PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Father's diet before conception affects offspring's body fat in mice

2013-06-17
(Press-News.org) SAN FRANCISCO—- When fathers eat a high-fat diet before conception of offspring, the male offspring have increased body weight after weaning and high body fat in midlife despite eating a low-fat diet, a new study in mice finds. The results were presented Sunday at The Endocrine Society's 95th Annual Meeting in San Francisco.

"Many researchers have studied the effects of maternal diet on the risk of obesity in their children. We found that the father's diet also affects the offspring in ways that are inherited," said the study's principal investigator, Felicia V. Nowak, MD, PhD, associate professor of molecular endocrinology at Ohio University in Athens.

The inherited differences in metabolism in the offspring of obese fathers appear to be epigenetic—changes in how genes are expressed that are "not hardwired" into the genes, meaning that they are modifiable by internal and external environmental factors, Nowak said. The cause of these changes was not behavioral because the offspring did not observe what their fathers ate nor did they have access to a high-fat diet, she noted.

In their study, the researchers fed male mice a 13-week diet that was either high fat (45 percent of calories derived from fat) or low fat (10 percent of calories from fat; control mice) but contained the same number of calories. The mice that ate the high-fat food became obese. All mice were mated with females that had received the matched low-fat diet. All their offspring received standard laboratory mouse chow.

The mouse pups underwent testing of their body weight and fat at various ages: 20 days, which was right after weaning and is similar in age to human infants or toddlers, according to Nowak; 6 weeks, which is roughly equivalent to adolescence; 6 months, or young adulthood; and finally 12 months, or older adulthood.

Compared with offspring from control mice, the male offspring of paternal mice with diet-induced obesity had higher body weight starting at 6 weeks of age, and the increased weight was still present at 6 and 12 months, the authors reported. In addition, at 6 months, the male offspring of the obese paternal mice had a higher percentage of total body fat than control offspring did. There were, however, no observed differences in the amount of brown fat, the calorie-burning fat that both rodents and humans have.

Surprisingly, male offspring of the high-fat-fed paternal mice also showed increases in voluntary running at 6 weeks. Female offspring ran more than male offspring at 6 months and 12 months, Nowak said. She said they are studying possible causes for this behavior, which might offset the increased body fat and reduce the offspring's risk of metabolic disease such as diabetes and heart disease.

"Increasing numbers of children and adolescents are affected by obesity," Nowak said. "It is essential that we identify markers for early detection and prediction of obesity and diabetes. This will enable individuals to make healthy lifestyle choices and receive targeted health care interventions to delay or prevent the related disabilities and increase life expectancy."

Ohio University and its Heritage College of Medicine provided grant funding for this study.

###

Founded in 1916, The Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 16,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter.


ELSE PRESS RELEASES FROM THIS DATE:

JCI early table of contents for June 17, 2013

2013-06-17
Scouring the genome of adenoid cystic carcinoma Adenoid cystic carcinoma (ACC) is a slow-growing and often fatal malignancy that can occur at multiple organ site, but is most frequently found in the salivary glands. The primary treatment is surgical removal; however, the majority of patients develop metastatic disease. In this issue of the Journal of Clinical Investigation, researchers led by Andrew Futreal at the Wellcome Trust Sanger Institute in Cambridge, MA, performed a type of genetic sequencing known as whole exome sequencing of 24 ACC cases. They identified a genetic ...

Scouring the genome of adenoid cystic carcinoma

2013-06-17
Adenoid cystic carcinoma (ACC) is a slow-growing and often fatal malignancy that can occur at multiple organ site, but is most frequently found in the salivary glands. The primary treatment is surgical removal; however, the majority of patients develop metastatic disease. In this issue of the Journal of Clinical Investigation, researchers led by Andrew Futreal at the Wellcome Trust Sanger Institute in Cambridge, MA, performed a type of genetic sequencing known as whole exome sequencing of 24 ACC cases. They identified a genetic translocation that can precipitate disease ...

Variants in the SIM1 gene are associated with severe obesity

2013-06-17
Although body weight is largely determined by lifestyle factors, increasingly research is revealing that genetics also play an important role in determining an individual's susceptibility to obesity. Identifying the mutations that underlie the fraction of obese patients with monogenic obesity can help us to understand complex processes like metabolic rate, eating behavior, growth, and fat storage. In this issue of the Journal of Clinical Investigation, two groups identified obesity-linked mutations in the gene SIM1. Sadaf Farooqi and colleagues at Addenbrooke's Hospital ...

Eating behaviors of preschoolers may be related to future risk of heart disease

2013-06-17
Eating behaviours of preschoolers may be associated with risk of cardiovascular disease in later life, suggests a study published in CMAJ (Canadian Medical Association Journal). A study of 1076 preschool children aged 3–5 years in the TARGet Kids! practice-based research network in Toronto, Ontario, looked at the link between eating habits and serum levels of non–high-density lipoprotein (HDL) cholesterol, which is a surrogate marker of later cardiovascular risk. Parents filled out questionnaires assessing eating behaviours, such as watching television while eating, dietary ...

Mobile health devices can improve health care access in developing countries, remote regions

2013-06-17
Mobile health technology has substantial potential for improving access to health care in the developing world and in remote regions of developed countries, states an article in CMAJ (Canadian Medical Association Journal). In many countries, access to health care is hampered by lack of medical professionals and health care infrastructure, limited or poor equipment, sporadic power and other obstacles. However, the development of remote-presence medical devices can help fill this void by connecting people in remote locations with experienced health care professionals for ...

Abnormalities in new molecular pathway may increase breast cancer risk

2013-06-17
PHILADELPHIA — A new molecular pathway involving the gene ZNF365 has been identified and abnormalities in that pathway may predict worse outcomes for patients with breast cancer, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research. "Genomic instability is an increased tendency for abnormal changes in DNA, like the addition of extra copies of chromosomes, DNA breaks and mutations," said Ji-Hye Paik, Ph.D., assistant professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College in ...

Exposure to BPA in developing prostate increases risk of later cancer

2013-06-17
Early exposure to BPA (bisphenol A) – an additive commonly found in plastic water bottles and soup can liners – causes an increased cancer risk in an animal model of human prostate cancer, according to University of Illinois at Chicago researcher Gail Prins. Prins presented her findings at the ENDO 2013 meeting in San Francisco June 17. "This is the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day environment, increases the risk for prostate cancer in human prostate tissue," said Prins, professor of physiology and director ...

New 'embryonic' subduction zone found

2013-06-17
A new subduction zone forming off the coast of Portugal heralds the beginning of a cycle that will see the Atlantic Ocean close as continental Europe moves closer to America. Published in Geology, new research led by Monash University geologists has detected the first evidence that a passive margin in the Atlantic ocean is becoming active. Subduction zones, such as the one beginning near Iberia, are areas where one of the tectonic plates that cover the Earth's surface dives beneath another plate into the mantle - the layer just below the crust. Lead author Dr João Duarte, ...

An innovative material for the green Earth

2013-06-17
Ulsan, S. Korea, June 17, 2013 - Researchers from Ulsan National Institute of Science and Technology (UNIST), S. Korea, developed a novel, simple method to synthesize hierarchically nanoporous frameworks of nanocrystalline metal oxides such as magnesia and ceria by the thermal conversion of well-designed metal-organic frameworks (MOFs). The novel material developed by the UNIST research team has exceptionally high CO2 adsorption capacity which could pave the way to save the Earth from CO2 pollution. Nanoporous materials consist of organic or inorganic frameworks with ...

Researchers unmask Janus-faced nature of mechanical forces with the Julich supercomputer

2013-06-17
The harder you pull, the quicker it goes. At least, that used to be the rule in mechanochemistry, a method that researchers apply to set chemical reactions in motion by means of mechanical forces. However, as chemists led by Professor Dominik Marx, Chair of Theoretical Chemistry at the Ruhr-Universität Bochum now report in the journal "Nature Chemistry", more force cannot in fact be translated one to one into a faster reaction. With complex molecular dynamic simulations on the Jülich supercomputer "JUQUEEN" they unmasked the Janus-faced nature of mechanochemistry. Up to ...

LAST 30 PRESS RELEASES:

Einstein Probe releases its Science White Paper

Music-based therapy may improve depressive symptoms in people with dementia

No evidence that substituting NHS doctors with physician associates is necessarily safe

At-home brain speed tests bridge cognitive data gaps

CRF appoints Josep Rodés-Cabau, M.D., Ph.D., as editor-in-chief of structural heart: the journal of the heart team

Violent crime is indeed a root cause of migration, according to new study

Customized smartphone app shows promise in preventing further cognitive decline among older adults diagnosed with mild impairment

Impact of COVID-19 on education not going away, UM study finds

School of Public Health researchers receive National Academies grant to assess environmental conditions in two Houston neighborhoods

Three Speculum articles recognized with prizes

ACM A.M. Turing Award honors two researchers who led the development of cornerstone AI technology

Incarcerated people are disproportionately impacted by climate change, CU doctors say

ESA 2025 Graduate Student Policy Award Cohort Named

Insomnia, lack of sleep linked to high blood pressure in teens

Heart & stroke risks vary among Asian American, Native Hawaiian & Pacific Islander adults

Levels of select vitamins & minerals in pregnancy may be linked to lower midlife BP risk

Large study of dietary habits suggests more plant oils, less butter could lead to better health

Butter and plant-based oils intake and mortality

20% of butterflies in the U.S. have disappeared since 2000

Bacterial ‘jumping genes’ can target and control chromosome ends

Scientists identify genes that make humans and Labradors more likely to become obese

Early-life gut microbes may protect against diabetes, research in mice suggests

Study raises the possibility of a country without butterflies

Study reveals obesity gene in dogs that is relevant to human obesity studies

A rapid decline in US butterfly populations

Indigenous farming practices have shaped manioc’s genetic diversity for millennia

Controlling electrons in molecules at ultrafast timescales

Tropical forests in the Americas are struggling to keep pace with climate change

Brain mapping unlocks key Alzheimer’s insights

Clinical trial tests novel stem-cell treatment for Parkinson’s disease

[Press-News.org] Father's diet before conception affects offspring's body fat in mice