PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Pattern of higher blood pressure in early adulthood helps predict risk of heart disease

2014-02-05
(Press-News.org) Contact information: Marla Paul
marla-paul@northwestern.edu
312-503-8928
The JAMA Network Journals
Pattern of higher blood pressure in early adulthood helps predict risk of heart disease In an analysis of blood pressure patterns over a 25-year span from young adulthood to middle age, individuals who exhibited elevated and increasing blood pressure levels throughout this time period had greater odds of having higher measures of coronary artery calcification (a measure of coronary artery atherosclerosis), according to a study in the February 5 issue of JAMA.

"Blood pressure (BP) represents a major modifiable risk factor for cardiovascular disease (CVD). Current risk prediction models take into account BP level only at the time of risk prediction, usually in middle or older age, and do not consider the potential effect of BP levels earlier in life or the changes in BP levels over time," according to background information in the article.

Norrina B. Allen, Ph.D., M.P.H., of the Feinberg School of Medicine, Northwestern University, Chicago, and colleagues identified common BP trajectories (patterns) throughout early adulthood and sought to determine their association with the presence of coronary artery calcification (CAC) during middle age among 4,681 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study. The participants were black and white men and women, 18 to 30 years of age at the beginning of the study in 1985-1986. Data were collected through 25 years of follow-up on systolic BP, diastolic BP, and mid-BP (calculated as [SBP+DBP]/2, an important marker of coronary heart disease risk among younger populations). The primary measured outcome for the study was a higher level of coronary artery calcification detected by computed tomography scan.

The researchers identified 5 distinct trajectories in mid-BP from young adulthood to middle age: 22 percent of participants maintained low BP throughout follow-up (low-stable group); 42 percent had moderate BP levels (moderate-stable group); 12 percent started with moderate BP levels which increased at an average age of 35 years (moderate-increasing group); 19 percent had relatively elevated BP levels throughout (elevated-stable group); and 5 percent started with elevated BP's which increased during follow-up (elevated-increasing group).

The prevalence of a high CAC score varied from 4 percent in the low-stable BP trajectory group to 25 percent in the elevated-increasing BP trajectory group. Participants who exhibited elevated BP levels throughout the study period and those who had increases in BP levels over this time had larger odds of having a high CAC score.

"Although BP has been a well-known risk factor for CVD for decades, these findings suggest that an individual's long-term patterns of change in BP starting in early adulthood may provide additional information about his or her risk of development of coronary calcium," the authors write. "Additional research is needed to examine the utility of specific BP trajectories in risk prediction for clinical CVD events and to explore the effect of lifestyle modification, treatment, and timing of intervention on lifetime trajectories in BP and outcomes." (doi:10.1001/jama.2013.285122; Available pre-embargo to the media at http://media.jamanetwork.com)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

There will also be a digital news release available for this study, including the JAMA Report video, embedded and downloadable video, audio files, text, documents, and related links. This content will be available at 3 p.m. CT Tuesday, February 4 at this link.

Editorial: Early Patterns of Blood Pressure Change and Future Coronary Atherosclerosis

Pantelis A. Sarafidis, M.D., M.Sc., Ph.D., of Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece, and George L. Bakris, M.D., of University of Chicago Medicine, comment on the findings of this study in an accompanying editorial.

"The study by Allen and colleagues presents a novel approach for assessing coronary heart disease and CVD risk, and the data offer an important perspective to support a preventive approach to reduce coronary heart disease risk by demonstrating the existence of widely different BP trajectories ranging from young adulthood through middle age … Further research is warranted to explore the associations of BP trajectories with development of advancing chronic kidney disease and heart failure and to provide novel tools for risk prediction to guide interventions for BP lowering in everyday practice." (doi:10.1001/jama.2013.285123; Available pre-embargo to the media at http://media.jamanetwork.com)

Editor's Note: Please see the article for additional information, including financial disclosures, funding and support, etc. ### END


ELSE PRESS RELEASES FROM THIS DATE:

Study shows potential usefulness of non-invasive measure of heart tissue scarring

2014-02-05
Scarring of tissue in the upper chamber of the heart (atrium) was associated with recurrent rhythm disorder after treatment, according to a study in the February 5 issue of JAMA. ...

Pre-term infants with severe retinopathy more likely to have non-visual disabilities

2014-02-05
In a group of very low-birth-weight infants, severe retinopathy of prematurity was associated with nonvisual disabilities at age 5 years, according to a study in the February ...

Do you have a sweet tooth? Honeybees have a sweet claw

2014-02-05
New research on the ability of honeybees to taste with claws on their forelegs reveals details on how this information is processed, according to a study published in the open-access journal, Frontiers in Behavioral Neuroscience. Insects ...

Clearer labels needed on drugs containing animal products

2014-02-05
Dr Kinesh Patel and Dr Kate Tatham say most medications prescribed in primary care contain animal derived products and it ...

Is institutional racism happening in our hospitals?

2014-02-05
Dr Nadeem Moghal, from George Eliot Hospital in Warwickshire, draws on the Macpherson report (the police ...

Time to act on mobile phone use while driving, say experts

2014-02-05
Charles and Barry Pless argue that, with a quarter of crashes in the United States now attributed to mobile phone use, "we can't wait for perfect evidence before ...

Largest evolutionary study of sponges sheds new light on animal evolution

2014-02-05
Sponges are an important animal for marine and freshwater ecology and represent a rich animal diversity ...

Orca's survival during the Ice Age

2014-02-05
In the ocean, the killer whale rules as a top predator, feeding on everything from seals to sharks. Being at the apex of the food chain, ...

How your memory rewrites the past

2014-02-05
CHICAGO --- Your memory is a wily time traveler, plucking fragments of the present and inserting them into the past, reports a new Northwestern Medicine® ...

Mediterranean diet linked with lower risk of heart disease among young US workers

2014-02-05
Boston, MA -- Among a large group of Midwestern firefighters, greater adherence to Mediterranean-style diet was associated with lower risk factors for cardiovascular disease ...

LAST 30 PRESS RELEASES:

Life after near death: Research reveals how to improve support for near-death experiencers

Illinois Chat is launched for campus community

FAU receives $3M federal grant to prevent substance use in at-risk youth

New report shows action to improve gender equity linked to career gains and better business performance

Kiwis could help manage chronic constipation

Breast, lung, and bladder cancer phase 3 trials led by Dana-Farber presented at ESMO Congress 2025

New open-source software allows for efficient 3D printing with multiple materials

Decoding the secrets of ‘chemo brain’

‘Far from negligible’: New Australian fossil fuel site will have major impact on people and the planet

UK heatwaves overwhelm natural ecological safeguards to increase wildfire risk

Key ExoMars Rover part ships from Aberystwyth

90% of Science Is Lost: Frontiers’ revolutionary AI-powered service transforms data sharing to deliver breakthroughs faster

Skin symptoms may forewarn mental health risks

Brain test predicts ability to achieve orgasm – but only in patients taking antidepressants

‘New reality’ as world reaches first climate tipping point

Non-English primary language may raise risk of delirium after surgery, study finds

Children fast from clear liquids much longer before surgery than guidelines recommend, large study shows

Food insecurity, loneliness can increase the risk of developing chronic pain after surgery

Cesarean delivery linked to higher risk of pain and sleep problems after childbirth

New global burden of disease study: Mortality declines, youth deaths rise, widening health inequities

Chemobiological platform enables renewable conversion of sugars into core aromatic hydrocarbons of petroleum

Individualized perioperative blood pressure management in patients undergoing major abdominal surgery

Proactive vs reactive treatment of hypotension during surgery

Different types of depression linked to different cardiometabolic diseases

Ketogenic diet may protect against stress experienced in the womb

Adults 65 years and older not immune to the opioid epidemic, new study finds

Artificial intelligence emerging as powerful patient safety tool in pediatric anesthesia

Mother’s ZIP code, lack of access to prenatal care can negatively impact baby’s health at birth, new studies show

American Society of Anesthesiologists honors John M. Zerwas, M.D., FASA, with Distinguished Service Award

A centimeter-scale quadruped piezoelectric robot with high integration and strong robustness

[Press-News.org] Pattern of higher blood pressure in early adulthood helps predict risk of heart disease