PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Bone loss associated with increased production of ROS

2013-10-15
(Press-News.org) Bone is constantly being broken down and remodeled. Osteoporosis results when bone resorption outpaces bone regeneration. Production of reactive oxygen species, a form of oxidative stress, has been predicted to promote bone loss, but a source of reactive oxygen is unknown.

In this issue of the Journal of Clinical Investigation, Katrin Schröder and colleagues at Goethe-University identify a relationship between NADPH oxidase 4 (NOX4), an enzyme that promotes reactive oxygen species formation, and bone resorption. In a mouse model of osteoporosis, genetic disruption or drug-induced loss of NOX4 protected the mice from bone loss. Additionally, the authors identify a small nuclear polymorphism in NOX4 in human patients that associated with increased bone turnover. Together, these data suggest treatments targeting NOX4 activity may benefit osteoporosis patients.

INFORMATION:

TITLE: NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

AUTHOR CONTACT: Katrin Schröder
Klinikum der Johann-Wolfgang-Goethe-Universität, Frankfurt, UNK, DEU
Phone: 004969630183660; Fax: ; E-mail: schroeder@vrc.uni-frankfurt.de

View this article at: http://www.jci.org/articles/view/67603?key=b63670ba8b7f0b31366d

END



ELSE PRESS RELEASES FROM THIS DATE:

How tiny organisms make a big impact on clean water

2013-10-15
VIDEO: This video shows Vorticella movements with nutrients and without nutrients. Click here for more information. Nearly every body of water, from a puddle or a pond to a vast ocean, contains microscopic organisms that live attached to rocks, plants, and animals. These so-called sessile suspension feeders are critical to aquatic ecosystems and play an important role in cleaning up environmental contaminants by consuming bacteria. A study published by Cell Press on October ...

Neurosurgical residents improve quality and reduce costs

2013-10-15
Charlottesville, VA (October 15, 2013). An incentive program to reduce the number of unnecessary diagnostic laboratory tests performed in neurosurgical patients at UC San Francisco (UCSF) was highly successful. Resident trainees in neurosurgery identified five frequently scheduled laboratory tests that rarely yield information that would change patient care. A new set of guidelines was developed to determine when these tests should be performed. The result was a 47% reduction in the number of targeted tests, which was attended by cost savings of $1.7 million in one year. ...

Mindfulness-based stress reduction helps lower blood pressure, reports study in Psychosomatic Medicine

2013-10-15
Philadelphia, Pa. (October 15, 2013) -- Blood pressure is effectively lowered by mindfulness-based stress reduction (MBSR) for patients with borderline high blood pressure or "prehypertension." This finding is reported in the October issue of Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. "Our results provide evidence that MBSR, when added to lifestyle modification advice, may be an appropriate complementary ...

Mayo Clinic study: Teachers more likely to have progressive speech and language disorders

2013-10-15
ROCHESTER, Minn. -- Mayo Clinic researchers have found a surprising occupational hazard for teachers: progressive speech and language disorders. The research, recently published in the American Journal of Alzheimer's Disease & Other Dementias, found that people with speech and language disorders are about 3.5 times more likely to be teachers than patients with Alzheimer's dementia. Speech and language disorders are typically characterized by people losing their ability to communicate -- they can't find words to use in sentences, or they'll speak around a word. They may ...

Lung infections offer clue to unlocking the mystery of life-saving heart drug

2013-10-15
Scientists from the University of Sheffield have discovered ground breaking clues as to how the pioneering heart drug ticagrelor might reduce the risk of dying following a heart attack, in comparison to previous standard treatments. The new findings, published in Platelets, show that ticagrelor may reduce the risk of dying as a result of a lung infection after suffering a heart attack compared to patients treated with the drug clopidogrel. The analysis, which was led by researchers from the University of Sheffield and Uppsala University Sweden, is the latest to come ...

Newly discovered mechanism propels micromotors

2013-10-15
WASHINGTON, D.C. Oct. 15, 2013 -- Scientists studying the behavior of platinum particles immersed in hydrogen peroxide may have discovered a new way to propel microscopic machines. The new mechanism is described in The Journal of Chemical Physics, which is produced by AIP Publishing. Micro-sized machines operate under very different conditions than their macro-sized counterparts. The high surface-area-to-mass ratio of tiny motors means they require a constant driving force to keep them going. In the past, researchers have relied on asymmetric chemical reactions on the ...

Illinois river otters exposed to chemicals banned decades ago

2013-10-15
CHAMPAIGN, Ill. -- Researchers report that river otters in Central Illinois are being exposed to polychlorinated biphenyls (PCBs) and pesticides that were banned in the U.S. in the 1970s and '80s. Their analysis appears in the journal Ecotoxicology and Environmental Safety. The Illinois Department of Natural Resources collected 23 river otters between 2009 and 2011, after the animals were incidentally killed (hit by cars or accidentally caught in traps, for example). The agency passed the carcasses along to researchers at the Illinois Natural History Survey (INHS) for ...

Individuals genetically predisposed to anxiousness may be less likely to volunteer and help others

2013-10-15
COLUMBIA, Mo. -- Scientists increasingly are uncovering answers for human behavior through genetic research. Now, a University of Missouri researcher has found that prosocial behavior, such as volunteering and helping others, is related to the same gene that predisposes individuals to anxiety disorders. Helping such individuals cope with their anxiety may increase their prosocial behavior, the researcher said. "Prosocial behavior is linked closely to strong social skills and is considered a marker of individuals' health and well-being," said Gustavo Carlo, Millsap Professor ...

What makes telenovelas so popular?

2013-10-15
A particular type of consumer enjoys stories with plots, characters, and imagery that allow them to get lost in the narrative, according to a new study in the Journal of Consumer Research. "Stories have the power to change people's behavior," write authors Tom van Laer (ESCP Europe Business School), Ko de Ruyter (Maastricht University), Luca M. Visconti (ESCP Europe Business School), and Martin Wetzels (Maastricht University). "Contemporary examples include the persuasive power of Latin American telenovelas, which influence family planning choices and enrollment in adult ...

Scientists unravel mechanisms in chronic itching

2013-10-15
Anyone who has suffered through sleepless nights due to uncontrollable itching knows that not all itching is the same. New research at Washington University School of Medicine in St. Louis explains why. Working in mice, the scientists have shown that chronic itching, which can occur in many medical conditions, from eczema and psoriasis to kidney failure and liver disease, is different from the fleeting urge to scratch a mosquito bite. That's because chronic itching appears to incorporate more than just the nerve cells, or neurons, that normally transmit itch signals. ...

LAST 30 PRESS RELEASES:

Female bodybuilders at risk of sudden cardiac death

Garment factories are sweltering. These simple fixes could keep workers safe

‘Slums’ of Victorian Manchester housed wealthy doctors and engineers, new study reveals

Winners of Applied Microbiology International Horizon Awards 2025 announced

Most of Wine Country’s agricultural workers have been exposed to wildfires, new survey finds

Obesity-related cancer rising among both younger and older adults worldwide

A 'Rosetta Stone' for molecular systems

What goes up must come down – scientists unearth “universal thermal performance curve” that shackles evolution

Physical activity increases total daily energy use, study shows

National study finds public Montessori programs strengthens early learning outcomes -- at sharply lower costs compared to traditional preschool

National poll: 1 in 10 young children play outdoors as little as once a week

How do people learn new facts?

Exploring how storytelling strategies shape memories

How people process mental images versus real-life visuals 

Blood test could help predict blood pressure after weight loss surgery in teens

Ultra-endurance athletes test the metabolic limits of the human body

Revealing the 'carbon hoofprint' of meat consumption for American cities

Like radar, a brain wave sweeps a cortical region to read out information held in working memory

Resistance to epilepsy treatments may wane over time

Precision reprogramming: How AI tricks cancer’s toughest cells

US physician Medicare program participation and exit, 2013-2023

A direct-to-patient digital health program for lung cancer screening

Belgian scientists discover how cells protect our skin from inflammatory disease – paving the way for new treatments

Effectiveness of colchicine for the treatment of long COVID

Distance to care and telehealth abortion demand after Dobbs

Epidural electrical stimulation for functional recovery in incomplete spinal cord injury

Transformative eye research expands donor pool for corneal transplant patients

Retinal implant restores central vision in patients with advanced AMD, study co-led by Pitt investigator shows

Eye prosthesis is the first to restore sight lost to macular degeneration

Pioneering eye device restores reading vision to blind eyes

[Press-News.org] Bone loss associated with increased production of ROS