(Press-News.org) Denver, CO (May 11, 2013): Use of TYRX, Inc.'s AIGISRx® Antibacterial Envelope reduced major infection rates by more than 90% in patients undergoing Cardiovascular Implantable Electronic Device (CIED) replacement procedures compared to similar high-risk cohorts, according to the CITADEL & CENTURION clinical study results presented on Saturday at the Late Breaking Clinical Trials session at Heart Rhythm 2013, the Heart Rhythm Society's 34th Annual Scientific Sessions.
CITADEL / CENTURION is a prospective, multicenter clinical study to evaluate the major device infection and mechanical complication rates in the 12 months after implantation, in patients at high risk for CIED infection who have their CIED implanted with an AIGISRx Antibacterial Envelope. Study patients were enrolled at 55 US centers, and were at high-risk for infection because they were undergoing a CIED replacement procedure with an implantable cardioverter-defibrillator (ICD), (CITADEL), or a cardiac resynchronization therapy (CRT) device (CENTURION).
The results from a planned interim analysis of the primary endpoints for the first 1000 eligible patients after 90 days of follow up were presented by Dr. Charles A. Henrikson, the Chief of Electrophysiology at the Oregon Health Sciences University.
Key study findings include:
The CITADEL / CENTURION cohort at 90 days of follow-up had 95% fewer major CIED infections than the pre-defined published control cohort of 533 ICD and CRT replacement procedures (Gould et al. JAMA 2006, 295(16); 1907-1911) which had a major CIED infection rate of 1.88% at a mean follow-up of 81 days (0.1% vs. 1.88%; P
Extremely low 90-day cardiac device infection rates with TYRX antibacterial envelope use
New prospective data presented on 1,000 patients at 2013 Heart Rhythm Society shows over 90 percent fewer major device infections
2013-05-11
ELSE PRESS RELEASES FROM THIS DATE:
Study shows lower rate of inappropriate shocks in patients with Sorin dual chamber ICD devices
2013-05-11
Denver, Colorado, USA, May 11, 2013 –Sorin Group, (Reuters Code: SORN.MI), a global medical company and a leader in the treatment of cardiovascular diseases, announced findings from the landmark OPTION study1 demonstrating that patients with Sorin dual-chamber implantable cardioverter defibrillators (ICDs) experienced a significantly lower incidence of inappropriate shocks compared with patients with standard single-chamber devices (4.3% vs.10.3%, p=0.015).The study also found that there was no difference in all-cause mortality between the two groups.
The OPTION study ...
UCLA stem cell researchers move toward treatment for rare genetic nerve disease
2013-05-11
Led by Dr. Peiyee Lee and Dr. Richard Gatti, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have used induced pluripotent stem (iPS) cells to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia (A-T).
Their discovery shows the positive effects of drugs that may lead to effective new treatments for the neurodegenerative disease. iPS cells are made from patients' skin cells, rather than from embryos, and they can become any type of cells, including brain cells, in the laboratory. ...
Private insurers' Medicare Advantage plans cost Medicare an extra $34.1 billion in 2012
2013-05-11
A study published online today finds that the private insurance companies that participate in Medicare under the Medicare Advantage program and its predecessors have cost the publicly funded program for the elderly and disabled an extra $282.6 billion since 1985, most of it over the past eight years. In 2012 alone, private insurers were overpaid $34.1 billion.
That's wasted money that should have been spent on improving patient care, shoring up Medicare's trust fund or reducing the federal deficit, the researchers say.
The findings appear in an article published in ...
Cocaine vaccine passes key testing hurdle
2013-05-11
NEW YORK (May 10, 2013) -- Researchers at Weill Cornell Medical College have successfully tested their novel anti-cocaine vaccine in primates, bringing them closer to launching human clinical trials.
Their study, published online by the journal Neuropsychopharmacology, used a radiological technique to demonstrate that the anti-cocaine vaccine prevented the drug from reaching the brain and producing a dopamine-induced high.
"The vaccine eats up the cocaine in the blood like a little Pac-man before it can reach the brain," says the study's lead investigator, Dr. Ronald ...
Research reveals possible reason for cholesterol-drug side effects
2013-05-11
The U.S. Food and Drug Administration and physicians continue to document that some patients experience fuzzy thinking and memory loss while taking statins, a class of global top-selling cholesterol-lowering drugs.
A University of Arizona research team has made a novel discovery in brain cells being treated with statin drugs: unusual swellings within neurons, which the team has termed the "beads-on-a-string" effect.
The team is not entirely sure why the beads form, said UA neuroscientist Linda L. Restifo, who leads the investigation. However, the team believes that ...
NASA sees 2 tropical cyclones competing in the Indian Ocean
2013-05-11
The Indian Ocean is alive with tropical activity today, May 10, as there's a tropical storm in both the northern and southern oceans. Tropical Cyclone Jamala (formerly 24S) and newborn Tropical Cyclone 01B were both captured on one image from NASA's Terra satellite today.
The Moderate Resolution Imaging Spectroradiometer (MODIS) instrument that flies aboard NASA's Terra satellite captured this visible image of compact Tropical Cyclone Jamala in the southern Indian Ocean and the much larger Tropical Cyclone One B (01B) in the Northern Indian Ocean on May 10 at 04:25 UTC ...
Wildfires in Siberia
2013-05-11
The Aqua satellite provided this satellite image showing a series of hotspots found in the Siberian region of Russia. These hotspots have been categorized as wildfires rather than agricultural fires by the website: http://fires.kosmosnimki.ru/ The popular Kosmosnimki.Ru web resource introduces the "hybrid" view option – map layers over satellite-based image. MODIS fire hotspots have been layered over the satellite image and provide clickable areas to see exactly how many hotspots are being detected and what type they are. Because we are getting into the hot, dry time of ...
Potential flu pandemic lurks
2013-05-11
CAMBRIDGE, MA -- In the summer of 1968, a new strain of influenza appeared in Hong Kong. This strain, known as H3N2, spread around the globe and eventually killed an estimated 1 million people.
A new study from MIT reveals that there are many strains of H3N2 circulating in birds and pigs that are genetically similar to the 1968 strain and have the potential to generate a pandemic if they leap to humans. The researchers, led by Ram Sasisekharan, the Alfred H. Caspary Professor of Biological Engineering at MIT, also found that current flu vaccines might not offer protection ...
Sacred lotus genome sequence enlightens scientists
2013-05-11
CHAMPAIGN, Ill. — The sacred lotus (Nelumbo nucifera) is a symbol of spiritual purity and longevity. Its seeds can survive up to 1,300 years, its petals and leaves repel grime and water, and its flowers generate heat to attract pollinators.
Now researchers report in the journal Genome Biology that they have sequenced the lotus genome, and the results offer insight into the heart of some of its mysteries. The sequence reveals that of all the plants sequenced so far – and there are dozens – sacred lotus bears the closest resemblance to the ancestor of all eudicots, a broad ...
Intermountain Medical Center reseachers develop new 3-D technology to treat atrial fibrillation
2013-05-11
SALT LAKE CITY – Researchers at the Intermountain Heart Institute at Intermountain Medical Center have developed a new 3-D technology that for the first time allows cardiologists the ability to see the precise source of atrial fibrillation in the heart – a breakthrough for a condition that affects nearly three million Americans.
This new technology that maps the electronic signals of the heart three dimensionally significantly improves the chances of successfully eliminating the heart rhythm disorder with a catheter ablation procedure, according to a new study presented ...
LAST 30 PRESS RELEASES:
Beyond our solar system: scientists identify a new exoplanet candidate
Amphibians bounce-back from Earth’s greatest mass extinction
Better semen quality is linked to men living longer
Enhancing mosquito repellent effectiveness
Prenatal maternal stressors linked to higher blood pressure during first year after birth, study shows
Resistance exercise may be best type for tackling insomnia in older age
Global 130%+ rise in postmenopausal osteoarthritis and associated disability over past 3 decades
OU Health Sciences rises to 102 in national ranking
Bonobos and chimps offer clues to how our early ancestors had sex for social purposes
Lebanon multidimensional crisis diminishing trust in public education and worsening inequality, study shows
Cold atoms on a chip
Rice University study reveals how rising temperatures could lead to population crashes
WVU research reveals adults with disabilities misuse prescription drugs at high rates
Consumers value domestic vanilla -- when informed, research shows
Are higher doses of folic acid in pregnancy safe?
Survey confirms radiation and orthopedic health hazards in cardiac catheterization laboratories are ‘unacceptable’
Study finds consumer devices can be used to assess brain health
Teachers' negative emotions impact engagement of students, new study finds
Researchers see breakthrough with biofuel
White blood cells use brute force to dislodge bacteria
Foundation AI model predicts postoperative risks from clinical notes
Brain functional networks adapt in response to surgery and Botox for facial palsy
Multimodal AI tool supports ecological applications
New University of Minnesota research shows impact of anxiety and apathy on decision-making
Fred Hutch announces 10 recipients of the 2025 Harold M. Weintraub Graduate Student Award
30 million euros for a novel method of monitoring the world's oceans and coastal regions using telecommunications cables
New multicenter study shows: Which treatment helps best with high-risk acute pulmonary embolism
Hidden dangers and myths: What you need to know about HPV and cancer
SNU researchers develop world’s first technology to observe atomic structural changes of nanoparticles in 3D
SNU researchers develop a new synthesis technology of single crystal 2D semiconductors, “Hypotaxy,” to enhance the commercialization of next-generation 2D semiconductors
[Press-News.org] Extremely low 90-day cardiac device infection rates with TYRX antibacterial envelope useNew prospective data presented on 1,000 patients at 2013 Heart Rhythm Society shows over 90 percent fewer major device infections