(Press-News.org) Contact information: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Want a good night's sleep in the new year? Quit smoking
New research in The FASEB Journal identifies the mechanism by which tobacco smoke affects the expression of clock genes in the lung and resets levels of locomotor activity in the brain
As if cancer, heart disease and other diseases were not enough motivation to make quitting smoking your New Year's resolution, here's another wake-up call: New research published in the January 2014 issue of The FASEB Journal suggests that smoking disrupts the circadian clock function in both the lungs and the brain. Translation: Smoking ruins productive sleep, leading to cognitive dysfunction, mood disorders, depression and anxiety.
"This study has found a common pathway whereby cigarette smoke impacts both pulmonary and neurophysiological function. Further, the results suggest the possible therapeutic value of targeting this pathway with compounds that could improve both lung and brain functions in smokers," said Irfan Rahman, Ph.D., a researcher involved in the work from the Department of Environmental Medicine at the University of Rochester Medical Center in Rochester, N.Y. "We envisage that our findings will be the basis for future developments in the treatment of those patients who are suffering with tobacco smoke-mediated injuries and diseases.
Rahman and colleagues found that tobacco smoke affects clock gene expression rhythms in the lung by producing parallel inflammation and depressed levels of brain locomotor activity. Short- and long- term smoking decreased a molecule known as SIRTUIN1 (SIRT1, an anti-aging molecule) and this reduction altered the level of the clock protein (BMAL1) in both lung and brain tissues in mice. A similar reduction was seen in lung tissue from human smokers and patients with chronic obstructive pulmonary disease (COPD). They made this discovery using two groups of mice which were placed in smoking chambers for short-term and long-term tobacco inhalation. One of the groups was exposed to clean air only and the other was exposed to different numbers of cigarettes during the day. Researchers monitored their daily activity patterns and found that these mice were considerably less active following smoke exposure.
Scientists then used mice deficient in SIRT1 and found that tobacco smoke caused a dramatic decline in activity but this effect was attenuated in mice that over expressed this protein or were treated with a small pharmacological activator of the anti-aging protein. Further results suggest that the clock protein, BMAL1, was regulated by SIRT1, and the decrease in SIRT1 damaged BMAL1, resulting in a disturbance in the sleep cycle/molecular clock in mice and human smokers. However, this defect was restored by a small molecule activator of SIRT1.
"If you only stick to one New Year's resolution this year, make it quitting smoking," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Only Santa Claus has a list longer than that of the ailments caused or worsened by smoking. If you like having a good night's sleep, then that's just another reason to never smoke."
###
Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is among the most cited biology journals worldwide according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.
FASEB is composed of 27 societies with more than 110,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
Details: Jae-Woong Hwang, Isaac K. Sundar, Hongwei Yao, Michael T. Sellix, and Irfan Rahman
Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. FASEB J. January 2014 28:176-194; doi:10.1096/fj.13-232629 ; http://www.fasebj.org/content/28/1/176.abstract
Want a good night's sleep in the new year? Quit smoking
New research in The FASEB Journal identifies the mechanism by which tobacco smoke affects the expression of clock genes in the lung and resets levels of locomotor activity in the brain
2014-01-02
ELSE PRESS RELEASES FROM THIS DATE:
No scrounging for scraps: UC research uncovers the diets of the middle and lower class in Pompeii
2014-01-02
No scrounging for scraps: UC research uncovers the diets of the middle and lower class in Pompeii
University of Cincinnati archaeologists are turning up discoveries in the famed Roman city of Pompeii that are wiping out the historic perceptions of how the Romans dined, ...
Researchers find ways to minimize power grid disruptions from wind power
2014-01-02
Researchers find ways to minimize power grid disruptions from wind power
Researchers from North Carolina State University and Johns Hopkins University have found that an increase in the use of wind power generation can make the power grid more fragile and ...
When being called 'incredibly good' is bad for children
2014-01-02
When being called 'incredibly good' is bad for children
Study shows inflated praise can harm kids with low self-esteem
COLUMBUS, Ohio – Parents and other adults heap the highest praise on children who are most likely to be hurt by the compliments, a new study finds.
Researchers ...
Survival rates similar for gunshot/stabbing victims whether brought to the hospital by police or EMS
2014-01-02
Survival rates similar for gunshot/stabbing victims whether brought to the hospital by police or EMS
Philadelphia 'Scoop and Run' penetrating trauma victims studied over 5-year period
PHILADELPHIA - A new study from the Perelman ...
Study supports a causal role in narcolepsy for a common genetic variant
2014-01-02
Study supports a causal role in narcolepsy for a common genetic variant
Results show a remarkable genetic association of almost 100 percent
DARIEN, IL – A new study conducted across Europe found an extraordinary association between narcolepsy and a specific ...
Study finds patients give 'broad endorsement' to stem cell research
2014-01-02
Study finds patients give 'broad endorsement' to stem cell research
In an early indication of lay opinions on research with induced pluripotent stem cells (iPSCs), which are stem cells made from skin or other tissues, a new study by bioethicists at Johns Hopkins University ...
Hispanic women are less aware of weight and heart disease risk
2014-01-02
Hispanic women are less aware of weight and heart disease risk
New Rochelle, NY, January 2, 2014—Minority women tend to be less aware of the increased risk of cardiovascular disease (CVD) they face by being overweight or obese. The results ...
Study: Open collaboration, which led to Bitcoin, TedX & Wikipedia, likely to grow
2014-01-02
Study: Open collaboration, which led to Bitcoin, TedX & Wikipedia, likely to grow
New research in INFORMS Journal shows that open collaboration brings innovation
Open collaboration – which has brought the world Bitcoin, TEDx ...
The people's agenda -- America's priorities and outlook for 2014
2014-01-02
The people's agenda -- America's priorities and outlook for 2014
Associated Press-NORC Center for Public Affairs Research survey reveals the American people's list of key issues that need government attention in the year ahead
Chicago, January 2, 2014—The ...
More evidence suggests type 2 diabetes is an inflammatory disease
2014-01-02
More evidence suggests type 2 diabetes is an inflammatory disease
New research published in the Journal of Leukocyte Biology suggests that macrophages invade the diabetic pancreas, producing large amounts of cytokines that contribute ...
LAST 30 PRESS RELEASES:
Transcatheter or surgical treatment of patients with aortic stenosis at low to intermediate risk
Promising new drug for people with stubborn high blood pressure
One shot of RSV vaccine effective against hospitalization in older adults for two seasons
Bivalent RSV prefusion F protein–based vaccine for preventing cardiovascular hospitalizations in older adults
Clonal hematopoiesis and risk of new-onset myocarditis and pericarditis
Risk of myocarditis or pericarditis with high-dose vs standard-dose influenza vaccine
High-dose vs standard-dose influenza vaccine and cardiovascular outcomes in older adults
Prevalence, determinants, and time trends of cardiovascular health in the WHO African region
New study finds that, after a heart attack, women have worse prognosis when treated with beta-blockers
CNIC-led REBOOT clinical trial challenges 40-year-old standard of care for heart attack patients
Systolic blood pressure and microaxial flow pump–associated survival in infarct-related cardiogenic shock
Beta blockers, the standard treatment after a heart attack, may offer no benefit for heart attack patients and women can have worse outcomes
High Mountain Asia’s shrinking glaciers linked to monsoon changes
All DRII-ed up: How do plants recover after drought?
Research on stigma says to just ‘shake it off’
Scientists track lightning “pollution” in real time using NASA satellite
Millions of women rely on contraceptives, but new Rice study shows they may do more than just prevent pregnancy
Hot days make for icy weather, Philippine study finds
Roxana Mehran, MD, receives the most prestigious award given by the European Society of Cardiology
World's first clinical trial showing lubiprostone aids kidney function
Capturing language change through the genes
Public trust in elections increases with clear facts
Thawing permafrost raised carbon dioxide levels after the last ice age
New DNA test reveals plants’ hidden climate role
Retinitis pigmentosa mouse models reflect pathobiology of human RP59
Cell’s ‘antenna’ could be key to curing diseases
Tiny ocean partnership between algae and bacteria reveals secrets of evolution
Scientists uncover cellular “toolkit” to reprogram immune cells for cancer therapy
Blocking protein control pathway slows rhabdomyosarcoma growth in mice
2026 Hertz Fellowship Application Now Open
[Press-News.org] Want a good night's sleep in the new year? Quit smokingNew research in The FASEB Journal identifies the mechanism by which tobacco smoke affects the expression of clock genes in the lung and resets levels of locomotor activity in the brain