(Press-News.org) CHICAGO, IL—Obese patients with Type 2 diabetes who don't have excessive surgical risk may find that Roux-en-Y gastric bypass (RYGB) surgery can help them reduce their risk of heart disease, a new clinical trial shows. The results were presented Tuesday at ICE/ENDO 2014, the joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago.
"There is emerging evidence highlighting the potential health benefits of bariatric surgery in managing obese patients with Type 2 diabetes. In the past, lifestyle advice and medications provided the mainstay of treatment for this group of patients, but despite the substantial improvements in pharmacotherapy for adults with Type 2 diabetes, many patients still do not achieve targeted health goals," said lead author Su Ann Ding, MBBS, a research fellow at Joslin Diabetes Center in Boston, Massachusetts.
"Roux-en-Y gastric bypass surgery is an acceptable therapeutic option for risk reduction in heart disease in obese patients with Type 2 diabetes in whom surgical risk is not excessive," she said.
To compare the benefits of RYGB surgery with lifestyle and medication modification in these patients, the researchers conducted the randomized prospective SLIMM-T2D clinical trial in Boston.
They recruited 38 obese patients between 21 and 65 years of age who had at least one year of established Type 2 diabetes, a body mass index between 30 and 42 kg/m2, a strong desire for substantial weight loss and a commitment to life-long medical and nutritional follow up. The study participants did not have active cardiovascular or other diseases that would prevent them from exercising safely or undergoing a bariatric surgical procedure and had not smoked for over two months.
The researchers randomly assigned all patients to either have Roux-en-Y gastric bypass surgery at Brigham and Women's Hospital, or to take part in a medical diabetes and weight management program at the Joslin Diabetes Center.
Patients in the medical treatment group enrolled in Joslin's comprehensive Weight Achievement and Intensive Treatment (Why WAIT) program, and worked with an endocrinologist, a registered dietician, an exercise physiologist, a mental health provider, and a certified diabetes nurse educator. For the first 12 weeks, they took part in two-hour weekly group sessions and they followed this with monthly individual counseling.
Patients in both groups lost significant weight and kept it off for 2 years, but the surgical group lost more. The Roux-en-Y group lost roughly 57 pounds on average (25% of their initial body weight) compared with the lifestyle and medication modification group's 13 pounds (6% of their initial body weight). The surgical group also showed better improvements in blood sugar control, blood pressure and cholesterol levels, all of which helped them reduce their risk of developing coronary heart disease.
INFORMATION:
National Institute of Diabetes and Digestive and Kidney Diseases, a branch of the National Institute of Health principally supported the trial. Covidien; Lifescan, a Division of Johnson & Johnson; Nestlé Nutrition, Inc.; Novo Nordisk; and Mercodia provided additional support.
Founded in 1916, the Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, the Endocrine Society's membership consists of over 17,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Washington, DC. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.
Roux-en-Y gastric bypass surgery may reduce heart disease risk
2014-06-24
ELSE PRESS RELEASES FROM THIS DATE:
Sleep, mood improves after substantial weight loss
2014-06-24
CHICAGO, IL—Obese adults who lose at least 5 percent of their body weight report that they sleep better and longer after six months of weight loss, according to a new study. The results were presented Tuesday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.
"This study confirms several studies reporting that weight loss is associated with increased sleep duration," said the study's lead investigator, Nasreen Alfaris, MD, MPH, a fellow in the Department of Medicine at the Perelman School of Medicine ...
Gastric bypass surgery improves diabetic patients' quality of life
2014-06-24
CHICAGO, IL—An intensive weight loss program involving lifestyle modifications improves obese diabetic patients' physical and mental health as well as gastric bypass surgery does over two years, but the weight loss surgery leads to a greater reduction in adverse effects of obesity on quality of life. These results, from a new study in patients with Type 2 diabetes, were presented Tuesday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.
Gastric bypass also led to patients having a somewhat greater reduction ...
Synthetic triterpenoids show promise in preventing colitis-associated colon cancer
2014-06-24
Researchers from Case Western Reserve and Dartmouth universities have shown that a class of small antioxidant molecules carries enormous promise for supressing colon cancer associated with colitis. These findings, published in an early June edition of the Journal of Clinical Investigation, offer hope that physicians ultimately will be able to reduce dramatically the number of sufferers of this inflammatory bowel disease (IBD) who go on to develop colon cancer.
The molecules, known as synthetic triterpenoids, appear to achieve their positive effect in two ways. First, ...
Helpful bouncing babies show that moving together to music builds bonds
2014-06-24
HAMILTON, ON, June 24, 2014 — Whether they march in unison, row in the same boat or dance to the same song, people who move in time with one another are more likely to bond and work together afterward.
It's a principle established by previous studies, but now researchers at McMaster University have shown that moving in time with others even affects the social behavior of babies who have barely learned to walk.
"Moving in sync with others is an important part of musical activities," says Laura Cirelli, lead author of a paper now posted online and scheduled to appear ...
Food scientists working to diminish, mask bitter tastes in foods
2014-06-24
Food scientists are working to block, mask and/or distract from bitter tastes in foods to make them more palatable to consumers, many of whom are genetically sensitive to bitter tastes, according to a new presentation at the 2014 Institute of Food Technologists (IFT) Annual Meeting & Food Expo® in New Orleans.
"Many factors go into why we eat what we do," said John Hayes, PhD, assistant professor of food science and director of the Sensory Evaluation Center at Pennsylvania State University, with taste consistently ranking as number one. There's also "a huge variability ...
Not everyone wants cheering up, new study suggests
2014-06-24
You may want to rethink cheering up your friends who have low self-esteem because chances are they don't want to hear it.
People with low self-esteem have overly negative views of themselves, and often interpret critical feedback, romantic rejections, or unsuccessful job applications as evidence of their general unworthiness. A new study from researchers at the University of Waterloo and Wilfrid Laurier University found that they likely don't want you to try to boost their spirits.
"People with low self-esteem want their loved ones to see them as they see themselves. ...
Metal particles in solids aren't as fixed as they seem, new memristor study shows
2014-06-24
ANN ARBOR—In work that unmasks some of the magic behind memristors and "resistive random access memory," or RRAM—cutting-edge computer components that combine logic and memory functions—researchers have shown that the metal particles in memristors don't stay put as previously thought.
The findings have broad implications for the semiconductor industry and beyond. They show, for the first time, exactly how some memristors remember.
"Most people have thought you can't move metal particles in a solid material," said Wei Lu, associate professor of electrical and computer ...
Researchers at Intermountain Medical Center develop new smartphone technology and app to diagnose and monitor adrenal gland diseases
2014-06-24
Diseases of the adrenal gland have long been difficult to diagnose. But now, researchers have found an affordable and easy way to diagnose and monitor endocrine diseases of the adrenal gland by using saliva and a smartphone.
Researchers at Intermountain Medical Center in Murray, Utah, have developed new smartphone technology to help screen patients for a number of adrenal gland diseases, including Cushing's syndrome. The new tool also helps to identify adrenal insufficiency, monitor cortisol replacement and assess physiologic changes in adrenal function.
Adrenal diseases ...
To advance care for patients with brain metastases: Reject five myths
2014-06-24
New York, NY – A blue-ribbon team of national experts on brain cancer says that professional pessimism and out-of-date "myths," rather than current science, are guiding -- and compromising -- the care of patients with cancers that spread to the brain.
In a special article published in the July issue of Neurosurgery, the team, led by an NYU Langone Medical Center neurosurgeon, argues that many past, key clinical trials were designed with out-of-date assumptions and the tendency of some physicians to "lump together" brain metastases of diverse kinds of cancer, often results ...
Mayo Clinic researchers say gene in brain linked to kidney cancer
2014-06-24
JACKSONVILLE, Fla. — A gene known to control brain growth and development is heavily involved in promoting clear cell renal cell carcinoma, the most common form of kidney cancer, researchers from Mayo Clinic in Florida are reporting.
Their study, published in Cancer Research, reveals that the gene NPTX2, plays an essential role in this cancer type, which is resistant to common chemotherapy and has a five-year overall survival rate of less than 10 percent in patients with metastatic disease.
MULTIMEDIA ALERT: Video and audio are available for download on the Mayo Clinic ...