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Expanding seasonal immunization access could minimize off-season RSV epidemics

2025-11-26
PROVIDENCE, R.I. [Brown University] — Providing year-round access to RSV immunization would minimize the risk of large seasonal outbreaks across the nation, including in both urban and rural areas. That’s according to a new study, published in Science Advances, which examined differences in viral spread in areas with different population density. The study showed that in urban areas, higher rates of interpersonal contact led to a higher proportion of hospitalizations in infants under age 1 and a more prolonged, lower-intensity RSV outbreak. Rural areas, on the other hand, saw shorter, spikier outbreaks. The ...

First-of-its-kind 3D model lets you explore Easter Island statues up close

2025-11-26
Located in the middle of the South Pacific, thousands of miles from the nearest continent, Easter Island (Rapa Nui) is one of the most remote inhabited places on Earth. To visit it and marvel at the quarries where its iconic moai statues were created is a luxury few get to experience – until now. You can now explore Rano Raraku, one of the major quarries on Easter Island, from the comfort of your home. A research team including faculty at Binghamton University, State University of New York has created the first-ever high-resolution 3D model of the quarry, providing people ...

foldable and rollable interlaced origami structure: Folds and rolls up for storage and deploys with high strength

2025-11-26
Researchers at the Department of Mechanical Engineering, Seoul National University, led by Professor Kyu-Jin Cho—Director of the Human-Centered Soft Robotics Research Center and a founding member of the SNU Robotics Institute (SNU RI)—have applied the principle of interlacing to an origami-inspired structure and developed a “Foldable-and-Rollable corruGated Structure (FoRoGated-Structure)” that can be smoothly folded and rolled up for compact storage while maintaining very high strength when deployed. The study ...

Possible therapeutic approach to treat diabetic nerve damage discovered

2025-11-26
Nerve damage is one of the most common and burdensome complications of diabetes. Millions of patients worldwide suffer from pain, numbness, and restricted movement, largely because damaged nerve fibres do not regenerate sufficiently. The reasons for this are unclear. A research team led by Professor Dr Dietmar Fischer, Professor of Pharmacology at the University of Cologne’s Faculty of Medicine, and Director of the Center for Pharmacology at University Hospital Cologne, has now identified a central mechanism that explains limited regeneration ...

UBC ‘body-swap’ robot helps reveal how the brain keeps us upright

2025-11-26
What if a robot could show us how the brain keeps us balanced? UBC scientists built one – and their discovery could help shape new ways to reduce fall risk for millions of people. A towering ‘body-swap’ robot built by University of British Columbia researchers is giving scientists an unprecedented look at how the brain keeps us standing—a skill we barely notice until affected by age or disease. Their findings, published today in Science Robotics with collaborators at Erasmus Medical Clinic, reveal that to stay balanced, the brain treats delays in sensory feedback almost the same way it handles changes in body mechanics. ...

Extensive survey of Eastern tropical Pacific finds remote protected areas harbor some of the highest concentrations of sharks

2025-11-26
Puerto Ayora, Galapagos | 26 November, 2025 – One of the most comprehensive surveys to date of shark and other large predator fish in the Eastern Tropical Pacific (ETP) ocean finds that  remote Marine Protected Areas (MPAs)—including the Galapagos, Malpelo, Clipperton, and Revillagigedo islands—support some of the largest numbers of sharks reported globally, including the critically endangered scalloped hammerhead, while coastal MPAs are showing signs of severe depletion.  “The oceanic islands of the Eastern Tropical ...

High risk of metastatic recurrence among young cancer patients

2025-11-26
A new study of adolescents and young adults (AYAs) with seven common cancers reveals that nearly one in ten patients diagnosed with non-metastatic disease later develop metastatic recurrence — a condition associated with significantly worse survival outcomes. Metastasis is when cancer cells spread from the initial or primary site to other parts of the body. It comes with significantly worse survival outcomes. UC Davis Comprehensive Cancer Center scientists led the research. The findings highlight the urgent need to identify and address survivorship needs for young cancer survivors. “As treatments improve survival, young patients with cancer face unique challenges,” ...

Global Virus Network statement on the Marburg virus outbreak in Ethiopia

2025-11-26
Tampa, FL, USA, November 26, 2025: The Global Virus Network (GVN), a coalition of leading human and animal virologists in more than 40 countries dedicated to advancing pandemic preparedness through research, education and training, and global health solutions, today issued a statement on the newly confirmed outbreak of Marburg virus disease (MVD) in southern Ethiopia. This represents the country’s first documented outbreak of Marburg virus and raises urgent public health, research, and surveillance imperatives. According to the World Health Organization ...

'Exploitative' online money gaming in India causing financial, health and social harm, analysis shows

2025-11-26
“Exploitative” online money gaming in India is harming people’s financial and mental health and causing deep social problems, a new study shows. The analysis says new legislation which bans these games is constitutionally defensible and justified. It highlights how the business models of companies running the games are designed to exploit users through aggressive promotional spending and addictive design features. The study alleges some companies are spending up to 70 per cent of revenue on promotional activities designed to create addicted users who will subsequently lose far more than they receive ...

Mayo Clinic researchers identify why some lung tumors respond well to immunotherapy

2025-11-26
ROCHESTER, Minn. — For some patients with the most common type of lung cancer, known as lung adenocarcinoma, there's new hope. In a new study published in Cell Reports, Mayo Clinic researchers have found several previously unknown genetic and cellular processes that occur in lung adenocarcinoma tumors that respond well to immunotherapy. A recently approved group of drugs — immune checkpoint inhibitors — can boost the body's ability to eliminate a tumor and even keep the cancer from coming back. However, while the medications work well for some people, the drugs aren't ...

The pterosaur rapidly evolved flight abilities, in contrast to modern bird ancestors, new study suggests

2025-11-26
In a study of fossils, a research team led by an evolutionary biologist at Johns Hopkins Medicine suggests that a group of giant reptiles alive up to 220 million years ago may have acquired the ability to fly when the animal first appeared, in contrast to prehistoric ancestors of modern birds that developed flight more gradually and with a bigger brain. A report on the study, which used advanced imaging tools to study the brain cavities of pterosaur fossils, and was funded in part by the National Science Foundation, was published Nov. 26 in Current Biology. The findings add to ...

Farms could be our secret climate weapon, QUT-led study finds

2025-11-26
The world’s farms could become one of the most powerful tools in the fight against climate change according to a new international study led by QUT. Published in Plant Physiology, the paper lays out a framework to assess how plant agriculture and synthetic biology innovations can help mitigate climate change by cutting greenhouse gas emissions and increasing carbon storage. Lead author Professor Claudia Vickers, from the QUT School of Biology and Environmental Science, Centre for Agriculture and the Bioeconomy, QUT Centre for Environment and Society, and the ARC Centre of Excellence in Synthetic Biology, ...

New research by ASU paleoanthropologists gives valuable insight into how two ancient human ancestors coexisted in the same area

2025-11-26
With the help of newly identified bones, an enigmatic 3.4-million-year-old hominin foot found in 2009, is assigned to a species different from that of the famous fossil Lucy providing further proof that two ancient species of hominins co-existed at the same time and in the same region. In 2009, scientists led by Arizona State University paleoanthropologist Yohannes Haile-Selassie, found eight bones from the foot of an ancient human ancestor within layers of 3.4-million-year-old sediments in the Afar Rift in Ethiopia. The fossil, called the Burtele Nature Foot, ...

Therapeutic use of cannabis and cannabinoids

2025-11-26
About The Study: Evidence is insufficient for the use of cannabis or cannabinoids for most medical indications. Clear guidance from clinicians is essential to support safe, evidence-based decision-making. Clinicians should weigh benefits against risks when engaging patients in informed discussions about cannabis or cannabinoid use. Corresponding Author: To contact the corresponding author, Kevin P. Hill, MD, MHS, email khill1@bidmc.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.19433) Editor’s Note: Please see the article for additional information, including other ...

‘Cognitive Legos’ help the brain build complex behaviors

2025-11-26
PRINCETON, NJ — Artificial intelligence may write award-winning essays and diagnose disease with remarkable accuracy, but biological brains still hold the upper hand in at least one crucial domain: flexibility. Humans, for example, can quickly adapt to new information and unfamiliar challenges with relative ease — learning new computer software, following a recipe, or picking up a new game — while AI systems struggle to learn ‘on the fly’. In a new study, Princeton neuroscientists uncover one reason for the brain’s advantage over AI: it reuses the same cognitive “blocks” across many ...

From inhibition to destruction – kinase drugs found to trigger protein degradation

2025-11-26
Protein kinases are the molecular switches of the cell. They control growth, division, communication, and survival by attaching phosphate groups to other proteins. When these switches are stuck in the “on” position, they can drive cancer and other diseases. Not surprisingly, kinases have become one of the most important drug target families in modern medicine: today, more than 80 kinase inhibitors are FDA-approved, and nearly twice as many are in clinical development. These drugs were designed to block enzymatic activity. But a new study led by CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna), the AITHYRA ...

Diamond defects, now in pairs, reveal hidden fluctuations in the quantum world

2025-11-26
In spaces smaller than a wavelength of light, electric currents jump from point to point and magnetic fields corkscrew through atomic lattices in ways that defy intuition. Scientists have only ever dreamed of observing these marvels directly. Now Princeton researchers have developed a diamond-based quantum sensor that reveals rich new information about magnetic phenomena at this minute scale. The technique uncovers fluctuations that are beyond the reach of existing instruments and provides key insight into materials such as graphene and superconductors. Superconductors have enabled today’s most advanced medical imaging tools and form the basis of hoped-for technologies like lossless ...

Metastatic recurrence among adolescents and young adults with cancer

2025-11-26
About The Study: The findings from this cohort study highlight the overall burden of metastatic disease in adolescents and young adults, expanding the knowledge of metastatic recurrences that help improve care for adolescent and young adult survivors throughout the cancer survivorship spectrum.  Corresponding Author: To contact the corresponding author, Ann Brunson, MS, email ambrunson@health.ucdavis.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaoncol.2025.4971) Editor’s ...

Disrupted federal funding for extramural cancer research

2025-11-26
About The Study: The monetary consequences of National Cancer Institute recissions is substantial despite the limited relevance of cancer research to ideological controversies. Disrupted grants affected most states and many public and private institutions. Many grant terminations affected research trainees and junior faculty, suggesting that these terminations not only interrupted the continuity of research studies, but also jeopardized career trajectories of early-stage investigators, with potential downstream consequences on the research workforce and innovation pipeline.  Corresponding Author: To contact the corresponding ...

Glucagon-like peptide-1 receptor agonists and chronic cough

2025-11-26
About The Study: The results of this cohort study suggest an association between glucagon-like peptide-1 receptor agonist (GLP-1RA) use and chronic cough. Further research is needed to confirm the existence, strength, and mechanisms of this association. Corresponding Author: To contact the corresponding author, Anca M. Barbu, MD, email anca.barbu@cshs.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaoto.2025.4181) Editor’s Note: Please see the article for additional information, including other authors, author contributions ...

The 2025 Los Angeles wildfires and outpatient acute health care utilization

2025-11-26
About The Study: This cohort study observed substantial increases in acute health care utilization, especially virtual care-seeking following the Los Angeles fires. As disruptive climate events increase, such data are essential to inform health care preparedness and response. Corresponding Author: To contact the corresponding author, Joan A. Casey, PhD, email jacasey@uw.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamahealthforum.2025.4632) Editor’s Note: Please see the article for additional information, including other authors, author contributions ...

Why watching someone get hurt on screen makes you wince

2025-11-26
If watching Robert De Niro ordering hammer-based retribution on a cheat’s hand in Casino instinctively made you wince, you are not alone. Many people say that seeing bodily injury on film makes them flinch, as if they ‘feel’ it themselves. It is as if the sting leaps straight off the screen and into your skin.   But explaining why and how this happens has puzzled scientists for a long time. Now, scientists from the University of Reading, Free University Amsterdam, and Minnesota, USA, have uncovered a major clue as ...

Data-driven surgical supply lists can reduce hospital cost and waste

2025-11-26
Researchers at University of California San Diego School of Medicine, in collaboration with Data Science Alliance, a nonprofit promoting the importance of a responsible science environment, led a study showing that hospitals could save millions of dollars and significantly reduce surgical waste by rethinking supply lists used to prepare operating rooms, without compromising patient safety.  The study, published in the November 26, 2025, online edition of JAMA Surgery, found that preference cards — hospital checklists of tools and supplies for surgeries — often ...

Plants use engineering principles to push through hard soil

2025-11-26
Across the globe, soil compaction is becoming an ever more serious challenge. Heavy vehicles and machinery in modern agriculture compress the soil to such an extent that crops struggle to grow. In many regions, the problem is aggravated by drought linked to climate change. But plants may in fact be able to solve part of the problem themselves – with a little help from us. It is already known that when soil becomes dense and difficult to penetrate, plants can respond by thickening their roots. Until now, however, it has remained unclear how they manage this, beyond the fact that the plant hormone ethylene plays a key role. Researchers from the University ...

Global burden and mortality of amyotrophic lateral sclerosis and other motor neuron diseases in 204 countries and territories, 1990–2021

2025-11-26
Background and objectives Amyotrophic lateral sclerosis (ALS) and other motor neuron diseases (MNDs) are major global causes of death. However, their global incidence, mortality, and disability-adjusted life years remain largely unknown, despite their importance for disease prevention and resource allocation. We therefore examined the global epidemiology of ALS/MNDs. Methods This study analyzed data from the Global Burden of Disease 2021 database for 204 regions (1990–2021), focusing on ALS/MNDs. Data from the world, China, and the G8 countries were analyzed separately. Age-standardized ...
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