Cocaine may increase stroke risk within 24 hours of use

Abstract: WMP57 (Room Hall G)

2014-02-12

(Press-News.org) Cocaine greatly increases ischemic stroke risk in young adults within 24 hours of use, according to research presented at the American Stroke Association's International Stroke Conference 2014. Ischemic strokes occur when a blood vessel supplying blood to the brain becomes blocked, preventing a continuous supply of blood to the brain. "We set out to understand what factors contribute to stroke risk in young adults," said Yu-Ching Cheng, Ph.D., research scientist at Baltimore Veterans Affairs Medical Center and assistant professor of medicine at the University of Maryland School of Medicine. "These factors could be personal behaviors, medical or environmental factors, or genetic factors. "Cocaine use is one of the risk factors we investigated and we were surprised at how strong an association there is between cocaine and stroke risk in young adults. We found the stroke risk associated with acute cocaine use is much higher than some other stroke risk factors, such as diabetes, high blood pressure and smoking." Researchers compared 1,101 people 15 to 49 years old in the Baltimore-Washington, D.C. area who had strokes in 1991-2008 to 1,154 people of similar ages in the general population. More than a quarter of the people in both groups said they had a history of cocaine use, with men being twice as likely as women to report using the drug. Researchers found: Having a history of cocaine use wasn't associated with ischemic stroke, regardless of a person's gender or ethnicity; however, reported acute use of cocaine in the 24 hours prior to stroke was strongly associated with increased risk of stroke across different ethnicities. Participants were six to seven times more likely to suffer an ischemic stroke within 24 hours of cocaine use. This elevated stroke risk seemed similar in Caucasians and African-Americans. "Cocaine is not only addictive, it can also lead to disability or death from stroke," Cheng said. "With few exceptions, we believe every young stroke patient should be screened for drug abuse at the time of hospital admission. "Despite the strong stroke risk associated with acute cocaine use, in our study only about one-third of young stroke patients had toxicology screenings done during hospitalization. We think the percentage of cocaine use could be higher than we've reported." INFORMATION: Co-authors are Saad A. Qadwai, M.D.; Kathleen A. Ryan, M.P.H.; John W. Cole, M.D., M.S.; and Steven J. Kittner, M.D., M.P.H. Author disclosures are on the abstract. The National Institutes of Health, the Centers for Disease Control and Prevention and the Department of Veterans Affairs funded the study. Downloadable video/audio interviews, B-roll, animation and images related to this news release are on the right column of the release link at http://newsroom.heart.org/news/cocaine-may-increase-stroke-risk-within-24-hours-of-use?preview=67523230c5c6c59655862baae30128ca. Video clips with researchers/authors of the studies will be added to the release link after embargo.

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Statements and conclusions of study authors that are presented at American Stroke Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.heart.org/corporatefunding.

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Cocaine may increase stroke risk within 24 hours of use

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