PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Report outlines progress, challenges in childhood cancer

2014-01-31
(Press-News.org) Contact information: David Sampson
david.sampson@cancer.org
American Cancer Society
Report outlines progress, challenges in childhood cancer ATLANTA – Jan. 31, 2014–A new report from the American Cancer Society outlines progress made and –more importantly—challenges that remain in fighting childhood cancer. The report estimates the number of new cancer cases and deaths for children and adolescents in the United States, summarizes the most recent and comprehensive data on cancer incidence, mortality, and survival, and outlines what is known and where answers are still needed for childhood cancers. It appears in CA: A Cancer Journal for Clinicians and also as a Special Section in Cancer Facts & Figures 2014. The American Cancer Society created the report to inform clinicians and the public about progress and challenges in preventing and averting suffering and death from the cancers that affect children and adolescents.

The report calls the diagnosis of cancer in children and adolescents "a life-altering event for [children and adolescents] as well as their families." It points out that although advances in the treatment of childhood cancer have saved many lives over recent decades, there has been less progress made in understanding the causes and prevention of childhood and adolescent cancers. And while there have been substantial improvements in survival for many cancers of childhood, others have seen little progress. For example, progress against central nervous system (CNS) cancers has been significant overall, but for some subtypes, survival times remain tragically low. For diffuse intrinsic pontine glioma (DIPG), the median survival time after diagnosis remains less than one year.

The report says in 2014, an estimated 15,780 new cases of cancer will be diagnosed and 1960 deaths will occur among children and adolescents aged birth to 19 years. Annual incidence of cancer from birth to age 19 is 18.8 per 100,000; approximately 1 in 285 children will be diagnosed with cancer before age 20. Today, about 1 in 530 young adults between the ages of 20 and 39 is a childhood cancer survivor.

Among the issues the report outlines that need to be addressed: while advances in survival for many types of malignancies have resulted from advances in surgical techniques, delivery of radiation therapy, and use of chemotherapy, children treated for many cancers have a high risk of long-term health issues. For example, children treated for brain tumors, a leading cancer in children, may experience seizures, weakness in the arms and legs, blindness, hearing loss, neuroendocrine effects, including growth hormone deficiency, hypothyroidism, abnormal timing of menarche, and neurocognitive deficits. Other cancers and their treatments also have serious long-term effects.

In addition, unlike adult cancers, only a relatively small percentage of all childhood cancers have known preventable causes. Also, early detection of cancer in children is made much more difficult because of the similarity of some symptoms to those of more common childhood diseases. Some symptoms of childhood cancer that should alert parents and health care providers include an unusual mass or swelling; unexplained pallor or loss of energy; a sudden tendency to bruise; a persistent, localized pain or limping; a prolonged, unexplained fever or illness; frequent headaches, often with vomiting; sudden changes in vision; and excessive, rapid weight loss.

"Progress in childhood cancer has been dramatic for some sites, but we cannot let that blind us from the fact that progress has been disappointingly slow for other sites, and that cancer remains the second leading cause of death in children," said Otis W. Brawley, M.D., American Cancer Society chief medical officer. "There is much work to be done to improve outcomes, to reduce side effects associated with cancer and its treatment, and, we hope, to understand more about the molecular events that lead to childhood cancer in order to come up with ways to prevent or detect it early."

"It is important to recognize that all of the issues identified in this report, including the long term and late effects of cancer treatment, came about due to the foresight and dedication of pediatric oncologists, researchers, and other health professionals who have dedicated their lives to fighting these deadly cancers," said lead author Elizabeth Ward, PhD. "This report, which was compiled from published research, is intended to inform the broader clinical community and public about the unique and complex challenges faced by children and adolescents with cancer and the growing number of survivors of these cancers."

In an accompanying commentary also published in CA, Jennifer Cullen, PhD, MPH, a cancer epidemiologist, mother of a child diagnosed with cancer, and a board member of the American Childhood Cancer Organization (acco.org), writes that "[a]s a cancer epidemiologist, I was better equipped than most parents to face down this crisis. But that realization frequently left me wondering: how did families with little medical knowledge or inflexible work schedules manage their fears and navigate the numerous daily unknowns? …Having to choose between treatment strategies that are terrible and terrible really presents no choice at all."

"We have seen successes for some cancers, but others remain incurable and untreatable," she continues. The new report "is an essential inventory to help evaluate our progress and shortfalls. Importantly, for the first time in over a decade, instead of presenting these figures in the aggregate, these more comprehensive data tease out several specific cancer types to capture a clearer picture of the actual childhood cancer landscape today. These figures demonstrate tremendous variation in survival and success rates across the different cancers affecting children."

### Article: Ward, E., DeSantis, C., Robbins, A., Kohler, B., and Jemal, A. (2014), Childhood and Adolescent Cancer Statistics, 2014. CA Cancer Journal for Clinicians. doi: 10.3322/caac.21219. Published online ahead of print January 31, 2014.

Commentary: Cullen, J. (2014), Because Statistics Don't Tell the Whole Story: A Call for Comprehensive Care for Children With Cancer. CA Cancer Journal for Clinicians. doi: 10.3322/caac.21215. Published online ahead of print January 31, 2014. END


ELSE PRESS RELEASES FROM THIS DATE:

Teaching young wolves new tricks

2014-01-31
Wolves were domesticated more than 15,000 years ago and it is widely assumed that the ability of domestic dogs to form close relationships with humans stems from changes during the domestication ...

Gastric bypass improves insulin secretion in pigs

2014-01-31
The majority of gastric bypass patients mysteriously recover from their type 2 diabetes within days, before any weight loss has taken place. A study at Lund University Diabetes Centre in Sweden has now shown that the insulin-producing ...

Quicker method paves the way for atomic-level design

2014-01-31
A new X-ray method will enable the development of more efficient catalysts. The method opens up new opportunities to work on atomic level in a number of areas of materials science. Researchers from Lund University ...

Researchers identify 9 steps to save waterways

2014-01-31
The key to clean waterways and sustainable fisheries is to follow nine guiding principles of water management, says a team of Canadian biologists. Fish habitats need waterways that are rich in food with places ...

Cc to the brain: How neurons control fine motor behavior of the arm

2014-01-31
Motor commands issued by the brain to activate arm muscles take two different routes. As the research group led by Professor Silvia Arber at the University of Basel's Biozentrum and the Friedrich ...

Impaired cell division leads to neuronal disorder

2014-01-31
Prof. Erich Nigg and his research group at the Biozentrum of the University of Basel have discovered an amino acid signal essential for error-free cell division. This signal regulates the number of centrosomes in the cell, and ...

Vibrations influence the circadian clock of a fruit fly

2014-01-31
The internal circadian clock of a Drosophila (fruit fly) can be synchronised using vibrations, according to research published today in the journal Science. The results suggest that an animal's own movements ...

Quantum dots provide complete control of photons

2014-01-31
By emitting photons from a quantum dot at the top of a micropyramid, researchers at Linköping University are creating a polarized light source for such things as energy-saving computer screens and wiretap-proof communications. Polarized ...

Forensic experts compile guide on how to ID child abuse, starvation

2014-01-31
Forensic science experts from North Carolina State University have just published a comprehensive overview of forensic research that can be used to identify child abuse and starvation. "By ...

One planet, 2 stars: New research shows how circumbinary planets form

2014-01-31
Luke Skywalker's home planet Tatooine would have formed far from its current location in the Star Wars universe, a new University of Bristol study into its real world counterparts, ...

LAST 30 PRESS RELEASES:

SCAI expresses disappointment over ABMS decision to deny independent cardiovascular medicine boar

Rice researchers develop efficient lithium extraction method, setting stage for sustainable EV battery supply chains

Statement on ABMS denying new cardiovascular board

St. Jude scientists solve mystery of how the drug retinoic acid works to treat neuroblastoma

New device could allow you to taste a cake in virtual reality

Illinois researchers develop next-generation organic nanozymes and point-of-use system for food and agricultural uses

Kicking yourself: Going against one’s better judgment amplifies self-blame

Rice researchers harness gravity to create low-cost device for rapid cell analysis

Revolutionary copper-infused microvesicles: a new era in biofunctional medicine

Primary care practices with NPs are key to increasing health care access in less advantaged areas, Columbia Nursing study shows

TTUHSC conducting study to help patients that experience traumatic blood loss

Next top model: Competition-based AI study aims to lower data center costs

Innovative startup awarded $10,000 to tackle cardiovascular disparities

Study compares indoor transmission-risk metrics for infectious diseases

Micro-expression detection in ASD movies: a YOLOv8-SMART approach

Machine learning on blockchain: A new approach to engineering computational security

Vacuum glazing: A promising solution for low-carbon buildings

Racial and ethnic differences in out-of-pocket spending for maternity care

Study reveals racial and ethnic disparities in maternity care spending

Changes in food insecurity among US adults with low income during the COVID-19 pandemic

After NIH decision to cap indirect costs, prominent molecular biologist calls for swift action, petition signatures

Omitting race from lung function equations increases detection of asthma in Black children

The role of solute carrier family transporters in hepatic steatosis and hepatic fibrosis

Cold sore discovery IDs unknown trigger for those annoying flare-ups

Health organizations join forces on Rare Disease Day for idiopathic pulmonary fibrosis

How many languages can you learn at the same time? – Ghanaian babies grow up speaking two to six languages

Virginia Tech to lead $10 million critical mineral research coalition in Appalachia

CFRP and UHPC: New insights into strengthening reinforced concrete beams under thermocyclic distress

Armsworth receives SEC Faculty Achievement Award

Novel network dynamic approach presents new way for aeroengine performance evaluation

[Press-News.org] Report outlines progress, challenges in childhood cancer