PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Reduction of reactive oxygen species in diabetes-associated nephrology

2013-10-25
(Press-News.org) Contact information: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Reduction of reactive oxygen species in diabetes-associated nephrology Diabetes-associated complications, including retinopathy, neuropathy, and nephropathy are associated with increased glucose levels, but it is not understood how glucose drives these manifestations. There is evidence that cultured cells exposed to high levels of glucose produce reactive oxygen species (ROS); however it is unknown if ROS contributes directly to diabetes complications. In this issue of the Journal of Clinical Investigation, Kumar Sharma and colleagues at the University of California, San Diego determined that ROS production was actually reduced in kidneys of diabetic mice, and this decrease was associated with lowered activity of the major energy-sensing enzyme, AMPK. Furthermore, AMPK activity was also reduced in kidneys of diabetic patients. Treatment of diabetic mice with a compound that increased AMPK activity reduced kidney-associated symptoms, including fibrosis and albuminuria. In the companion commentary, Dwight Towler of the Sanford-Burnham Medical Institute discusses how this view of ROS in diabetes will require a new look at therapeutic approaches for relieving diabetes complications.### TITLE: AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function AUTHOR CONTACT: Kumar Sharma
UCSD, La Jolla, CA, USA
Phone: 858-822-0870; Fax: 858-822-7483; E-mail: kusharma@ucsd.edu View this article at: http://www.jci.org/articles/view/66218?key=5fad8f958699794ef103 ACCOMPANYING COMMENTARY TITLE: Mitochondrial ROS deficiency and diabetic complications: AMP[K]-lifying the adaptation to hyperglycemia AUTHOR CONTACT: Dwight Towler
Sanford-Burnham Medical Research Institute, orlando, , USA
Phone: 407-745-2079; Fax: ; E-mail: dtowler@sanfordburnham.org View this article at: http://www.jci.org/articles/view/72326?key=dcdae15a08a5b61c4 END


ELSE PRESS RELEASES FROM THIS DATE:

Synthetic vitamin D receptor ligands reduce murine kidney fibrosis

2013-10-25
Synthetic vitamin D receptor ligands reduce murine kidney fibrosis Vitamin D deficiency has been associated with kidney disease including fibrosis. Some studies have even suggested that treatment with vitamin D or vitamin D analogs can reduce renal fibrosis; ...

Itch maintains regulatory T cell stability

2013-10-25
Itch maintains regulatory T cell stability Regulatory T cells (Tregs) function to suppress immune responses of other cells, and their dysfunction has been associated with development of immune disorders. Recent studies suggest that Tregs maintain plasticity ...

'High-risk' organs from deceased donors safe when screened with current methods

2013-10-25
'High-risk' organs from deceased donors safe when screened with current methods Relabeling them may provide additional organs to patients in need Atlanta, GA (October 25, 2013)—Approximately 10% of deceased donor kidneys are considered "high-risk" for ...

Johns Hopkins Medicine news tips from the 2013 American Society of Human Genetics conference

2013-10-25
Johns Hopkins Medicine news tips from the 2013 American Society of Human Genetics conference INVESTIGATING THE GENETIC MECHANISM BEHIND DELUSIONS IN SCHIZOPHRENICS Wednesday, October 23, 3:30 PM EST SESSION 15 – Psychiatric Disease: GWAS to Genes Room 253, Level ...

Expert panel issues recommendations for 'Dyspnea Crisis'

2013-10-25
Expert panel issues recommendations for 'Dyspnea Crisis' Report calls for improved care for patients who experience severe shortness of breath PORTLAND, Ore., October 25, 2013 – An American Thoracic Society panel of experts is calling for better care for thousands ...

Genetic variants associated with bronchodilator responsiveness

2013-10-25
Genetic variants associated with bronchodilator responsiveness How patients with COPD respond to their meds may be influenced by their DNA Boston, MA – A new study from Brigham and Women's Hospital (BWH) reveals several new ...

Baylor, DNAnexus, Amazon Web Services collaboration enables largest-ever cloud-based analysis of genomic data

2013-10-25
Baylor, DNAnexus, Amazon Web Services collaboration enables largest-ever cloud-based analysis of genomic data HOUSTON – (Oct. 25, 2013) – With their participation in the completion of the largest cloud-based analysis of genome sequence data, researchers from the Baylor ...

New low-cost, nondestructive technology cuts risk from mercury hot spots

2013-10-25
New low-cost, nondestructive technology cuts risk from mercury hot spots Hot spots of mercury pollution in aquatic sediments and soils can contaminate local food webs and threaten ecosystems, but cleaning them up can be expensive and destructive. Researchers from the Smithsonian ...

Lou Gehrig's disease: From patient stem cells to potential treatment strategy in one study

2013-10-25
Lou Gehrig's disease: From patient stem cells to potential treatment strategy in one study Translational research goes seamless: After creating neurons from patients' skin cells, cedars-sinai-led researchers 'treat' gene defect in a dish, indicating the therapy may ...

Recognizing cancer diseases at an early stage

2013-10-25
Recognizing cancer diseases at an early stage RUB researchers develop label-free automatic cancer diagnostics Researchers at the Ruhr-Universität Bochum (RUB) have developed a new spectroscopic method to support pathologists in diagnosing cancer. In the ...

LAST 30 PRESS RELEASES:

BioChatter: making large language models accessible for biomedical research

Grass surfaces drastically reduce drone noise making the way for soundless city skies

Extent of microfibre pollution from textiles to be explored at new research hub

Many Roads Lead to… the embryo

Dining out with San Francisco’s coyotes

What’s the mechanism behind behavioral side effects of popular weight loss drugs?

How employee trust in AI drives performance and adoption

Does sleep apnea treatment influence patients’ risk of getting into car accidents?

Do minimum wage hikes negatively impact students’ summer employment?

Exposure to stress during early pregnancy affects offspring into adulthood

Curious blue rings in trees and shrubs reveal cold summers of the past — potentially caused by volcanic eruptions

New frontiers in organic chemistry: Synthesis of a promising mushroom-derived compound

Biodegradable nylon precursor produced through artificial photosynthesis

GenEditScan: novel k-mer analysis tool based on next-generation sequencing for foreign DNA detection in genome-edited products

Survey: While most Americans use a device to monitor their heart, few share that data with their doctor

Dolphins use a 'fat taste' system to get their mother’s milk

Clarifying the mechanism of coupled plasma fluctuations using simulations

Here’s what’s causing the Great Salt Lake to shrink, according to PSU study

Can DNA-nanoparticle motors get up to speed with motor proteins?

Childhood poverty and/or parental mental illness may double teens’ risk of violence and police contact

Fizzy water might aid weight loss by boosting glucose uptake and metabolism

Muscular strength and good physical fitness linked to lower risk of death in people with cancer

Recommendations for studying the impact of AI on young people's mental health  proposed by Oxford researchers

Trump clusters: How an English lit graduate used AI to make sense of Twitter bios

Empty headed? Largest study of its kind proves ‘bird brain’ is a misnomer

Wild baboons not capable of visual self-awareness when viewing their own reflection

$14 million supports work to diversify human genome research

New study uncovers key mechanism behind learning and memory

Seeing the unseen: New method reveals ’hyperaccessible’ window in freshly replicated DNA

Extreme climate pushed thousands of lakes in West Greenland ‘across a tipping point,’ study finds

[Press-News.org] Reduction of reactive oxygen species in diabetes-associated nephrology