PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Association between glioma susceptibility and XRCC1 Arg399Gln polymorphism

2013-10-29
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Association between glioma susceptibility and XRCC1 Arg399Gln polymorphism DNA damage is an important mechanism of glioma. X-ray cross-complementing group 1 (XRCC1) is a DNA repair gene that participates in the base excision repair pathway. To date, many studies have been performed to investigate the association between the XRCC1 polymorphisms and risk of cancers such as breast cancer, and gastroesophageal cancer, but the number of studies that focused on glioma is relatively small. Evidence regarding the role of the single nucleotide polymorphisms in XRCC1 as genetic markers for glioma risk is inconsistent. Prof. Xinquan Gu and team from China-Japan Union Hospital of Jilin University, China performed a meta-analysis to identify statistical evidence for an association between the XRCC1 Arg399Gln, Arg194Trp, Arg280His polymorphisms and glioma risk by accumulating all published data. Meta-analysis results verified that the XRCC1 Arg399Gln polymorphism may be a biomarker of glioma susceptibility, especially in Asian populations. The Arg194Trp and Arg280His polymorphisms were found not to be associated with overall glioma risk. These findings, published in the Neural Regeneration Research (Vol. 8, No. 26, 2013), provide the necessary scientific basis for the glioma pathogenesis and glioma risk population screening.

### Article: " Correlation between X-ray cross-complementing group 1 polymorphisms and the onset risk of glioma: a meta-analysis " by Xinquan Gu1, Hongyan Sun2, Liping Chang3, Ran Sun2, Hongfeng Yang4, Xuewen Zhang2, Xianling Cong2, 4 (1 Department of Urinary Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China; 2 Tissue Bank, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China; 3 Department of Cardiopathy, the Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China; 4 Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China)

Gu XQ, Sun HY, Chang LP, Sun R, Yang HF, Zhang XW, Cong XL. Correlation between X-ray cross-complementing group 1 polymorphisms and the onset risk of glioma: a meta-analysis. Neural Regen Res. 2013;8(26):2468-2477.



ELSE PRESS RELEASES FROM THIS DATE:

A new DNA vaccine induces a Th2 immune response in Alzheimer's disease mice

2013-10-29
A new DNA vaccine induces a Th2 immune response in Alzheimer's disease mice Amyloid-beta (Aβ) active immunization in Alzheimer's disease can increase the rate of Aβ clearance, and delay cognitive dysfunction, but it is easy to induce meningoencephalitis, ...

New drug to help common bowel disease

2013-10-29
New drug to help common bowel disease An international team led by University of Adelaide researchers has identified the mechanism of pain relief of a new drug for treating Irritable Bowel Syndrome with Constipation (IBS-C), based on nonclinical ...

Human immune system shapes skin microbiome

2013-10-29
Human immune system shapes skin microbiome October 29, 2013 -- Our skin plays host to millions of beneficial and potentially disease-causing microorganisms; however, whether our immune system influences these microbial communities to prevent disease is ...

Pregnant rats exposed to obesity hormone lose birth's protective effect on breast cancer

2013-10-29
Pregnant rats exposed to obesity hormone lose birth's protective effect on breast cancer WASHINGTON — Like humans, young rats that give birth have a reduced risk of breast cancer later in life. But a new study shows that this protective effect in animals is negated ...

A potential new class of fast-acting antidepressant

2013-10-29
A potential new class of fast-acting antidepressant More than 1 in 10 Americans take antidepressants, but these medications can take weeks—and for some patients, months—before they begin to alleviate symptoms. Now, scientists from the University ...

Extracting energy from bacteria

2013-10-29
Extracting energy from bacteria Most of us wouldn't consider bacteria a promising energy source of the future. That would be shortsighted, says Leonard Tender, a microbial-electrochemist at the Naval Research Laboratory in Washington, D.C., who believes that ...

New forensic technique for identifying cloth fibers

2013-10-29
New forensic technique for identifying cloth fibers Crime-scene investigators may soon have a new tool to help them catch evildoers. Researchers have demonstrated the proof-of-principle for a new forensic technique to identify individual fibers of cloth, which ...

Scientists reduce behaviors associated with problem gambling in rats

2013-10-29
Scientists reduce behaviors associated with problem gambling in rats With the help of a rat casino, University of British Columbia brain researchers have successfully reduced behaviours in rats that are commonly associated with compulsive gambling in humans. The ...

Child sexual abuse via the Internet on the rise

2013-10-29
Child sexual abuse via the Internet on the rise Sexual abuse of children and adolescents can have serious health consequences for victims. Early studies have revealed that child sexual abuse is associated with an increased risk of later mental and physical ...

Scientists gain new insights into dolphin's evolutionary history and conversation

2013-10-29
Scientists gain new insights into dolphin's evolutionary history and conversation October 29, 2013, Shenzhen, China - Researchers from Nanjing Normal University and BGI report their original genomic research on Baiji, also known as Yangtze River dolphin (Lipotes vexillifer). The study gives ...

LAST 30 PRESS RELEASES:

Be Well Texas at UT Health San Antonio to lead major statewide expansion of opioid use disorder and recovery services

Freshwater fish, too, attracted to artificial root structures

In hard-to-treat form of tuberculosis, shorter, gentler therapy shows unequal benefit

Warming oceans a turn-off for female Critically Endangered sharks

University of Surrey launches Space Institute to drive the UK's small satellite boom and tackle urgent global challenges

Look to the data, not the marketing: Turfgrass research shows no differences in ‘penetrant’ and ‘retainer’ wetting agents

New organ recovery technique could make more heart transplants available

NCSA supporting Georgia Tech in new AI venture

Revised, more accurate Baltic ringed seal count – Hunting slows population growth

Eight babies born after Mitochondrial Donation treatment to reduce transmission of mitochondrial DNA disease

Music may reduce distress for dementia patients

The American Ornithological Society announces its 2025 research grantees

Fetal exposure to vape liquids linked to changes in skull shape

Did a meteor impact trigger a landslide in the Grand Canyon?

Study suggests some maternal HIV infections may be missed during pregnancy

Bacterial genomes hold clues for creating personalized probiotics

Rice University scientists discover way to engineer stronger soft devices through smarter silicone bonding

Innovation Crossroads welcomes six entrepreneurs for Cohort 2025

Researchers explore ways to better safeguard romaine supply

Spider’s visual trickery can fool AI

During pregnancy, are newer antiseizure medications safer than older drugs?

Do race and ethnicity play a role in a person’s risk of peripheral neuropathy?

Older adults who increased their regular walking pace by just 14 steps per minute were more likely to experience clinically significant improvements in a test of aerobic capacity and walking endurance

For adults with hearing loss, linear amplification (amplification across all sound levels, available with some hearing aids) might restore their ability to recognize emotion in voices

Self-reporting climate anxiety in the United States is linked to being young, female, believing climate change will impact you personally, and more frequent media and community discussions around clim

A “silent epidemic” of stimulant use is shadowing the most recent opioid epidemic

Food insecurity causes anxiety and depression

New approach to kidney transplant matching could lead to better long-term outcomes

The patterns of elites who conceal their assets offshore

Elephant robot demonstrates bioinspired 3D printing technology

[Press-News.org] Association between glioma susceptibility and XRCC1 Arg399Gln polymorphism