(Press-News.org) Adult mesenchymal stem cells, specifically adipose-derived stem cells have self-renewal and multiple differentiation potentials and have shown to be the ideal candidate for therapeutic applications in regenerative medicine, particularly in peripheral nerve regeneration. Adipose-derived stem cells are easily harvested, although they may show the effects of aging, hence their potential in nerve repair may be limited by cellular senescence or donor age. Cellular senescence is a complex process whereby stem cells grow old as consequence of intrinsic events (e.g., DNA damage) or environmental cues (e.g., stressful stimuli or diseases), which determine a permanent growth arrest. Prof. Magnaghi and his team from University of Milan in Italy reported some of the most important factors modulating the senescence process, which can influence adipose-derived stem cell morphology and function, and compromise their clinical application for peripheral nerve regenerative cell therapy. These findings, published in the Neural Regeneration Research (Vol. 9, No. 1, 2014).
Article: " Senescence in adipose-derived stem cells and its implications in nerve regeneration " by Cristina Mantovani1 , Giorgio Terenghi2, Valerio Magnaghi1 (1 Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy 2 Blond McIndoe Laboratories, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK)
Mantovani C, Terenghi G, Magnaghi V. Senescence in adipose-derived stem cells and its implications in nerve regeneration. Neural Regen Res. 2014;9(1):10-15.
Contact: Meng Zhao
Neural Regeneration Research
Senescence in adipose-derived stem cells and its implications in nerve regeneration
ELSE PRESS RELEASES FROM THIS DATE:
A new way to generate insulin-producing cells in Type 1 diabetes
VIDEO: Researchers discover a simple peptide that can induce new beta-cell formation in the pancreas. The findings show promise for a new approach to treating Type 1 diabetes. Click here for more information. La Jolla, Calif., July 31, 2014 -- A new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has found that a peptide called caerulein can convert existing cells in the pancreas into those cells destroyed in type 1 diabetes-insulin-producing ...
Researchers uncover cause of gum disease related to type 2 diabetes
Going to the dentist isn't fun for anyone, but for those with periodontal disease related to type 2 diabetes, a new research discovery may have them smiling. In a report appearing in the August 2014 issue of the Journal of Leukocyte Biology, one of the most important blood cells involved in the human immune response, B cells, are shown to promote inflammation and bone loss in type 2 diabetes-associated periodontal disease. These findings support the idea that treatments that manipulate the responses of B cells may treat or prevent this complication. "Our study identified ...
Breakthrough in understanding of important blood protein
The human body contains a unique protein that has the unusual property of destroying itself after a few hours of existence - it must therefore be continually recreated and is no stable protein. The protein, called PAI-1, affects many physiological functions, including the dissolving of coagulated blood. If you get a blood clot, it is due to the fact that the a clot has accumulated in a blood vessel, and therefore PAI-1 is extremely important – for the human body's survival in general and for helping people with a blood clot or other blood diseases in which coagulation plays ...
Common drugs adversely impair older adults' physical as well as cognitive functioning
INDIANAPOLIS -- A class of medications previously linked to cognitive impairment in older adults also appears to negatively affect their physical functioning according to investigators from the Regenstrief Institute, the Indiana University Center for Aging Research, the University of East Anglia and several other United Kingdom institutions. In a systemic review of more than a decade of studies on the effects of drugs with anticholinergic properties, they report that these drugs have a significant adverse effect on both cognitive and physical functioning, including the ...
Research finds numerous unknown jets from young stars and planetary nebulae
For many years astronomers have known that young 'protostars' drive supersonic jets of gas from their north and south poles. However, this is the first time that so many of them have been detected at once. The results come from a five year survey undertaken with the UK Infra-Red Telescope and are expected to prompt significant changes in the understanding of the planetary nebulae population in the Galaxy, as well as the properties of jets ejected from young forming stars. By examining images of excited hydrogen molecules at infrared wavelengths, scientists have been ...
The Rim Fire 1 year later: A natural experiment in fire ecology and management
The enormous conflagration known as the Rim Fire was in full fury, raging swiftly from crown to crown among mature trees, when it entered the backcountry of Yosemite National Park in California's Sierra Nevada in late August 2013. But inside the park, the battle began to turn, enacting a case study in the way management decisions and drought can combine to fuel large, severe fires. "When the Rim Fire hit the park, it eventually encountered lands where fire had been used as a management tool, rather than immediately suppressed," said Hugh Safford, a regional ecologist ...
Congressional rift over environment influences public
American citizens are increasingly divided over the issue of environmental protection and seem to be taking their cue primarily from Congress, finds new research led by a Michigan State University scholar. The gap between conservatives who oppose environmental protection and liberals who support it has risen drastically in the past 20 years, a trend seen among lawmakers, activists and – as the study indicates – the general public as well, said sociologist Aaron M. McCright. The findings echo a June 12 Pew Research Center poll showing that, in general, Republicans and ...
Surgeons report significant migraine relief from cosmetic eyelid surgery technique
New Orleans, LA – Dr. Oren Tessler, Assistant Professor of Clinical Surgery at LSU Health Sciences Center New Orleans School of Medicine, is part of a team of plastic and reconstructive surgeons who report a high success rate using a method to screen and select patients for a specific surgical migraine treatment technique. More than 90% of the patients who underwent this surgery to decompress the nerves that trigger migraines experienced relief and also got a bonus cosmetic eyelid surgery. The study, which confirms the benefit of surgical treatment for migraines and expands ...
Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures
BLOOMINGTON, Ind. -- Chemists at Indiana University Bloomington have described the self-assembly of large, symmetrical molecules in bricks-and-mortar fashion, a development with potential value for the field of organic electronic devices such as field-effect transistors and photovoltaic cells. Their paper, "Anion-Induced Dimerization of 5-fold Symmetric Cyanostars in 3D Crystalline Solids and 2D Self-Assembled Crystals," has been published online by Chemical Communications, a journal of the Royal Society of Chemistry. It is the first collaboration by Amar Flood, the James ...
Women in military less likely to drink than civilian women
Los Angeles, CA (August 1, 2014) While it is known that members of the U.S. military overall are more likely to use alcohol, a new study finds that female enlistees and female veterans are actually less likely to drink than their civilian counterparts. This study was published today in Armed Forces & Society, a SAGE journal published on behalf of the Inter-University Seminar on Armed Forces and Society. Researchers Jay Teachman, Carter Anderson, and Lucky Tedrow studied surveys of nearly 9,000 men and women who were currently members of the U.S. military or who were military ...