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Children with ADHD more likely to be moderately disabled after mild traumatic brain injury

2013-06-25
(Press-News.org) CHARLOTTESVILLE, VA (June 25, 2013). Researchers at Children's Hospital of Pittsburgh, the University of Pittsburgh, and the University of Chicago have found that children with attention deficit hyperactivity disorder (ADHD) are more likely to demonstrate a moderate disability after sustaining a mild traumatic brain injury than children without ADHD. Detailed findings of this phenomenon are reported and discussed in "The impact of attention deficit hyperactivity disorder on recovery from mild traumatic brain injury. Clinical article," by Christopher M. Bonfield, M.D., Sandi Lam, M.D., M.B.A., Yimo Lin, B.A., and Stephanie Greene, M.D., published today online, ahead of print, in the Journal of Neurosurgery: Pediatrics (http://thejns.org/doi/full/10.3171/2013.5.PEDS12424).

The researchers set out to find whether ADHD has an effect on outcome following mild traumatic brain injury (TBI). They examined the charts of all patients with ADHD who received a diagnosis of mild closed-head injury (an injury in which no neurosurgical treatment is required) at Children's Hospital of Pittsburgh between January 2003 and December 2010. A mild closed-head injury results in what is termed a mild TBI, which is categorized by an initial Glasgow Coma Scale score of 13 to 15. From their review of patient charts, Dr. Bonfield and colleagues identified 48 children with ADHD who had sustained a mild TBI. They paired this group of patients with a randomly selected age-matched control group of 45 patients without ADHD who also had sustained a mild TBI. The researchers compared outcomes in the two groups of patients by using the King's Outcome Scale for Childhood Head Injury (KOSCHI). Based on the Glasgow Outcome Scale, which is used commonly to assess long-term disability following TBI in adults, the KOSCHI offers greater differentiation of deficits across the milder range of disabilities. In addition to outcomes, the researchers compared patient demographics and injury-related factors.

Dr. Bonfield and colleagues found that 25% of the patients with ADHD had a moderate disability (KOSCHI Category 4b) and 56% were completely recovered (KOSCHI Category 5b) at the end of the follow-up period (mean 24.9 weeks). These results compared unfavorably to findings in the group of patients without ADHD, in which 2% of patients had a moderate disability (KOSCHI Category 4b) and 84% were completely recovered (KOSCHI Category 5b) at the end of a much shorter follow-up period (mean 7.2 weeks). Statistical analysis in this study showed that "patients with ADHD were statistically significantly more disabled after mild TBI than were control patients without ADHD, even when controlling for age, sex, initial GCS [Glasgow Coma Scale] score, hospital length of stay, length of follow-up, mechanism of injury, and presence of other (extracranial) injury." It came as no surprise that a multivariate analysis demonstrated an association between the length of follow-up and KOSCHI category, with children having greater disabilities requiring a longer follow-up period.

In the Discussion section of their paper, the researchers evaluate several possible explanations for the significant differences between patient groups, some of which include the possibility that ADHD is associated with a greater vulnerability to brain injury, impairs the healing process, or renders rehabilitation programs less effective.

Dr. Bonfield and colleagues list recommendations based on the findings of this study:

Prevention of TBI in children with ADHD is important because outcomes can be more severe in these children than in children without ADHD. The authors suggest that perhaps children with ADHD should be steered away from engaging in sports or hobbies that carry increased risks of sustaining a TBI. Clinical management of closed head injury may have to be adjusted when treating children with ADHD, perhaps by introducing better monitoring and initiating more intensive treatment and rehabilitation. Physicians must counsel families of children with ADHD about expected outcomes following mild TBI.

Dr. Bonfield and colleagues also point out the need for additional studies on the effect of ADHD on more severe TBIs as well as on the mechanisms underlying the relationship between ADHD and TBI.

When asked to comment on the study, Dr. Bonfield replied, "Our study provides evidence that for children with ADHD who sustain a TBI, different treatment and patient and family education may be necessary to achieve optimal outcomes."

###

Bonfield CM, Lam S, Lin Y, Greene S. The impact of attention deficit hyperactivity disorder on recovery from mild traumatic brain injury. Clinical article. Journal of Neurosurgery: Pediatrics, published online, ahead of print, June 25, 2013; DOI: 10.3171/2013.5.PEDS12424.

Disclosure: The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

For additional information, please contact:
Ms. Jo Ann M. Eliason, MA, ELS
Communications Manager
Journal of Neurosurgery Publishing Group
One Morton Drive, Suite 200
Charlottesville, VA 22903
Email: jaeliason@thejns.org
Telephone 434-982-1209
Fax 434-924-2702

The Journal of Neurosurgery: Pediatrics is a monthly peer-reviewed journal focused on diseases and disorders of the central nervous system and spine in children. This journal contains a variety of articles, including descriptions of preclinical and clinical research as well as case reports and technical notes. The Journal of Neurosurgery: Pediatrics is one of four monthly journals published by the JNS Publishing Group, the scholarly journal division of the American Association of Neurological Surgeons. Other peer-reviewed journals published by the JNS Publishing Group each month include the Journal of Neurosurgery, Neurosurgical Focus, and the Journal of Neurosurgery: Spine. All four journals can be accessed at http://www.thejns.org.

Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 8,300 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. All active members of the AANS are certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons (Neurosurgery) of Canada or the Mexican Council of Neurological Surgery, AC. Neurological surgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the entire nervous system including the brain, spinal column, spinal cord, and peripheral nerves. For more information, visit http://www.AANS.org.

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[Press-News.org] Children with ADHD more likely to be moderately disabled after mild traumatic brain injury