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Whiteness as a fundamental determinant of health in rural America

2024-12-05
WASHINGTON -- White people in rural America have unique factors that drive worse health outcomes than their urban counterparts, prompting a team of public health researchers to label whiteness as a fundamental determinant of health.  They say while the health and well-being of racially minoritized populations should continue to be a research priority they urge researchers to consider factors that influence the health of majoritized populations. In an analytic essay, "Whiteness: A Fundamental Determinant of the Health of Rural White Americans,” published Dec. 5 in the American Journal of Public Health, Caroline Efird, PhD, MPH, ...

Analyzing multiple mammograms improves breast cancer risk prediction

Analyzing multiple mammograms improves breast cancer risk prediction
2024-12-05
A new study from Washington University School of Medicine in St. Louis describes an innovative method of analyzing mammograms that significantly improves the accuracy of predicting the risk of breast cancer development over the following five years. Using up to three years of previous mammograms, the new method identified individuals at high risk of developing breast cancer 2.3 times more accurately than the standard method, which is based on questionnaires assessing clinical risk factors alone, such as age, race and family history of breast cancer. The study is published ...

Molecular zip code draws killer T cells straight to brain tumors

2024-12-05
More information, including a copy of the paper, can be found online at the Science press package at https://www.eurekalert.org/press/scipak. Molecular Zip Code Draws Killer T Cells Straight to Brain Tumors Researchers have found a way to program immune cells to attack glioblastoma and treat the inflammation of multiple sclerosis in mice. The technology will soon be tested in a clinical trial for people with glioblastoma. UCSF scientists have developed a “molecular GPS” to guide immune cells into the brain and kill tumors without harming healthy tissue.  This living cell therapy can navigate through the body to a specific organ, addressing ...

Engineered immune cells may be able to tame inflammation

2024-12-05
More information, including a copy of the paper, can be found online at the Science press package at https://www.eurekalert.org/press/scipak. Engineered Immune Cells May Be Able to Tame Inflammation Immune cells that are designed to soothe could improve treatment for organ transplants, type 1 diabetes and other autoimmune conditions. When the immune system overreacts and starts attacking the body, the only option may be to shut the entire system down and risk developing infections or cancer. But now, scientists at UC San Francisco may have found a more precise way to dial the immune system down. The technology ...

Rapid surge in global warming mainly due to reduced planetary albedo

Rapid surge in global warming mainly due to reduced planetary albedo
2024-12-05
Rising sea levels, melting glaciers, heatwaves at sea – 2023 set a number of alarming new records. The global mean temperature also rose to nearly 1.5 degrees above the preindustrial level, another record. Seeking to identify the causes of this sudden rise has proven a challenge for researchers. After all, factoring in the effects of anthropogenic influences like the accumulation of greenhouse gases in the atmosphere, of the weather phenomenon El Niño, and of natural events like volcanic eruptions, can account for a major portion of the warming. But doing so still leaves a gap of roughly 0.2 degrees Celsius, which has never been satisfactorily ...

Single mutation in bovine H5N1 switches viral binding specificity to human receptors

2024-12-05
A single mutation in bovine influenza H5N1 – a clade of the highly pathogenic avian influenza virus that has been increasingly detected among North American livestock herds – can cause the virus to switch affinity from animal-type receptors to human-type receptors, according to a new study. The findings highlight the crucial need for continuous surveillance of emerging H5N1 mutations, as even subtle genetic changes could increase the virus's capacity for human adaptation and transmission, potentially triggering a future influenza pandemic. In 2021, the highly pathogenic influenza H5N1 clade ...

Discovered: the neuroendocrine circuit that dictates when fish are ready to hatch

2024-12-05
Researchers have uncovered a previously unknown yet crucial role for thyrotropin-releasing hormone (Trh) in zebrafish hatching and reveal how this hormone activates a transient neuroendocrine circuit that controls when fish larvae are ready to leave the egg and swim free. For egg-born animals, hatching marks a pivotal shift, transitioning from the sheltered environment of an egg capsule to external conditions. This crucial event is not strictly hardwired into the embryo’s developmental program. Rather, hatching is a regulated ...

Climate change threatens global biodiversity, with extinction risks escalating at higher temperatures

2024-12-05
Climate change is driving global extinction risks, with 1.6% of species threatened at 1.3°C of warming and risks escalating to 29.7% at 5.4°C, according to a new meta-analysis encompassing more than 30 years of research. Climate change is reshaping ecosystems and biodiversity globally, altering species distributions, interactions, and population dynamics. While some species adapt or migrate to track shifting climates, others face population declines, shrinking ranges, and potential extinction. ...

Scientists ‘turn up the heat’ on understanding coffee wilt disease which threatens our favourite daily brew

Scientists ‘turn up the heat’ on understanding coffee wilt disease which threatens our favourite daily brew
2024-12-05
Scientists, including those from Imperial College London, University of Oxford and CABI, have ‘turned up the heat’ on how repeated outbreaks of coffee wilt disease threatened arabica and robusta varieties of our favourite daily coffee brew. The scientists, who present their findings in the journal PLoS Biology, say the fungal pathogen Fusarium xylarioides continues to pose a significant threat to coffee production and incomes across sub-Saharan Africa. Their work supports earlier findings, based on DNA markers and crossing experiments which suggested that F. xylarioides is ...

Researchers crack the code of how fish pick their own birthday

Researchers crack the code of how fish pick their own birthday
2024-12-05
New research has revealed that fish embryos actively control their hatching timing through a neurohormone, Thyrotropin-Releasing Hormone (TRH), which triggers the release of enzymes that dissolve the egg wall. This groundbreaking discovery uncovers a previously unknown neural mechanism that governs a critical life-stage transition, showing that embryos are not passive but instead actively make life-or-death decisions. The finding has significant evolutionary implications, offering new insights into neurobiology, survival strategies, and environmental adaptation in vertebrates. Dr. ...

Shaking sensor continuously monitors inflammation

Shaking sensor continuously monitors inflammation
2024-12-05
Northwestern University scientists have designed a new implantable device that can monitor fluctuating levels of proteins within the body in real time. Inspired by fruit shaking off the branches of a tree, the device comprises strands of DNA that stick to proteins, shake them off and then grab more proteins. This creative strategy enables the device to sample various proteins over time to measure changes in inflammatory markers. In proof-of-concept experiments, the sensors accurately and sensitively measured protein biomarkers of inflammation in diabetic rats. ...

Scripps Research scientists identify mutation that could facilitate H5N1 “bird flu” virus infection and potential transmission in humans

Scripps Research scientists identify mutation that could facilitate H5N1 “bird flu” virus infection and potential transmission in humans
2024-12-05
LA JOLLA, CA—Avian influenza viruses typically require several mutations to adapt and spread among humans, but what happens when just one change can increase the risk of becoming a pandemic virus? A recent study led by scientists at Scripps Research reveals that a single mutation in the H5N1 “bird flu” virus that has recently infected dairy cows in the U.S. could enhance the virus’ ability to attach to human cells, potentially increasing the risk of passing from person to person. The findings—published in ...

Queen Mary University of London vaccination tool boosts uptake of MMR vaccine in children

2024-12-05
A software tool developed by Queen Mary University of London’s Clinical Effectiveness Group (CEG) and used as part of a facilitated quality improvement programme has increased the number of children receiving their first MMR vaccination on time in North East London. The success of this programme highlights the potential of a learning health system and data-driven solutions to enhance public health and improve vaccination uptake across the UK.  An evaluation published in Vaccine revealed that the APL-Imms ...

Implantable sensors unlock ability to continuously monitor inflammation

Implantable sensors unlock ability to continuously monitor inflammation
2024-12-05
Implantable Sensors Unlock Ability to Continuously Monitor Inflammation  The Chan Zuckerberg Biohub Chicago’s milestone achievement tracks protein levels in real time, enabling monitoring of inflammation at the cellular level   Proteins are the building blocks of life, and changes in protein levels can indicate improving health or impending illness, including signs of inflammation. While protein levels can be measured in periodic blood or urine tests, it has been an uphill challenge to figure out how to continuously monitor protein levels in the human body in real time. Now, a team of bioengineers at Chan Zuckerberg Biohub Chicago, supported by the ...

Buffalo besties: Feral female buffalo build friendships based on similar personality traits

Buffalo besties: Feral female buffalo build friendships based on similar personality traits
2024-12-05
HONG KONG (29 November 2024)—Similar social personalities strongly influence friendships in humans, yet we know relatively little about how animals choose their friends. But a new study by researchers at City University of Hong Kong (CityUHK) investigating a unique free-ranging feral population of water buffalo on Lantau Island in Hong Kong has discovered that close spatial proximity serves as an indicator of friendship based on the predictive patterns of certain personality traits. “Our research provides evidence that friendships among water buffalo can form among individuals with similar behaviours. These findings ...

UNC researchers awarded up to $10M to leverage data science to accelerate cancer diagnosis and optimize delivery of precision oncology

UNC researchers awarded up to $10M to leverage data science to accelerate cancer diagnosis and optimize delivery of precision oncology
2024-12-05
UNC researchers awarded up to $10M to leverage data science to accelerate cancer diagnosis and optimize delivery of precision oncology CHAPEL HILL, North Carolina—A team of UNC-Chapel Hill researchers has been awarded up to $10 million in Advanced Research Projects Agency for Health (ARPA-H) funding to develop the Cancer Identification and Precision Oncology Center (CIPOC). The project is designed to improve cancer diagnosis and support personalized treatments by quickly aggregating and analyzing ...

Cardiovascular disease symptoms surprisingly high in young refugees

2024-12-05
Many individuals seeking asylum in the United States show increased stress and pain symptoms that are associated with indications of cardiovascular disease according to Weill Cornell Medicine researchers.   “We would not have expected the rates of these illnesses or conditions to be this high in such a young, otherwise healthy population,” said the study’s senior author, Dr. Gunisha Kaur, associate professor of anesthesiology and an anesthesiologist at NewYork-Presbyterian/Weill Cornell Medical Center. The study, published Dec. 5 in Nature Mental Health, analyzed medical evaluations from 453 U.S. asylum seekers for symptoms associated with psychological ...

To remember conversations, keep making new brain cells

To remember conversations, keep making new brain cells
2024-12-05
Why do adults make new brain cells? A new study published in Cell Stem Cell provides the first cellular evidence that making new brain cells in adults supports verbal learning and memory, which enables people to have conversations and to remember what they hear. This discovery could point to new approaches to restore cognitive function.  The study, led by scientists from USC Stem Cell and the USC Neurorestoration Center at the Keck School of Medicine of USC, relied on brain tissue from patients with drug-resistant cases of mesial temporal lobe epilepsy (MTLE), which involves seizures as well as accelerated cognitive decline.  “Treating patients with epilepsy ...

RNA modifications in individual cells better understood with new modelling

RNA modifications in individual cells better understood with new modelling
2024-12-05
Researchers have developed a new tool that will help scientists study how genes are expressed in our cells. The tool, called SigRM, is used to analyse data from single-cell epitranscriptomics, a method for studying RNA modifications in individual cells. This research could lead to important insights into health and disease. Recent advances in single-cell technology have enabled researchers to analyse thousands of individual cells at once, providing rich information about the expression and activity of genes and proteins, as well as chemical changes that affect gene expression. A major tool in these studies is single-cell epitranscriptomics, which studies RNA ...

In five cancer types, prevention and screening have been major contributors to saving lives

2024-12-05
Improvements in cancer prevention and screening have averted more deaths from five cancer types combined over the past 45 years than treatment advances, according to a modeling study led by researchers at the National Institutes of Health (NIH). The study, published Dec. 5, 2024, in JAMA Oncology, looked at deaths from breast, cervical, colorectal, lung, and prostate cancer that were averted by the combination of prevention, screening, and treatment advances. The researchers focused on these five cancers because they are among the most common causes of cancer deaths and strategies ...

Estimation of cancer deaths averted from prevention, screening, and treatment efforts, 1975-2020

2024-12-05
About The Study: In this model-based study using population-level cancer mortality data, an estimated 5.94 million cancer deaths were averted for breast, cervical, colorectal, lung, and prostate cancers combined from 1975 to 2020. Prevention and screening accounted for 8 of every 10 averted deaths, and the contribution varied by cancer site. Despite progress, efforts to reduce the U.S. cancer burden will require increased dissemination of effective interventions and new technologies and discoveries.  Corresponding ...

Estimated reduction in health care spending associated with weight loss in adults

2024-12-05
About The Study: In this cross-sectional study, projected annual savings from weight loss among U.S. adults with obesity were substantial for both Medicare and employer-based insurance.  Corresponding Author: To contact the corresponding author, Kenneth E. Thorpe, PhD, email kthorpe@emory.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.49200) Editor’s Note: Please see the article for additional information, including other authors, author contributions ...

Satellite-based and street-view green space and adiposity in US children

2024-12-05
About The Study: The results of this cohort study of U.S. children suggest that higher levels of satellite-based normalized difference vegetation index greenness and percentages of street-level green space components (flowers, plants, and fields) were associated with lower adiposity. The findings support the exploration of increasing residential green space levels and adding specific green space components as an urban planning and public health intervention strategy to combat the prevalence of childhood obesity in the U.S. Corresponding Author: To contact the corresponding author, Li Yi, PhD, email li_yi@hsph.harvard.edu. To access the embargoed study: ...

Psilocybin therapy helps clinicians process COVID despair

Psilocybin therapy helps clinicians process COVID despair
2024-12-05
Psilocybin-assisted psychotherapy resulted in significant reductions in depression among clinicians who provided front-line COVID-19 care in 2020 and 2021. These reductions were measurably greater than those experienced by the cohort of clinicians who received a placebo instead. Findings from this double-blind, randomized clinical trial are to be published in JAMA Network Open at 8 a.m. PST Thursday, Dec. 5.. “For doctors and nurses who feel burned out or disillusioned or disconnected from the patient care they want to provide, this study shows that psilocybin ...

Feminist mothers may be compromising their own children's sex education at home

2024-12-05
Parents don't need to be blamed or shamed when providing sex education to their children, they need better support to help them safely parent their children in an increasingly complicated, digital world without compromising their values, say researchers from the University of Surrey.  In a new study, researchers from Surrey's School of Sociology found that self-identified feminist mothers across England unintendedly compromised their values about children's rights to comprehensive sex education due to societal pressures and fears of judgement.  While participants shared their ...
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