Institutional rearing may increase risk attention-deficit disorder

Reports new study in Biological Psychiatry

2014-10-14

(Press-News.org) Philadelphia, PA, October 14, 2014 – Over the past decades, we have seen numerous tragic examples where the failure of institutions to meet the needs of infants for social contact and stimulation has led to the failure of these infants to thrive.

Infancy and childhood are critical life periods that shape the development of the cortex. A generation of research suggests that enriched environments, full of interesting stimuli to explore, promote cortical development and cognitive function. In contrast, deprivation and stress may compromise cortical development and attenuate some cognitive functions.

Young children who are raised in environments of psychosocial neglect, such as those who grow up in institutions for orphaned or abandoned children, are at markedly elevated risk for developing a wide range of mental health problems, including attention-deficit/hyperactivity disorder (ADHD).

Now, new data from the Bucharest Early Intervention Project (BEIP), published in the current issue of Biological Psychiatry, suggests that this type of deprived early environment is associated with drastic changes in brain development in children.

BEIP is a longitudinal study that has followed a sample of children raised from early infancy in institutions in Romania. The authors of the current report used data from 58 of those children and compared it with 22 typically-reared children from the same community. All children underwent a structural imaging scan and were assessed for symptoms of ADHD.

The researchers discovered that children raised in institutional settings exhibited widespread reductions in cortical thickness in multiple brain regions including the prefrontal, parietal, and temporal cortices relative to children raised in families in the community.

The data also revealed that the reduced cortical thickness in several of those same brain regions was associated with greater ADHD symptoms of inattention and impulsivity.

This is consistent with previous research that has implicated those brain regions in regulating attention, memory, and other vital cognitive processes.

"Perhaps most importantly, the new findings indicate that the high rates of ADHD among children raised in these deprived environments are explained, in part, by these atypical patterns of brain development," explained first author Dr. Katie McLaughlin, Assistant Professor at the University of Washington.

"These disturbing data provide a mechanism that links institutional rearing to compromised cortical development," said Dr. John Krystal, Editor of Biological Psychiatry. "They suggest that society may have to choose between investing in enriching institutional environments and enhancing the capacity of these institutions to offer mental health support on the one hand and bearing the cost of ADHD and its impact on social and vocational productivity on the other."

McLaughlin agrees and added, "The early caregiving environment has lasting effects on brain development in children. Identifying strategies for mitigating these effects is critical for improving mental health and educational outcomes among children raised in deprived environments."

INFORMATION: The article is "Widespread Reductions in Cortical Thickness Following Severe Early-Life Deprivation: A Neurodevelopmental Pathway to Attention-Deficit/Hyperactivity Disorder" by Katie A. McLaughlin, Margaret A. Sheridan, Warren Winter, Nathan A. Fox, Charles H. Zeanah, and Charles A. Nelson (doi: 10.1016/j.biopsych.2013.08.016). The article appears in Biological Psychiatry, Volume 76, Issue 8 (October 15, 2014), published by Elsevier.

Notes for editors Full text of the article is available to credentialed journalists upon request; contact Rhiannon Bugno at +1 214 648 0880 or Biol.Psych@utsouthwestern.edu. Journalists wishing to interview the authors may contact Dr. Katie A. McLaughlin at +1 206 616 7863 or mclaughk@uw.edu.

The authors' affiliations, and disclosures of financial and conflicts of interests are available in the article.

John H. Krystal, M.D., is Chairman of the Department of Psychiatry at the Yale University School of Medicine, Chief of Psychiatry at Yale-New Haven Hospital, and a research psychiatrist at the VA Connecticut Healthcare System. His disclosures of financial and conflicts of interests are available here.

About Biological Psychiatry Biological Psychiatry is the official journal of the Society of Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal publishes both basic and clinical contributions from all disciplines and research areas relevant to the pathophysiology and treatment of major psychiatric disorders.

The journal publishes novel results of original research which represent an important new lead or significant impact on the field, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. Reviews and commentaries that focus on topics of current research and interest are also encouraged.

Biological Psychiatry is one of the most selective and highly cited journals in the field of psychiatric neuroscience. It is ranked 5th out of 135 Psychiatry titles and 14th out of 251 Neurosciences titles in the Journal Citations Reports® published by Thomson Reuters. The 2013 Impact Factor score for Biological Psychiatry is 9.472.

About Elsevier Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Elsevier Research Intelligence and ClinicalKey — and publishes nearly 2,200 journals, including The Lancet and Cell, and over 25,000 book titles, including a number of iconic reference works.

The company is part of Reed Elsevier Group PLC, a world-leading provider of professional information solutions in the Science, Medical, Legal and Risk and Business sectors, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).

ELSE PRESS RELEASES FROM THIS DATE:

New discovery will enhance yield and quality of cereal and bioenergy crops

2014-10-14

ST. LOUIS, MO – October 13, 2014 –A team of scientists led by Thomas Brutnell, Ph.D., director of the Enterprise Rent-A-Car Institute for Renewable Fuels at the Donald Danforth Plant Science Center have developed a new way of identifying genes that are important for photosynthesis in maize, and in rice. Their research helps to prioritize candidate genes that can be used for crop improvement and revealed new pathways and information about how plants fix carbon. The findings, published in "Comparative analyses of C4 and C3 photosynthesis in developing leaves of ...

Scientists link ALS progression to increased protein instability

2014-10-14

LA JOLLA, CA—October 13, 2014—A new study by scientists from The Scripps Research Institute (TSRI), Lawrence Berkeley National Laboratory (Berkeley Lab) and other institutions suggests a cause of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. "Our work supports a common theme whereby loss of protein stability leads to disease," said John A. Tainer, professor of structural biology at TSRI and senior scientist at Berkeley Lab, who shared senior authorship of the new research with TSRI Professor Elizabeth Getzoff. Getzoff, Tainer and ...

Taking infestation with a grain of salt

2014-10-14

Twenty years ago, biologists Kathy Boyer and Joy Zedler, then researchers at San Diego State University, speculated that too many insects feeding on cordgrass in the marshes of San Diego Bay could endanger the grass, and in turn endanger the bay wildlife that relies on it. Picking up where Boyer and Zedler left off, SDSU biologist Jeremy Long is currently further exploring the dimensions of this relationship. What he's found so far suggests that it's not a simple as saying too many insects spell death for a host plant. Instead, his research suggests a complex interplay ...

Fermented milk made by Lactococcus lactis H61 improves skin of healthy young women

2014-10-14

Philadelphia, PA, October 13, 2014 – There has been much interest in the potential for using probiotic bacteria for treating skin diseases and other disorders. Japanese researchers have now found that milk that has been fermented using a probiotic dairy starter can also benefit the skin of young healthy women, reports the Journal of Dairy Science®. Probiotics have been defined by the Food and Agriculture Organization-World Health Organization as "live microorganisms which, when administered in adequate amounts, confer a health benefit to the host." "Although ...

Study reveals how deadly MERS virus enters human cells

2014-10-14

ITHACA, N.Y. – Cornell University researchers have uncovered details of how the deadly Middle East respiratory syndrome coronavirus (MERS-CoV) enters host cells, and offer possible new avenues for treatment. The study, appearing online this month in the Proceedings of the National Academy of Sciences, discovered that a common protease enzyme known as furin activates the MERS-CoV to fuse with cell membranes and enter host cells. The researchers, Gary Whittaker, Cornell professor of virology, and Jean Millet, a postdoctoral associate in Whittaker's lab, suggest ...

Turtle tumors linked to excessive nitrogen from land-based pollution

2014-10-14

Hawai'i's sea turtles are afflicted with chronic and often lethal tumors caused by consuming non-native algae "superweeds" along coastlines where nutrient pollution is unchecked. The disease that causes these tumors is considered the leading cause of death in endangered green sea turtles. The new research was just published in the scientific journal PeerJ. Turtles that graze on blooms of invasive seaweeds end up with a diet that is rich in a particular amino acid, arginine, which promotes the virus that creates the tumors. Scientists at the University of Hawai'i at Mānoa ...

QUT study helps outdoor workers reduce their skin cancer risk

2014-10-14

Skin cancer is one of the biggest fears for one in two outdoor workers and when the boss and staff work together the sun safe message gets through, a QUT study has found. The study, which found more than 50 per cent of outdoor workers rated UV radiation exposure at work as one of their biggest concerns, also identified how a workplace intervention could improve workers' behaviours and attitudes towards sun protection to reduce their risk of skin cancer. QUT in collaboration with Cancer Council Queensland and Curtin University worked with 14 Queensland outdoor workplaces ...

Mediterranean diet, olive oil and nuts can help reverse metabolic syndrome

2014-10-14

For people with metabolic syndrome, a Mediterranean diet supplemented with extra-virgin olive oil or nuts may help reverse the condition, indicate findings from a clinical trial published in CMAJ (Canadian Medical Association Journal). About 25% of adults around the world have metabolic syndrome. The syndrome exists in the presence of three or more factors such as large waist circumference, high blood pressure, low HDL-cholesterol, high levels of triglycerides and high blood sugar concentrations that can increase the risk of diabetes, heart disease and death. Spanish ...

For one family, zebrafish help provide genetic answers

2014-10-14

Research in zebrafish has helped identify the cause of an unknown genetic disorder affecting a boy and two of his uncles, scientists report in an article published October 14 in the journal Genetics. The findings demonstrate the growing importance of zebrafish as laboratory models of rare diseases. Such models allow geneticists to make sense of the deluge of candidate disease genes being uncovered by advances in sequencing technologies. Although rare diseases are uncommon individually, together they affect as many as 25 million people in the United States. The project ...

Side effects of cancer prevention surgery can be helped with education program

2014-10-14

BOSTON –– More women are having ovary-removing surgery as a cancer prevention measure, but many are often unaware of sexual or psychological side effects of the procedure. A new study by researchers at Dana-Farber Cancer Institute shows a half-day educational program can help successfully deal with these issues by educating women on how to address them. The program taught women how to manage some of the physical and emotional difficulties that can follow ovary-removing surgery and helped many participants resume satisfying sexual activity and reduce feelings ...

Institutional rearing may increase risk attention-deficit disorder

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: