(Press-News.org) Contact information: Cathy Yarbrough
press@ashg.org
858-243-1814
American Society of Human Genetics
Multiple, distinct Y chromosomes associated with significant excess risk of prostate cancer
Genealogical and medical records of males in Utah's multi-generational families were analyzed
An analysis of the genealogical and medical records of males in Utah's multi-generational families strongly supports the case that inherited variations in the Y chromosome, the male sex chromosome, play a role in the development of prostate cancer, according to a study presented today (Friday, Oct. 25) at the American Society of Human Genetics 2013 meeting in Boston.
The study identified multiple, distinct Y chromosomes associated with a significant excess risk of prostate cancer, said Lisa Cannon-Albright, Ph.D., Professor and Chief of the Division of Genetic Epidemiology at the University of Utah School of Medicine.
Dr. Cannon-Albright, who headed the study and presented the results today, said that her lab plans to search these Y chromosomes for the genetic mutations that can predispose a man to develop prostate cancer, the second most frequently diagnosed cancer in the U.S.
Because most of the Y chromosome does not recombine during cell division, it is passed virtually unchanged from father to son. "As a result, each male resident of Utah shares the Y chromosome of his father and his father's father and so on," she said. "This provided the ability to estimate the risk for prostate cancer in independent Y chromosomes represented in Utah."
The study relied upon the Utah Population Data Base (UPDB), which identifies over 6.5 million individuals, including many of the Utah pioneers in the 1800s. The pioneer genealogies in the UPDB are typically large, spanning 15 generations. The Utah population represented in the UPDB is genetically representative of Northern Europe. The database was created in the 1970s to define familial clustering and identify evidence for heritable contribution to cancer.
The Y-chromosomes associated with prostate cancer risk were detected through an analysis of male lineage in the computerized genealogical UPDB. Because UPDB is linked to the Utah Cancer Registry, an NCI Surveillance, Epidemiology and End Results (SEER) registry, the researchers were able to identify the men who developed prostate cancer.
The researchers began the study with 1.25 million living and deceased males who had at least 2 parents, 4 grandparents and 6 or 8 great grandparents in the database. All males whose fathers were not identified in the database were labeled as founders. Each founder was then assigned a unique, sequential Y chromosome identification (YID). The founder's sons, his son's sons and so on also were assigned this same YID.
The YID groups with at least two males sharing the same Y chromosome totaled 257,252. "We effectively identified each independent Y chromosome in the UPDB," Dr. Cannon-Albright said. Each group of males with the same YID was theorized to share the same Y chromosome since they descended from the same male founder.
The researchers used the Utah cancer registry to estimate specific rates of prostate cancer in the UPDB, birth year and birth state. To estimate the number of prostate cancer cases expected to occur in each YID group, the researchers applied the results to all males in each group. The researchers compared the observed number of prostate cancers to the expected number of cases.
Dr. Cannon-Albright and her team focused on the 1,000 YID groups that included the most men. These groups ranged from 167 to 2,264 men. In 73 Y chromosome groups, the prostate cancer incidence was significantly higher (p END
Multiple, distinct Y chromosomes associated with significant excess risk of prostate cancer
Genealogical and medical records of males in Utah's multi-generational families were analyzed
2013-10-26
ELSE PRESS RELEASES FROM THIS DATE:
How bacteria with a sweet tooth may keep us healthy
2013-10-26
How bacteria with a sweet tooth may keep us healthy
Some gut bacterial strains are specifically adapted to use sugars in our gut lining to aid colonisation, potentially giving them a major influence over our gut health.
We live in a symbiotic relationship ...
BUSM researchers identify molecule that could aid lung cancer detection, treatment
2013-10-26
BUSM researchers identify molecule that could aid lung cancer detection, treatment
(Boston) – Researchers at Boston University School of Medicine (BUSM) have discovered a molecule that could help lead to the non-invasive detection of lung cancer ...
Depressiona key link between intimate partner violence and food insecurity
2013-10-26
Depressiona key link between intimate partner violence and food insecurity
New study from the University of Houston Texas Obesity Research Center urges new interventions
Women who experience physical, mental or sexual abuse at the hands of their partners have an increased ...
Nanoscale engineering boosts performance of quantum dot light emitting diodes
2013-10-26
Nanoscale engineering boosts performance of quantum dot light emitting diodes
Making the light at the end of the tunnel more efficient
LOS ALAMOS, N.M., October 25, 2013—Dramatic advances in the field of quantum dot light emitting diodes (QD-LEDs) could ...
Call for World Bank to redefine poverty indicator to include the life of the unborn child
2013-10-26
Call for World Bank to redefine poverty indicator to include the life of the unborn child
London (25 October 2013). The World Bank must define life expectancy, its key poverty indicator, as starting at the time of conception and not at the time of birth if millions ...
ASU, Georgia Tech create breakthrough for solar cell efficiency
2013-10-26
ASU, Georgia Tech create breakthrough for solar cell efficiency
New atomic layer-by-layer InGaN technology offers perfect crystal
Did you know that crystals form the basis for the penetrating icy blue glare of car headlights and could be fundamental ...
New study shows positive personal growth following breast cancer diagnosis
2013-10-26
New study shows positive personal growth following breast cancer diagnosis
WINSTON-SALEM, N.C. – Oct. 25, 2013 – Although being diagnosed with breast cancer is usually an extremely stressful experience for most women, a new study by researchers ...
GVSU students contribute to growing medical field
2013-10-26
GVSU students contribute to growing medical field
GRAND RAPIDS, Mich. — A group of students and faculty at Grand Valley State University have been working with Van Andel Institute to develop new methods to further a growing medical field that aims to improve ...
Peer pressure can influence food choices at restaurants
2013-10-26
Peer pressure can influence food choices at restaurants
URBANA, Ill. – If you want to eat healthier when dining out, research recommends surrounding yourself with friends who make healthy food choices. ...
Enzyme restores function with diabetic kidney disease
2013-10-26
Enzyme restores function with diabetic kidney disease
Mouse findings reverse prevailing theory; point to potential treatment options
Researchers at the University of California, San Diego School of Medicine say that, while a prevailing theory suggests ...
LAST 30 PRESS RELEASES:
Study identifies candidates for therapeutic targets in pediatric germ cell tumors
Media alert: The global burden of CVD
Study illuminates contributing factors to blood vessel leakage
What nations around the world can learn from Ukraine
Mixing tree species does not always make forests more drought-resilient
Public confidence in U.S. health agencies slides, fueled by declines among Democrats
“Quantum squeezing” a nanoscale particle for the first time
El Niño spurs extreme daily rain events despite drier monsoons in India
Two studies explore the genomic diversity of deadly mosquito vectors
Zebra finches categorize their vocal calls by meaning
Analysis challenges conventional wisdom about partisan support for US science funding
New model can accurately predict a forest’s future
‘Like talking on the telephone’: Quantum computing engineers get atoms chatting long distance
Genomic evolution of major malaria-transmitting mosquito species uncovered
Overcoming the barriers of hydrogen storage with a low-temperature hydrogen battery
Tuberculosis vulnerability of people with HIV: a viral protein implicated
Partnership with Kenya's Turkana community helps scientists discover genes involved in adaptation to desert living
Decoding the selfish gene, from evolutionary cheaters to disease control
Major review highlights latest evidence on real-time test for blood – clotting in childbirth emergencies
Inspired by bacteria’s defense strategies
Research spotlight: Combination therapy shows promise for overcoming treatment resistance in glioblastoma
University of Houston co-leads $25 million NIH-funded grant to study the delay of nearsightedness in children
NRG Oncology PREDICT-RT study completes patient accrual, tests individualized concurrent therapy and radiation for high-risk prostate cancer
Taking aim at nearsightedness in kids before it’s diagnosed
With no prior training, dogs can infer how similar types of toys work, even when they don’t look alike
Three deadliest risk factors of a common liver disease identified in new study
Dogs can extend word meanings to new objects based on function, not appearance
Palaeontology: South American amber deposit ‘abuzz’ with ancient insects
Oral microbes linked to increased risk of pancreatic cancer
Soccer heading does most damage to brain area critical for cognition
[Press-News.org] Multiple, distinct Y chromosomes associated with significant excess risk of prostate cancerGenealogical and medical records of males in Utah's multi-generational families were analyzed