(Press-News.org) COLUMBUS, Ohio - It's estimated that six out of 1,000 children worldwide are affected by autism spectrum disorder (ASD), and 50 percent demonstrate serious and disruptive behavior, including tantrums, aggression, self-injury and noncompliance.
For children with ASD, serious disruptive behavior interrupts daily functioning and social skills development, limits their ability to benefit from education and speech therapy, can increase social isolation and intensify caregiver stress.
Luc Lecavalier and his team of researchers from The Ohio State University Wexner Medical Center conducted a 24-week parent training study designed to effectively reduce serious behavioral problems in young children with ASD.
The study, the largest randomized, multi-center trial to evaluate behavioral interventions for ASD, appears today in the Journal of the American Medical Association.
"The results are overwhelmingly in favor of parent training when it comes to managing disruptive and noncompliant behavior in young children with ASD. We thought the outcomes would send a clear message, but we didn't expect the tremendous number of parents who responded so positively," said Lecavalier, professor of psychology and psychiatry and principal investigator at Ohio State's Nisonger Center.
Researchers randomly assigned 180 children (ages 3-7) with ASD to parent training or parent education programs. Programming included 11 sessions of one-on-one therapy, brief coaching and intervention and homework.
Parent education was designed to control for time and therapist attention and provided useful information about ASD without providing specific techniques to reduce the disruptive behaviors. While parent ratings of child behavior improved in both groups, the parent training program showed behavior problems were reduced by almost half, compared to roughly 30 percent for those in the parent education group.
In addition, a clinician who was blind to treatment assignment reported 70 percent of children with ASD in the parent training group showed a positive response, compared to 40 percent for parent education. Also, 79 percent of children who showed positive response to parent training intervention at week 24 maintained improvement six months post treatment.
Lecavalier said parent training is an exportable treatment for young children with ASD that could be implemented across a wide range of settings, such as clinics and schools. He believes results of the study may inform policy discussions.
"Parents of young children with ASD face many unknowns and we're hopeful that our study's results will empower other parents to seek efficient methods to manage serious disruptive behavior," Lecavalier said.
INFORMATION:
Researchers from the Marcus Autism Center at Emory University, University of Rochester, Indiana University, University of Pittsburgh and Yale University also participated in the study.
The National Institute of Mental Health supported the research.
In a small study that included seven children and teens with Wiskott-Aldrich syndrome, a rare immunodeficiency disorder, use of gene therapy resulted in clinical improvement in infectious complications, severe eczema, and symptoms of autoimmunity, according to a study in the April 21 issue of JAMA, a theme issue on child health.
Wiskott-Aldrich syndrome (WAS) is caused by loss-of-function mutations in the WAS gene. The condition is characterized by thrombocytopenia (low platelet count), eczema, and recurring infections. In the absence of definitive treatment, patients ...
In a study that included approximately 95,000 children with older siblings, receipt of the measles-mumps-rubella (MMR) vaccine was not associated with an increased risk of autism spectrum disorders (ASD), regardless of whether older siblings had ASD, findings that indicate no harmful association between receipt of MMR vaccine and ASD even among children already at higher risk for ASD, according to a study in the April 21 issue of JAMA, a theme issue on child health.
Although a substantial body of research over the last 15 years has found no link between the MMR vaccine ...
A 24 week parent training program, which provided specific techniques to manage disruptive behaviors of children with autism spectrum disorder, resulted in a greater reduction in disruptive and noncompliant behavior compared to parent education, according to a study in the April 21 issue of JAMA, a theme issue on child health.
Autism spectrum disorder (ASD) affects an estimated 6 per 1,000 children worldwide and is a major public health challenge. As many as 50 percent of children with ASD exhibit behavioral problems, including tantrums, noncompliance, aggression, and ...
In a pilot study that included children at high risk for type 1 diabetes, daily high-dose oral insulin, compared with placebo, resulted in an immune response to insulin without hypoglycemia, findings that support the need for a phase 3 trial to determine whether oral insulin can prevent islet autoimmunity and diabetes in high-risk children, according to a study in the April 21 issue of JAMA, a theme issue on child health.
A few specific proteins are often the trigger for immune responses that cause autoimmune diseases. This has led to the experimental use of antigenspecific ...
The incidence of a potentially life-threatening complication of diabetes, diabetic ketoacidosis, in youth in Colorado at the time of diagnosis of type 1 diabetes increased by 55 percent between 1998 and 2012, suggesting a growing number of youth may experience delays in diagnosis and treatment, according to a study in the April 21 issue of JAMA, a theme issue on child health.
Diabetic ketoacidosis (DKA) at the time of type 1 diabetes (T1D) diagnosis has detrimental long-term effects and is characterized by dangerously high blood sugar and the presence of substances in ...
A multi-site study sponsored by the National Institute of Mental Health (NIMH) finds young children with autism spectrum disorder and serious behavioral problems respond positively to a 24-week structured parent training. The benefits of parent training endured for up to six months post intervention.
Published in the April 21 issue of the Journal of the American Medical Association the study found parent training was more effective in reducing disruptive and aggressive behavior than 24 weeks of parent education. Parent training provided parents with specific strategies ...
Researchers from the University of Tokyo have revamped an old e-paper concept to make an inexpensive handwriting-enabled e-paper well suited to large displays like whiteboards. They describe the e-paper in the Journal of Applied Physics, from AIP Publishing.
Traditional ink and paper is convenient for both reading and writing. In e-paper development the writing feature has generally lagged behind. Handwriting-enabled displays mainly show up in the inexpensive, but feature-limited realm of children's toys, and in the high-end realm of touch-screen e-readers and smart ...
French teams from CIC Biothérapie (AP-HP/Inserm), from pediatric hematology department of Necker Hospital for Children (AP-HP), led by Marina Cavazzana, Salima Hacein Bey Albina and Alain Fischer and from Genethon led by Anne Galy (Genethon/Inserm UMR-S951), and English teams from UCL Institute of Child Health and Great Ormond Street Hospital in London led by Adrian Thrasher and Bobby Gaspar demonstrated the efficacy of gene therapy treatment for Wiskott-Aldrich Syndrome (WAS). Six children that were treated and followed for at least 9 months had their immune system ...
BOULDER, Colo. -- In another advance at the far
frontiers of timekeeping by National Institute of
Standards and Technology (NIST) researchers, the
latest modification of a record-setting strontium atomic
clock has achieved precision and stability levels that
now mean the clock would neither gain nor lose one
second in some 15 billion years*--roughly the age of
the universe.
Precision timekeeping has broad potential
impacts on advanced communications, positioning technologies (such as GPS) and many
other technologies. Besides keeping future technologies on schedule, ...
Scientists from the DFG Center for Regenerative Therapies Dresden, TU Dresden and the Institut für Diabetesforschung, Helmholtz Zentrum München, together with researchers from Vienna, Bristol and Denver (USA) have successfully completed the first step in development of an insulin vaccine to prevent type 1 diabetes.
As reported by these diabetes researchers in the current edition of the renowned scientific journal JAMA, evaluations of the international Pre-POINT study point to a positive immune response in persons at risk for the disease who were given oral doses ...