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Penn study: Incisionless transcatheter aortic valve replacement surgery cuts hospital length of stay

2014-07-24
(Press-News.org) PHILADELPHIA – New research from Penn Medicine shows that incisionless transcatheter aortic valve replacement (TAVR) surgery cuts length of hospital stay by 30 percent and has no impact on post-operative vascular complication rates when compared with conventional transfemoral TAVR, which requires an incision in the groin. The complete study is available in the current issue of Circulation: Cardiovascular Interventions.

TAVR involves the replacement of the aortic valve without a traditional open-heart surgical approach. It is a treatment for aortic stenosis, a narrowing of the aortic valve opening. The surgery can be performed in two ways, both involving the insertion of a sheath into the femoral artery which allows the new valve to be threaded up to the patient's chest via a catheter. The traditional transfemoral approach requires a several inch incision in the groin. More recently, physicians have begun to employ an incisionless or percutaneous approach, which requires no more than a pin-prick to access the femoral artery. Patients leave the hospital without an incision of any kind and little to no trace that a surgery was performed.

"It has been our clinical experience that there is little difference in vascular outcomes between traditional and percutaneous TAVR surgery but we wanted to take a closer look at the data and understand how these techniques performed in a side by side comparison on vascular complications, outcomes and hospital length of stay," says senior author Jay Giri, MD, MPH, assistant professor in the division of Cardiovascular Medicine at the Perelman School of Medicine at the University of Pennsylvania.

Giri and his co-authors examined 120 patients who underwent TAVR via the traditional method and 211 patients who had percutaneous TAVR surgery at the Hospital of the University of Pennsylvania or Penn Presbyterian Medical Center between 2007 and 2013. They observed a shorter postprocedural length of hospital stay (7.5 versus 9.9 days) in patients who received percutaneous surgery versus traditional TAVR surgery and no difference in vascular complication rates between the two procedures.

Vascular complications can include hematomas, large bruises under the skin; dissections, tears in the vessel walls putting the vessels at risk for closure; and the rupture of blood vessels, among others. The Penn researchers discovered that vascular complications were tied to the sex of the patient, with females appearing to be at greater risk of complications than males. This issue will be the subject of further research.

Higher rates of vascular complications were also associated with larger valve introducer sheath outer diameter compared with patients' artery diameter. The "introducer" sheaths can easily nick or disrupt the vessels in transit and cause complications for the patient, whether they have traditional or percutaneous surgery. "While there are clinical circumstances when oversized sheaths must be used to accomplish a life-saving procedure, we discovered that, contrary to conventional wisdom, there really is no such thing as a 'safe oversize', says Giri."

Previous studies had not examined the association of percutaneous and traditional surgery approaches with vascular complications in a wide cross section of patients with the full range of sheath sizes available in the US. This is also the first study to show increasing harm with increasing sheath oversizing. Vascular complication rates are expected to decrease as technology advances and sheath sizes continue to decrease in relation to artery diameter. Currently, however, the authors warn, careful preprocedural planning with respect to the relationship between sheath size and artery diameter is warranted.

INFORMATION: Additional Penn authors include Mitul B. Kadakia, Howard C. Herrmann, Nimeshi D. Desai, Zachary Fox, Jeffrey Ogbara, Saif Anwaruddin, Dinesh Jagasia, Joseph E. Bavaria, Wilson Szeto, Prashanth Vallabhajosyula, Robert Li, Rohan Menon and Dale M. Kobrin. Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise. The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 17 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $392 million awarded in the 2013 fiscal year. The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; Chester County Hospital; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine. Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2013, Penn Medicine provided $814 million to benefit our community.


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[Press-News.org] Penn study: Incisionless transcatheter aortic valve replacement surgery cuts hospital length of stay