(Press-News.org) Chicago, October 29, 2014 – Aortic valve replacement (AVR) can safely be used to treat severe aortic stenosis in patients age 90 years and older and is associated with a low risk of operative stroke and mortality, according to a study in the November 2014 issue of The Annals of Thoracic Surgery.
Key points
Aortic valve replacement appears to be safe and effective for patients over age 90 years with severe aortic stenosis.
Four out of five (81.3%) patients were alive 1 year following AVR.
TAVR had similar rates of morbidity and mortality as traditional surgical AVR.
The elderly population in the US is steadily growing. From 2000 to 2010 alone, the Department of Health & Human Services Administration on Aging reports an increase of 1.3 million elderly people.
Takashi Murashita, MD, Kevin L. Greason, MD, and colleagues from Mayo Clinic in Rochester, Minn., reviewed the records of 59 patients who were at least 90 years of age (nonagenarians) and who underwent aortic valve replacement for severe aortic stenosis (narrowing of the aortic valve which obstructs blood flow from the heart).
"An increasing number of nonagenarian patients are willing to undergo AVR to improve both the quality and quantity of their life," said Dr. Murashita.
Among the patients in the study, surgical AVR (SAVR) was used in 33 (56%) and transcatheter AVR (TAVR; minimally invasive treatment for patients who can't undergo open heart surgery) was used in 26 (44%). Three patients died following AVR, including two patients who received SAVR and one who received TAVR. Survival at 1-year post-surgery was 81.3% with no significant difference between the two groups. Twenty-two patients (37.3%) had operative complications, which included acute renal failure and stroke.
Among patients in the SAVR group, five (21.7%) were discharged home compared with 12 patients (48%) in the TAVR group. The remaining 31 patients were all discharged to a skilled nursing home facility.
"We hope that, through our results, providers will understand that aortic valve replacement should not be denied in select symptomatic nonagenarian patients with severe aortic valve stenosis," said Dr. Greason. "Nearly 80% of our patients had significant heart failure symptoms prior to surgery and most experienced marked improvement following the operation."
Dr. Murashita added that, as TAVR becomes more widely available, an increasing number of nonagenarian patients may opt for the less invasive procedure.
INFORMATION:
Notes for editors
"Aortic Valve Replacement for Severe Aortic Valve Stenosis in the Nonagenarian Patient"
(10.1016/j.athoracsur.2014.06.015)The Annals of Thoracic Surgery published by Elsevier. http://www.sciencedirect.com/science/article/pii/S000349751401296X
Full text of the article is available to credentialed journalists upon request; contact Cassie McNulty cmcnulty@sts.org at +1 312 202 5865
About The Annals of Thoracic Surgery
The Annals of Thoracic Surgery is the official journal of the Society of Thoracic Surgeons (STS) and the Southern Thoracic Surgical Association. Founded in 1964, The Society of Thoracic Surgeons is a not-for-profit organization representing more than 6,800 cardiothoracic surgeons, researchers, and allied health care professionals worldwide who are dedicated to ensuring the best possible outcomes for surgeries of the heart, lung, and esophagus, as well as other surgical procedures within the chest. The Society's mission is to enhance the ability of cardiothoracic surgeons to provide the highest quality patient care through education, research, and advocacy.
About Elsevier
Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Elsevier Research Intelligence and ClinicalKey — and publishes nearly 2,200 journals, including The Lancet and Cell, and over 25,000 book titles, including a number of iconic reference works.
The company is part of Reed Elsevier Group PLC, a world-leading provider of professional information solutions in the Science, Medical, Legal and Risk and Business sectors, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).
Aortic valve replacement appears safe, effective in very elderly patients
New study published in The Annals of Thoracic Surgery
2014-10-29
ELSE PRESS RELEASES FROM THIS DATE:
Support for fecal testing in familial colorectal cancer screening
2014-10-29
Bethesda, MD (Oct. 29, 2014) — Fecal immunochemical tests (FIT) may be as effective as colonoscopies when it comes to detecting colorectal cancer among first-degree relatives of patients with colorectal cancer, according to a new study in Gastroenterology1, the official journal of the American Gastroenterological Association.
"In our study, repeat FIT screening detected all colorectal cancers in asymptomatic first-degree relatives of patients with colorectal cancer," said lead study authors Enrique Quintero, MD, PhD, and Marta Carrillo, MD, from Hospital Universitario ...
Georgia Tech releases 2015 Emerging Cyber Threats Report
2014-10-29
In its latest Emerging Cyber Threats Report, Georgia Tech warns about loss of privacy; abuse of trust between users and machines; attacks against the mobile ecosystem; rogue insiders; and the increasing involvement of cyberspace in nation-state conflicts.
Such topics are discussed at length in the annual report, which is published by the Georgia Tech Information Security Center (GTISC) and the Georgia Tech Research Institute (GTRI). The report will be released this week at the 12th Georgia Tech Cyber Security Summit (GT CSS), which has become the Atlanta IT community's ...
New technology shows promise for delivery of therapeutics to the brain
2014-10-29
A new technology that may assist in the treatment of brain cancer and other neurological diseases is the subject of an article in a recent issue of the journal Technology, published by World Scientific Publishing Company.
According to the authors, the current medical use of chemotherapy to treat brain cancer can be inefficient because of the blood-brain-barrier that impedes the delivery of drugs out of blood vessels and into the tumor.
The researchers from the Virginia Tech – Wake Forest University School of Biomedical Engineering and Sciences described in their ...
Smoke and haze over China
2014-10-29
Smoke and haze hang over a large portion of eastern China in this image captured by the Aqua satellite on October 29, 2014. China uses the method of "slash and burn" agriculture to rid their fields of leftover plants. Farmers often use fire to return nutrients to the soil and to clear the ground of unwanted plants. While fire helps enhance crops and grasses for pasture, the fires also produce smoke that degrades air quality as seen in this image.
The U.S. Consulate in Beijing records an air quality index of 226 for October 29 putting it in the "Very Unhealthy" region. ...
Microrockets fueled by water neutralize chemical and biological warfare agents
2014-10-29
With fears growing over chemical and biological weapons falling into the wrong hands, scientists are developing microrockets to fight back against these dangerous agents, should the need arise. In the journal ACS Nano, they describe new spherical micromotors that rapidly neutralize chemical and biological agents and use water as fuel.
Joseph Wang and colleagues point out that titanium dioxide is one of the most promising materials available for degrading chemical and biological warfare agents. It doesn't require harsh chemicals or result in toxic by-products. Current ...
Why plants don't get sunburn
2014-10-29
Plants rely on sunlight to make their food, but they also need protection from its harmful rays, just like humans do. Recently, scientists discovered a group of molecules in plants that shields them from sun damage. Now, in an article in the Journal of the American Chemical Society, one team reports on the mechanics of how these natural plant sunscreens work.
Timothy Zwier and colleagues at Purdue University note that the harsh ultraviolet radiation plants are exposed to daily can cause serious damage to plant DNA and, as a result, hinder plant growth. Biochemical tests ...
Scientists rank thousands of substances according to potential exposure level
2014-10-29
An overwhelming number of chemicals from household and industrial products are in the environment – and hundreds are in our bodies. But for most of them, scientists have yet to determine whether they cause health problems. Now they've taken the first step toward doing that by estimating which substances people are exposed to the most. Their new method is published in the ACS journal Environmental Science & Technology.
John F. Wambaugh and colleagues note that the risks to human health of any given substance depend primarily on two factors: the potential hazards ...
Nestling birds struggle in noisy environments
2014-10-29
WASHINGTON, D.C., October 29, 2014--Unable to fly, nestling birds depend on their parents for both food and protection: vocal communication between parents and offspring helps young birds to determine when they should beg for food and when they should crouch in the nest to avoid a predator seeking an easy meal.
A group of researchers from Dalhousie University in Halifax, Nova Scotia has found that ambient, anthropomorphic noise – from traffic, construction and other human activities – can break this vital communications link, leaving nestlings vulnerable ...
Integrins losing their grip lead to activation of T cell immune response
2014-10-29
Integrins are adhesion molecules expressed on the surface of cells. They play a crucial role in "integrating" the cell exterior and the interior cytoskeleton in cells. The beta2-integrin family members are highly expressed in dendritic cells that are very important in immune responses. Dendritic cells pick up antigens in inflamed tissues and move to lymph nodes where they present the antigen to T cells and activate them to help fight infection.
Dr Susanna Fagerholm's groups at the Institute of Biotechnology in Helsinki, Finland, and at the University of Dundee, UK, found ...
Planck 2013 results
2014-10-29
Astronomy & Astrophysics is publishing a special feature of 31 articles describing the data gathered by Planck over 15 months of observations and released by ESA and the Planck Collaboration in March 2013. This series of papers presents the initial scientific results extracted from this first Planck dataset.
The Planck satellite was launched in May 2009. With the highest accuracy to date, it measures the remnants of the radiation that filled the Universe immediately after the Big Bang. It is the oldest light in the Universe, emitted when it was 380000 years old. This ...
LAST 30 PRESS RELEASES:
Call for papers: 14th Asia-Pacific Conference on Transportation and the Environment (APTE 2025)
A novel disturbance rejection optimal guidance method for enhancing precision landing performance of reusable rockets
New scan method unveils lung function secrets
Searching for hidden medieval stories from the island of the Sagas
Breakthrough study reveals bumetanide treatment restores early social communication in fragile X syndrome mouse model
Neuroscience leader reveals oxytocin's crucial role beyond the 'love hormone' label
Twelve questions to ask your doctor for better brain health in the new year
Microelectronics Science Research Centers to lead charge on next-generation designs and prototypes
Study identifies genetic cause for yellow nail syndrome
New drug to prevent migraine may start working right away
Good news for people with MS: COVID-19 infection not tied to worsening symptoms
Department of Energy announces $179 million for Microelectronics Science Research Centers
Human-related activities continue to threaten global climate and productivity
Public shows greater acceptance of RSV vaccine as vaccine hesitancy appears to have plateaued
Unraveling the power and influence of language
Gene editing tool reduces Alzheimer’s plaque precursor in mice
TNF inhibitors prevent complications in kids with Crohn's disease, recommended as first-line therapies
Twisted Edison: Bright, elliptically polarized incandescent light
Structural cell protein also directly regulates gene transcription
Breaking boundaries: Researchers isolate quantum coherence in classical light systems
Brain map clarifies neuronal connectivity behind motor function
Researchers find compromised indoor air in homes following Marshall Fire
Months after Colorado's Marshall Fire, residents of surviving homes reported health symptoms, poor air quality
Identification of chemical constituents and blood-absorbed components of Shenqi Fuzheng extract based on UPLC-triple-TOF/MS technology
'Glass fences' hinder Japanese female faculty in international research, study finds
Vector winds forecast by numerical weather prediction models still in need of optimization
New research identifies key cellular mechanism driving Alzheimer’s disease
Trends in buprenorphine dispensing among adolescents and young adults in the US
Emergency department physicians vary widely in their likelihood of hospitalizing a patient, even within the same facility
Firearm and motor vehicle pediatric deaths— intersections of age, sex, race, and ethnicity
[Press-News.org] Aortic valve replacement appears safe, effective in very elderly patientsNew study published in The Annals of Thoracic Surgery