New in the Hastings Center Report April 2015
The Structure of Clinical Translation: Efficiency, Information, and Ethics Jonathan Kimmelman and Alex John London The so-called drug pipeline is widely regarded as being rife with waste and inefficiency. To reduce these problems, the authors propose the first explicit model of clinical translation. They conclude that any attempt to improve clinical translation will require a shift in perception--recognizing that the principal output is not only new drugs, vaccines, devices, and diagnostics but also information. Key information is whether the translation process furnishes clinicians with what they need to know to treat patients who differ from the participants in drug trials. Jonathan Kimmelman is associate professor of biomedical ethics at McGill University. Alex John London is a professor of philosophy and the director of the Center for Ethics and Policy at Carnegie Mellon University.
Men and Abortion Decisions John Hardwig The male sexual partner often has no voice in the decision about whether to go forward with a pregnancy, and the standard view in bioethics is that he ought not to have. But the author disagrees, arguing that this position is based exclusively on the limited experience of pregnancy itself and not on the enduring role of parenting. Because "the burden of an unplanned pregnancy or even of an unavoidable childbirth . . . is only a small part of the burden of being a parent, then it is no longer clear why the decision about having a child should be [the woman's] alone," writes the author, a professor emeritus of philosophy at the University of Tennessee, Knoxville.
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Also in this issue:
Case Study: Temporizing after Spinal Cord Injury
Mr. C is a twenty-two-year-old who was flown to a trauma center after diving headfirst into shallow water. At the scene, he had been conscious but was paralyzed. The emergency medical services team intubated him for airway protection before transport. Mr. C expressed a desire for extubation, but it was not clear that he had the capacity to make this (or any other) decision. What does it mean to respect his autonomy?
Commentaries are by Rebecca L. Volpe and Joshua S. Crites of Pennsylvania State College of Medicine, and Kristi L. Kirschner, University of Illinois at Chicago.
At Law: World Health Organization Reform: Lessons Learned from the Ebola Epidemic
Lawrence O. Gostin
Ebola represents an infection point requiring fundamental reform for the World Health Organization. A failure of leadership will impact its status and legitimacy for a generation. Lawrence O. Gostin offers five reforms that would transform it and ensure that it fulfills its constitutional missions as "the directing and coordinating authority on international health work." Gostin is University Professor and faculty director of the O'Neill Institute for National and Global Health Law at Georgetown University. He directs the World Health Organization Collaborating Center on Public Health Law and Human Rights.