A new study published in AI Materials presents a comprehensive multi-scale computational framework capable of predicting the mechanical responses of Fe–Cr–Al alloys while incorporating both solid-solution effects and processing-induced microstructural evolution. By coupling Molecular Dynamics (MD), Phase-Field Method (PFM), and Finite Element Method (FEM) through a temperature-dependent crystal plasticity model, the work provides a pathway for quantitatively linking composition, microstructure, and mechanical performance within the broader context of the Materials Genome Initiative. Why This Matters Fe–Cr–Al alloys are among the leading candidates for accident-tolerant ...

  SAN ANTONIO – Preoperative radiation improved T-cell infiltration (TCI) in patients with hormone receptor (HR)-positive, HER2-negative breast cancer when administered in combination with pembrolizumab (Keytruda) and chemotherapy and led to improved treatment responses prior to surgery, according to the results of the phase II P-RAD clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025. “Many patients with HR-positive, HER2-negative breast cancer—the most common type of breast cancer—experience late recurrences, and there is a critical need to improve ...

SAN ANTONIO – Patients with stage 1 or 2, hormone receptor (HR)-negative breast cancer had similar five-year rates of locoregional recurrence whether or not they underwent preoperative breast magnetic resonance imaging (MRI) in addition to diagnostic mammography to determine the extent of their cancer, according to results from the phase III Alliance A011104/ACRIN 6694 clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025. Breast MRI is commonly included as part of the diagnostic workup of breast cancer ...

SAN ANTONIO – Skipping sentinel lymph node biopsy (SLNB) in patients with clinically node-negative, hormonal receptor (HR)-positive, HER2-negative early-stage breast cancer did not compromise regional control or survival after a median five years of follow-up, according to results from the BOOG 2013-08 phase III clinical trial, presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025. “Over the past two decades, breast cancer care has shifted toward minimizing invasiveness while preserving oncologic safety,” said Marjolein Smidt, MD, PhD, presenter of this study and professor at the Maastricht University Medical Center ...

PULLMAN, Wash. -- It isn’t just people – when given the chance rats may also use cannabis to cope with stress, according to a study by researchers at Washington State University. Published in the journal Neuropsychopharmacology, the study was designed to examine cannabis-seeking behavior and found that rats with higher natural stress levels are far more likely to self-administer the popular recreational drug. "We ran rats through this extensive battery of behavioral and biological tests, and what we found was that when we look at all of these different factors and all the variables that we measured, stress ...

As Americans gear up for the holiday season, new research offers a timely reminder to reflect on the long-term health effects of raising a celebratory glass – or two. Alcohol is known to increase the risk of several cancers even at moderate levels. Yet drinking remains widespread, and important questions persist about how both the frequency and amount of alcohol people consume shape their cancer risk. Moreover, risks differ across groups, and existing alcohol policies rarely emphasize their link to cancer. To help close these critical gaps, researchers from Florida Atlantic University’s Charles E. Schmidt College of Medicine, conducted a comprehensive systematic ...

Ever notice that as you get older, some foods no longer sit with you the same? This could be due to a breakdown of the intestinal epithelium, a single layer of cells that forms the organ’s lining. The intestine plays a crucial role in many health functions, including digestion. Under normal conditions, the entire intestinal epithelium typically regenerates every three to five days. However, with damage from old age or cancer radiation, regeneration can stop or slow. That can lead to inflammation and diseases like leaky gut syndrome. Now, Cold Spring ...

Trailblazing geneticist Pengfei Liu, Ph.D., Associate Professor in the Department of Molecular and Human Genetics at Baylor College of Medicine, is the recipient of the 2026 Edith and Peter O’Donnell Award in Medicine from TAMEST. He was chosen for his transformative use of genome and RNA sequencing to improve the diagnosis and treatment of rare genetic diseases.   A global leader in his field, Dr. Liu has consistently expanded the boundaries in the diagnosis and treatment of rare genetic disorders. His contributions span nearly every major advancement in modern clinical genetics – from early discoveries of genome rearrangement mechanisms ...

Renowned molecular biologist Yunsun Nam, Ph.D., Professor in the Departments of Biochemistry and Biophysics and the Doris and Bryan Wildenthal Distinguished Chair in Medical Science at UT Southwestern Medical Center, is the recipient of the 2026 Edith and Peter O’Donnell Award in Biological Sciences from TAMEST. She was chosen for her groundbreaking research into how RNAs and proteins interact at the molecular level – providing key insights for gene regulation, cancer biology and RNA-based therapeutics.   Crucial ...

Groundbreaking electrical engineer Bilal Akin, Ph.D., Professor in the Department of Electrical and Computer Engineering at The University of Texas at Dallas, is the recipient of the 2026 Edith and Peter O’Donnell Award in Engineering from TAMEST. He was chosen for his cutting-edge advancement of sustainable and high-efficiency energy conversion systems for electric vehicles (EVs) and industrial automation.   Dr. Akin’s research focuses on making power electronics systems more efficient, reliable and sustainable, with major ...

Pioneering theoretical physicist Fan Zhang, Ph.D., Professor in the Department of Physics at The University of Texas at Dallas, is the recipient of the 2026 Edith and Peter O’Donnell Award in Physical Sciences from TAMEST. He was chosen for his transformational research exploring new topological quantum matter, which has changed how we think about physics.   Dr. Zhang studies how millions of electrons in atomically thin materials interact to produce collective quantum effects such as magnetic, superconducting and topological phases. His ...

Artificial Intelligence (AI) innovator Yue Hu, Ph.D., AI Specialist – Production Technology at bp, is the recipient of the 2026 Edith and Peter O’Donnell Award in Technology Innovation from TAMEST. She was chosen for her cutting-edge work applying AI to optimize real-time industrial processes in the energy sector.   Dr. Hu specializes in reinforcement learning (RL), an AI approach that learns by trial and error. While RL has proven powerful in fields like robotics and gaming, it had rarely been applied successfully to high-stakes oilfield operations. By combining AI with bp’s powerful computing systems, Dr. Hu has successfully applied RL ...

People who lean politically to the right are more likely to fall for conspiracy theories than those on the left – but not for other types of false or misleading information. And regardless of ideology, we tend to accept political claims that align with our own beliefs. This is shown in a doctoral thesis from Linköping University, Sweden. “Conspiracy theories can have a very strong mobilising force, as seen during the storming of the Capitol. Several of those who took part believe in conspiracy ...

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers. The latest results from this program have just been published in the Journal of Medicinal Chemistry, describing the discovery and comprehensive preclinical evaluation of Compound 10, a novel, potent, selective and orally administered DGKα inhibitor.  The compound exhibits a differentiated pharmacokinetic and safety profile and ...

Pancreatic cancer is one of the deadliest malignancies, with survival rates remaining dismally low despite major advances in oncology. One of the key reasons lies in the disease’s unique fibrotic microenvironment—a dense, collagen-rich tissue that acts as a physical and biochemical barrier, preventing drugs from reaching tumor cells effectively.   Now, a research team from Okayama University and Tohoku University has uncovered a promising new way to breach this barrier. Led by Assistant Professor Hiroyoshi Y. Tanaka from the Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, the group demonstrated that blocking ...

Vienna, Austria – 11 December 2025: Valvular heart disease, identified through cardiovascular imaging, is common in cancer patients. Interventions to treat valvular heart disease significantly improved survival.1 These findings were presented today at EACVI 2025, the flagship congress of the European Association of Cardiovascular Imaging (EACVI), a branch of the European Society of Cardiology (ESC). Treatment advances have led to improved survival for patients with cancer. As patients live longer, they are at an increased risk of developing valvular heart disease after successful cancer therapy. Furthermore, it is now well recognised that certain cancer treatments can cause ...

Socially responsible investors (SRIs) often see themselves as agents of social or environmental progress. They buy into polluting or “dirty” companies believing that their capital can nudge a business toward a cleaner path. Their intention is straightforward: to invest in the bad to make it good. But a new study by finance professors at the University of Rochester, Johns Hopkins University, and the Stockholm School of Economics argues that this logic can backfire. Instead of accelerating environmental reforms, SRIs may unintentionally create incentives for firms to ...

Statement Highlights: Over the past decade, the number and type of cuffless devices to measure blood pressure, such as smartwatches, rings, patches and fingertip monitors, have increased significantly. However, many personal wearable devices have not been proven to be accurate or reliable for real world use, such as during exercise, sleep or daily activity or after taking medication that affects blood pressure. In addition, variables like arm position, skin color and how recently the device was calibrated, can also affect results and contribute to inaccurate blood pressure measurements. More research and standardized validation protocols are needed before cuffless blood pressure technologies ...

Vienna, Austria – 11 December 2025: Reduced coronary blood flow, measured with an artificial intelligence-based imaging tool, predicted future cardiovascular events in patients with suspected stable coronary artery disease.1 These findings were presented today at EACVI 2025, the flagship congress of the European Association of Cardiovascular Imaging (EACVI), a branch of the European Society of Cardiology (ESC). Stable coronary artery disease (CAD) refers to the common syndrome of recurrent, transient episodes of chest symptoms, often manifesting as angina. Coronary computed tomography angiography (CCTA) is a non-invasive heart scan that is used as the ...

A team of researchers at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), has reconstructed for the first time how the cerebellum establishes its connections with the rest of the brain during the earliest stages of life. The work, published in the journal Proceedings of the National Academy of Sciences (PNAS), describes in detail the phases in which these neural connections emerge, expand, and are refined, offering the first comprehensive map of the development of cerebellar projections across the mouse brain. Although the cerebellum ...

Daily scans taken during prostate cancer radiotherapy could be repurposed to guide changes to treatment, reducing the risk of side effects, a study suggests. Using AI, scientists found that images originally taken to help position patients for radiotherapy could also identify changes linked to future rectal bleeding as early as one week into treatment. Monitoring these early changes could help doctors decide when to adapt radiotherapy to limit side effects while maintaining cancer control, experts ...

AI-supported recommender systems should provide users with the best possible suggestions for their enquiries. These systems often have to serve different target groups and take other stakeholders into account who also influence the machine’s response: e.g. service providers, municipalities or tourism associations. So how can a fair and transparent recommendation be achieved here? Researchers from Graz University of Technology (TU Graz), the University of Graz and Know Center investigated this using a cycling tour app from the Graz-based start-up Cyclebee. They conducted research into how the diversity of human needs can be taken into account by AI. ...

Sea urchins are ecosystem engineers, the marine equivalent of mega-herbivores on land. By grazing and shredding seaweed and seagrass, they control algal growth and promote the survival of slow-growing organisms like corals and some calcifying algae. They are likewise prey for a plethora of marine mammals, fish, crustaceans, and sea stars. However, when they become overabundant, for example when these predators are overhunted or overfished, sea urchins can also inflict substantial damage to marine habits and form so-called ‘urchin barrens’. Now, a study in Frontiers in Marine Science has revealed that over the last four years, an unrecognized pandemic that ...

A new study from Flinders University offers insight into how two of the world’s most popular beverages, coffee and tea, may influence bone health in older women. The research, published in the journal Nutrients, followed nearly 10,000 women aged 65 and older over a decade to explore whether their daily habits of sipping coffee or tea were linked to changes in bone mineral density (BMD), a key indicator of osteoporosis risk. Osteoporosis is a major global health concern, affecting one in three women over 50 and contributing to millions of fractures each year. With coffee and tea consumed daily by billions worldwide, understanding their impact on bone health ...

Free or subsidized school meals lead to modest gains in math and school enrolment, according to a new Cochrane review that examined the global impact of school feeding programs on disadvantaged children in both high-income countries and low- and middle-income countries. The research team, led by scientists from University of Ottawa, found that providing free or subsidized meals in schools slightly improves math achievement and enrolment rates in low- and middle-income countries (LMICs), and likely contributes to small gains in physical growth indicators such as height-for-age ...