PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Scripps Florida scientists pinpoint proteins vital to long-term memory

2013-09-13
(Press-News.org) JUPITER, FL – September 12, 2013 – Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found a group of proteins essential to the formation of long-term memories.

The study, published online ahead of print on September 12, 2013 by the journal Cell Reports, focuses on a family of proteins called Wnts. These proteins send signals from the outside to the inside of a cell, inducing a cellular response crucial for many aspects of embryonic development, including stem cell differentiation, as well as for normal functioning of the adult brain.

"By removing the function of three proteins in the Wnt signaling pathway, we produced a deficit in long-term but not short-term memory," said Ron Davis, chair of the TSRI Department of Neuroscience.

"The pathway is clearly part of the conversion of short-term memory to the long-term stable form, which occurs through changes in gene expression."

The findings stem from experiments probing the role of Wnt signaling components in olfactory memory formation in Drosophila, the common fruit fly—a widely used doppelgänger for human memory studies. In the new study, the scientists inactivated the expression of several Wnt signaling proteins in the mushroom bodies of adult flies—part of the fly brain that plays a role in learning and memory.

The resulting memory disruption, Davis said, suggests that Wnt signaling participates actively in the formation of long-term memory, rather than having some general, non-specific effect on behavior.

"What is interesting is that the molecular mechanisms of adult memory use the same processes that guide the early development of the organism, except that they are repurposed for memory formation," he said. "One difference, however, is that during early development the signals are intrinsic, while in adults they require an outside stimulus to create a memory."



INFORMATION:

The first author of the study, "Wnt signaling is required for long-term memory formation," is Ying Tan of the Baylor College of Medicine. Other authors include Germain U. Busto of TSRI and Curtis Wilson of Baylor College of Medicine.

The study was supported by the National Institutes of Health (NS19904).



ELSE PRESS RELEASES FROM THIS DATE:

Voyager 1 spacecraft reaches interstellar space

2013-09-13
University of Iowa space physicist Don Gurnett says there is solid evidence that NASA's Voyager 1 spacecraft has become the first manmade object to reach interstellar space, more than 11 billion miles distant and 36 years after it was launched. The finding is reported in a paper published in the Sept. 12 online issue of the journal Science. "On April 9, the Voyager 1 Plasma Wave instrument, built at the UI in the mid-1970s, began detecting locally generated waves, called electron plasma oscillations, at a frequency that corresponds to an electron density about 40 times ...

Voyager 1 spotted from Earth with NRAO's VLBA and GBT telescopes

2013-09-13
Astronomers using the National Science Foundation's (NSF) Very Long Baseline Array (VLBA) and Green Bank Telescope (GBT) spotted the faint radio glow from NASA's famed Voyager 1 spacecraft -- the most distant man-made object. According to NASA's Jet Propulsion Laboratory (JPL), the VLBA imaged the signal from Voyager 1's main transmitter after the spacecraft had already passed beyond the edge of the heliosphere, the bubble of charged particles from the Sun that surrounds our Solar System. Using NASA's Deep Space Network, JPL continually tracks Voyager and calculates ...

Toxic methylmercury-producing microbes more widespread than realized

2013-09-13
Microbes that live in rice paddies, northern peat bogs and other previously unexpected environments are among the bacteria that can generate highly toxic methylmercury, researchers at Oak Ridge National Laboratory and the Smithsonian Environmental Research Center have learned. This finding, published in Environmental Science and Technology, explains why deadly methylated mercury is produced in areas where the neurotoxin's presence has puzzled researchers for decades. Methylmercury — the most dangerous form of mercury — damages the brain and immune system and is especially ...

Trans-Nino years could foster tornado super outbreaks

2013-09-13
Alexandria, VA – One tornado can be damaging enough; severe weather systems that spawn hundreds of deadly tornadoes in super-outbreaks pose special challenges to the scientific and emergency management communities. Now, scientists have identified certain conditions in the Pacific Ocean that may lead to super-outbreaks over the U.S.' tornado alley. Researchers are trying to determine if Trans-Niño years, which mark the onset or ebbing of El Niño and La Niña, are the main culprits behind the deadly super-outbreaks. According to the study, fueled by a powerfully interconnected ...

Esteem issues determine how people put their best Facebook forward

2013-09-13
How social media users create and monitor their online personas may hint at their feelings of self-esteem and self-determination, according to an international team of researchers. "The types of actions users take and the kinds of information they are adding to their Facebook walls and profiles are a refection of their identities," said S. Shyam Sundar, Distinguished Professor of Communications and co-director of the Media Effects Research Laboratory, Penn State. "You are your Facebook, basically, and despite all its socialness, Facebook is a deeply personal medium." People ...

Research shows denser seagrass beds hold more baby blue crabs

2013-09-13
When it comes to nursery habitat, scientists have long known that blue crabs prefer seagrass beds compared to open areas in the same neighborhood. A new study by researchers at William & Mary's Virginia Institute of Marine Science refines that knowledge, showing that it's not just the presence of a seagrass bed that matters to young crabs, but also its quality—with denser beds holding exponentially more crabs per square meter than more open beds where plants are separated by small patches of mud or sand. The study, led by VIMS graduate student Gina Ralph, appeared recently ...

Exposure/ritual prevention therapy boosts antidepressant treatment of OCD

2013-09-13
NIMH grantees have demonstrated that a form of behavioral therapy can augment antidepressant treatment of obsessive compulsive disorder (OCD) better than an antipsychotic. The researchers recommend that this specific form of cognitive behavior therapy (CBT) – exposure and ritual prevention – be offered to OCD patients who don't respond adequately to treatment with an antidepressant alone, which is often the case. Current guidelines favor augmentation with antipsychotics. In the controlled trial with 100 antidepressant-refractory OCD patients, 80 percent of those who ...

Medicare Center of Excellence Policy may limit minority access to weight-loss surgery

2013-09-13
Safety measures intended to improve bariatric surgery outcomes may impede obese minorities' access to care. This is according to a new research letter published online in the September 12 issue of JAMA which compares rates of bariatric (weight-loss) surgery for minority Medicare vs. non-Medicare patients before and after implementation of a Medicare coverage policy. The policy limits Medicare patients seeking bariatric surgery to high-volume hospitals designated as centers of excellence. Led by faculty from the Johns Hopkins Bloomberg School of Public Health, the researchers ...

Revised Medicaid policy could reduce unintended pregnancies, save millions in health costs

2013-09-13
PITTSBURGH, Sept. 12, 2013 – A revised Medicaid sterilization policy that removes logistical barriers, including a mandatory 30-day waiting period, could potentially honor women's reproductive decisions, reduce the number of unintended pregnancies and save $215 million in public health costs each year, according to researchers at the University of Pittsburgh School of Medicine. Their findings, published today in the journal Contraception, support growing evidence for the need to revisit a national policy that disproportionately affects low-income and minority women at high ...

NASA's Terra satellite spots Hurricane Humberto's cloud-filled eye

2013-09-13
The MODIS instrument aboard NASA's Terra satellite captured a visible image of Hurricane Humberto that showed it's eye was cloud-filled. Humberto was moving away from the Cape Verde Islands in the Atlantic Ocean. On Thursday, Sept. 12 at 11 a.m. EDT/1500 UTC, Hurricane Humberto has maximum near 85 mph/140 kph, and the National Hurricane Center (NHC) expects gradual weakening later in the day. The center of Hurricane Humberto was located near latitude 21.8 north and longitude 29.0 west, about 515 miles/830 km northwest of the Cape Verde Islands. Humberto is moving toward ...

LAST 30 PRESS RELEASES:

Heartier Heinz? How scientists are learning to help tomatoes beat the heat

Breaking carbon–hydrogen bonds to make complex molecules

Sometimes you're the windshield: Utah State University researcher says vehicles cause significant bee deaths

AMS Science Preview: Turbulence & thunderstorms, heat stress, future derechos

Study of mountaineering mice sheds light on evolutionary adaptation

Geologists rewrite textbooks with new insights from the bottom of the Grand Canyon

MSU researcher develops promising new genetic breast cancer model

McCombs announces 2024 Hall of Fame inductees and rising stars

Stalling a disease that could annihilate banana production is a high-return investment in Colombia

Measurements from ‘lost’ Seaglider offer new insights into Antarctic ice melting

Grant to support new research to address alcohol-related partner violence among sexual minorities

Biodiversity change amidst disappearing human traditions

New approaches to synthesize compounds for pharmaceutical research

Cohesion through resilient democratic communities

UC Santa Cruz chemists discover new process to make biodiesel production easier, less energy intensive

MD Anderson launches Institute for Cell Therapy Discovery & Innovation to deliver transformational new therapies

New quantum encoding methods slash circuit complexity in machine learning

New research promises an unprecedented look at how psychosocial stress affects military service members’ heart health

Faster measurement of response to antibiotic treatment in sepsis patients using Dimeric HNL

Cleveland Clinic announces updated findings in preventive breast cancer vaccine study

Intergenerational effects of adversity on mind-body health: Pathways through the gut-brain axis

Watch this elephant turn a hose into a sophisticated showering tool

Chimpanzees perform better on challenging computer tasks when they have an audience

New medical AI tool identifies more cases of long COVID from patient health records

Heat waves and adverse health events among dually eligible individuals 65 years and older

Catastrophic health expenditures for in-state and out-of-state abortion care

State divorce laws, reproductive care policies, and pregnancy-associated homicide rates

Emerging roles of high-mobility group box-1 in liver disease

Exploring the systematic anticancer mechanism in selected medicinal plants

University of Cincinnati researchers pen editorial analyzing present, future of emergency consent in stroke trials

[Press-News.org] Scripps Florida scientists pinpoint proteins vital to long-term memory