Regular exercise beneficial in suppressing inflammation in rheumatic disease

Exercise results in physiological changes that decrease inflammation on a local and systemic level

2014-06-12

(Press-News.org) Research findings presented today at the European League Against Rheumatism Annual Congress (EULAR 2014) suggest that exercise transiently suppresses local and systemic inflammation, reinforcing the beneficial effects of exercise and the need for this to be regular in order to achieve clinical efficacy in rheumatic disease.

Chronic inflammation, swelling and pain in the joints characterise the more than 200 rheumatic diseases. Persistent inflammation over time can damage affected joints, but previous research has established that exercise can decrease joint inflammation in rheumatoid arthritis.

These new research findings focused on the physiological changes created by exercise and their impact on inflammation. The researchers have found that exercise generates a true biological response and induces changes on a molecular level that stimulate anti-inflammatory effects.

"As the inflammatory process in rheumatic diseases is a major cause of disability, we are excited to uncover the process by which exercise works on a molecular level to decrease this inflammation. Our results show the benefits that exercise could have in decreasing the great burden of rheumatic diseases. They also highlight the need for frequent exercise in order to create clinically significant results," said Dr. Nicholas Young, presenting author from The Ohio State University Wexner Medical Center, Columbus, Ohio, US.

This in-vivo study measured the regulation and activation of NF-kB* in mice. NF-kB, a protein complex that controls many genes involved in inflammation, is found to be chronically active in many inflammatory diseases, such as inflammatory bowel disease and arthritis.

An inflammatory response was created in mice both before and after exercise through an injection of lipopolysaccharides† (LPS). The impact of exercise was measured over time following the inflammatory response.

There was a strong systemic and local inflammatory response upon injection of LPS, which was strongest at 2 hours post-injection. NF-kB activation was seen as a result of the LPS and was detected in lymphatic tissues throughout the mouse. In those groups where mice were exercised pre- and post-LPS injection, the NF-kB activation was significantly inhibited in whole-body systemic analysis.

The effect of exercise on the inhibition of NF-kB activation was identified as a transient effect, lasting only 24 hours after exercise.

The role of exercise in inhibiting NF-kB activation was linked to the suppression of multiple pro-inflammatory cytokines. Cytokines are produced by a wide range of cells including macrophages and are involved in cell signalling. Rheumatic disease is a term used to describe over 200 conditions characterised by inflammation, swelling and pain in the joints or muscles. They are leading causes of morbidity and disability, giving rise to enormous healthcare expenditures and loss of work.

INFORMATION: Abstract Number: OP0109

NOTES TO EDITORS: For further information on this study, or to request an interview with the study lead, please contact us via: EULAR congress Press Office: Room 104, Palais des congrès de Paris Email: eularpressoffice@cohnwolfe.com Onsite tel: +44 (0) 7880 173209 Twitter: @EULAR_Press

About EULAR The European League Against Rheumatism (EULAR) is an umbrella organisation which represents scientific societies, health professional associations and organisations for people with rheumatic diseases throughout Europe.

EULAR aims to promote, stimulate and support the research, prevention, and treatment of rheumatic diseases and the rehabilitation of those it affects. With 45 scientific member societies, 35 People with Arthritis and Rheumatism in Europe (PARE) organisations, 17 health professionals associations and 26 corporate members, EULAR highlights the importance of combating rheumatic diseases through both medical means and patient care.

EULAR 2014 is set to be the biggest rheumatology event in Europe with almost 14,000 scientists, physicians, allied health professionals and related audiences in attendance from 130 countries. 1Over the course of the congress there will be 302 oral and 1,806 poster abstract presentations, 155 sessions, 725 lectures, 33 poster tours with 421 invited speakers. To find out more about the activities of EULAR, visit: http://www.eular.org

1 Blazek A, Knapik D, Young NA et al. Exercise suppresses systemic inflammation via inhibition of NF-KB activation in monocytes. EULAR 2014, Paris. OP0109 2 Monaco C, Andreakos E, Kiriakidis S, et al. Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc. Natl. Acad. Sci. U.S.A 2004; 101(15): 5634𔃇 3 World Health Organization. Chronic Rheumatic Conditions. http://www.who.int/chp/topics/rheumatic/en/ [Accessed 05/06/2014

* NF-kB is known in full as nuclear factor kappa-light-chain-enhancer of activated B cell

† Bacterial cell wall components that elicit a strong immune response

ELSE PRESS RELEASES FROM THIS DATE:

Cranial ultrasound may replace temporal artery biopsy in diagnosis of giant cell arteritis

2014-06-12

A new study presented for the first time today at the European League Against Rheumatism Annual Congress (EULAR 2014), shows that cranial ultrasound has a greater sensitivity than temporal artery biopsy,* and a comparable specificity in the diagnosis of Giant Cell Arteritis (GCA).1 Giant Cell Arteritis (GCA), a condition in which medium and large arteries mainly in the head and neck, become inflamed and narrowed, can cause blindness due to occlusion of the artery supplying the back of the eye. It is therefore essential that a prompt, accurate diagnosis of GCA is made ...

New study sheds light on what happens to 'cool' kids

2014-06-12

Teens who tried to act cool in early adolescence were more likely than their peers who didn't act cool to experience a range of problems in early adulthood, according to a new decade-long study. The study, by researchers at the University of Virginia, appears in the journal Child Development. While cool teens are often idolized in popular media—in depictions ranging from James Dean's Rebel Without a Cause to Tina Fey's Mean Girls—seeking popularity and attention by trying to act older than one's age may not yield the expected benefits, according to the study. Researchers ...

Toddlers whose parents use subsidies to buy center-based care more likely to enroll in Head Start

2014-06-12

Children of parents who use subsidies to purchase center-based care in the toddler years are more likely to be enrolled in Head Start or public prekindergarten in their preschool years, according to a new study. The research, conducted at Georgetown University and Columbia University, appears in the journal Child Development. The federally funded child care subsidy program—the Child Care and Development Fund (CCDF)—serves nearly 2 million children a month and is one of the government's biggest investments in the early care and education of low-income children. While the ...

Cancer drug boosts levels of vascular-protective gene, KLF2

2014-06-12

Case Western Reserve University researchers have discovered that an existing drug used to help cancer patients has the potential to protect thousands of others from the often-deadly impact of vascular clots. In 2008, the Food and Drug Administration approved bortezomib (Velcade) to treat multiple myeloma, which is a type of bone cancer and mantle cell lymphoma — a particularly aggressive form of non-Hodgkin lymphoma. In addition to attacking cancer cells, the drug has been shown to help prevent clot development common to many forms of the disease. As hematologist Lalitha ...

Childhood cancer survivors hospitalized frequently years after cancer treatment

2014-06-12

PHILADELPHIA — Survivors of childhood cancers were hospitalized more often and for longer durations because of blood disorders and other problems, many years after cancer treatment was completed, compared with the general population, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. "Our findings demonstrate that childhood cancer survivors face ongoing problems that can lead to hospitalization, even for those who are decades past their original cancer diagnosis. This can negatively ...

6,000 steps a day keeps knee OA limitations away

2014-06-12

A new study shows that walking reduces risk of functional limitation associated with knee osteoarthritis (OA). In fact, the study funded in part by grants from the National Institutes of Health (NIH) and published in the American College of Rheumatology (ACR) journal, Arthritis Care & Research, suggests that walking 6,000 or more steps per day may protect those with or at risk of knee of OA from developing mobility issues, such as difficulty getting up from a chair and climbing stairs. Nearly 27 million Americans age 25 and older are diagnosed with OA according to a ...

Low cholesterol linked with worse survival in patients with kidney cancer

2014-06-12

People are often told to reduce their cholesterol to improve their heart health, but new research suggests that low cholesterol may increase kidney cancer patients' risk of dying from their disease. The findings, which are published in BJU International, indicate that cholesterol testing may help doctors as they monitor and treat patients with kidney cancer. Increasing evidence suggests that alterations in cholesterol and other lipids are associated with the development, progression, and prognosis of various cancers. To assess the situation as it relates to kidney cancer, ...

Scientists weed out pesky poison ivy with discovery of killer fungus

2014-06-12

Much to the chagrin of gardeners, hikers, and virtually anyone enjoying the outdoors, one of the hazards of summer is picking up an itchy poison ivy rash. But researchers in the Virginia Tech College of Agriculture and Life Sciences have found a natural and effective way to kill poison ivy using a naturally occurring fungus that grows on the fleshy tissue surrounding the plant's seed, potentially giving homeowners and forest managers the ability to rid landscapes of the pernicious pest. Their findings could make the maddening itch of the summer season a thing of the ...

Content kingmaker -- quality or webpage position?

2014-06-12

In today's Information Age, it's easy get overwhelmed by online content. On YouTube alone, over 100 hours worth of video is uploaded every minute. Showcasing the most interesting content allows providers to convey a certain level of quality to its audiences and encourages users to stay on the website, consuming content and winning advertising dollars for its provider. However, this influx of information makes it difficult for both content providers and users to determine what is interesting and worth consuming. Due to the sheer volume of submitted content, some providers ...

Spectrum Health among first to implant neurostimulator for epilepsy

2014-06-12

GRAND RAPIDS, Mich., June 11, 2013 – Spectrum Health is the first health system in Michigan and among the first in the nation to successfully implant a recently FDA-approved device that uses electric stimulation of the brain to treat adult epilepsy patients whose seizures have not responded to medication. The NeuroPace® Responsive Neurostimulation (RNS®) System is an implantable therapeutic device designed to detect abnormal electrical activity in the brain and respond by delivering imperceptible electrical stimulation to normalize brain activity before an individual ...

UK study shows there is less stigma against LGBTQ people than you might think, but people with mental health problems continue to experience higher levels of stigma

Regular exercise beneficial in suppressing inflammation in rheumatic disease

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: