PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Maintain, don't gain: A new way to fight obesity

2013-08-27
(Press-News.org) DURHAM, N.C. -- Programs aimed at helping obese black women lose weight have not had the same success as programs for black men and white men and women.

But new research from Duke University has found that a successful alternative could be a "maintain, don't gain" approach.

The study, which appears in the Aug. 26 issue of JAMA Internal Medicine, compared changes in weight and risk for diabetes, heart disease or stroke among 194 premenopausal black women, aged 25-44. They were recruited from Piedmont Health's six nonprofit community health centers in a multi-county area of central North Carolina, which serves predominantly poor patients.

For the study, half of the participants -- 97 women -- were randomly placed in a primary care-based intervention program called Shape, while the other 97 received usual care from their physicians, generally weight-loss counseling.

The intervention program used software built by Duke researchers that personalized the intervention for each woman. Each woman received an individualized set of behavior-change goals for diet and physical activity. They tracked how well they were doing each week via automated phone calls, and had a personal health coach and a gym membership.

After 12 months, the intervention group stabilized their weight, while participants in the usual care group continued to gain weight. Sixty-two percent of intervention participants were at or below their weight at the onset of the program, compared to 45 percent of usual-care participants. After 18 months, intervention participants still maintained their weight while the usual care group continued to gain weight.

"Many people go to great lengths to lose weight when their doctor recommends it. They may try a series of diets or join a gym or undergo really complex medical regimens. The complexity of these treatments can make it difficult for many to lose a sufficient amount of weight," said lead author Gary Bennett, an associate professor of psychology and neuroscience and global health at Duke who studies obesity prevention.

"Our approach was different. We simply asked our patients to maintain their weight," Bennett said. "By maintaining their current weight, these patients can reduce their likelihood of experiencing health problems later on in life."

The study, funded by a grant from the National Institute for Diabetes and Digestive and Kidney Diseases, cited other research showing that overweight and slightly obese premenopausal black women face far lower risks for many chronic diseases than do obese whites and other racial groups.

But by ages 40-59, black women have more than twice the prevalence of class 2 (moderate) obesity and three times the rate of class 3 (extreme) obesity than white women, the study said. This combination of rapid premenopausal weight gain and extreme obesity contributes to disproportionate chronic disease risk among black women, researchers said.

Preventing weight gain could reduce the odds of developing a host of health problems, such as high blood pressure, high cholesterol diabetes, cardiovascular disease, stroke and some cancers, the authors said.

A "maintain, don't gain" approach could be particularly effective for this group for the following reasons:

-- Compared to white women, black women are typically more satisfied with their weight and face fewer social pressures to lose weight, Bennett said. Consequently, they may be particularly receptive to intervention messages about maintaining their weight.

-- Preventing weight gain is less intense than trying to lose it, so this approach could be achieved more easily.

"It's true that there are some health risks for these overweight and slightly obese women," Bennett said. "However, these health risks increase dramatically as women continue to gain weight, usually 2 to 4 pounds, year after year."

"We could reduce these health risks if women simply maintained their current weight," Bennett said. "Fortunately, it's much easier to maintain weight than it is to lose it. We think this 'maintain, don't gain' approach can help some women reduce their risk of obesity-related chronic disease."

### CITATION: "Behavioral Treatment for Weight Gain Prevention Among Black Women in Primary Care Practice: A Randomized Controlled Trial," lead author Gary Bennett, Perry Foley, Erica Levine, Sandy Askew, Dori Steinberg, Bryan Batch, Duke University; Jessica Whiteley, University of Massachusetts Boston; Mary Greaney, Dana-Farber Cancer Institute; Heather Miranda, Thomas Wroth, Marni Holder, Piedmont Health Services; Karen Emmons, Dana-Farber Cancer Institute and Harvard School of Public Health; Elaine Puleo, University of Massachusetts Amherst. Trial funded by grant R01DK078798 from the National Institute for Diabetes and Digestive and Kidney Diseases. Dr. Emmons was supported by K05CA124415 and Dr. Bennett was supported by K22CA126992. JAMA Internal Medicine, online Aug. 26, 2013; DOI:10.1001/jamainternmed.2013.9263.


ELSE PRESS RELEASES FROM THIS DATE:

Disabling enzyme reduces tumor growth, cripples cancer cells, finds new study

2013-08-27
Berkeley — Knocking out a single enzyme dramatically cripples the ability of aggressive cancer cells to spread and grow tumors, offering a promising new target in the development of cancer treatments, according to a new study by researchers at the University of California, Berkeley. The paper, to be published Monday, Aug. 26, in the journal Proceedings of the National Academy of Sciences, sheds new light on the importance of lipids, a group of molecules that includes fatty acids and cholesterol, in the development of cancer. Researchers have long known that cancer ...

Immune system, skin microbiome 'complement' one another, finds Penn Medicine study

2013-08-27
PHILADELPHIA – Researchers from the Perelman School of Medicine at the University of Pennsylvania demonstrate for the first time that the immune system influences the skin microbiome. A new study found that the skin microbiome – a collection of microorganisms inhabiting the human body – is governed, at least in part, by an ancient branch of the immune system called complement. In turn, it appears microbes on the skin tweak the complement system, as well as immune surveillance of the skin. They found that complement may, in part, be responsible for maintaining a diverse ...

Comprehensive Parkinson's biomarker test has prognostic and diagnostic value

2013-08-27
PHILADELPHIA - Perelman School of Medicine researchers at the University of Pennsylvania report the first biomarker results reported from the Parkinson's Progression Markers Initiative (PPMI), showing that a comprehensive test of protein biomarkers in spinal fluid have prognostic and diagnostic value in early stages of Parkinson's disease. The study is reported in JAMA Neurology. Compared to healthy adults, the study found that people with early Parkinson's had lower levels of amyloid beta, tau and alpha synuclein in their spinal fluid. In addition, those with lower ...

Terminology used to describe preinvasive breast cancer may affect patients' treatment preferences

2013-08-27
When ductal carcinoma in situ (DCIS, a preinvasive malignancy of the breast) is described as a high-risk condition rather than cancer, more women report that they would opt for nonsurgical treatments, according to a research letter by Zehra B. Omer, B.A., of Massachusetts General Hospital—Institute for Technology Assessment, Boston, and colleagues. A total of 394 healthy women without a history of breast cancer participated in the study and were presented with three scenarios that described a diagnosis of DCIS as noninvasive breast cancer, breast lesion, or abnormal cells. ...

Intervention appears effective to prevent weight gain among black women

2013-08-27
An intervention not focused on weight loss was effective for weight gain prevention among socioeconomically disadvantaged black women, according to a report published by JAMA Internal Medicine, a JAMA Network publication. Promoting clinically meaningful weight loss among black women has been a challenge. Compared to white women, "black women have higher rates of body weight satisfaction, fewer social pressures to lose weight, and sociocultural norms that tolerate heavier body weights," according to the study background. "New weight management strategies are necessary ...

Thyroid ultrasound imaging may be useful to reduce biopsies in patients with low risk of cancer

2013-08-27
Thyroid ultrasound imaging could be used to identify patients who have a low risk of cancer for whom biopsy could be postponed, according to a study by Rebecca Smith-Bindman, M.D., of the University of California, San Francisco, and colleagues. The retrospective case-control study of 8,806 patients who underwent 11,618 thyroid ultrasound imaging examinations from January 2000 through March 2005 included 105 patients diagnosed as having thyroid cancer. Thyroid nodules were common in patients diagnosed as having cancer (96.9 percent) and patients not diagnosed as having ...

Extremely preterm infants and risk of developing neurodevelopmental impairment later in childhood

2013-08-27
A meta-analysis of previously reported studies by Gregory P. Moore, M.D., F.R.C.P.C., of The Ottawa Hospital, Ontario, Canada, and colleagues examined the rate of moderate to severe and severe neurodevelopmental impairment by gestational age in extremely preterm survivors followed up between ages 4 and 8 years, and determined whether there is a significant difference in impairment rates between the successive weeks of gestation of survivors. The search of English-language publications found nine studies that met inclusion criteria of being published after 2004, a prospective ...

Interpretation of do-not-resuscitate order appears to vary among pediatric physicians

2013-08-27
Clinicians use the do-not-resuscitate (DNR) order not only as a guide for therapeutic decisions during a cardiopulmonary arrest but also as a surrogate for broader treatment directives, according to a study by Amy Sanderson M.D., of Boston Children's Hospital, M.A., and colleagues. A total of 107 physicians and 159 nurses responded to a survey regarding their attitudes and behaviors about DNR orders for pediatric patients. There was substantial variability in the interpretation of the DNR order. Most clinicians (66.9 percent) reported that they considered that a DNR order ...

Genome-wide survey examines recessive alzheimer disease gene

2013-08-27
Runs of homozygosity (ROHs, regions of the genome where the copies inherited from parents are identical) may contribute to the etiology (origin) of Alzheimer disease (AD), according to a study by Mahdi Ghani, Ph.D., of the University of Toronto, Ontario, Canada, and colleagues. Caribbean Hispanics are known to have an elevated risk for AD and tend to have large families with evidence of inbreeding, according to the study background. A Caribbean Hispanic data set of 547 unrelated cases (48.8 percent with familial AD) and 542 controls collected from a population known ...

Study examines cerebrospinal fluid biomarkers in early Parkinson disease

2013-08-27
Cerebrospinal fluid (CSF) levels of tau proteins, ɑ-synuclein, and β-amyloid 1-42 (Αβ1-42) appear to be associated with early stage Parkinson disease (PD) in a group of untreated patients compared with healthy patients, according to a study by Ju-Hee Kang, M.D., of the University of Pennsylvania, and colleagues. The study included the initial 102 research volunteers (63 patients with PD and 39 healthy control patients) of the Parkinson's Progression Markers Initiative (PPMI) study. Results indicate that slightly, but significantly, lower levels of ...

LAST 30 PRESS RELEASES:

SGLT2 inhibitors and kidney outcomes by glomerular filtration rate and albuminuria

Comprehensive analysis supports routine use of metabolic drug for people with all levels of kidney function

Temporary benefit for immune system in early HIV treatment, but dysregulation returns

Chronic kidney disease is now the ninth leading cause of death

Chronic kidney disease has more than doubled since 1990, now affecting nearly 800 million people worldwide

Participant experiences in a kidney failure care intervention in the navigate-kidney study

Community health worker support for Hispanic and Latino individuals receiving hemodialysis

Scientists unveil new strategies to balance farming and ecological protection in Northeast China

UT Health San Antonio scientist helps shape new traumatic brain injury guidelines

Rising nitrogen and rainfall could supercharge greenhouse gas emissions from the world’s largest grasslands

Study uncovers glomerular disease outcomes across the lifespan

Sotagliflozin outperforms dapagliflozin for reducing salt- sensitive hypertension and kidney injury in rats

Trial analysis reveals almost all adults with hypertensive chronic kidney disease would benefit from intensive blood pressure lowering

A husband’s self-esteem may protect against preterm births, study finds

Michigan State University's James Madison College receives over $1 million to launch civic education academy

White paper on recovering from burnout through mentoring released by University of Phoenix College of Doctoral Studies

Defunct Pennsylvania oil and gas wells may leak methane, metals into water

Kessler Foundation’s John DeLuca, PhD, honored with Reitan Clinical Excellence Award from National Academy of Neuropsychology

Discordance in creatinine- and cystatin C–based eGFR and clinical outcomes

Disagreement between two kidney function tests predicts serious health problems

American College of Cardiology, OpenEvidence to advance AI-enabled, evidence-based cardiovascular care

OHSU researchers develop promising drug for aggressive breast cancer

Evaluating the potential of a sleep intervention among youth at high-risk for borderline personality disorder

Saturn’s icy moon may host a stable ocean fit for life, study finds

More children, shorter lifespan? Clear evidence from the Great Finnish Famine

Climate intervention techniques could reduce the nutritional value of crops

Mapping resilient supply solutions for graphite, a critical mineral powering energy storage: Rice experts’ take

Effects of sodium glucose cotransporter 2 inhibitors by diabetes status and level of albuminuria

Young people using unregulated nicotine pouches despite health risks

New study finds family and caregivers can help spot post-surgery delirium early

[Press-News.org] Maintain, don't gain: A new way to fight obesity