(Press-News.org) NEW YORK, NY - March 13, 2015 - Data from a meta-analysis published today in The Lancet found that extended duration dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation was associated with significantly higher rates of mortality compared to shorter DAPT.
The optimal duration of DAPT has been a matter of debate since the introduction of DES. A meta-analysis using multiple analytical approaches to investigate mortality and other clinical outcomes with different DAPT strategies was conducted.
Researchers examined 31,666 patients from 10 randomized trials comparing different durations of DAPT in patients treated with DES. The primary endpoint was all-cause mortality. Secondary pre-specified endpoints included cardiac death, non-cardiac death, myocardial infarction (MI), stroke, stent thrombosis (definite or probable), major bleeding, and any bleeding. DAPT duration was categorized in each study as "shorter" vs. "longer," and ?6 months vs. 1 year vs. ?1 year. Analyses were performed by both frequentist and Bayesian approaches.
Shorter DAPT was associated with significantly lower rates of all-cause mortality compared to longer DAPT (HR=0.82, 95% CI 0.69-0.98, p=0.02; number needed to treat [NNT] =325). This difference was driven by a significant reduction of non-cardiac mortality with shorter DAPT (HR=0.67, 95% CI 0.51-0.89, p=0.006; NNT=347). No significant difference in cardiac mortality was found between the shorter and longer strategies (HR=0.93, 95% CI 0.73-1.17, p=0.52). No significant heterogeneity across trials or between pooled trials stratified by DAPT duration was apparent.
Shorter DAPT was also associated with significantly lower rates of major bleeding (HR=0.58, 95% CI 0.47-0.72, p END
Meta-analysis finds extended DAPT related to increased mortality after DES implantation
Findings published in The Lancet
2015-03-17
ELSE PRESS RELEASES FROM THIS DATE:
Findings from the BRIGHT trial published in JAMA
2015-03-17
NEW YORK, NY - March 16, 2015 - Data from the BRIGHT trial published today in the Journal of the American Medical Association demonstrated that bivalirudin was superior to both heparin monotherapy and heparin plus tirofiban for patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Findings were first reported at last year's Transcatheter Cardiovascular Therapeutics (TCT), the annual scientific symposium of the Cardiovascular Research Foundation (CRF).
There has been recent controversy surrounding the optimal anticoagulant ...
What's on the menu for young African sawflies?
2015-03-17
Sawflies belong to the same insect group as wasps, bees and ants. Unlike many of the latter, sawflies seldom make themselves conspicuous to humans, although the young stages (larvae) of some species, nearly all of which feed on plants, sometimes attract attention by damaging these.
In a reversal of the pattern found in most insect groups, a larger number of sawfly species occur in regions with a cooler climate, rather than in the tropics. On the other hand, many of the sawflies found in Africa south of the Sahara (the Afrotropical faunal region) belong to genera that ...
Heart valve repair improves emotional wellbeing in patients with mitral regurgitation
2015-03-17
Chicago, March 17, 2015 - Patients with severe mitral regurgitation (MR) often suffer from psycho-emotional symptoms, such as depression and anxiety, but after undergoing mitral valve repair surgery patients experience a marked improvement in emotional and physical wellbeing, according to an article in the March 2015 issue of The Annals of Thoracic Surgery.
Key points
Patients with severe mitral regurgitation, who had suffered from anxiety and post-traumatic stress symptoms prior to mitral valve surgery, experienced a marked improvement in emotional and physical ...
By land and by sea: Scientists find differences in tanning treatments for materials
2015-03-17
Cod liver oil and willow bark extract used in the tanning of skins for clothing and other products offer notable differences in treatment, a study by a team of scientists shows. Their findings show the promise of a technique that may be used to identify the aging behavior of materials and to examine delicate works of art.
The research, which appears in the journal Analytical Chemistry, relies on a method employing nuclear magnetic resonance spectroscopy, or NMR spectroscopy, which reveals the physical and chemical properties of atoms in a given substance, as well as the ...
Spherical nucleic acids set stage for new paradigm in drug development
2015-03-17
A research team led by Northwestern University nanomedicine expert Chad A. Mirkin and Sergei Gryaznov of AuraSense Therapeutics is the first to show spherical nucleic acids (SNAs) can be used as potent drugs to effectively train the immune system to fight disease, by either boosting or dampening the immune response. The initial treatment triggers a cell-specific immune response all over the body.
By increasing the body's immune response toward a specific cell type, SNAs could be used to target anything from influenza to different forms of cancer. They also can be used ...
Study finds imaging tool to diagnose heart conditions is more accurate and safer
2015-03-17
New heart imaging technology to diagnose coronary heart disease and other heart disorders is significantly more accurate, less expensive and safer than traditional methods, according to a new study by researchers from the Intermountain Medical Center Heart Institute in Salt Lake City.
Researchers at the Intermountain Medical Center Heart Institute compared Single Photon Emission Computed Tomography (SPECT), currently the most commonly used imaging diagnostic tool, with a new imaging technology -- coronary-specific Positron Emission Tomography (cardiac PET/CT).
They ...
Researchers rethink how our feathered friends evolved
2015-03-17
A recently published global genome study that used the data-intensive Gordon supercomputer at the San Diego Supercomputer at the University of California, San Diego, has researchers rethinking how avian lineages diverged after the extinction of the dinosaurs.
The four-year project, called the Avian Genome Consortium and published in the journal Science, resulted in a new family "tree" for nearly all of the 10,000 species of birds alive today by comparing the entire DNA codes (genomes) of 48 species as varied as parrot, penguin, downy woodpecker, and Anna's hummingbird. ...
Complete angioplasty safe for certain heart attack survivors
2015-03-17
SAN DIEGO (March 16, 2015) -- Patients who experience the deadliest form of heart attack--ST segment elevation myocardial infarction (STEMI)--and suffer from substantial narrowing in multiple heart arteries may benefit from receiving angioplasty in constricted arteries not affected by the heart attack, thereby reducing the need for future angioplasty, according to research presented at the American College of Cardiology's 64th Annual Scientific Session.
The study is the largest prospective, controlled trial to evaluate whether patients should receive preventive angioplasty, ...
Health system factors improve medication adherence among seniors with diabetes
2015-03-17
OAKLAND, Calif. -- Specific system-level factors controlled by health care systems - including prescriptions with a medication supply greater than 90 days, mail-order pharmacy use, and lower copayments and out-of-pocket maximums - nearly doubled the likelihood that patients adhered to prescribed heart and diabetes medications, according to a new study published in the journal Medical Care.
"This study is the first to look at all four of these system-level factors at once in the senior population," said Julie A. Schmittdiel, PhD, research scientist with the Kaiser Permanente ...
New study: Food TV a recipe for weight gain
2015-03-17
If you're a fan of food television, it's fine to be entertained by the programming, but if you take recipes for the rich meals the networks favor into your own kitchen, you're at risk of putting on pounds, according to a study just published online by the journal Appetite.
"The message is clear," said Lizzy Pope of the University of Vermont, the study's lead author. "Food TV should be a viewing experience only, not a cooking experience."
The study asked 501 women, aged 20 to 35, where they obtained information about new foods, how frequently they cooked from scratch, ...
LAST 30 PRESS RELEASES:
Printed skin to replace animal testing
Precision medicine could be possible in the fight against antibiotic resistance
Researchers at the Lewis Katz School of Medicine at Temple University identify new targeted approach to protect neurons against degeneration
Western diet causes inflammation, traditional African food protects
Electrochemical method supports nitrogen circular economy
How researchers are shining a light on kidney disease
Some gut bacteria could make certain drugs less effective
PEPITEM sequence shows effects in psoriasis, comparable to steroid cream
Older teens who start vaping post-high school risk rapid progress to frequent use
Corpse flowers are threatened by spotty recordkeeping
Riding the AI wave toward rapid, precise ocean simulations
Are lifetimes of big appliances really shrinking?
Pink skies
Monkeys are world’s best yodellers - new research
Key differences between visual- and memory-led Alzheimer’s discovered
% weight loss targets in obesity management – is this the wrong objective?
An app can change how you see yourself at work
NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals
New research shows that propaganda is on the rise in China
Even the richest Americans face shorter lifespans than their European counterparts, study finds
Novel genes linked to rare childhood diarrhea
New computer model reveals how Bronze Age Scandinavians could have crossed the sea
Novel point-of-care technology delivers accurate HIV results in minutes
Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others
Study finds nearly five-fold increase in hospitalizations for common cause of stroke
Study reveals how alcohol abuse damages cognition
Medicinal cannabis is linked to long-term benefits in health-related quality of life
Microplastics detected in cat placentas and fetuses during early pregnancy
Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming
Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly
[Press-News.org] Meta-analysis finds extended DAPT related to increased mortality after DES implantationFindings published in The Lancet