"This is the first randomized, controlled clinical study that examines the effects of exercise on insulin sensitivity and other cardio and metabolic risk factors following bariatric surgery," said Bret Goodpaster, Ph.D., director of the Exercise Metabolism Core, senior investigator at the TRI-MD, and professor at Sanford-Burnham Medical Research Institute. "The data support the inclusion of an exercise program following bariatric surgery to further enhance the health of individuals who opt for surgery to lose weight."
Study Results The study, published in The Journal of Clinical Investigation, examined two groups of patients that had recently undergone Roux-en-Y bypass (RYGB) bariatric surgery. The first group participated in an education program after surgery and the second group participated in the education program plus an exercise program after surgery. The education program consisted of six sessions per month and included lectures, discussions, and demonstrations providing up-to-date information on topics such as medication use, nutrition, and upper-body stretching. The exercise group performed 120 minutes per week of exercise. A total of 119 participants completed the 24-week study.
Compared to the education group, the exercise group showed significant improvement in insulin sensitivity and glucose metabolism. Low insulin sensitivity and poor glucose metabolism can cause type 2 diabetes, and are associated with the risk of developing the disease. Both are common in pre-diabetes--a condition that means your blood-sugar level is higher than normal but not high enough to be classified as type 2 diabetes.
The exercise group also showed significantly improved cardiorespiratory fitness--a reference to the ability of the circulatory and respiratory system to supply oxygen to muscles during exercise. Cardiovascular fitness reduces the risk of heart disease, type 2 diabetes, lung cancer, and stroke, and is an effective predictor of future mortality.
Although both groups lost weight--approximately 50 lbs.--as a result of RYGB surgery, there were no differences in the total amount of weight loss between the two groups.
"Importantly, our study showed that aerobic exercise is feasible in this population--a result that directly counters the perception that severely obese individuals cannot respond to lifestyle interventions," said Goodpaster. "Moreover, we have identified specific, non-weight-related health benefits that exercise confers on these individuals. We look forward to additional studies to determine the optimal amount and type of exercise that produces the best physiological results."
Bariatric Surgery Bariatric surgery is a surgical procedure recommended by the U.S. National Institutes of Health (NIH) for clinically obese individuals that have a body mass index (BMI), a measurement based on height and weight, of 40.That translates to 294 pounds for someone who is six feet tall, and 218 pounds for someone who is five feet two. More than 200,000 individuals undergo bariatric surgery each year in the U.S.
The Roux-end-Y bypass (RYGB) gastric bypass surgery is the most commonly performed metabolic surgery in the U.S. The surgery involves taking a small part of the stomach to create a new stomach pouch, roughly the size of an egg. The smaller stomach is connected to the small intestine at a location that limits the amount of food you can eat and causes food to bypass the stomach and small intestine to reduce the amount of fat and calories you can absorb from food.
INFORMATION:
The study was performed in collaboration with the Division of Endocrinology and Metabolism, Department of Medicine, Department of Health and Physical Activity, and the Department of Surgery at the University of Pittsburgh, Pa., and the Department of Kinesiology, East Carolina University, Greenville, N.C.
This study was funded by the NIH/National Institute of Diabetes and Digestive Kidney Diseases (RO1 DK078192) and was registered at http://www.clinicaltris.gov (Trial ID NCT00692367).
About Sanford-Burnham Medical Research Institute
Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham takes a collaborative approach to medical research with major programs in cancer, neurodegeneration and stem cells, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is recognized for its National Cancer Institute-designated Cancer Center, its NIH-designated Neuroscience Center Cores, and expertise in drug discovery technologies. Sanford-Burnham is a nonprofit, independent institute that employs more than 1,100 scientists and staff in San Diego (La Jolla), Calif., and Orlando (Lake Nona), Fla. For more information, visit us at sanfordburnham.org.
Sanford-Burnham can also be found on Facebook at facebook.com/sanfordburnham and on Twitter @sanfordburnham.
About Florida Hospital
Opened in 1908, Florida Hospital is a faith-based institution focused on providing whole person care. It is one of the largest not-for-profit hospitals in the country, caring for more than a million patient visits per year - more than any other hospital in the country, according to the American Hospital Association. The more than 2,500-bed system is comprised of eight hospitals, including the Walt Disney Pavilion at Florida Hospital for Children, and dozens outpatient facilities and urgent care centers known as Centra Cares across the state.
With advanced research and industry partnerships, Florida Hospital seeks to extend and improve the quality of lives through the translation of fundamental scientific discoveries to the diagnosis and treatment of human disease.
About the Translational Research Institute for Metabolism and Diabetes
The TRI-MD is a joint venture between Florida Hospital and Sanford-Burnham Medical Research Institute that bridges the gap between discovery research and clinical care, with particular focus on diabetes and obesity. How exercise works, or why exercise is beneficial for health is not well understood, and how metabolism plays a role in obesity, diabetes, and cardiovascular disease remains unclear. Understanding these mechanisms require an interdisciplinary approach, hence the TRI-MD and this Florida Hospital and Sanford-Burnham Medical Research Institute collaboration.
