PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Hypoglycemia link to HbA1c has declined in type 1 diabetes

2014-10-07
(Press-News.org) The link between low average glucose blood levels and greater risk for severe hypoglycemia and hypoglycemic coma substantially declined between 1995 and 2012 in young Germans and Austrians with type 1 diabetes, according to a study published by Beate Karges and colleagues from the RWTH Aachen University, Germany in this week's PLOS Medicine.

The researchers obtained measurements of average blood glucose levels (measured as HbA1c) and the incidents of severe hypoglycemia and hypoglycemic coma from 37,539 children and young adults with type 1 diabetes between 1995 and 2012 in Austria and Germany. From 1995 to 2012, the relative risk for severe hypoglycemia and hypoglycemic coma per 1% decrease in HbA1c levels declined from 1.28 to 1.05 for severe hypoglycemia and from 1.39 to 1.01 for coma, corresponding to a drop in risk of 1.2% and 1.9% each year, respectively. This decrease mainly occurred because of substantial reductions in the risk of hypoglycemia in patients with lower average blood glucose levels measured as HbA1c between 6.0% and 7.9%.

While the study does not examine the causes of this reduction, the authors do note that the use of insulin analogs and of insulin pumps increased and there was an increase in how often patients monitored their blood glucose level over this time period.

The authors say: "The previously strong association of low HbA1c with severe hypoglycemia and coma in young individuals with type 1 diabetes has substantially decreased in the last decade, allowing achievement of near-normal glycemic control in these patients."

INFORMATION: Research Article

Funding: This work was supported by the Competence Network for Diabetes Mellitus, funded by the BMBF Federal Ministry of Education and Research (FKZ01GI1106 and 01GI1109B), Berlin, Germany; and the European Foundation for the Study of Diabetes. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

Citation: : Karges B, Rosenbauer J, Kapellen T, Wagner VM, Schober E, et al. (2014) Hemoglobin A1c Levels and Risk of Severe Hypoglycemia in Children and Young Adults with Type 1 Diabetes from Germany and Austria: A Trend Analysis in a Cohort of 37,539 Patients between 1995 and 2012. PLoS Med 11(10): e1001742.doi:10.1371/journal.pmed.1001742

Author Affiliations: RWTH Aachen University, GERMANY German Diabetes Center, Leibniz Center at University of Dusseldorf, GERMANY University of Leipzig, GERMANY University of Lubeck, GERMANY Medical University of Vienna, AUSTRIA University of Ulm, GERMANY



Contact: Beate Karges
RWTH Aachen University
GERMANY
+49 241 8080867
bkarges@ukaachen.de


ELSE PRESS RELEASES FROM THIS DATE:

Oral chelation for environmental lead toxicity

2014-10-07
Treatment with dimercaptosuccinic acid (DMSA), an oral chelation agent, was linked to reductions in the amount of lead in blood in young children in Zamfara State, Nigeria following environmental lead contamination, according to a study by Jane Greig and colleagues from Médecins Sans Frontières (MSF) published in this week's PLOS Medicine. The researchers report findings from an MSF program initiated in May 2010 to reduce lead poisoning in children following widespread environmental lead contamination due to gold mining in Zamfara State, Nigeria, leading to ...

How female flies know when to say 'yes'

2014-10-07
A fundamental question in neurobiology is how animals, including humans, make decisions. A new study publishing in the open access journal PLOS Biology on October 7 reveals how fruit fly females make a very important decision: to either accept or reject male courtship. This decision appears to be generated by a very small number of excitatory neurons that use acetylcholine as their neurotransmitter located in three brain regions. This study provides the framework to understand how decisions are generated and suggests that a decision is reached because that option is literally ...

New at-risk group identified for gastrointestinal stromal tumors

New at-risk group identified for gastrointestinal stromal tumors
2014-10-07
Researchers at the University of California, San Diego School of Medicine have, for the first time, clearly defined the epidemiology of gastrointestinal stromal tumors (GIST), which occur primarily in the lining of the stomach and small intestine. One key finding: Patients of Asian descent, who have not previously been identified as an at-risk population, are 1.5 times more likely than other patient groups to be diagnosed with this type of tumor. Results of the study were published this week in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association ...

George Washington physician addresses stigma against patients and providers with disabilities

2014-10-07
WASHINGTON (Oct. 7, 2014) — Nearly 20 percent of Americans have a disability, yet only 25 percent of medical schools include in their curricula caring for people with disabilities. Numerous reports have documented that people with disabilities have poorer health and receive inferior care. In a Narrative Matters essay published in Health Affairs, Leana Wen, M.D., director of patient-centered care research and assistant professor of emergency medicine at the George Washington University School of Medicine and Health Sciences, shares her own experiences to highlight ...

Survival molecule helps cancer cells hide from the immune system

2014-10-07
COLUMBUS, Ohio – A molecule that helps cancer cells evade programmed self-destruction, an internal source of death, might also help malignant cells hide from the immune system, an external source of death. A new study by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) shows that a molecule called nuclear factor kappa B (NF-kB) helps cancer cells by inhibiting the immune system's ability to detect and destroy them. The molecule regulates genes ...

Researchers identify 'Achilles heel' in metabolic pathway that could lead to new cancer treatment

Researchers identify Achilles heel in metabolic pathway that could lead to new cancer treatment
2014-10-07
DALLAS – Oct. 7, 2014 – Researchers at UT Southwestern Medical Center have found an "Achilles heel" in a metabolic pathway crucial to stopping the growth of lung cancer cells. At the heart of this pathway lies PPARγ (peroxisome proliferation-activated receptor gamma), a protein that regulates glucose and lipid metabolism in normal cells. Researchers demonstrated that by activating PPARγ with antidiabetic drugs in lung cancer cells, they could stop these tumor cells from dividing. "We found that activation of PPARγ causes a major metabolic ...

State policies can influence access to heroin treatment, study finds

2014-10-07
State policies can influence the number of physicians licensed to prescribe buprenorphine, a drug that can treat addiction to heroin and other opioids in outpatient settings, according to a new RAND Corporation study. Examining county-level numbers of physicians approved to prescribe buprenorphine, researchers found a significant link between the number of approved physicians and both specific state guidance regarding the use of buprenorphine and the distribution of clinical guidelines for buprenorphine treatment. The findings were published online by the Journal of ...

Sleeping in dentures doubles the risk of pneumonia in the elderly

2014-10-07
Alexandria, Va., USA – Poor oral health and hygiene are increasingly recognized as major risk factors for pneumonia among the elderly. To identify modifiable oral health-related risk factors, lead researcher Toshimitsu Iinuma, Nihon University School of Dentistry, Japan, and a team of researchers prospectively investigated associations between a constellation of oral health behaviors and incidences of pneumonia in the community-living of elders 85 years of age or older. This study, titled "Denture Wearing During Sleep Doubles the Risk of Pneumonia in Very Elderly," ...

The sex difference in distance running has disappeared for participation but not for competitiveness

The sex difference in distance running has disappeared for participation but not for competitiveness
2014-10-07
ALLENDALE, Mich. — Even among contemporary U.S. distance runners, men are still much more likely than women to have a competitive orientation, according to researchers at Grand Valley State University in Allendale, Michigan. The findings were published in the online journal, Evolutionary Psychology at http://www.epjournal.net/articles/u-s-masters-track-participation-reveals-a-stable-sex-difference-in-competitiveness/ The new research, led by Robert Deaner, associate professor of psychology at Grand Valley State, shows that, on average, American men participate at ...

Live and let-7: MicroRNA plays surprising role in cell survival

Live and let-7: MicroRNA plays surprising role in cell survival
2014-10-07
Researchers at the University of California, San Diego School of Medicine have identified a microRNA molecule as a surprisingly crucial player in managing cell survival and growth. The findings, published in the October 7 issue of Cell Metabolism, underscore the emerging recognition that non-coding RNAs – small molecules that are not translated into working proteins – help regulate basic cellular processes and may be key to developing new drugs and therapies. Specifically, principal investigator Albert R. La Spada, MD, PhD, professor of cellular and molecular ...

LAST 30 PRESS RELEASES:

Rare combination of ovarian tumors found in one patient

AI-driven clinical recommendations may aid physician decision making to improve quality of care

Artificial intelligence has potential to aid physician decisions during virtual urgent care

ACP and Annals of Internal Medicine present breaking scientific news at ACP’s Internal Medicine Meeting 2025

New study reveals polymers with flawed fillers boost heat transfer in plastics

Signs identified that precede sudden arrhythmic death syndrome in young people

Discovery of bacteria's defence against viruses becomes a piece of the puzzle against resistance

Pre-eclampsia is associated with earlier onset and higher incidence of cardiovascular risk factors

Warwick astronomers discover doomed pair of spiralling stars on our cosmic doorstep

Soil conditions significantly increase rainfall in world’s megastorm hotspots

NK cells complexed with bispecific antibody yield high response rates in patients with lymphoma

Planetary health diet and mediterranean diet associated with similar survival and sustainability benefits

Singapore launches national standard to validate antimicrobial disinfectant products

Molecular stool test could improve detection of tuberculosis in adults with HIV

Suspected fibrocartilaginous embolus in Asian small-clawed otter (Aonyx cinereus)

Enhancing heat transfer using the turbulent flow of viscoelastic fluids

Exercise as an anti-ageing intervention to avoid detrimental impact of mental fatigue

UMass Amherst Nursing Professor Emerita honored as ‘Living Legend’

New guidelines aim to improve cystic fibrosis screening

Picky eaters by day, buffet by night: Butterfly, moth diets sync to plant aromas

Pennington Biomedical’s Dr. Leanne Redman honored with the E. V. McCollum Award from the American Society for Nutrition

CCNY physicists uncover electronic interactions mediated via spin waves

Researchers’ 3D-printing formula may transform future of foam

Nurture more important than nature for robotic hand

Drug-delivering aptamers target leukemia stem cells for one-two knockout punch

New study finds that over 95% of sponsored influencer posts on Twitter were not disclosed

New sea grant report helps great lakes fish farmers navigate aquaculture regulations

Strain “trick” improves perovskite solar cells’ efficiency

How GPS helps older drivers stay on the roads

Estrogen and progesterone stimulate the body to make opioids

[Press-News.org] Hypoglycemia link to HbA1c has declined in type 1 diabetes