(Press-News.org) NOS1 expression predicts melanoma-dependent immune dysfunction
Individuals with cancer often exhibit dysfunctional immune signaling in response to interferon (IFN) stimulation. Furthermore, recent evidence indicates that pSTAT-1 levels, which are indicative of IFN responsiveness, in circulating immune cells are predictive of clinical outcome in melanoma patients. In this issue of the Journal of Clinical Investigation, Qiuzhen Liu and colleagues at Southern Medical University, Guangzhou, China determined that melanoma cells have differing capacity to dampen IFN responses in peripheral blood mononuclear cells and that NOS1 expression is indicative of the inhibitory potential of a particular melanoma. In melanoma patient metastases there was an inverse relationship between NOS1 expression and patient response to adoptive T cell therapy. These findings establish a link between a melanoma specific factors and immune dysfunction and suggest that NOS1 expression can be used as a predictive biomarker in melanoma.
TITLE:
Melanoma NOS1 expression promotes dysfunctional IFN signaling
AUTHOR CONTACT:
Qiu-Zhen Liu
Southern Medical University, Guangzhou, CHN
Phone: 86.20.62789410; E-mail: liuqiuzhen@126.com
View this article at: http://www.jci.org/articles/view/69611
Murine model of glucocorticoid-induced glaucoma
Patients with inflammatory diseases, including allergy, asthma, and autoimmune disorders are often prescribed glucocorticoids; however, a subset of patients develop secondary glaucoma in response to treatment and must stop use of these beneficial steroid hormones. In this issue of the Journal of Clinical Investigation, Val Sheffield and colleagues at the University of Iowa developed a murine model of glucocorticoid-induced glaucoma in which topical administration of 0.1% dexamethasone to the eye produces clinical hallmarks of human disease, including a substantial increase in intraocular pressure (IOP), functional and structural loss of retinal ganglion cells, axonal degeneration, and ECM alterations within cells of the trabecular meshwork (TM). Evaluation of human TM cells revealed chronic ER stress in response to dexamethasone. Moreover, increased IOP in response to dexamethasone was prevented in animals lacking the ER stress-associated transcription factor CHOP or treated with the chemical chaperone sodium 4-phenylbutyrate. These results indicate that ER stress contributes to the etiology of glucocorticoid-induced glaucoma and suggest that reducing ER stress has therapeutic potential for relieving elevated IOP.
TITLE:
Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma
AUTHOR CONTACT:
Val C. Sheffield
Dept. Of Pediatrics, Iowa City, IA, USA
Phone: 319/335-6898 office; Fax: 319-335-7588; E-mail: val-sheffield@uiowa.edu
View this article at: http://www.jci.org/articles/view/69774
CELL BIOLOGY
TITLE:
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators
AUTHOR CONTACT:
Nicholas Katsanis
Duke University Medical Center, Durham, NC, USA
E-mail: katsanis@cellbio.duke.edu
View this article at: http://www.jci.org/articles/view/71898
HEMATOLOGY
TITLE:
Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis
AUTHOR CONTACT:
Daniel Simon
Case Western Reserve University School of, Cleveland, OH, USA
Phone: 216-844-8151; Fax: 216-983-3202; E-mail: Daniel.Simon@UHhospitals.org
View this article at: http://www.jci.org/articles/view/70966?key=5779faf807faaa6c6485
IMMUNOLOGY
TITLE:
Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE
AUTHOR CONTACT:
Markus Schwaninger
University of Luebeck, Luebeck, , DEU
Phone: +49-451-5002681; E-mail: markus.schwaninger@pharma.uni-luebeck.de
View this article at: http://www.jci.org/articles/view/72151
TITLE:
Laminins affect T cell trafficking and allograft fate
AUTHOR CONTACT:
Bryna Burrell
University of Maryland School of Medicine, Baltimore, MD, USA
Phone: 410 706 8070; E-mail: brynaeburrell@yahoo.com
View this article at: http://www.jci.org/articles/view/73683
NEUROSCIENCE
TITLE:
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis
AUTHOR CONTACT:
Heike Heuer
Leibniz Institute for Age Research/Fritz Lipmann Institute, Jena, UNK, DEU
Phone: 00493641656021; Fax: 00493641656335; E-mail: hheuer@fli-leibniz.de
View this article at: http://www.jci.org/articles/view/70324
ONCOLOGY
TITLE:
Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer
AUTHOR CONTACT:
Robert J. Coffey
Vanderbilt University Medical Center, Nashville, TN, USA
Phone: 615 343-6228; Fax: 615-343-1591; E-mail: robert.coffey@vanderbilt.edu
View this article at: http://www.jci.org/articles/view/71103
TITLE:
Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
AUTHOR CONTACT:
Gregory David
New York University School of Medicine, New York, NY, USA
Phone: 212-263-7111; E-mail: Gregory.David@nyumc.org
View this article at: http://www.jci.org/articles/view/72619
VIROLOGY
TITLE:
Cytomegalovirus pp65 limits dissemination but is dispensable for persistence
AUTHOR CONTACT:
Klaus Frueh
Oregon Health and Science University, Beaverton, OR, USA
Phone: 503 418 2735; Fax: 503 418 2722; E-mail: fruehk@ohsu.edu
View this article at: http://www.jci.org/articles/view/67420
INFORMATION: END
JCI Online ahead of print table of contents for April 1, 2014
2014-04-02
ELSE PRESS RELEASES FROM THIS DATE:
Scientists eager to participate in public discourse on environment
2014-04-02
A survey of more than 500 researchers indicates that scientists have the desire to get more involved in public discussion and policy decisions regarding environmental issues, but have concerns about how their efforts might be perceived.
"Scientists debate whether they have a role in advocacy," says Gerald Singh, a PhD student in the Institute for Resources, Environment and Sustainability at UBC, who conducted the survey with his colleagues. "Some feel they need to remain objective and can't engage. Others feel they have a duty to get involved so that decisions are made ...
Eyes in the cereal aisle -- how Cap'n Crunch's gaze is influencing your purchasing
2014-04-02
Director of Cornell's Food and Brand Lab Brian Wansink and post-doctoral lab researcher Aner Tal, are releasing a new study today published in the Journal of Environment and Behavior that discovered consumers are 16 percent more likely to trust a brand of cereal when the characters on the boxes on the supermarket shelves look them straight in the eye. Not surprisingly, the study also found that the gaze of characters on children's cereal boxes is at a downward, 9.6-degree angle, while characters on adult cereal boxes look almost straight ahead.
Wansink says:
"If you ...
Positive, negative thinkers' brains revealed
2014-04-02
EAST LANSING, Mich. --- The ability to stay positive when times get tough -- and, conversely, of being negative -- may be hardwired in the brain, finds new research led by a Michigan State University psychologist.
The study, which appears in the Journal of Abnormal Psychology, is the first to provide biological evidence validating the idea that there are, in fact, positive and negative people in the world.
"It's the first time we've been able to find a brain marker that really distinguishes negative thinkers from positive thinkers," said Jason Moser, lead investigator ...
Cereal box psychology
2014-04-02
Silly rabbit, Trix are for kids! In a study of 65 cereals in 10 different grocery stores, Cornell researchers found that cereals marketed to kids are placed half as high on supermarket shelves as adult cereals—the average height for children's cereal boxes is 23 inches verses 48 inches for adult cereal. A second key finding from the same study is that the average angle of the gaze of cereal spokes-characters on cereal boxes marketed to kids is downward at a 9.6 degree angle whereas spokes-characters on adult cereal look almost straight ahead.
To examine the influence ...
An easier, safer, and more accurate treatment for pancreatic cancer
2014-04-02
(Lebanon, NH, 4/2/14) — Using CT scans with contrast enhancement, Dartmouth researchers measured treatment response to pancreatic cancer photodynamic therapy (PDT) according to a paper published in Physics in Medicine and Biology.
The research team at Dartmouth set out to reduce the imaging obstacles for PDT, a minimally invasive and nontoxic treatment for cancer. "This study implies that treatment response can be reliably predicted using contrast CT. This would represent a major breakthrough in PDT for pancreas cancer that allows for easier, faster treatment tailored ...
Galactic serial killer
2014-04-02
Several clues in the structure of NGC 1316 reveal that its past was turbulent. For instance, it has some unusual dust lanes [1] embedded within a much larger envelope of stars, and a population of unusually small globular star clusters. These suggest that it may have already swallowed a dust-rich spiral galaxy about three billion years ago.
Also seen around the galaxy are very faint tidal tails — wisps and shells of stars that have been torn from their original locations and flung into intergalactic space. These features are produced by complex gravitational effects on ...
Colorado grandparents may be able to seek visitation or custody
2014-04-02
Colorado grandparents may be able to seek visitation or custody
Article provided by Littman Family Law
Visit us at http://www.davidlittmanpc.com
The relationship between a child and his or her grandparents can be a huge factor in that child's happiness. Grandparents spoil us, teach us about our family's history, give us practical skills and shower us with love.
In spite of the importance of the grandparent/grandchild relationship, in some circumstances, a grandparent is cut off from his or her grandchild because of a dispute or disagreement with the child's parent ...
Ohio employer charged in a payroll tax dispute
2014-04-02
Ohio employer charged in a payroll tax dispute
Article provided by Terrence A. Grady & Associates Co., L.P.A.
Visit us at http://www.tgradylaw.com
When one thinks of tax liability or tax evasion, he or she may first imagine an employee who failed to report earned income. However, legal responsibility comes in varied forms. For example, employers or managers responsible for deducting pay roll taxes could be under the microscope, too. It is the duty of such person to forward deducted taxes to the Internal Revenue Service (IRS). If one fails to do so, he or she ...
Fatalities from stroller accidents trigger new regulations
2014-04-02
Fatalities from stroller accidents trigger new regulations
Article provided by The Epstein Law Firm, P.A.
Visit us at http://www.theepsteinlawfirm.com
The Consumer Product Safety Commission issued a new safety standard for strollers in the United States. The changes were prompted by multiple reported amputations, lacerations and four fatalities since 2008.
Key changes aimed at reducing the risk of releasing a defective or dangerous product that could injure a child include:
-Braking systems. One of the reported lacerations occurred when a stroller rolled off ...
TrackResults Software is selected by Club Leisure Group
2014-04-02
Club Leisure Group, the largest timeshare sales and property management company in South Africa, has contracted to use TrackResults Software sales management analysis tools to keep track of its growing business. Leadership at Club Leisure wanted more flexible reporting, plus the ability to run instant analytics on their data without an additional burden to the IT Department.
Award-winning TrackResults Software, known around sales and marketing circles in the vacation ownership industry as being easy and ready-to-use with precise sales management analysis tools is used ...