PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Reported link between early life exposure to paracetamol and asthma 'overstated'

Respiratory infections likely to have influential role; current evidence doesn't warrant change in guidance

2014-11-26
(Press-News.org) Respiratory infections are likely to have an influential role, the findings suggest. And the evidence is simply not strong enough to warrant changes to current guidance on the use of this medicine, say the researchers.

The use of paracetamol during pregnancy and/or a child's early life has been implicated in the development of childhood asthma, prompting concerns to be raised about the drug's continued use during these periods.

The researchers wanted to find out if the available evidence was sufficient to rule out the role of common respiratory infections, which paracetamol is often used to treat, and which are themselves risk factors for the development of asthma.

They therefore trawled research databases for published evidence, spanning a period from 1967 to 2013. Out of the 1192 potentially relevant studies, 11 were suitable for inclusion in the analysis.

The seven studies covering the potential link between exposure to paracetamol while in the womb and subsequent childhood asthma reached widely varying conclusions, and only one took account of the potential role of respiratory infections during pregnancy.

Six of the studies looked at exposure to paracetamol during the first two years of life--a critical period for lung development.

Although these studies consistently pointed to a link between the drug and the development of asthma, the association was considerably weakened after respiratory tract infections during infancy had been accounted for.

And while a link was found between the number of times a child had been given paracetamol and that child's asthma risk, this link all but disappeared when respiratory tract infections were taken into consideration, "making it unlikely that paracetamol is a clinically important risk factor asthma," write the authors.

It remains unclear what role, if any, maternal respiratory infection during pregnancy might have, as only one study took this into account.

A proper trial looking at the influence of paracetamol on the development of asthma is highly unlikely as it would require some babies to be given a dummy pill, which many parents would not be willing to do, say the authors.

All in all, the current evidence for a link between the drug's use and the development of asthma is "weak," they say.

And they conclude: "The evidence of an association between early life paracetamol and asthma is often overstated, and there is currently insufficient evidence to support changing guidelines in the use of this medicine."

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

The Lancet: Most comprehensive global study to date shows wide gulf in cancer survival between countries

2014-11-26
The most comprehensive international comparison of cancer survival to date, covering countries that are home to two-thirds of the world's population, shows extremely wide differences in survival between countries. The CONCORD-2 study, published in The Lancet, reports 5-year survival estimates for 25.7 million cancer patients diagnosed with one of 10 common cancers [1] and 75 000 children diagnosed with acute lymphoblastic leukaemia between 1995 and 2009, using individual patient data from 279 cancer registries in 67 countries [2]. Even after researchers had adjusted ...

The Lancet Oncology: Overweight and obesity linked to nearly 500,000 new cancers in 2012

2014-11-26
Excess body weight causes around 481 000 new cancer cases a year in adults--or 3.6% of cancers worldwide--new estimates published in The Lancet Oncology suggest. The burden is far higher in more developed countries, with almost two-thirds (64%) of these obesity-related cancers occurring in North America and Europe. Based on the results, the researchers led by Dr Melina Arnold from the International Agency for Research on Cancer (IARC), estimate that a quarter of all obesity-related cancers in 2012 (118 000 cases) were attributable to the rising average body mass index ...

Therapy found effective in older, African-American lung cancer patients

2014-11-26
CINCINNATI--University of Cincinnati (UC) researchers have found in a phase-2 clinical trial that a Food and Drug Administration-approved therapy could be effective in treating both older and African American patients with advanced lung cancer who may not be candidates for chemotherapy. These findings are published Nov. 25, 2014, in the online journal Clinical Medicine Insights: Oncology. Nagla Karim, MD, PhD, associate professor in the division of hematology oncology at the UC College of Medicine and member of the Cincinnati Cancer Center and the UC Cancer Institute, ...

Endangered Idaho salmon regaining fitness advantage

2014-11-25
Endangered Snake River sockeye salmon are regaining the fitness of their wild ancestors, with naturally spawned juvenile sockeye migrating to the ocean and returning as adults at a much higher rate than others released from hatcheries, according to a newly published analysis. The analysis indicates that the program to save the species has succeeded and is now increasingly shifting to rebuilding populations in the wild. Biologists believe the increased return rate of sockeye spawned naturally by hatchery-produced parents is high enough for the species to eventually sustain ...

Full-day preschool linked with increased school readiness compared with part-day

2014-11-25
Children who attended a full-day preschool program had higher scores on measures of school readiness skills (language, math, socio-emotional development, and physical health), increased attendance, and reduced chronic absences compared to children who attended part-day preschool, according to a study in the November 26 issue of JAMA. Participation in high-quality early childhood programs at ages 3 and 4 years is associated with greater school readiness and achievement, higher rates of educational attainment and socioeconomic status, and lower rates of crime. Although ...

Study examines FDA influence on design of pivotal drug studies

2014-11-25
An examination of the potential interaction between pharmaceutical companies and the U.S. Food and Drug Administration (FDA) to discuss future studies finds that one-quarter of recent new drug approvals occurred without any meeting, and when such meetings occurred, pharmaceutical companies did not comply with one-quarter of the recommendations made by the FDA regarding study design or primary outcome, according to a study in the November 26 issue of JAMA. To enhance protocol quality, federal regulations encourage but do not require meetings between pharmaceutical companies ...

Satellite views early Thanksgiving travel trouble areas in US

Satellite views early Thanksgiving travel trouble areas in US
2014-11-25
As the U.S. Thanksgiving holiday approaches this Thursday, November 27, NOAA's GOES-East and GOES-West satellites are keeping a weather eye out for storms that may affect early travelers. In an image from Nov. 25, the satellites show an active weather pattern is in place for travelers across the central and eastern U.S. NOAA's GOES-East satellite provides visible and infrared images over the eastern U.S. and the Atlantic Ocean, while NOAA's GOES-West satellite covers the western U.S. and Pacific Ocean from its fixed orbit in space. Data from both satellites were combined ...

New insights into breast cancer spread could yield better tests and treatments

2014-11-25
November 25, 2014--(BRONX, NY)--A study combining tumor cells from patients with breast cancer with a laboratory model of blood vessel lining provides the most compelling evidence so far that a specific trio of cells is required for the spread of breast cancer. The findings could lead to better tests for predicting whether a woman's breast cancer will spread and to new anti-cancer therapies. The study, led by researchers at the NCI-designated Albert Einstein Cancer Center and Montefiore Einstein Center for Cancer Care(MECCC), was published online today in Science Signaling. According ...

Penn researchers identify protein that predicts post-concussion severity in professional athletes

2014-11-25
PHILADELPHIA - New Penn Medicine research has found that elevated levels in the blood of the brain-enriched protein calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly after sports-related concussion can predict the severity of post-concussion symptoms in professional athletes. The complete findings were released today in the Journal of Neurotrauma. This new study builds on previous research from this group showing that elevated blood levels of SNTF on the day of a mild traumatic brain injury treated in the emergency room predicted those ...

Novel type 1 diabetes treatment shown to work on human beta cells transplanted into mice

Novel type 1 diabetes treatment shown to work on human beta cells transplanted into mice
2014-11-25
TORONTO, Nov. 29, 2014--A chemical produced in the pancreas that prevented and even reversed Type 1 diabetes in mice had the same effect on human beta cells transplanted into mice, new research has found. GABA, or gamma-aminobutryic acid, is an amino acid produced by the same beta cells that make and secrete insulin. Drs. Gerald Prud'homme and Qinghua Wang of the Keenan Research Centre for Biomedical Sciences of St. Michael's Hospital published a paper in 2011 showing for the first time that GABA injections not only prevented Type 1 diabetes in mice, but even reversed ...

LAST 30 PRESS RELEASES:

Lessons from Ascension’s shark troubles could help boost conservation

Fire provides long-lasting benefits to bird populations in Sierra Nevada National Parks

Menstrual cycle affects women’s reaction time but not as much as being active

Housing associations more effective than government in supporting unemployed in deprived areas

Biochar helps composting go greener by cutting greenhouse gas emissions

Ulrich named president-elect of the AACI

Multitasking makes you more likely to fall for phishing emails

Researchers solve model that can improve sustainable design, groundwater management, nuclear waste storage, and more

Parched soils can spark hot drought a nation away

Uncovering new physics in metals manufacturing

Sped-up evolution may help bacteria take hold in gut microbiome, UCLA-led research team finds

The dose-dependent effects of dissolved biochar on C. elegans: Insights into the physiological and transcriptomic responses

New research reveals genetic link to most common pediatric bone cancer

Research conducted during 2024 eclipse reveals importance of light on bird behavior

Why does female fertility decline so fast? The key is the ovary

Total solar eclipse triggers dawn behavior in birds

Europe’s largest bats hunt and eat migrating birds on the wing, high in the sky

China’s emerging AI regulation could foster an open and safe future for AI

The secret to naked mole-rat’s longevity: Enhanced DNA repair

Acidic tumor environment promotes survival and growth of cancer cells

New biosensor tracks plants’ immune hormone in real time

New study finds gaps in REDD+ forest carbon offsets with most overstating climate impacts

Mystery solved: How Europe’s largest bat catches and eats passerines mid-air

Pan-disease atlas maps molecular fingerprints of health, disease and aging

New clinical trial to target cancer’s elusive growth switch

Ochsner Health launches Genetic Wellness Assessment to identify cancer risks early

Researchers find potential link between chronic pain, immune condition

A study by UPF reveals discrimination on grounds of ethnic background in Spain’s leading online second-hand marketplace, especially when buying

Research examines the good, bad and ugly of true crime media

Research shows National Living Wage has reduced labor mobility across firms, but at what cost?

[Press-News.org] Reported link between early life exposure to paracetamol and asthma 'overstated'
Respiratory infections likely to have influential role; current evidence doesn't warrant change in guidance