PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Evaluation of mangafodipir treatment for oxaliplatin-associated neuropathy

2013-12-20
(Press-News.org) Contact information: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Evaluation of mangafodipir treatment for oxaliplatin-associated neuropathy An unfortunate side effect of the platinum-chemotherapy drug oxaliplatin is the development of neurotoxicity, which can adversely affect a patient's quality of life; therefore, the benefit of oxaliplatin-based therapy must be balanced with prevention of neuropathies. Currently, there are no therapeutic interventions available to relieve oxaliplatin-associated neurological symptoms, which are thought to be a result of reactive oxygen species-associated damage.

In this issue of the Journal of Clinical Investigation, Frédéric Batteux and colleagues at the Laboratoire d'Immunologie evaluated use of the MRI contrast agent mangafodipir, which has antioxidant properties, for relief of oxaliplatin-associated neuropathies. In a mouse model of oxaliplatin-induced neurologic damage, administration of mangafodipir reduced neurotoxicity and the presence of oxidized protein products. Furthermore, in a cohort of 22 patients with oxaliplatin-associated neuropathy, mangafodipir treatment appeared to decrease neurological symptoms.

In their accompanying commentary, Charles Loprinzi and colleagues at the May Clinic caution that even though these results seem promising, larger clinical trails have not been able to confirm similar results from other agents that have shown promise for treating chemotherapy-induced neuropathy in animal models and small phase II small.

INFORMATION:

TITLE: Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir

AUTHOR CONTACT: Frederic Batteux
Faculté de médecine, Université Paris-Descartes, Sorbonne Paris-Cité, Paris, , FRA
Phone: 00 33 1 58 41 20 07; Fax: 00 33 1 58 41 20 08; E-mail: frederic.batteux@cch.aphp.fr

View this article at: http://www.jci.org/articles/view/68730?key=6064e89c86534c430e19

ACCOMPANYING COMMENTARY

TITLE: The search for treatments to reduce chemotherapy-induced peripheral neuropathy

AUTHOR CONTACT: Charles Loprinzi
Mayo Clinic, Rochester, , USA
Phone: 507-284-4849; Fax: 507-284-1803; E-mail: cloprinzi@mayo.edu

View this article at: http://www.jci.org/articles/view/73908?key=e458bafc63766b2f6665

END



ELSE PRESS RELEASES FROM THIS DATE:

New research offers hope for vaccine and therapies for deadly infections

2013-12-20
New research offers hope for vaccine and therapies for deadly infections LA BioMed researcher leads team that finds antibodies to protect against mucormycosis LOS ANGELES – (Dec. 20, 2013) – Mucormycosis ...

UBC-VCH scientists use drug to repair rare birth defect

2013-12-20
UBC-VCH scientists use drug to repair rare birth defect Success in mouse model is first instance of drug reversing a congenital deformity University of British Columbia and Vancouver Coastal Health scientists have developed a potential cure for a rare eye disease, ...

Enlisting cells' protein recycling machinery to regulate plant products

2013-12-20
Enlisting cells' protein recycling machinery to regulate plant products New molecular tools for controlling production of compounds important for flavors, human health, and biofuels UPTON, NY--Scientists at the U.S. Department of Energy's Brookhaven ...

New mechanism that permits selective capture of microRNAs in nanovesicles that shuttle between cells

2013-12-20
New mechanism that permits selective capture of microRNAs in nanovesicles that shuttle between cells The study presents the first description of a set of related nuceleotide sequences essential for the role of these small molecules in ...

More mentions in the FT linked to greater popularity of stocks

2013-12-20
More mentions in the FT linked to greater popularity of stocks A 6-year study of the Financial Times has found that the more frequently a company is mentioned in the newspaper in the morning, the greater the volume of shares traded in that company during the ...

Efforts to curb climate change require greater emphasis on livestock

2013-12-20
Efforts to curb climate change require greater emphasis on livestock CORVALLIS, Ore. – While climate change negotiators struggle to agree on ways to reduce carbon dioxide (CO2) emissions, they have paid inadequate attention to other greenhouse gases associated ...

Birth of black hole kills the radio star

2013-12-20
Birth of black hole kills the radio star Research clears telescope, disproves long-held theory Astronomers led by a Curtin University researcher have discovered a new population of exploding stars that "switch off" their radio transmissions before collapsing ...

An earthquake or a snow avalanche has its own shape

2013-12-20
An earthquake or a snow avalanche has its own shape However, it is crucial what one observes – paper fracture or the avalanching of snow. The results were just published in the Nature Communications journal. Avalanches of snow or earthquakes can be described in other ...

Smooth or grainy?

2013-12-20
Smooth or grainy? A SISSA paper reviews research on the grain of space-time Smooth" or grainy? Is space-time continuous or is it made up of very fine (10-35 metres on the "Planck scale") but discrete grains, if we look at it very ...

IRB develops ChroGPS, a new generation visual browser of the epigenome

2013-12-20
IRB develops ChroGPS, a new generation visual browser of the epigenome This is a software application that provides easily interpretable maps from which to analyse and understand the immense volume of epigenetic and genetic ...

LAST 30 PRESS RELEASES:

UAlbany researcher partners on $1.2 million NSF grant to explore tropical monsoon rainfall patterns

Checkup time for Fido? Wait might be longer in the country

Genetic variation impact scores: A new tool for earlier heart disease detection

The Lundquist Institute awarded $9 million to launch Community Center of Excellence for Regenerative Medicine

'Really bizarre and exciting': The quantum oscillations are coming from inside

Is AI becoming selfish?

New molten salt method gives old lithium batteries a second life

Leg, foot amputations increased 65% in Illinois hospitals between 2016-2023

Moffitt studies uncover complementary strategies to overcome resistance to KRAS G12Cinhibitors in lung cancer

National summit of experts charts unprecedented roadmap to reduce harms from firearms in new ways

Global environmental DNA (eDNA) surveys significantly expand known geographic and ecological niche ranges of marine fish, highlighting current biases in conservation and ecological modeling

Hundreds of animal studies on brain damage after stroke flagged for problematic images

Prize winner’s research reveals how complex neural circuits are correctly wired during brain development

Supershear rupture sustained in thick fault zone during 2025 Mandalay earthquake, study in research package shows

Study reveals how brain cell networks stabilize memory formation

CTE: More than just head trauma, suggests new study

New psychology study suggests chimpanzees might be rational thinkers

Study links genetic variants to higher 'bad' cholesterol and heart attack risk

Myanmar fault had ideal geometry to produce 2025 supershear earthquake

Breakthrough in BRCA2 research: a novel mechanism behind chemoresistance discovered

New funding for health economics research on substance use disorder treatments

Tying protein to fraying DNA solves mystery of illness for patients around the world

MD Anderson shares latest research breakthroughs

19 women’s college basketball coaches join forces to improve women’s cardiovascular health

Palaeontology: How ammolite gemstones get their vivid colours

New study explores ‘legacy effects’ of soil microbes on plants across Kansas

Nanotyrannus confirmed: Dueling dinosaurs fossil rewrites the story of T. rex

How do planets get wet? Experiments show water creation during planet formation process

The diagnosis and evolving treatment landscape of systemic light chain amyloidosis

Lactylation in gynecological malignancies: a bridge between lactate metabolism and epigenetic therapy

[Press-News.org] Evaluation of mangafodipir treatment for oxaliplatin-associated neuropathy