A study of triple-negative breast cancer reveals that fibroblasts in the tumor microenvironment - not cancer cells - produce the growth signal IGF2 that drives tumor progression, while reduced levels of the regulatory protein IGFBP6 allow immune cells to switch sides and support recurrence.

UCSF researchers built a deep neural network that analyzes multiple echocardiogram views at once, improving diagnostic accuracy for ventricular abnormalities, diastolic dysfunction, and valve regurgitation compared to models that examine only one view at a time.

Stanford researchers developed a scaffold-free approach to muscle regeneration that uses simple molds to grow dense, custom-shaped muscle tissue. Without artificial biomaterials taking up space, more healing cells reach the injury site and self-organize into tissue with stronger muscle identity.

Linkoping University researchers created functional qubits from perovskite crystals doped with chromium - a material theorists said should be too noisy for quantum computing. The qubits work at higher temperatures than superconducting alternatives and can convert quantum information into optical signals.

Instead of modifying a superconductor's chemistry, Chalmers University researchers engineered nanoscale ridges on the supporting substrate, enabling an ultrathin cuprate film to superconduct at higher temperatures and withstand strong magnetic fields - a new design principle for energy-efficient electronics.

Researchers at Shanghai Jiao Tong University found that in noisy environments, closing your eyes impairs sound detection rather than enhancing it, while watching a matching video significantly improves hearing sensitivity - explained by EEG-measured shifts in neural criticality.

The metapipeline-DNA tool automates quality control and variant calling for large DNA sequencing datasets, runs on any computing infrastructure, validates configurations before execution, and has been benchmarked against NIST standards - built by 43 contributors making over 1,400 code contributions.

Researchers pinpointed that 60% of dengue cases in Peru's hardest-hit districts during the 2023 outbreak were caused by cyclone-driven extreme rainfall and heat, and climate modeling shows such conditions are now three times more likely than in pre-industrial times.

Three anesthesia drugs with completely different molecular targets all cause unconsciousness by the same mechanism: progressively destabilizing the brain's balance between stability and excitability until neural activity can no longer recover, MIT researchers report in Cell Reports.

A mixed-methods cohort study of Australian women who inject drugs finds that violence against them is pervasive and severe, yet healthcare-seeking rates remain extremely low - driven by intersecting social and structural barriers including stigma, criminalization, and distrust of services.

Researchers applied chaos theory to atopic dermatitis and found that while suppressing a flare-up requires predictable, proportional medication, maintaining remission is governed by nonlinear dynamics where small changes in skin barrier or immune function can massively escalate the treatment needed.

A JAMA Network Open cohort study shows that people with hypertension who maintain a healthy diet, don't smoke, exercise regularly, drink moderately, and keep a healthy BMI have significantly lower cardiometabolic disease risk - regardless of antihypertensive medication use.

Analysis of ancient bowhead whale bones spanning 11,000 years shows the species weathered every climate shift of the Holocene without losing genetic diversity - until commercial whaling from 1540 to 1931 stripped it away, with consequences that will compound for generations.

A University of Michigan survey of over 7,000 adults finds that 7% of Americans have thought about shooting someone, firearm owners are no likelier to have these thoughts than non-owners, and 21% of those with such thoughts told someone - suggesting real opportunities for prevention.

Australian-born historian Lyndal Roper, emeritus Regius Chair of History at Oxford, has been named the 2026 Holberg Prize Laureate for pioneering scholarship that reshaped the study of witch persecutions, Martin Luther, and the German Peasants' War through the lenses of gender, psyche, and bodily experience.

MDI Bio Lab researchers show that regenerating zebrafish kidneys solve the plumbing problem of regenerative medicine: new nephrons connect to existing tubules through coordinated cell protrusions guided by Wnt signaling, offering clues for making lab-grown kidney tissue functional.

By combining biologically inspired event cameras with topological data analysis, researchers at the University of Tsukuba can passively measure the amplitude, phase, and frequency of structural vibrations - no laser, no intense lighting, no contact required.

Peking University researchers used single-cell RNA sequencing to map the immune landscape in the gut of IgA nephropathy patients, identifying expanded BCMA-positive plasma cells as the source of disease-driving antibodies and demonstrating that a BCMA-targeting bispecific antibody slashes serum IgA levels in primates.

A newly identified macrophage population called Mrep drives normal muscle regeneration through activin A signaling. But in patients with fibrodysplasia ossificans progressiva, the same cells hijack that repair pathway to form bone inside muscle tissue, pointing to a precise therapeutic target.

A systematic review in JMA Journal documents 68 cases of acute carbon monoxide poisoning from waterpipe smoking worldwide, finding that one-fifth occurred after less than an hour of use and another fifth happened outdoors - conditions most users consider safe.

An interrupted time-series analysis of Japan's restaurant database shows the 2020 indoor smoking ban raised smoke-free establishments by 5.7 percentage points nationally, while stricter Tokyo and Chiba ordinances added another 7.8 points - but izakaya and bars remain largely unprotected.

A new study in Risk Analysis introduces biologically plausible dose-response models specific to pregnant individuals and Listeria, filling a gap in food safety policy that has long relied on generic population estimates to protect one of the most vulnerable groups.

Researchers tracking 218 children from birth found that those with higher blood levels of PFOA had lower forearm bone density at age 12, with stronger associations in females - suggesting that PFAS exposure during critical developmental windows may compromise peak bone mass.

Researchers at Case Western Reserve University developed OSM CAR-T cells that target oncostatin M receptors on osteosarcoma cells, showing anti-tumor effects against all patient samples tested and killing metastatic tumors in mouse models - the first effective immunotherapy approach for the most common bone cancer in children.

Acoustic tagging of seven juvenile smalltooth sawfish in Florida's Indian River Lagoon shows strong site fidelity to a tiny stretch of the Saint Lucie River, with residency rates up to 87% - providing the first evidence that this historically important nursery is functioning again for an endangered species.