PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy

2013-11-18
(Press-News.org) Contact information: Lisa Worley
lworley2@med.miami.edu
305-458-9654
The JAMA Network Journals
Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy Chicago – Alan W. Heldman, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine the safety of transendocardial stem cell injection (TESI) with autologous mesenchymal stem cells and bone marrow mononuclear cells in patients with ischemic cardiomyopathy.

An effective proregenerative treatment for ischemic cardiomyopathy would address a major unmet need for many patients. An unresolved issue is whether mesenchymal stem cells have similar safety and possibly greater efficacy than bone marrow mononuclear cells, according to background information in the article.

The included 65 patients with ischemic cardiomyopathy and compared injection of mesenchymal stem cells (n=19) with placebo (n = 11) and bone marrow mononuclear cells (n = 19) with placebo (n = 10), with 1 year of follow-up. The primary measured outcome was treatment-emergent 30-day serious adverse event rate defined as a composite of death, heart attack, stroke, hospitalization for worsening heart failure, perforation (rupture), tamponade (compression of the heart due to collection of blood or fluid), or sustained ventricular arrhythmias.

No patient had treatment emergent-serious adverse event at day 30. Exploratory analyses of 1-year incidence of serious adverse events was 31.6 percent for mesenchymal stem cells, 31.6 percent for bone marrow cells, and 38.1 percent for placebo. Over 1 year, the Minnesota Living with Heart Failure score (a measure of quality of life) improved with mesenchymal stem cells and with bone marrow cells but not with placebo. The 6-minute walk distance increased with mesenchymal stem cells only.

"These results provide the basis for larger studies to provide definitive assessment of safety and to assess efficacy of this new therapeutic approach," the authors write.### (doi:10.l001/jama.2013.282909; Available pre-embargo to the media at http://media.jamanetwork.com)


ELSE PRESS RELEASES FROM THIS DATE:

Addition of certain drugs to diuretic therapy does not improve kidney function

2013-11-18
Addition of certain drugs to diuretic therapy does not improve kidney function Chicago – Horng H. Chen, M.B.B.Ch., of the Mayo Clinic, Rochester, Minn., and colleagues conducted a randomized trial to determine whether, as compared with placebo, the addition of ...

More than skin deep: New layer to the body's fight against infection

2013-11-18
More than skin deep: New layer to the body's fight against infection The layers of skin that form the first line of defence in the body's fight against infection have revealed a unanticipated secret. The single cell type that was thought to be behind ...

Bacteria use lethal cytotoxins to evade antibiotic treatment

2013-11-18
Bacteria use lethal cytotoxins to evade antibiotic treatment In spite of the fact that the first antibiotics were discovered almost a century ago, infectious diseases such as tuberculosis, encephalitis and meningitis are still serious diseases for humans in the ...

Manipulation of protein could help stop spread of cancer cells

2013-11-18
Manipulation of protein could help stop spread of cancer cells DNA regulator stops cancer cells in their tracks Understanding how and why cancer cells move away from their original location is important to find ways to stop the spread of the disease. ...

Vismodegib in basal cell carcinoma: Added benefit not proven

2013-11-18
Vismodegib in basal cell carcinoma: Added benefit not proven Hardly any patient-relevant outcomes were investigated/ studies without control groups The drug vismodegib (trade name: Erivedge) is approved for the treatment of patients ...

Amber provides new insights into the evolution of the Earth's atmosphere

2013-11-18
Amber provides new insights into the evolution of the Earth's atmosphere Scientists encounter big challenges when reconstructing atmospheric compositions in the Earth's geological past because of the lack of useable sample material. One of the few ...

Would an 'anti-ketamine' also treat depression?

2013-11-18
Would an 'anti-ketamine' also treat depression? Yes, says a new study in Biological Psychiatry Philadelphia, PA, November 18, 2013 – Thirteen years ago, an article in this journal first reported that the anesthetic medication, ketamine, showed evidence of producing ...

More than 600 ancient seals and amulets found

2013-11-18
More than 600 ancient seals and amulets found Archaeologists from the Cluster of Excellence make an unusually large find in Turkey -- surprisingly vivid insights into the piety of the time Classical scholars from the Cluster of Excellence "Religion ...

Nature: Single-atom bit forms smallest memory in the world

2013-11-18
Nature: Single-atom bit forms smallest memory in the world This news release is available in German. One atom equals one bit: According to this design principle, we would like to construct magnetic data memories in the future. Presently, a compound of several ...

First EU e-Inclusion map measures the potential for improved digital literacy

2013-11-18
First EU e-Inclusion map measures the potential for improved digital literacy An EU-27 survey of intermediary organisations operating on the education, social and employment sectors and providing IT training has produced a first ever assessment ...

LAST 30 PRESS RELEASES:

ACP’s Best Practice Advice addresses use of cannabis, cannabinoids for chronic noncancer pain

Beyond photorespiration: A systematic approach to unlocking enhanced plant productivity

How a small number of mutations can fuel outbreaks of western equine encephalitis virus

Exposure to wildfire smoke linked with worsening mental health conditions

Research uncovers hidden spread of one of the most common hospital-associated infections

Many older adults send their doctors portal messages, but who pays?

Fine particulate matter from 2020 California wildfires and mental health–related emergency department visits

Gender inequity in institutional leadership roles in US academic medical centers

Pancreatic cells ‘remember’ epigenetic precancerous marks without genetic sequence mutations

Rare combination of ovarian tumors found in one patient

AI-driven clinical recommendations may aid physician decision making to improve quality of care

Artificial intelligence has potential to aid physician decisions during virtual urgent care

ACP and Annals of Internal Medicine present breaking scientific news at ACP’s Internal Medicine Meeting 2025

New study reveals polymers with flawed fillers boost heat transfer in plastics

Signs identified that precede sudden arrhythmic death syndrome in young people

Discovery of bacteria's defence against viruses becomes a piece of the puzzle against resistance

Pre-eclampsia is associated with earlier onset and higher incidence of cardiovascular risk factors

Warwick astronomers discover doomed pair of spiralling stars on our cosmic doorstep

Soil conditions significantly increase rainfall in world’s megastorm hotspots

NK cells complexed with bispecific antibody yield high response rates in patients with lymphoma

Planetary health diet and mediterranean diet associated with similar survival and sustainability benefits

Singapore launches national standard to validate antimicrobial disinfectant products

Molecular stool test could improve detection of tuberculosis in adults with HIV

Suspected fibrocartilaginous embolus in Asian small-clawed otter (Aonyx cinereus)

Enhancing heat transfer using the turbulent flow of viscoelastic fluids

Exercise as an anti-ageing intervention to avoid detrimental impact of mental fatigue

UMass Amherst Nursing Professor Emerita honored as ‘Living Legend’

New guidelines aim to improve cystic fibrosis screening

Picky eaters by day, buffet by night: Butterfly, moth diets sync to plant aromas

Pennington Biomedical’s Dr. Leanne Redman honored with the E. V. McCollum Award from the American Society for Nutrition

[Press-News.org] Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy