Hydrazine is not a prevalent contaminant in smokeless tobacco products
After many years of speculation, it has finally been established that hydrazine is not a prevalent contaminant in contemporary smokeless tobacco products (STPs).
The presence of hydrazine has only been reported once in a limited sample of cigarette tobacco and tobacco smoke some 40 years ago1. But this study has been cited many times as evidence that hydrazine is present in smokeless tobacco products. To date, no one has examined STPs for its presence.
Hydrazine is found in maleic hydrazine, which is used as a sucker growth inhibitor on tobacco crops - suckers are side shoots, which if not removed affect the quality and yield of the tobacco plant. Hydrazine is classified as a possible human carcinogen by the International Agency for Research on Cancer, which can have negative effects on the central nervous system, liver and kidneys.
Hydrazine is on the list of the FDA's "Harmful and Potentially Harmful Constituents" HPHC list, which is why there is a public health interest in the compound and to what degree it occurs in tobacco
Scientists at British American Tobacco, in collaboration with Professor Brad Rodu of the University of Louisville, undertook a comprehensive survey of toxicants in STPs. They developed and carefully validated a highly sensitive method for determining levels of hydrazine in STPs2.
This method involves first treating aqueous extracts of STPs with pentafluorobenzaldehyde, which reacts with hydrazine to form decafluorobenzaldehydeazine (DFBA). The DFBA is then quantified by gas chromatography-mass spectrometry to determine hydrazine levels. This method was validated using five different types of STPs. The researchers used the validated method to analyse hydrazine content in a wide range of commercial STPs from the USA and Sweden. The product types included in the survey were snus, chewing tobacco, moist snuff, dry snuff, plug and pellet products, representing 90% market share of the major STP categories.
None of the STPs were found to contain hydrazine above the current limits for detection ( END
The presence of hydrazine has only been reported once in a limited sample of cigarette tobacco and tobacco smoke some 40 years ago1. But this study has been cited many times as evidence that hydrazine is present in smokeless tobacco products. To date, no one has examined STPs for its presence.
Hydrazine is found in maleic hydrazine, which is used as a sucker growth inhibitor on tobacco crops - suckers are side shoots, which if not removed affect the quality and yield of the tobacco plant. Hydrazine is classified as a possible human carcinogen by the International Agency for Research on Cancer, which can have negative effects on the central nervous system, liver and kidneys.
Hydrazine is on the list of the FDA's "Harmful and Potentially Harmful Constituents" HPHC list, which is why there is a public health interest in the compound and to what degree it occurs in tobacco
Scientists at British American Tobacco, in collaboration with Professor Brad Rodu of the University of Louisville, undertook a comprehensive survey of toxicants in STPs. They developed and carefully validated a highly sensitive method for determining levels of hydrazine in STPs2.
This method involves first treating aqueous extracts of STPs with pentafluorobenzaldehyde, which reacts with hydrazine to form decafluorobenzaldehydeazine (DFBA). The DFBA is then quantified by gas chromatography-mass spectrometry to determine hydrazine levels. This method was validated using five different types of STPs. The researchers used the validated method to analyse hydrazine content in a wide range of commercial STPs from the USA and Sweden. The product types included in the survey were snus, chewing tobacco, moist snuff, dry snuff, plug and pellet products, representing 90% market share of the major STP categories.
None of the STPs were found to contain hydrazine above the current limits for detection ( END