 2019 to 2023, the number of LEDs in England and Wales rocketed by 75% to 36,831 doctors. Freedom of Information (FoI) data obtained by The BMJ show that almost nine in 10 UK acute trusts use local contracts - some dating back as far as 2002 without ...

Key points Higher and lower than recommended gestational weight gain is associated with increased pregnancy complications Support is needed to improve health for women across the globe Findings may help inform global standards for healthy weight gain in pregnancy Around two-thirds of pregnancies have weight gain that is more or less than recommended and is associated with complications such as preterm birth, large birth weight, and admission to intensive care. The findings are part of a Monash University-led systematic review of data from 1.6 million women, published by The BMJ. Gaining too much or too little weight during pregnancy, known as gestational ...

Large-scale livestock farming is accelerating the spread of antibiotic resistance and heavy metal contamination in agricultural soils at a pace and scale that poses new risks to global food safety and public health, new research reveals. Scientists have uncovered how even “low-risk” organic fertilizers like dried poultry manure can inadvertently drive a dramatic surge in dangerous antibiotic resistance genes, once released into vegetable plots used for food crops. The peer-reviewed study, published this week in Biocontaminant, focused on ...

DALLAS, Nov. 19, 2025 — National Women’s Soccer League and Angel City FC defender Savy King are teaming up with the American Heart Association on a groundbreaking league-wide initiative to equip all NWSL 16 teams with the lifesaving skills of Hands-Only cardiopulmonary resuscitation (CPR) and automatic external defibrillator (AED) education. The initiative aims to empower players, staff and coaches with the knowledge and confidence to act in a cardiac emergency. The initiative was announced tonight at the NWSL Awards ceremonies in San Jose, California and broadcast on ...

A University of California, Riverside-led study shows that holding underperforming schools accountable can yield life-changing benefits for their most vulnerable students. The research, led by UCR economist and professor Ozkan Eren, found that when high schools receive the state’s lowest performance rating—and are subsequently compelled to make changes—students are significantly less likely to have run-ins with law enforcement later in life. “In terms of long-run criminal involvement, we find that if the school has a ...

Just over half (51%) of published novelists in the UK believe that artificial intelligence is likely to end up entirely replacing their work as fiction writers, a new University of Cambridge report shows. Close to two-thirds (59%) of novelists say they know their work has been used to train AI large language models (LLMs) without permission or payment. Over a third (39%) of novelists say their income has already taken a hit from generative AI, for example due to loss of other work that facilitates novel writing. Most (85%) novelists expect their future ...

UK Biobank has today [Thursday 20 November] released the final set of data on nearly 250 metabolites – the molecules in our blood produced by our bodies as we go about our lives – in half a million volunteers. This completes the world’s largest ever metabolomic study, which will help researchers to better predict who is at highest risk of disease and drive treatment strategies for neurological conditions, ...

Media Contact: pr@cos.io The Center for Open Science (COS) has been awarded a grant from the Robert Wood Johnson Foundation (RWJF) to develop a community-driven strategic plan for ensuring the long-term preservation, accessibility, and usability of federally-funded scientific data. COS has long championed policies and practices that increase the openness, integrity, and trustworthiness of research. The success of the open science movement relies on the integrity, sustainability, and resilience of infrastructures that promote access to research outputs, like scientific data. In 2025, the sudden removal of public data from multiple federal agency ...

Philadelphia, November 19, 2025 – Researchers at Children’s Hospital of Philadelphia (CHOP) revealed important genetic components that affect bone density in children and adolescents. This information could help identify pediatric patients who may benefit from strategies to help improve their bone health at an early age, helping them maintain healthy bones and prevent fractures in adulthood. Many children experience fractures due to accidents and recover quickly, but there are many reasons why children may have weak bones or be at risk for developing fragile bones. Chronic health conditions, dietary restrictions and steroid use all impact bone mineral metabolism. ...

Using lasers as tweezers to understand cloud electrification might sound like science fiction but at the Institute of Science and Technology Austria (ISTA) it is a reality. By trapping and charging micron-sized particles with lasers, researchers can now observe their charging and discharging dynamics over time. This method, published in Physical Review Letters, could provide key insights into what sparks lightning. Aerosols are liquid or solid particles that float in the air. They are all around us. Some are large and visible, such ...