Contact Information:

Media Contact

Melissa Di Costanzo
DiCostanzoM@smh.ca
416-860-6060 x6537

Twitter: StMikesHospital

http://www.stmichaelshospital.com/




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.
PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Study may explain low blood oxygen for cystic fibrosis patients with infected lungs


2015-03-18
(Press-News.org) TORONTO, March 18, 2015--Researchers have defined a new bodily process in mice that may explain why blood oxygen levels are lower for patients with cystic fibrosis when they get a lung infection.

"Infected areas of the lung are not as capable as healthy tissue at adding oxygen to the bloodstream, but no one has shown why this is the case," said Dr. Wolfgang Kuebler, a scientist in the Keenan Research Centre for Biomedical Science of St. Michael's Hospital. "We've shown that the protein produced by a gene known as CFTR is required to direct blood flow away from infected areas in the lung so that oxygen can reach the bloodstream."

In cystic fibrosis patients, the CFTR gene is mutated and doesn't work. Blood flowing to infected areas of the lung is not re-routed by the CFTR protein, resulting in impaired blood oxygenation.

Certain infections may inhibit the CFTR protein even in patients without cystic fibrosis.

"Our findings indicate that strategies aimed at restoring or activating the CFTR protein in patients with lung infection, particularly those with cystic fibrosis, might help improve blood oxygen levels and improve circulation," said Dr. Kuebler, who is also co-director of the Critical Illness and Injury Research Centre of St. Michael's.

The study was published in the journal Proceedings of the National Academy of Sciences.

INFORMATION:

The project was supported by a Canadian Institutes of Health Research open operating grant, by German Research Foundation grants and by the Intramural Research Program of the National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases grant.

About St. Michael's Hospital St Michael's Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future health care professionals in more than 23 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, care of the homeless and global health are among the hospital's recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Centre, which make up the Li Ka Shing Knowledge Institute, research and education at St. Michael's Hospital are recognized and make an impact around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto.


ELSE PRESS RELEASES FROM THIS DATE:

Electronic waste has energy value

2015-03-18
This news release is available in Spanish. Using discarded electronic boards, the UPV/EHU researcher Andoni Salbidegoitia has, in collaboration with international researchers, developed a system for obtaining clean hydrogen that can be used as fuel. The researchers have already registered the patent of the process in Japan. The Chemical Technologies for Environmental Sustainability (TQSA) Group of the Department of Chemical Engineering of the UPV/EHU's Faculty of Science and Technology is aiming to make use of discarded plastic as effectively as possible from the ...

Bats are surprisingly fast decision makers

Bats are surprisingly fast decision makers
2015-03-18
Bats are not as stereotyped when they hunt as previously believed. New research shows that these flying mammals are capable of making ultra-fast decisions about how to attack their prey - or maybe even call off the attack. It takes only milliseconds. Bats use echolocation for orientation. They emit ultrasonic sounds, which hit potential prey nearby, sending an echo back to the bat. From this echo the bat can define where the prey is and attack it. A new study has examined how hunting bats react when approaching their prey. The study concludes that bats are capable of ...

World's first method for continuous purification of valuable antibodies

Worlds first method for continuous purification of valuable antibodies
2015-03-18
Imagine a loved relative suffering from cancer - and you could not afford a treatment because the drugs are too expensive. The Austrian Centre of Industrial Biotechnology (acib) developed a method with the power to reduce production costs of highly valued drugs significantly. Without antibodies we would be at the mercy of pathogens or cancer cells. Therapeutic antibodies are used as passive vaccines, for cancer therapy or for controlling autoimmune diseases such as multiple sclerosis. According to "bccresearch.com" the global market for antibody drugs was worth nearly ...

An improved method for coating gold nanorods

2015-03-18
Researchers have fine-tuned a technique for coating gold nanorods with silica shells, allowing engineers to create large quantities of the nanorods and giving them more control over the thickness of the shell. Gold nanorods are being investigated for use in a wide variety of biomedical applications, and this advance paves the way for more stable gold nanorods and for chemically functionalizing the surface of the shells. Gold nanorods have a lot of potential applications, because they have a surface plasmon resonance - meaning they can absorb and scatter light. And by ...

A speech-based system for the early detection of Alzheimer's disease

2015-03-18
This news release is available in Spanish. Alzheimer's disease is the most significant cause of dementia in the elderly: it affects over 35 million people worldwide. It is reckoned that Alzheimer's could reach epidemic proportions in developed countries unless therapies to cure or prevent it are obtained. Studies conducted so far reveal that the therapies are more effective when they are applied before the brain has become severely damaged. What is more, the spotting of early phases of the disease may help to develop new treatments. Right now, to make a clinical diagnosis ...

New molecular tool assesses vaginal microbiome health, diagnoses infections -- fast

2015-03-18
A new microarray-based tool, called VaginArray, offers the potential to provide a fast, reliable and low-cost assessment of vaginal health and diagnoses of infections. The research is published ahead of print March 2, in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology. The VaginArray has 17 probe sets, each one specific for one of the most representative bacterial species inhabiting the vaginal ecosystem, including those associated with both healthy and unhealthy conditions. Each probe set is designed to be complementary to the ...

Iron rain fell on early Earth, new Z machine data supports

Iron rain fell on early Earth, new Z machine data supports
2015-03-18
ALBUQUERQUE, N.M. -- Researchers at Sandia National Laboratories' Z machine have helped untangle a long-standing mystery of astrophysics: why iron is found spattered throughout Earth's mantle, the roughly 2,000-mile thick region between Earth's core and its crust. At first blush, it seemed more reasonable that iron arriving from collisions between Earth and planetesimals -- ranging from several meters to hundreds of kilometers in diameter -- during Earth's late formative stages should have powered bullet-like directly to Earth's core, where so much iron already exists. A ...

An antihypertensive drug improves corticosteroid-based skin treatments

2015-03-18
This news release is available in French. Basic research on blood pressure has led researchers from Inserm (Inserm Unit 1138, "Cordeliers Research Centre") to obtain unexpected results: drugs used to treat hypertension (high blood pressure) reduce side effects from corticosteroid-based creams used to treat certain skin diseases. This work is published in the Journal of Investigative Dermatology. Corticosteroid-based dermatological creams are indicated for the symptomatic treatment of inflammatory skin conditions, such as atopic dermatitis and psoriasis, for example. ...

17-million-year-old whale fossil provides first exact date for East Africa's puzzling uplift

17-million-year-old whale fossil provides first exact date for East Africas puzzling uplift
2015-03-18
Uplift associated with the Great Rift Valley of East Africa and the environmental changes it produced have puzzled scientists for decades because the timing and starting elevation have been poorly constrained. Now paleontologists have tapped a fossil from the most precisely dated beaked whale in the world -- and the only stranded whale ever found so far inland on the African continent -- to pinpoint for the first time a date when East Africa's mysterious elevation began. The 17 million-year-old fossil is from the beaked Ziphiidae whale family. It was discovered 740 ...

30 years after C60: Fullerene chemistry with silicon

30 years after C60: Fullerene chemistry with silicon
2015-03-18
This news release is available in German. FRANKFURT. The discovery of the soccer ball-shaped C60 molecule in 1985 was a milestone for the development of nanotechnology. In parallel with the fast-blooming field of research into carbon fullerenes, researchers have spent a long time trying in vain to create structurally similar silicon cages. Goethe University chemists have now managed to synthesise a compound featuring an Si20 dodecahedron. The Platonic solid, which was published in the "Angewandte Chemie" journal, is not just aesthetically pleasing, it also opens ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Study may explain low blood oxygen for cystic fibrosis patients with infected lungs
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.