(Press-News.org) Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxidative stress is characterized by the overproduction of reactive oxygen species, which can induce mitochondrial DNA mutations, damage the mitochondrial respiratory chain, alter membrane permeability, and influence Ca2+ homeostasis and mitochondrial defense systems. All these changes are implicated in the development of these neurodegenerative diseases, mediating or amplifying neuronal dysfunction and triggering neurodegeneration. A recent article published in the Neural Regeneration Research (Vol. 8, No. 21, 2013), entitled "Oxidative stress, mitochondrial damage and neurodegenerative diseases", summarizes the contribution of oxidative stress and mitochondrial damage to the onset of neurodegenerative diseases and discusses strategies to modify mitochondrial dysfunction that may be attractive therapeutic interventions for the treatment of various neurodegenerative diseases.
###
Article: " Oxidative stress, mitochondrial damage and neurodegenerative diseases " by Chunyan Guo1, Li Sun2, Xueping Chen3, Danshen Zhang4 (1 Department of Pharmacy, Hebei North University, Zhangjiakou 075000, Hebei Province, China; 2 Life Science Research Center, Hebei North University, Zhangjiakou 075000, Hebei Province, China; 3 Department of Human Anatomy and Cell Science, University of Manitoba, Manitoba R3E 0J9, Canada; 4 Hebei University of Science and Technology, Shijiazhuang 050018, Hebei Province, China)
Guo CY, Sun L, Chen XP, Zhang DS. Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res. 2013;8(21):2003-2014.
Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/
Full text: http://www.sjzsyj.org:8080/Jweb_sjzs/CN/article/downloadArticleFile.do?attachType=PDF&id=671
Oxidative stress, mitochondrial damage and neurodegenerative diseases
2013-08-08
ELSE PRESS RELEASES FROM THIS DATE:
Our brains can (unconsciously) save us from temptation
2013-08-08
PHILADELPHIA (August 5, 2013) – Inhibitory self control – not picking up a cigarette, not having a second drink, not spending when we should be saving – can operate without our awareness or intention.
That was the finding by scientists at the University of Pennsylvania's Annenberg School for Communication and the University of Illinois at Urbana-Champaign. They demonstrated through neuroscience research that inaction-related words in our environment can unconsciously influence our self-control. Although we may mindlessly eat cookies at a party, stopping ourselves from ...
'Digging up' 4-billion-year-old fossil protein structures to reveal how they evolved
2013-08-08
Modern proteins exhibit an impressive degree of structural diversity, which has been well characterized, but very little is known about how and when over the course of evolution 3D protein structures arose. In a study published by Cell Press August 8 in Structure, researchers resurrected 4-billion-year-old Precambrian proteins in the laboratory and gained novel insights into protein evolution by analyzing their X-ray crystal structures. This method has revealed a remarkable degree of structural similarity among proteins since life first evolved on this planet, and it represents ...
JCI early table of contents for Aug. 8, 2013
2013-08-08
Engineered rice protects against rotavirus
For children and immune compromised adults in developing countries, diarrheal disease induced by rotavirus can be life threatening. Current rotaviral vaccines are highly effective in the Western world, but are not as effective in developing countries. Additionally, these vaccines are not appropriate for use outside of a very narrow age window or in immune compromised individuals. In the current issue of the Journal of Clinical Investigation Yoshikazu Yuki and colleagues at the University of Tokyo report the development of ...
Engineered rice protects against rotavirus infection
2013-08-08
TITLE: Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection
AUTHOR CONTACT: Daisuke Tokuhara
The Institute of Medical Science, The University of Tokyo, Tokyo, UNK, JPN
Phone: 81-3-5449-5271; Fax: 81-3-5449-5411; E-mail: tokuhara@ims.u-tokyo.ac.jp
View this article at: http://www.jci.org/articles/view/70266?key=de80321a713532149b56 END ...
Tumor microenvironment allows cancer cells to hide from the immune system
2013-08-08
Cancer progression is aided by the ability of tumors to evade recognition by the immune system. In this issue of the Journal of Clinical Investigation, Gerard Blobe and colleagues at Duke University identify a mechanism by which tumors evade detection. Using mouse models of breast cancer and melanoma, they show that loss of the Type III TGF-β receptor (TGFBR3) in tumors promotes cancer progression by altering signaling in tumor-associated immune cells.
This study supports the use of TGF-β inhibitors to enhance the efficacy of therapies that promote immune-mediated ...
Genetic analysis reveals historic demographic change that shaped today's population in India
2013-08-08
India experienced a demographic transformation several thousand years ago, from a region in which mixture between highly different populations was common to one in which mixture even between closely related groups became rare. The finding, which will be published online on August 8, 2013 in the American Journal of Human Genetics, published by Cell Press, provides new information about the peopling of India and improves our understanding of the changes that led to the present-day structure of Indian populations.
"Prior to the population mixture and as recently as a few ...
Virtual control room helps nuclear operators, industry
2013-08-08
IDAHO FALLS — Modernizing nuclear power plants to help extend their operating lifetimes is no small task. But the endeavor offers an opportunity to improve control-room design and layout.
The Department of Energy's new Human System Simulation Laboratory (HSSL) at Idaho National Laboratory is a full-scale virtual nuclear control room that can test the safety and reliability of proposed technology replacements before they are implemented in commercial nuclear control rooms. The facility is now helping Duke Energy embark on an upgrade project for several of its nuclear ...
Genetic evidence shows recent population mixture in India
2013-08-08
Scientists from Harvard Medical School and the CSIR-Centre for Cellular and Molecular Biology in Hyderabad, India, provide evidence that modern-day India is the result of recent population mixture among divergent demographic groups.
The findings, published August 8 in the American Journal of Human Genetics, describe how India transformed from a country where mixture between different populations was rampant to one where endogamy—that is, marrying within the local community and a key attribute of the caste system—became the norm.
"Only a few thousand years ago, the ...
LEC: A multi-purpose tool
2013-08-08
KANSAS CITY, MO—A little-studied factor known as the Little Elongation Complex (LEC) plays a critical and previously unknown role in the transcription of small nuclear RNAs (snRNA), according to a new study led by scientists at the Stowers Institute for Medical Research and published in the Aug. 22, 2013, issue of the journal Molecular Cell.
"We have found that LEC not only has a role in this process—it is like the "Swiss Army knife" of snRNA transcription," says Stowers Investigator Ali Shilatifard, senior author of the study. "LEC does it all." The findings shed new ...
Sanford-Burnham scientists identify key protein that modulates organismal aging
2013-08-08
LA JOLLA, Calif., August 8, 2013 — Scientists at Sanford-Burnham Medical Research Institute have identified a key factor that regulates the autophagy process, a kind of cleansing mechanism for cells in which waste material and cellular debris is gobbled up to protect cells from damage, and in turn, modulates aging. The findings, published in Nature Communications today, could lead to the development of new therapies for age-related disorders that are characterized by a breakdown in this process.
Malene Hansen, Ph.D., associate professor in Sanford-Burnham's Del E. Webb ...