PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Future directions for landmark diabetes study in journal Diabetes Care

UH Rainbow Babies & Children's Hospital diabetes physician-researcher charts course for Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications, most highly cited diabetes research trials

2014-01-29
(Press-News.org) Contact information: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals Case Medical Center
Future directions for landmark diabetes study in journal Diabetes Care UH Rainbow Babies & Children's Hospital diabetes physician-researcher charts course for Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications, most highly cited diabetes research trials CLEVELAND – The two most highly cited diabetes research trials – Diabetes Control and Complications Trial (DCCT) and its follow-up study Epidemiology of Diabetes Interventions and Complications (EDIC) – are marking their 30th anniversary. DCCT, which ran from 1982 to 1993, enrolled more than 1,400 adolescents and young adults with type 1 diabetes to evaluate if intensive control of diabetes could lower the risk of complications better than conventional control. EDIC launched in 1994 and continues to follow many patients from the original study.

This month, the journal Diabetes Care, published by the American Association of Diabetes, features a series of articles commemorating the anniversary of the groundbreaking studies. University Hospitals Rainbow Babies & Children's Hospital (UH Rainbow)/Case Western Reserve University School of Medicine together have constituted a lead center in DCCT/EDIC, the longest-running study funded by the National Institutes of Health.

Rose A. Gubitosi-Klug, MD, PhD, Interim Chief, Pediatric Endocrinology, Diabetes and Metabolism, UH Rainbow and Associate Professor of Pediatrics at Case Western Reserve School of Medicine, penned the series' summary and mapped out future directions for the research in the issue.

"DCCT/EDIC are landmark studies," said Dr. Gubitosi-Klug, who is Principal Investigator of the study's Clinical Coordinating Center at the School of Medicine and UH Rainbow. "They have set the standard of care for clinical management of type 1 diabetes, which has forever changed the course of its complications.

"The main message impacts the way we care for children with diabetes everyday: Earlier intervention is critical to prevent the complications of diabetes," said Dr. Gubitosi-Klug. "The message is clear: Controlling glucose levels is the major factor that can greatly lower the risk of the development and progression of the complications of type 1 diabetes, including eye and nerve damage and heart disease."

Intensive management of diabetes includes multiple daily injections of insulin and careful blood glucose monitoring.

The doctor said one of the amazing aspects of the study is the high rate of participation by the research subjects, even 30 years later. "We find participation levels greater than 80 to 90 percent in many follow-up studies," she said. "The research participants believe they are contributing to a greater good that will help future patients."

In the coming years, Dr. Gubitosi-Klug said that DCCT/EDIC hopes to study several new areas, including defining the relative time course of the development of retinopathy, nephropathy and neuropathy, and whether rates of progression in one can shed light on the development of the other complications; establishing evidence-based frequency of screening for these complications; refining self-monitoring to learn more about the role of variability in glucose levels on outcomes; exploring the effects of glucose control on cognition and continuing to monitor the bottom line – that intensive management prevents costly complications and is economically sage, among other initiatives.

Saul Genuth, MD, an endocrinologist at UH Case Medical Center and Professor of Medicine at Case Western Reserve School of Medicine, has co-chaired DCCT/EDIC since its inception.

An accompanying editorial in Diabetes Care, calls the study "the gift that keeps on giving." The complete anniversary issue is located at: http://care.diabetesjournals.org/site/misc/dcct.xhtml

###

About University Hospitals Rainbow Babies & Children's Hospital

Located on the campus of University Hospitals Case Medical Center in Cleveland, Ohio, University Hospitals Rainbow Babies & Children's Hospital is a 244-bed, full-service children's hospital and academic medical center dedicated to the healthcare needs of children. A trusted leader in children's health care for more than 125 years, UH Rainbow Babies & Children's Hospital consistently ranks among the top children's hospitals in the nation. As the region's premier resource for pediatric referrals, UH Rainbow Babies & Children's Hospital's dedicated team of more than 1,300 pediatric specialists uses the most advanced treatments and latest innovations to deliver the complete range of pediatric specialty services for more than 700,000 patient encounters each year. Learn more at RainbowBabies.org.

Among the nation's leading academic medical centers, UH Case Medical Center is the primary affiliate of Case Western Reserve University School of Medicine, a nationally recognized leader in medical research and education.

END



ELSE PRESS RELEASES FROM THIS DATE:

Targeted tutoring can reduce 'achievement gap' for CPS students, study finds

2014-01-29
High school students who were at risk for dropping out greatly improved their math test scores and school ...

Caffeine use disorder: A widespread health problem that needs more attention

2014-01-29
WASHINGTON, D.C. (Jan 28, 2014) -- "I'm a zombie without my morning coffee." "My blood type is ...

New molecule protects brain from detrimental effects linked to diabetes and high blood sugar

2014-01-29
Researchers at the Hebrew university of Jerusalem have created ...

'Chameleon of the sea' reveals its secrets

2014-01-29
Cambridge, Mass. – January 28, 2014 – Scientists at Harvard University and the Marine Biological Laboratory (MBL) hope new understanding ...

Low levels of pro-inflammatory agent help cognition in rats

2014-01-29
SAN ANTONIO (Jan. 28, 2014) — Although inflammation is frequently a cause of disease in the body, research from The University of Texas Health Science Center at San Antonio ...

Animal model demonstrates role for metabolic enzyme in acute myeloid leukemia

2014-01-29
BOSTON ...

'Weeding the garden' lets ALK+ lung cancer patients continue crizotinib

2014-01-29
A University of Colorado Cancer Center study published today in the International Journal of Radiation Oncology Biology and Physics shows that patients taking crizotinib for ALK+ non-small cell ...

Research shows arsenic, mercury and selenium in Asian carp not a health concern to most

2014-01-29
Researchers at the Prairie Research Institute's Illinois Natural History Survey have found that overall, concentrations of arsenic, selenium, and mercury in bighead ...

New NASA Laser Technology Reveals How Ice Measures Up

2014-01-29
New results from NASA's MABEL campaign demonstrated that a photon-counting technique will allow researchers to track the melt or growth of Earth's frozen regions. When a high-altitude aircraft ...

Parents unclear about process for specialist care for kids

2014-01-29
ANN ARBOR, Mich. – Parents vary widely in views about their ...

LAST 30 PRESS RELEASES:

Scientists shoot lasers into brain cells to uncover how illusions work

Your ecosystem engineer was a dinosaur

New digital cognitive test for diagnosing Alzheimer's disease

Parents of children with health conditions less confident about a positive school year

New guideline standardizes consent for research participants in Canada

Research as reconciliation: Oil sands and health

AI risks overwriting history and the skills of historians have never been more important, leading academic outlines in new paper

The Lancet Diabetes & Endocrinology: Higher doses of semaglutide can safely enhance weight loss and improve health for adults living with obesity, two new clinical trials confirm

Trauma focused therapy shows promise for children struggling with PTSD

School meals could drive economic growth and food system transformation

Home training for cerebellar ataxias

Dry eyes affect over half the general population, yet only a fifth receive diagnosis and treatment

Researchers sound warning about women with type 2 diabetes taking oral HRT

Overweight and obesity don’t always increase the risk of an early death, Danish study finds

Cannabis use associated with a quadrupling of risk of developing type 2 diabetes, finds study of over 4 million adults

Gestational diabetes linked to cognitive decline in mothers and increased risk of developmental delays, ADHD and autism among children

Could we use eye drops instead of reading glasses as we age?

Patients who had cataracts removed or their eyesight corrected with a new type of lens have good vision over all distances without spectacles

AI can spot which patients need treatment to prevent vision loss in young adults

Half of people stop taking popular weight-loss drug within a year, national study finds

Links between diabetes and depression are similar across Europe, study of over-50s in 18 countries finds

Smoking increases the risk of type 2 diabetes, regardless of its characteristics

Scientists trace origins of now extinct plant population from volcanically active Nishinoshima

AI algorithm based on routine mammogram + age can predict women’s major cardiovascular disease risk

New hurdle seen to prostate screening: primary-care docs

MSU researchers explore how virtual sports aid mental health

Working together, cells extend their senses

Cheese fungi help unlock secrets of evolution

Researchers find brain region that fuels compulsive drinking

Mental health effects of exposure to firearm violence persist long after direct exposure

[Press-News.org] Future directions for landmark diabetes study in journal Diabetes Care
UH Rainbow Babies & Children's Hospital diabetes physician-researcher charts course for Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications, most highly cited diabetes research trials