Metastasis occurs when cancer cells break away from the original tumor and travel through the bloodstream to form new tumors in other parts of the body. It is the leading cause of cancer-related death. Brain metastasis is particularly severe and affects 10-30% of patients with advanced lung, breast, and melanoma cancers. While therapies exist for established brain tumors, there are limited strategies that directly target the very first cancer “seed cells” that enter and lodge in the brain.  Our brains, however, are equipped with immune cells called microglia that rapidly respond to ...

UNDER EMBARGO UNTIL 15:00 GMT / 10:00 ET WEDNESDAY 10 DECEMBER 2025 New breakthrough in detecting ‘ghost particles’ from the Sun First observation of carbon-neutrino interactions opens new frontiers in nuclear and particle physics. More images available via the link in the Notes Section. Neutrinos are one of the most mysterious particles in the universe, often called 'ghost particles' because they rarely interact with anything else. Trillions stream through our bodies every second, ...

Offering screening for neurodivergence to people detained by the police could help ensure access to appropriate support and fairer treatment in the criminal justice system, say Cambridge researchers, after a study suggests that one in two individuals arrested and detained in London may have undiagnosed attention-deficit/hyperactivity disorder (ADHD) and one in 20 may have undiagnosed autism. Research has consistently found that neurodivergent individuals – particularly autistic people and those with ADHD – are overrepresented within prison populations. There is also growing evidence ...

Fukuoka, Japan—Whether you turn red when drinking alcohol, dislike certain smells, or metabolize drugs differently from others, the explanation often lies in your DNA, or more precisely, your gene types. People share the same genes but not the exact same gene types. These types are unique combinations of multiple DNA sequence differences that together shape our biological traits. Researchers have long investigated these genetic variations, but traditional tools analyze only 150-300 bases at a time, providing isolated “dots” of information. Advances ...

The African CDC has recently warned of a surge in cholera cases across the continent. Cholera, caused by certain strains of V. cholerae, is a waterborne infection that spreads rapidly, particularly in areas with limited access to clean water and sanitation. Africa bears the majority of the global burden of cholera, accounting for 46% of all cases and nearly 83% of all deaths. Yet, only about 1.3% of laboratories on the continent have the bacteriology capacity to confirm infections.   In 2024, representatives from ...

SAN ANTONIO — December 10, 2025 — Southwest Research Institute (SwRI) and Trinity University will improve a prodrug, a compound activated in the body, to mitigate tissue and organ damage associated with heart attacks, strokes and traumatic injuries. These conditions cause a lack of blood flow, but treatment to reverse blockages can also lead to lasting damage. A project collaboratively funded by SwRI and Trinity will address both the initial lack of blood (ischemia) and the rush of blood that follows treatment (reperfusion) referred to as ischemia/reperfusion injury (IRI). “The moment oxygen comes flooding back ...

SAN ANTONIO – The investigational, oral selective estrogen receptor degrader (SERD) giredestrant  given as an adjuvant therapy showed significant improvement in invasive disease-free survival (iDFS) compared with the current standard-of-care endocrine therapy in patients with early-stage, hormone receptor (HR)-positive, HER2-negative breast cancer, according to the results of the phase III IidERA trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025. “For patients with HR-positive breast cancer—which accounts for about 70% of breast cancer ...

Washington, D.C. December 10, 2025 – Gen Z views the world as a scary place, according to new research presented at the 2025 Society for Risk Analysis Conference. In ongoing research that began in Fall 2022, Gabriel Rubin, Ph.D. a justice studies professor at Montclair State University, has now conducted 104 long-form interviews with Gen Z young people in the Northeast United States about their views on politics, risk and protest—expanding on his initial findings from the study, Gen Z Risk Perceptions: ...

•    Measurement accuracy of oxidase biosensors for glucose, lactate, and creatinine increased from about 50 to 99 percent  •    Oxygen previously caused inaccuracies; the new method removes oxygen  •    Researchers see potential applications ranging from personalized medicine to agriculture Biosensors are helping people with chronic conditions worldwide live better lives. However, their measurement accuracy has often been relatively low, limiting the range of possible applications. ...

Researchers have harnessed a new statistical technique that allows forest managers to use incomplete satellite imagery for precise forest inventories, bypassing the need for complex and often uncertain data repair processes. The method, known as a "hybrid estimator," is particularly valuable for leveraging decades of archived data from the aging Landsat 7 satellite, which has been collecting images with systematic gaps since 2003. The study, published in Forest Ecosystems, addresses a critical challenge in forestry and climate science. Remote sensing is vital for large-scale ...

A chemical found in dark chocolate could slow the rate of biological ageing. Research from King’s College London has found that the chemical theobromine, a common plant compound that comes from cocoa, could have anti-ageing properties. The study, published today in Aging, compared levels of theobromine in people’s blood, with blood-based markers of biological ageing. Biological age markers indicate how old your body seems based on its health and function, as opposed to the years you have lived. These markers ...

Chronic hepatitis C infection affects an estimated 50 million people globally, causes approximately 242,000 deaths per year mostly due to cirrhosis and liver cancer Same-day results will help kickstart treatment for infection, which is curable with medication  Johns Hopkins scientists independently confirmed test’s 100% agreement when compared to commercial platforms CHICAGO --- Scientists at Northwestern University have developed the fastest test yet for diagnosing hepatitis C virus (HCV). The highly accurate diagnostic delivers results to patients in just 15 minutes — up to 75% faster than other rapid HCV tests. This ...

The planets in the Solar System are typically divided into three categories based on their composition: the four terrestrial rocky planets (Mercury, Venus, Earth and Mars), followed by the two gas giants (Jupiter and Saturn), and finally two ice giants (Uranus and Neptune).  According to the work carried by the UZH scientific team, Uranus and Neptune might actually be more rocky than icy. The new study does not claim the two blue planets to be one or the other type, water- or rock- rich, it rather challenges that ...

Ex vivo cultured organoids, tissue slices, and isolated organs are essential models for studying disease mechanisms and evaluating drug responses. Real-time, multisite electrophysiological monitoring is critical for capturing their dynamic behavior. However, conventional microelectrode arrays are limited in dynamic environments due to rigid structures, fixed electrode layouts, and cable constraints. Advances in soft, stretchable electronics offer solutions, but most devices lack active repositioning capabilities. “Magnetically actuated soft robots ...

Dementia is a group of disorders that gradually impair memory, thinking and daily functioning. Alzheimer’s disease (AD), the most common form of dementia, affects about 7.2 million Americans aged 65 and older in 2025. Frontotemporal dementia (FTD), while rarer, is the second most common cause of early-onset dementia, often striking people in their 40s to 60s. Although both diseases damage the brain, they do so in distinct ways. AD primarily affects memory and spatial awareness, while FTD targets regions responsible for behavior, personality and language. Because their symptoms can overlap, it often leads to misdiagnosis. ...

Acute myeloid leukemia (AML) is a malignancy characterized by the clonal proliferation of myeloid hematopoietic progenitor or stem cells, primarily affecting adults with a relatively high incidence and poor prognosis, with a 5-year survival rate of only 25% to 40%. Although the “7 + 3” induction chemotherapy regimen remains the standard treatment for AML, its nonselective cytotoxic mechanism often results in severe myelosuppression and organ toxicity, thus limiting long-term efficacy. AML exhibits considerable ...

Global Virus Network Announces Appointment of New Board Members Global leaders in science, medicine, and journalism join GVN’s Board to strengthen pandemic preparedness and global health Tampa, FL, USA – December 10, 2025 – The Global Virus Network (GVN), a worldwide coalition of leading human and animal virologists from 90+ Centers of Excellence and Affiliates in more than 40 countries dedicated to advancing research and strengthening pandemic preparedness against viral threats to public ...

VANCOUVER, Wash. — The use of artificial beaver dams to replicate the ecological benefits created by the industrious rodents shows promise for offsetting damage to fish habitat, water quality, and biodiversity arising from climate change. But as the use of such “beaver mimicry” spreads, particularly in the Pacific Northwest, there are key gaps in the research and a need for more studies that examine whether the outcomes seen in specific projects are broadly applicable. That is a key takeaway from a new review of scientific literature by Washington State University researchers and ...

For millions suffering from long COVID, their persistent breathlessness, brain fog and fatigue remain a maddening mystery, but a group of leading microbiologists think they may have cracked the case.  The culprit for some long COVID cases, they suggest, might be other infections that accompany SARS-CoV-2. A review published in eLife by 17 experts, including those from Rutgers Health, argues that co-infections acquired before or during COVID could cause symptoms to persist indefinitely for many people. "This is an aspect of long COVID that is not talked about a lot," ...

About The Study: Initiating resuscitation of preterm infants with fraction of inspired oxygen of 0.6 vs 0.3 did not affect the risk of death or brain injury by 36 weeks’ corrected gestational age. These results lay a foundation for future trials evaluating the effectiveness and safety of using higher initial fraction of inspired oxygen levels for preterm infant resuscitation. Corresponding Author: To contact the corresponding author, Ju Lee Oei, MD, email j.oei@uq.edu.au. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.23327) Editor’s ...

Using machine learning models, researchers at Michigan Medicine have identified a potential way to diagnose amyotrophic lateral sclerosis, or ALS, earlier from a blood sample, a study suggests. The models, which analyze blood for biomarkers through gene expression with RNA sequencing to detect ALS, also have the potential to predict disease severity — and how long a person might live with the neurodegenerative condition. The results are published in Nature Communications. “Our findings present an ...

Adhesives are essential in various industries, including aerospace, electronics, construction, marine, automotive, and biomedical fields. As these fields continue to advance, the demand for high-performance, multifunctional adhesives is also growing. However, such widespread use has also highlighted their environmental issues. Conventional adhesives, while effective and economical, release petroleum-based chemicals that are harmful to soil and water quality. Their production also contributes to environmental ...

The Jahn–Teller effect, proposed by Jahn and Teller in 1937, describes how molecules or crystals with degenerate electronic orbitals can lower their total energy by distorting their structure. This distortion lifts the degeneracy, stabilizing certain orbitals that become occupied by electrons. While many materials exhibiting this effect have been found, the involvement of spin—the source of magnetism—has rarely been observed because magnetic ordering usually occurs at much lower temperatures than structural distortions caused by the Jahn–Teller ...

As life expectancy continues to climb globally, the focus of many people has moved from longevity alone to living in good health. This has drawn attention to the need to extend “healthspan,” the period during which an individual maintains their vitality, independence, and good health, and is free from major age-related issues. Mitochondria, known popularly as the powerhouse of the cell, are central to this goal as they produce the energy essential for life in the form of adenosine triphosphate (ATP). Given that many age-related diseases and aging itself are strongly linked to the decline of mitochondrial function, mitochondria ...

Everyday acts of care—tightening a loose hinge, patching up a wall, or simply moving a crate—may seem mundane. But a new study from Ritsumeikan University shows that these small repairs are key to sustaining autonomy and an inclusive social life in a squatted space in Japan. The research, led by Associate Professor Kyoko Tominaga from the College of Social Sciences at Ritsumeikan University, Japan, explores how spatial practices within the squat at the Takayama Architecture Summer School (TASS) enable diverse residents to coexist through collaborative ...