PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Evaluation of mangafodipir treatment for oxaliplatin-associated neuropathy

2013-12-20
(Press-News.org) Contact information: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Evaluation of mangafodipir treatment for oxaliplatin-associated neuropathy An unfortunate side effect of the platinum-chemotherapy drug oxaliplatin is the development of neurotoxicity, which can adversely affect a patient's quality of life; therefore, the benefit of oxaliplatin-based therapy must be balanced with prevention of neuropathies. Currently, there are no therapeutic interventions available to relieve oxaliplatin-associated neurological symptoms, which are thought to be a result of reactive oxygen species-associated damage.

In this issue of the Journal of Clinical Investigation, Frédéric Batteux and colleagues at the Laboratoire d'Immunologie evaluated use of the MRI contrast agent mangafodipir, which has antioxidant properties, for relief of oxaliplatin-associated neuropathies. In a mouse model of oxaliplatin-induced neurologic damage, administration of mangafodipir reduced neurotoxicity and the presence of oxidized protein products. Furthermore, in a cohort of 22 patients with oxaliplatin-associated neuropathy, mangafodipir treatment appeared to decrease neurological symptoms.

In their accompanying commentary, Charles Loprinzi and colleagues at the May Clinic caution that even though these results seem promising, larger clinical trails have not been able to confirm similar results from other agents that have shown promise for treating chemotherapy-induced neuropathy in animal models and small phase II small.

INFORMATION:

TITLE: Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir

AUTHOR CONTACT: Frederic Batteux
Faculté de médecine, Université Paris-Descartes, Sorbonne Paris-Cité, Paris, , FRA
Phone: 00 33 1 58 41 20 07; Fax: 00 33 1 58 41 20 08; E-mail: frederic.batteux@cch.aphp.fr

View this article at: http://www.jci.org/articles/view/68730?key=6064e89c86534c430e19

ACCOMPANYING COMMENTARY

TITLE: The search for treatments to reduce chemotherapy-induced peripheral neuropathy

AUTHOR CONTACT: Charles Loprinzi
Mayo Clinic, Rochester, , USA
Phone: 507-284-4849; Fax: 507-284-1803; E-mail: cloprinzi@mayo.edu

View this article at: http://www.jci.org/articles/view/73908?key=e458bafc63766b2f6665

END



ELSE PRESS RELEASES FROM THIS DATE:

New research offers hope for vaccine and therapies for deadly infections

2013-12-20
New research offers hope for vaccine and therapies for deadly infections LA BioMed researcher leads team that finds antibodies to protect against mucormycosis LOS ANGELES – (Dec. 20, 2013) – Mucormycosis ...

UBC-VCH scientists use drug to repair rare birth defect

2013-12-20
UBC-VCH scientists use drug to repair rare birth defect Success in mouse model is first instance of drug reversing a congenital deformity University of British Columbia and Vancouver Coastal Health scientists have developed a potential cure for a rare eye disease, ...

Enlisting cells' protein recycling machinery to regulate plant products

2013-12-20
Enlisting cells' protein recycling machinery to regulate plant products New molecular tools for controlling production of compounds important for flavors, human health, and biofuels UPTON, NY--Scientists at the U.S. Department of Energy's Brookhaven ...

New mechanism that permits selective capture of microRNAs in nanovesicles that shuttle between cells

2013-12-20
New mechanism that permits selective capture of microRNAs in nanovesicles that shuttle between cells The study presents the first description of a set of related nuceleotide sequences essential for the role of these small molecules in ...

More mentions in the FT linked to greater popularity of stocks

2013-12-20
More mentions in the FT linked to greater popularity of stocks A 6-year study of the Financial Times has found that the more frequently a company is mentioned in the newspaper in the morning, the greater the volume of shares traded in that company during the ...

Efforts to curb climate change require greater emphasis on livestock

2013-12-20
Efforts to curb climate change require greater emphasis on livestock CORVALLIS, Ore. – While climate change negotiators struggle to agree on ways to reduce carbon dioxide (CO2) emissions, they have paid inadequate attention to other greenhouse gases associated ...

Birth of black hole kills the radio star

2013-12-20
Birth of black hole kills the radio star Research clears telescope, disproves long-held theory Astronomers led by a Curtin University researcher have discovered a new population of exploding stars that "switch off" their radio transmissions before collapsing ...

An earthquake or a snow avalanche has its own shape

2013-12-20
An earthquake or a snow avalanche has its own shape However, it is crucial what one observes – paper fracture or the avalanching of snow. The results were just published in the Nature Communications journal. Avalanches of snow or earthquakes can be described in other ...

Smooth or grainy?

2013-12-20
Smooth or grainy? A SISSA paper reviews research on the grain of space-time Smooth" or grainy? Is space-time continuous or is it made up of very fine (10-35 metres on the "Planck scale") but discrete grains, if we look at it very ...

IRB develops ChroGPS, a new generation visual browser of the epigenome

2013-12-20
IRB develops ChroGPS, a new generation visual browser of the epigenome This is a software application that provides easily interpretable maps from which to analyse and understand the immense volume of epigenetic and genetic ...

LAST 30 PRESS RELEASES:

Fig trees convert atmospheric CO2 to stone

Intra-arterial tenecteplase for acute stroke after successful endovascular therapy

Study reveals beneficial microbes that can sustain yields in unfertilized fields

Robotic probe quickly measures key properties of new materials

Climate change cuts milk production, even when farmers cool their cows

Frozen, but not sealed: Arctic Ocean remained open to life during ice ages

Some like it cold: Cryorhodopsins

Demystifying gut bacteria with AI

Human wellbeing on a finite planet towards 2100: new study shows humanity at a crossroads

Unlocking the hidden biodiversity of Europe’s villages

Planned hydrogen refuelling stations may lead to millions of euros in yearly losses

Planned C-sections increase the risk of certain childhood cancers

Adults who have survived childhood cancer are at increased risk of severe COVID-19

Drones reveal extreme coral mortality after bleaching

New genetic finding uncovers hidden cause of arsenic resistance in acute promyelocytic leukemia

Native habitats hold the key to the much-loved smashed avocado’s future

Using lightning to make ammonia out of thin air

Machine learning potential-driven insights into pH-dependent CO₂ reduction

Physician associates provide safe care for diagnosed patients when directly supervised by a doctor

How game-play with robots can bring out their human side

Asthma: patient expectations influence the course of the disease

UNM physician tests drug that causes nerve tissue to emit light, enabling faster, safer surgery

New study identifies EMP1 as a key driver of pancreatic cancer progression and poor prognosis

XPR1 identified as a key regulator of ovarian cancer growth through autophagy and immune evasion

Flexible, eco-friendly electronic plastic for wearable tech, sensors

Can the Large Hadron Collider snap string theory?

Stuckeman professor’s new book explores ‘socially sustainable’ architecture

Synthetic DNA nanoparticles for gene therapy

New model to find treatments for an aggressive blood cancer

Special issue of Journal of Intensive Medicine analyzes non-invasive respiratory support

[Press-News.org] Evaluation of mangafodipir treatment for oxaliplatin-associated neuropathy