(Press-News.org) A new study determined that children and adolescents with seizures involving the temporal lobe are likely to have clinically significant behavioral problems and psychiatric illness, especially depression. Findings published in Epilepsia, a journal published by Wiley on behalf of the International League Against Epilepsy (ILAE), highlight the importance of routine psychiatric evaluation for pediatric epilepsy patients—particularly for those who do not respond to anti-seizure medications and require epilepsy surgery.
Current medical evidence indicates that mental illness occurs in up to 40% of pediatric epilepsy patients, with depression, anxiety, attention issues and learning difficulties being the most common psychiatric conditions in children. Furthermore, a 2009 study of adult surgical patients found that depression was associated with seizures in the temporal lobe—a common focus for surgically treated epilepsy according to Sanchez-Gistau et al.1 However, such evidence is not well established in pediatric patients and is the focus of the present study.
"Our research examined whether psychiatric illness was more prominent in children who were unresponsive to anti-seizure medications and had seizures in the temporal lobe versus elsewhere in the brain," explains lead study author, Dr. Jay Salpekar with Children's National Medical Center in Washington, D.C. "In children who do not respond to drug therapy, epilepsy surgery may be the only option to improve their quality of life. Understanding the pediatric patients' mental health status is important, as the severity of psychiatric illness may impact the overall risk-benefit of epilepsy surgery."
For the current study, researchers reviewed case records for 40 children between the ages of 6 and 17, who did not respond to anti-seizure medications. Patients were given pre-surgical psychiatric evaluations and their parents completed the Child Behavioral Checklist (CBCL). The seizure location and suitability for surgical procedures were confirmed by epilepsy specialists.
The investigators found that this pediatric patient group had psychiatric and behavioral problems well beyond what is typically reported in children with chronic epilepsy. Nearly 80% of participants had significant psychiatric symptoms—far greater than the 20%-40% prevalence of mental illness generally found in chronic pediatric epilepsy. Furthermore, children with seizures suspected to be localized in the temporal lobe were more likely to have depression symptoms and more significant behavioral issues reported by parents compared to children with seizures in other brain regions.
Dr. Salpekar concludes, "Given that psychiatric illness, particularly depression, is so prominent in those with temporal lobe seizures, routine psychiatric evaluation appears to be important not only for adults, but also for children and adolescents prior to epilepsy surgery. In fact, it may be beneficial for most patients with medically refractory epilepsy to have a psychiatric assessment, regardless of seizure localization, to improve quality of life." Future studies are needed to investigate the variables associated with mental illness outcomes in patients following epilepsy surgery.
1 Sanchez-Gistau V, Pintor L, Sugranyes G, Bailles E, Carreno M, Donaire A, Boget T, Setoain X, Bargallo N, Rumia J. (2009) Prevalence of interictal psychiatric disorders in patients with refractory temporal and extratemporal lobe epilepsy in Spain. A comparative study. Epilepsia.
This study is published in Epilepsia. Media wishing to receive a PDF of the article may contact firstname.lastname@example.org.
Full citation: "Psychiatric Symptoms in Children Prior to Epilepsy Surgery Differ According to Suspected Seizure Focus."Jay A. Salpekar, Madison M. Berl, Kathryn Havens, Sandra Cushner-Weinstein, Joan A. Conry, Phillip L. Pearl, Amanda L. Yaun and William D. Gaillard. Epilepsia; Published Online: May 10, 2013 (DOI: 10.1111/epi.12205).
URL Upon Publication: http://doi.wiley.com/10.1111/epi.12205
Author Contact: Media wishing to speak with Dr. Salpekar may contact Paula Darte with Children's National Medical Center at PDarte@childrensnational.org.
About the Journal
Epilepsia is the leading, most authoritative source for current clinical and research results on all aspects of epilepsy. As the journal of the International League Against Epilepsy, subscribers every month will review scientific evidence and clinical methodology in: clinical neurology, neurophysiology, molecular biology, neuroimaging, neurochemistry, neurosurgery, pharmacology, neuroepidemiology, and therapeutic trials. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1528-1167.
About the International League Against Epilepsy
The International League Against Epilepsy (ILAE) is the world's preeminent association of physicians and health professionals working toward a world where no person's life is limited by epilepsy. Since 1909 the ILAE has provided educational and research resources that are essential in understanding, diagnosing and treating persons with epilepsy. The ILAE supports health professionals, patients, and their care providers, governments, and the general public worldwide by advancing knowledge of epilepsy.
Wiley is a global provider of content-enabled solutions that improve outcomes in research, education, and professional practice. Our core businesses produce scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising; professional books, subscription products, certification and training services and online applications; and education content and services including integrated online teaching and learning resources for undergraduate and graduate students and lifelong learners.
Founded in 1807, John Wiley & Sons, Inc. (NYSE: JWa, JWb), has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley and its acquired companies have published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace. Wiley's global headquarters are located in Hoboken, New Jersey, with operations in the U.S., Europe, Asia, Canada, and Australia. The Company's website can be accessed at http://www.wiley.com.
Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.
Depression common among children with temporal lobe epilepsy
ELSE PRESS RELEASES FROM THIS DATE:
ATS 2013, PHILADELPHIA ─ A new study from researchers in Japan indicates that obstructive sleep apnea (OSA) is independently associated with visceral (abdominal) fat accumulation only in men, perhaps explaining gender differences in the impact of OSA on cardiovascular disease and mortality. "Visceral fat accumulation, which is a risk factor for cardiovascular disease, is also associated with OSA, and gender differences in mortality related to sleep apnea have been reported in some studies. Accordingly, we examined if the relationship between OSA and visceral fat ...
MINNEAPOLIS – Older people with a history of migraines and depression may have smaller brain tissue volumes than people with only one or neither of the conditions, according to a new study in the May 22, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology. "Studies show that people with migraine have double the risk of depression compared to people without migraine," said study author Larus S. Gudmundsson, PhD, with the National Institute on Aging and the Uniformed Services University of the Health Sciences, in Bethesda, Md. Gudmundsson ...
An insect-eating pitcher plant teams up with ants to prevent mosquito larvae from stealing its nutrients, according to research published May 22 in the open access journal PLOS ONE by Mathias Scharmann and colleagues from the University of Cambridge and the University Brunei Darussalam. The unusual relationship between insect-eating pitcher plants and ants that live exclusively on them has long puzzled scientists. The Camponotus schmitzi ants live only on one species of Bornean pitcher plants (Nepenthes bicalcarata), where they walk across slippery pitcher traps, swim ...
Endangered brush-tail rock wallabies raised in captive breeding programs carry antibiotic resistance genes in their gut bacteria and may be able to transmit these genes into wild populations, according to research published May 22 in the open access journal PLOS ONE by Michelle Power and colleagues from Macquarie University in New South Wales, Australia. Brush-tail rock wallabies are currently being raised in species recovery programs and restored to the wild to bolster populations of this endangered species. Here, researchers found that nearly half of fecal samples ...
Two new species of cave-dwelling short-tailed whipscorpions have been discovered in northeastern Brazil, and are described in research published May 22 in the open access journal PLOS ONE by Adalberto Santos, from the Federal University of Minas Gerais (Brazil) and colleagues. The reddish-brown short-tailed whipscorpions inhabit cool, humid limestone caves in an otherwise arid region. Both new species, Rowlandius ubajara and Rowlandius potiguara, were found deep within the limestone caves, which are also home to bats. Bat guano and seed deposits harbor springtails and ...
Ann Arbor, Mich. – Every day, their baby stopped breathing, his collapsed bronchus blocking the crucial flow of air to his lungs. April and Bryan Gionfriddo watched helplessly, just praying that somehow the dire predictions weren't true. "Quite a few doctors said he had a good chance of not leaving the hospital alive," says April Gionfriddo, about her now 20-month-old son, Kaiba. "At that point, we were desperate. Anything that would work, we would take it and run with it." They found hope at the University of Michigan, where a new, bioresorbable device that could help ...
New research from North Carolina State University and the University of Colorado shows that households with dogs are home to more types of bacteria – including bacteria that are rarely found in households that do not have dogs. The finding is part of a larger study to improve our understanding of the microscopic life forms that live in our homes. "We wanted to know what variables influence the microbial ecosystems in our homes, and the biggest difference we've found so far is whether you own a dog," says Dr. Rob Dunn, an associate professor of biology at NC State and ...
Calorie information in fast food restaurants used by 40 percent of 9-18 year olds when making food choices
A new study published online today (Thursday) in the Journal of Public Health has found that of young people who visited fast food or chain restaurants in the U.S. in 2010, girls and youth who were obese were more likely to use calorie information given in the restaurants to inform their food choices. It also found that young people eating at fast food or chain restaurants twice a week or more were half as likely to use calorie information as those eating there once a week or less. Childhood obesity has tripled in recent decades. One potential contributing factor is fast ...
In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe cases of the disease, the immune system makes a unique subset of antibodies that have a disease-promoting role. Reporting in the journal Science Translational Medicine online May 22, the Johns Hopkins team describes how it found the novel antibodies to peptidylarginine deiminase 4, or PAD4, in blood samples from people with aggressive inflammation and connective tissue ...
Canadian and Swedish scientists today released genome sequences of two of the most economically important forest trees in the world. Conifers supply raw materials for the Canadian forestry industry, which accounted for $23.7 billion in Canada's economy in 2011. Gross output of the forest sector in Sweden in 2009 was $29.7 billion. At 20-30 billion base-pairs and up to 10 times larger than the human genome, the white spruce genome, published in Bioinformatics, and the Norway spruce genome, published in Nature, are also the largest genome sequence assemblies to date. ...