PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Reactivation of the AKT survival pathway by ERK1/2

Why inhibition of both pathways is important

2014-01-07
(Press-News.org) Contact information: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Reactivation of the AKT survival pathway by ERK1/2 Why inhibition of both pathways is important In the study by Toulany et al., it was demonstrated for the first time that long term treatment with inhibitors of PI3K (as it is performed clinically) results in a reactivation of the major survival component Akt through a so far unknown regulatory loop via ERK1/2. This reactivation of Akt limits quite efficiently the response of the tested tumor cell lines presenting constitutively active K-Ras activity (both through K-RAS mutation or over-expression of K-RAS wildtype) to antagonistic strategies directed against PI3K. Thus, the described ERK1/2 dependency of reactivation of Akt gives new insights into the underlying mechanisms of resistance accompanying EGFR and PI3K antagonizing strategies. Moreover and clinically perhaps even more importantly, these findings provide specific hints how the combination of MEK-ERK1/2 and PI3K inhibitors can efficiently be used to overcome therapy resistance of tumors presenting constitutively high K-Ras activity.

### For the full report by Toulany et al. in Cancer Biology & Therapy, visit the following link: https://www.landesbioscience.com/journals/cbt/article/27311/

Published by Landes Bioscience since 2002, Cancer Biology & Therapy publishes relevant and high-impact original research with a special focus on the molecular basis of cancer, including articles with translational relevance to diagnosis or therapy. Established in 2002, Landes Bioscience is an Austin, Texas-based publisher of biology research journals and books. For more information on Landes Bioscience, please visit http://www.landesbioscience.com/.


ELSE PRESS RELEASES FROM THIS DATE:

Inverse design: New route to design a practical invisibility cloak

2014-01-07
Inverse design: New route to design a practical invisibility cloak With the emergence of metamaterials and transformation optics in the past few years, invisibility has become a scientific possibility that has attracted sustainable research interest. Recently, a review ...

Jumping snails left grounded in future oceans

2014-01-07
Jumping snails left grounded in future oceans Sea snails that leap to escape their predators may soon lose their extraordinary jumping ability because of rising human carbon dioxide emissions, a team of international scientists ...

Nanoplasmonics: Towards efficient light harvesting

2014-01-07
Nanoplasmonics: Towards efficient light harvesting The control of light is vital to many applications, including imaging, communications, sensing, cancer treatment, and even welding processes for automobile parts. Transformation optics is an emerging field that has revolutionized ...

Cancer Statistics 2014: Death rates continue to drop

2014-01-07
Cancer Statistics 2014: Death rates continue to drop Progress most rapid for middle-aged African American men ATLANTA – Jan. 7, 2014–The annual cancer statistics report from the American Cancer Society finds steady declines in cancer death rates for the past two decades ...

Researchers discover molecule behind the benefits of exercise

2014-01-07
Researchers discover molecule behind the benefits of exercise While it's clear that exercise can improve health and longevity, the changes that occur in the body to facilitate these benefits are less clear. Now researchers publishing in the January issue of Cell Press journal ...

How fat might be controlled through the body clock

2014-01-07
How fat might be controlled through the body clock Australian researchers have shed more light on an underexplored aspect of the important brain-signaling system that controls appetite, body composition and energy use. Their findings suggest ...

Ketamine acts as antidepressant by boosting serotonin

2014-01-07
Ketamine acts as antidepressant by boosting serotonin PET molecular imaging of the brain reveals that ketamine may act as an antidepressant by boosting serotonin activity in brain areas involved in motivation Ketamine is a potent anesthetic employed in human and veterinary medicine, ...

U of Maryland undergraduates discover rare eclipsing double asteroid

2014-01-07
U of Maryland undergraduates discover rare eclipsing double asteroid Fewer than 100 such asteroids have been found in main asteroid belt COLLEGE PARK, MD – Students in a University of Maryland undergraduate astronomy class have made a rare discovery that wowed professional ...

Ancient sharks reared young in prehistoric river-delta nursery

2014-01-07
Ancient sharks reared young in prehistoric river-delta nursery ANN ARBOR—Like salmon in reverse, long-snouted Bandringa sharks migrated downstream from freshwater swamps to a tropical coastline to spawn 310 million years ago, leaving behind fossil evidence of one of ...

How you practice matters for learning a skill quickly

2014-01-07
How you practice matters for learning a skill quickly Practice alone doesn't make perfect, but learning can be optimized if you practice in the right way, according to new research based on online gaming data from more than 850,000 people. The ...

LAST 30 PRESS RELEASES:

Cercus electric stimulation enables cockroach with trajectory control and spatial cognition training

Day-long conference addresses difficult to diagnose lung disease

First-ever cardiogenic shock academy features simulation lab

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

[Press-News.org] Reactivation of the AKT survival pathway by ERK1/2
Why inhibition of both pathways is important